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Hongliang Li
Medical School
Wuhan University
Hubei
Language: English, Chinese
Cardiometabolic
Disease
Mechanisms
Prevention
Gene
Knockout
Transgenic
Animal
Models
Development
Areas of Focus
- Cardiometabolic disease mechanisms and prevention
- Development of gene knockout and transgenic animal models
Work Experience
- 2005.07-2006.02 Postdoctoral Researcher, Peking Union Medical College
- 2006.02-2006.11 Postdoctoral Researcher, Harvard Medical School
- 2006.11-2008.11 Postdoctoral Researcher, University of Toronto
- 2008.11-present Professor, First Clinical College of Wuhan University
- 2009-present Director, Hubei Provincial Model Animal Research Center
- 2013-2020 Director, Model Animal Research Center of Wuhan University
- 2015-2020 Director, Animal Experiment Center/ABSL- III Laboratory of Wuhan University
- 2016-2020 Director, Model Animal Research Institute of Wuhan University
- 2017-2020 Dean, Basic Medical College of Wuhan University
Academic Background & Achievements
- 1994-1999 Bachelor of Clinical Medicine, Guangdong Medical College
- 1999-2002 Master of Pharmacology, Jinan University
- 2002-2005 PhD in Biochemistry and Molecular Biology, Peking Union Medical College
- Received 6 National Natural Science Foundation of China grants
- Published over 200 international journal articles
Publications
- The E3 Ligase TRIM16 Is a Key Suppressor of Pathological Cardiac Hypertrophy, Li H et al., 2022
- N-acetylgalactosaminyltransferase-4 protects against hepatic ischemia/reperfusion injury by blocking apoptosis signal-regulating kinase 1 N-terminal dimerization, Li H et al., 2022
- Nonalcoholic Fatty Liver Disease: An Emerging Driver of Cardiac Arrhythmia, Li H et al., 2021
- Pharmacological inhibition of arachidonate 12-lipoxygenase ameliorates myocardial ischemia-reperfusion injury in multiple species, Li H et al., 2021
- TMBIM1 is an inhibitor of adipogenesis and its depletion promotes adipocyte hyperplasia and improves obesity-related metabolic disease, Li H et al., 2021
- A kinome screen reveals that Nemo-like kinase is a key suppressor of hepatic gluconeogenesis, Li H et al., 2021
- The Neutrophil-to-Lymphocyte Ratio Determines Clinical Efficacy of Corticosteroid Therapy in Patients with COVID-19, Li H et al., 2021
- Global Burden of Disease Study 2019 suggests that metabolic risk factors are the leading drivers of the burden of ischemic heart disease, Li H et al., 2021
- In-Hospital Use of Statins Is Associated with a Reduced Risk of Mortality among Individuals with COVID-19, Li H et al., 2020
- Low-Dose Sorafenib Acts as a Mitochondrial Uncoupler and Ameliorates Nonalcoholic Steatohepatitis, Li H et al., 2020
- Association of Blood Glucose Control and Outcomes in Patients with COVID-19 and Pre-existing Type 2 Diabetes, Li H et al., 2020
- Longitudinal association between markers of liver injury and mortality in COVID-19 in China, Li H et al., 2020
- Association of Inpatient Use of Angiotensin Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers with Mortality Among Patients With Hypertension Hospitalized With COVID-19, Li H et al., 2020
- Unexpected Rapid Increase in the Burden of Nonalcoholic Fatty Liver Disease in China From 2008 to 2018: A Systematic Review and Meta-Analysis, Li H et al., 2019
- Innate Immune Signaling in Nonalcoholic Fatty Liver Disease and Cardiovascular Diseases, Li H et al., 2019
- An ALOX12–12-HETE–GPR31 signaling axis is a key mediator of hepatic ischemia-reperfusion injury, Li H et al.
- The deubiquitinating enzyme TNFAIP3 mediates inactivation of hepatic ASK1 and ameliorates nonalcoholic steatohepatitis, Li H et al., 2018
- Restoration of Circulating MFGE8 (Milk Fat Globule-EGF Factor 8) Attenuates Cardiac Hypertrophy Through Inhibition of Akt Pathway, Li H et al., 2017
- Insights into innate immune signaling in controlling cardiac remodeling, Li H et al., 2017
- A long non-coding RNA defines an epigenetic check point for cardiac hypertrophy, Li H et al., 2016
Awards
- 2016 Hubei Province Science and Technology Progress First Prize: Development and Application of Gene Engineered Mouse Models of Cardio-Cerebrovascular Metabolic Diseases
- 2013 Hubei Province Science and Technology Progress First Prize: Pathogenesis and Clinical Prevention of Myocardial Remodeling
- 2011 National Science and Technology Progress Second Prize: Structural and Neural Remodeling Basis of Arrhythmia and its Clinical Prevention
