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台万一
Medical School
武汉大学
湖北省
Language: 中文, 英语
Sirna
化学修饰
递送
亲脂性
靶向
疏水性
稳定性
生物相容性
脂质体
外泌体
Areas of Focus
- 药剂学
- 抗体工程
- 生物大分子药物递送
Work Experience
- 2012.09 - 2013.11 美国北卡罗来纳大学教堂山分校生物医学工程系，博士后
- 2013.12 - 2018.12 美国华盛顿大学生物工程系，博士后
- 2019.02 - 2020.11 武汉大学药学院，特聘研究员
- 2020.12 - 现在 武汉大学药学院，教授
Academic Background & Achievements
- 2000.09 - 2004.07 中国药科大学，中药药剂学学士
- 2004.09 - 2007.07 中国科学院上海药物研究所，药物化学硕士
- 2007.08 - 2012.08 美国密苏里大学堪萨斯城分校，药剂学博士
Publications
- Insight into the siRNA transmembrane delivery — from cholesterol conjugating to tagging., Yan Zheng, Wanyi Tai*, 2019
- Current aspects of siRNA bioconjugate for in vitro and in vivo delivery., Wanyi Tai*, 2019
- Chemical Modulation of siRNA lipophilicity for efficient delivery., Wanyi Tai*, 2019
- Cytosolic delivery of proteins by cholesterol tagging., Wanyi Tai#, Pengfei Zhao#, Xiaohu Gao*, 2020
- Silencing ribonucleoprotein: a biomimetic platform for targeted siRNA delivery., Wanyi Tai, Xiaohu Gao*, 2019
- Synthetic polymer tag for intracellular delivery of siRNA., Wanyi Tai, Xiaohu Gao*, 2018
- A ribonucleoprotein octamer for targeted siRNA delivery., Wanyi Tai, Junwei Li, Eva Corey, Xiaohu Gao*, 2018
- Noncovalent tagging of siRNA with steroids for transmembrane delivery., Wanyi Tai, Xiaohu Gao*, 2018
- Functional peptides for siRNA delivery., Wanyi Tai, Xiaohu Gao*, 2017
- Bio-inspired nanovesicles for glucose-responsive release of insulin., Wanyi Tai, Ran Mo, Jin Di, Vinayak Subramanian, Xiao Gu, Zhen Gu*, 2014
- Folding graft copolymer with pendant drug segment for co-delivery of anticancer drugs., Wanyi Tai#, Ran Mo#, Yue Lu, Tianyue Jiang, Zhen Gu*, 2014
- A novel rapamycin-polymer conjugate based on a new poly(ethylene glycol) multiblock copolymer., Wanyi Tai, Zhijin Chen, Kun Cheng*, 2014
- Expression profile and functional activity of peptide transporters in prostate cancer cells., Wanyi Tai, Zhijin Chen, Kun Cheng*, 2013
- Development of a peptide-drug conjugate for prostate cancer therapy., Wanyi Tai, Ravi S. Shukla, Bin Qin, Benyi Li, Kun Cheng*, 2011
- Design, synthesis, and biological evaluation of ring‐opened bengamide analogues., Wan-Yi Tai#, Run-Tao Zhang#, Yi-Ming Ma, Min Gu, Gang Liu, Jia Li, Fa-Jun Nan*, 2011
- The role of HER2 in cancer therapy and targeted drug delivery., Wanyi Tai, Rubi Mahato, Kun Cheng*, 2010
- Inhibition of breast cancer cell growth and invasiveness by dual silencing of HER-2 and VEGF., Wanyi Tai, Bin Qin, Kun Cheng*, 2010
- Design, synthesis, and biological evaluation of caprolactam-modified bengamide analogues., Gang Liu#, Yi-Ming Ma#, Wan-Yi Tai#, Chuan-Ming Xie, Yu-Lin Li, Jia Li and Fa-Jun Nan*, 2008
