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Wanyi Tai
Medical School
Wuhan University
Hubei
Language: Chinese, English
Sirna
Chemical Modification
Delivery
Lipophilicity
Targeting
Hydrophobicity
Stability
Biocompatibility
Liposomes
Exosomes
Areas of Focus
- Pharmaceutics
- Antibody Engineering
- Biopharmaceutical Drug Delivery
Work Experience
- 2012.09 - 2013.11 Postdoctoral Researcher, Department of Biomedical Engineering, University of North Carolina at Chapel Hill
- 2013.12 - 2018.12 Postdoctoral Researcher, Department of Bioengineering, University of Washington
- 2019.02 - 2020.11 Distinguished Research Fellow, School of Pharmaceutical Sciences, Wuhan University
- 2020.12 - present Professor, School of Pharmaceutical Sciences, Wuhan University
Academic Background & Achievements
- 2000.09 - 2004.07 Bachelor in Traditional Chinese Pharmacy, China Pharmaceutical University
- 2004.09 - 2007.07 Master in Medicinal Chemistry, Shanghai Institute of Materia Medica, Chinese Academy of Sciences
- 2007.08 - 2012.08 PhD in Pharmaceutics, University of Missouri-Kansas City
Publications
- Insight into the siRNA transmembrane delivery — from cholesterol conjugating to tagging., Yan Zheng, Wanyi Tai*, 2019
- Current aspects of siRNA bioconjugate for in vitro and in vivo delivery., Wanyi Tai*, 2019
- Chemical Modulation of siRNA lipophilicity for efficient delivery., Wanyi Tai*, 2019
- Cytosolic delivery of proteins by cholesterol tagging., Wanyi Tai#, Pengfei Zhao#, Xiaohu Gao*, 2020
- Silencing ribonucleoprotein: a biomimetic platform for targeted siRNA delivery., Wanyi Tai, Xiaohu Gao*, 2019
- Synthetic polymer tag for intracellular delivery of siRNA., Wanyi Tai, Xiaohu Gao*, 2018
- A ribonucleoprotein octamer for targeted siRNA delivery., Wanyi Tai, Junwei Li, Eva Corey, Xiaohu Gao*, 2018
- Noncovalent tagging of siRNA with steroids for transmembrane delivery., Wanyi Tai, Xiaohu Gao*, 2018
- Functional peptides for siRNA delivery., Wanyi Tai, Xiaohu Gao*, 2017
- Bio-inspired nanovesicles for glucose-responsive release of insulin., Wanyi Tai, Ran Mo, Jin Di, Vinayak Subramanian, Xiao Gu, Zhen Gu*, 2014
- Folding graft copolymer with pendant drug segment for co-delivery of anticancer drugs., Wanyi Tai#, Ran Mo#, Yue Lu, Tianyue Jiang, Zhen Gu*, 2014
- A novel rapamycin-polymer conjugate based on a new poly(ethylene glycol) multiblock copolymer., Wanyi Tai, Zhijin Chen, Kun Cheng*, 2014
- Expression profile and functional activity of peptide transporters in prostate cancer cells., Wanyi Tai, Zhijin Chen, Kun Cheng*, 2013
- Development of a peptide-drug conjugate for prostate cancer therapy., Wanyi Tai, Ravi S. Shukla, Bin Qin, Benyi Li, Kun Cheng*, 2011
- Design, synthesis, and biological evaluation of ring‐opened bengamide analogues., Wan-Yi Tai#, Run-Tao Zhang#, Yi-Ming Ma, Min Gu, Gang Liu, Jia Li, Fa-Jun Nan*, 2011
- The role of HER2 in cancer therapy and targeted drug delivery., Wanyi Tai, Rubi Mahato, Kun Cheng*, 2010
- Inhibition of breast cancer cell growth and invasiveness by dual silencing of HER-2 and VEGF., Wanyi Tai, Bin Qin, Kun Cheng*, 2010
- Design, synthesis, and biological evaluation of caprolactam-modified bengamide analogues., Gang Liu#, Yi-Ming Ma#, Wan-Yi Tai#, Chuan-Ming Xie, Yu-Lin Li, Jia Li and Fa-Jun Nan*, 2008
