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Mingchang Li
Medical School
Wuhan University
Hubei
Language: Chinese, English
Microsurgery
Interventional Treatment
Cerebrovascular Diseases
Neuroprotection
Hemorrhagic Transformation
Cerebral Infarction
Clinical Research
Basic Research
Hemorrhagic Cerebrovascular
Stroke
Areas of Focus
- Microsurgery and interventional treatment of various complex cerebrovascular diseases
- Neuroprotection in hemorrhagic transformation of cerebral infarction
- Clinical and basic research on hemorrhagic cerebrovascular diseases
Work Experience
- 1996-1998 Resident Surgeon, Xiaogan Central Hospital, Hubei
- 2004-2006 Attending Neurosurgeon, Second Affiliated Hospital of Guangzhou Medical University
- 2006-2012 Associate Chief Physician in Neurosurgery, Second Affiliated Hospital of Guangzhou Medical University
- 2012-2015 Chief Physician and Associate Professor in Neurosurgery, Renmin Hospital of Wuhan University
- 2015-present Chief Physician and Professor in Neurosurgery, Renmin Hospital of Wuhan University
Academic Background & Achievements
- 1991-1996 Bachelor of Clinical Medicine, Wuhan University
- 1998-2001 Master of Surgery, Tongji Medical College, Huazhong University of Science and Technology
- 2001-2004 PhD in Neurosurgery, Sun Yat-sen University Medical School
- Lead 4 national natural science foundation projects, published over 90 papers
Publications
- Netrin-1 Alleviates Early Brain Injury by Regulating Ferroptosis via the PPARγ/Nrf2/GPX4 Signaling Pathway Following Subarachnoid Hemorrhage, Chen J, Wang Y, Li M, Zhu X, Liu Z, Chen Q, Xiong K, 2023
- Genetic modification of miR-34a enhances efficacy of transplanted human dental pulp stem cells after ischemic stroke, Wang J, He P, Tian Q, Luo Y, He Y, Liu C, Gong P, Guo Y, Ye Q, Li M, 2023
- Histone tyrosine sulfation by SULT1B1 regulates H4R3me2a and gene transcription, Yu W, Zhou R, Li N, Lei ZC, Guo D, Peng F, Li Y, Bai X, Feng S, Wang Y, He J, Yin S, Zeng X, He L, Gao Y, Li M, Guo YR, Liu K, Wang Y, 2023
- The mechanism and relevant mediators associated with neuronal apoptosis and potential therapeutic targets in subarachnoid hemorrhage, Tian Q, Liu S, Han SM, Zhang W, Qin XY, Chen JH, Liu CL, Guo YJ, Li MC, 2023
- Blocking P2RX7 Attenuates Ferroptosis in Endothelium and Reduces HG-induced Hemorrhagic Transformation After MCAO by Inhibiting ERK1/2 and P53 Signaling Pathways, Liu C, Tian Q, Wang J, He P, Han S, Guo Y, Yang C, Wang G, Wei H, Li M, 2023
- MSC based gene delivery methods and strategies improve the therapeutic efficacy of neurological diseases, Zhou H, He Y, Xiong W, Jing S, Duan X, Huang Z, Nahal GS, Peng Y, Li M, Zhu Y, Ye Q, 2022
- Taurine attenuates neuronal ferroptosis by regulating GABAB/AKT/GSK3β/β-catenin pathway after subarachnoid hemorrhage, Liu C, He P, Guo Y, Tian Q, Wang J, Wang G, Zhang Z, Li M, 2022
- Inhibition of CCR2 attenuates neuroinflammation and neuronal apoptosis after subarachnoid hemorrhage through the PI3K/Akt pathway, Tian Q, Guo Y, Feng S, Liu C, He P, Wang J, Han W, Yang C, Zhang Z, Li M, 2022
- Molecular mechanisms of neuronal death in brain injury after subarachnoid hemorrhage, Chen J, Li M, Liu Z, Wang Y, Xiong K, 2022
- Dental pulp stem cell transplantation facilitates neuronal neuroprotection following cerebral ischemic stroke, Gong P, Tian Q, He Y, He P, Wang J, Guo Y, Ye Q, Li M, 2022
- Diabetes or calcium channel blocker contribute to cerebral hemodynamics after bypass surgery in adult patients with moyamoya disease, Han S, Cai L, Tian Q, Wei H, Wang G, Wang J, He P, Liao J, Zhang S, Chen Q, Li M, 2023
- A web-based dynamic nomogram for rupture risk of posterior communicating artery aneurysms utilizing clinical, morphological, and hemodynamic characteristics, Wei H, Han W, Tian Q, Yao K, He P, Wang J, Guo Y, Chen Q, Li M, 2022
- Andrographolide Attenuates Blood-Brain Barrier Disruption, Neuronal Apoptosis, and Oxidative Stress Through Activation of Nrf2/HO-1 Signaling Pathway in Subarachnoid Hemorrhage, Gong P, Zhang W, Zou C, Han S, Tian Q, Wang J, He P, Guo Y, Li M, 2022
- Different Hemodynamic Characteristics and Resulting in Different Risks of Rupture Between Wide-Neck and Narrow-Neck Aneurysms, Wei H, Tian Q, Yao K, Wang J, He P, Guo Y, Han W, Gao W, Li M, 2022
- The eIF4A Inhibitor Silvestrol Blocks the Growth of Human Glioblastoma Cells by Inhibiting AKT/mTOR and ERK1/2 Signaling Pathway, Zhang W, Gong P, Tian Q, Han S, Wang J, He P, Guo Y, Wang G, Chen Q, Huang J, Li M, 2022
- Efficacy and safety of embolization for arteriovenous malformations of the basal ganglia and thalamus via the transarterial approach, Zhang W, Heng Wei, Qi Tian, Shoumeng Han, Wenrui Han, Yujia Guo, Guijun Wang, Shenqi Zhang, Gang Deng, Junming Wang, Qianxue Chen, Li M, 2022
Awards
- 2018 Wang Zhongcheng China Neurosurgery Physician Annual Youth Physician Award
- 2021 Second Prize, Hubei Province Science and Technology Progress Award for 'Molecular Mechanisms of Neuroprotection and Precision Treatment for Stroke'
