Professor | Liu Yun | Asia Growth Partners

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Name	Liu Yun
Contact Information	nyliu39@fudan.edu.cn
Language ability	English, Chinese
Province	Shanghai

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Name

Liu Yun

Contact Information

nyliu39@fudan.edu.cn

Language ability

English, Chinese

Province

Shanghai

University/Lab Affiliation and Title	Fudan University
Faculty	Basic Medical Sciences
Academic Background & Achievements	2003/09-2009/09 Ph.D.: Johns Hopkins University, School of Medicine, Department of Molecular Biology and Genetics 2007/09-2009/09 M.S.: Johns Hopkins University, School of Public Health, Department of Biostatistics 1999/09-2003/07 B.S.: Fudan University, School of Life Sciences
Work Experience	2014/06-Present - Fudan University - Researcher, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences 2009/10-2014/05 - Johns Hopkins University - Postdoctoral Fellow, Epigenetics Center, School of Medicine
Awards	2020: Shanghai Outstanding Academic Leader (Youth) 2014: National High-Level Talent Program

University/Lab Affiliation and Title

Fudan University

Faculty

Basic Medical Sciences

Academic Background & Achievements

2003/09-2009/09 Ph.D.: Johns Hopkins University, School of Medicine, Department of Molecular Biology and Genetics
2007/09-2009/09 M.S.: Johns Hopkins University, School of Public Health, Department of Biostatistics
1999/09-2003/07 B.S.: Fudan University, School of Life Sciences

Work Experience

2014/06-Present - Fudan University - Researcher, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences
2009/10-2014/05 - Johns Hopkins University - Postdoctoral Fellow, Epigenetics Center, School of Medicine

Awards

2020: Shanghai Outstanding Academic Leader (Youth)
2014: National High-Level Talent Program

Areas of Focus	Mechanisms of DNA methylation in common human diseases and cancer Clinical application of DNA methylation as molecular markers in precision medicine
Publications	Genotype-dependent epigenetic regulation of DLGAP2 in alcohol use and dependence, Meng, W., Sjöholm, LK., Kononenko, O., Tay, N., Zhang, D., Sarkisyan, D., Geske, JR., Ing, A., Qiu, W., Watanabe, H., Almamoun, R., Frieling, H., Bleich, S., Cui, D., Biernacka, JM., Mayfield, RD., Dang, Y., Karpyak, VM., Schumann, G.; IMAGEN Consortium, Bakalkin, G., Ekström, TJ., Rüegg, J., Liu, Y., 2021 Determination of local chromatin interactions using a combined CRISPR and peroxidase APEX2 system, Qiu, W., Xu, Z., Zhang, M., Zhang, D., Fan, H., Li, T., Wang, Q., Liu, P., Zhu, Z., Du, D., Tan, M., Wen, B., Liu, Y., 2019 Allele-Specific Methylation of SPDEF: A Novel Moderator of Psychosocial Stress and Substance Abuse, Tay N, Macare C, Liu Y, Ruggeri B, Jia T, Chu C, Biondo F, Ing A, Luo Q, Sarkysian D, Banaschewski T, Barker GJ, Bokde ALW, Bromberg U, Büchel C, Quinlan EB, Desrivières S, Flor H, Frouin V, Garavan H, Gowland P, Heinz A, Ittermann B, Martinot JL, Artiges E, Nees F, Orfanos DP, Paus T, Poustka L, Hohmann S, Fröhner JH, Smolka MN, Walter H, Whelan R, Frieling H, Bleich S, Barker ED, Syvänen AC, Rüegg J, Ekström TJ, Bakalkin G, Schumann G.; IMAGEN Consortium, 2019 DNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in multiple sclerosis, Kular L, Liu Y, Ruhrmann S, Zheleznyakova G, Marabita F, Gomez-Cabrero D, James T, Ewing E, Lindén M, Górnikiewicz B, Aeinehband S, Stridh P, Link J, Andlauer TFM, Gasperi C, Wiendl H, Zipp F, Gold R, Tackenberg B, Weber F, Hemmer B, Strauch K, Heilmann-Heimbach S, Rawal R, Schminke U, Schmidt CO, Kacprowski T, Franke A, Laudes M, Dilthey AT, Celius EG, Søndergaard HB, Tegnér J, Harbo HF, Oturai AB, Olafsson S, Eggertsson HP, Halldorsson BV, Hjaltason H, Olafsson E, Jonsdottir I, Stefansson K, Olsson T, Piehl F, Ekström TJ, Kockum I, Feinberg AP, Jagodic M., 2018 DNA hypomethylation of a transcription factor binding site within the promoter of a gout risk gene NRBP1 upregulates its expression by inhibition of TFAP2A binding, Zhu, Z., Meng, W., Liu, P., Zhu, X., Liu, Y., Zou, H., 2017 DNA methylation mediates genotype and smoking interaction in the development of anti-citrullinated peptide antibody-positive rheumatoid arthritis, Meng, W., Zhu, Z., Jiang, X., Too, CL., Uebe, S., Jagodic, M., Kockum, I., Murad, S., Ferrucci, L., Alfredsson, L., Zou, H., Klareskog, L., Feinberg, AP., Ekström, TJ., Padyukov, L., Liu, Y., 2017 Oestrogen receptor β regulates epigenetic patterns at specific genomic loci through interaction with thymine DNA glycosylase, Liu, Y., Duong, W., Krawczyk, C., Bretschneider, N., Borbely, G., Varshney, M., Zinser, C., Schar, P., Ruegg, J., 2016 GeMes: Clusters of DNA methylation under genetic control can inform genetic and epigenetic analysis of disease, Liu, Y., Li, X., Aryee, MJ., Ekstrom, TJ., Padyukov, L., Klareskog, L., Vandiver, A., Moore, AZ., Tanaka, T., Ferrucci, L., Fallin, MD., Feinberg, AP., 2014 Epigenome-wide association data implicate DNA methylation as an intermediary of generic risk in Rheumatoid Arthritis, Liu, Y., Aryee, MJ., Padyukov, L., Fallin, MD., Hesselberg, E., Runarsson, A., Reinius, L., Acevedo, N., Taub, M., Ronninger, M., Shchetynsky, K., Scheynius, A., Kere, J., Alfredsson, L., Klareskog, L., Ekstrom, TJ., Feinberg, AP., 2013 A Plant Homeodomain in RAG-2 that Binds Hypermethylated Lysine 4 of Histone H3 is Necessary For Efficient Antigen-Receptor-Gene Rearrangement, Liu, Y., Subrahmanyam, R., Chakraborty, T., Sen, R. and Desiderio, S., 2007

Areas of Focus

Mechanisms of DNA methylation in common human diseases and cancer
Clinical application of DNA methylation as molecular markers in precision medicine

Publications

Genotype-dependent epigenetic regulation of DLGAP2 in alcohol use and dependence, Meng, W., Sjöholm, LK., Kononenko, O., Tay, N., Zhang, D., Sarkisyan, D., Geske, JR., Ing, A., Qiu, W., Watanabe, H., Almamoun, R., Frieling, H., Bleich, S., Cui, D., Biernacka, JM., Mayfield, RD., Dang, Y., Karpyak, VM., Schumann, G.; IMAGEN Consortium, Bakalkin, G., Ekström, TJ., Rüegg, J., Liu, Y., 2021
Determination of local chromatin interactions using a combined CRISPR and peroxidase APEX2 system, Qiu, W., Xu, Z., Zhang, M., Zhang, D., Fan, H., Li, T., Wang, Q., Liu, P., Zhu, Z., Du, D., Tan, M., Wen, B., Liu, Y., 2019
Allele-Specific Methylation of SPDEF: A Novel Moderator of Psychosocial Stress and Substance Abuse, Tay N, Macare C, Liu Y, Ruggeri B, Jia T, Chu C, Biondo F, Ing A, Luo Q, Sarkysian D, Banaschewski T, Barker GJ, Bokde ALW, Bromberg U, Büchel C, Quinlan EB, Desrivières S, Flor H, Frouin V, Garavan H, Gowland P, Heinz A, Ittermann B, Martinot JL, Artiges E, Nees F, Orfanos DP, Paus T, Poustka L, Hohmann S, Fröhner JH, Smolka MN, Walter H, Whelan R, Frieling H, Bleich S, Barker ED, Syvänen AC, Rüegg J, Ekström TJ, Bakalkin G, Schumann G.; IMAGEN Consortium, 2019
DNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in multiple sclerosis, Kular L, Liu Y, Ruhrmann S, Zheleznyakova G, Marabita F, Gomez-Cabrero D, James T, Ewing E, Lindén M, Górnikiewicz B, Aeinehband S, Stridh P, Link J, Andlauer TFM, Gasperi C, Wiendl H, Zipp F, Gold R, Tackenberg B, Weber F, Hemmer B, Strauch K, Heilmann-Heimbach S, Rawal R, Schminke U, Schmidt CO, Kacprowski T, Franke A, Laudes M, Dilthey AT, Celius EG, Søndergaard HB, Tegnér J, Harbo HF, Oturai AB, Olafsson S, Eggertsson HP, Halldorsson BV, Hjaltason H, Olafsson E, Jonsdottir I, Stefansson K, Olsson T, Piehl F, Ekström TJ, Kockum I, Feinberg AP, Jagodic M., 2018
DNA hypomethylation of a transcription factor binding site within the promoter of a gout risk gene NRBP1 upregulates its expression by inhibition of TFAP2A binding, Zhu, Z., Meng, W., Liu, P., Zhu, X., Liu, Y., Zou, H., 2017
DNA methylation mediates genotype and smoking interaction in the development of anti-citrullinated peptide antibody-positive rheumatoid arthritis, Meng, W., Zhu, Z., Jiang, X., Too, CL., Uebe, S., Jagodic, M., Kockum, I., Murad, S., Ferrucci, L., Alfredsson, L., Zou, H., Klareskog, L., Feinberg, AP., Ekström, TJ., Padyukov, L., Liu, Y., 2017
Oestrogen receptor β regulates epigenetic patterns at specific genomic loci through interaction with thymine DNA glycosylase, Liu, Y., Duong, W., Krawczyk, C., Bretschneider, N., Borbely, G., Varshney, M., Zinser, C., Schar, P., Ruegg, J., 2016
GeMes: Clusters of DNA methylation under genetic control can inform genetic and epigenetic analysis of disease, Liu, Y., Li, X., Aryee, MJ., Ekstrom, TJ., Padyukov, L., Klareskog, L., Vandiver, A., Moore, AZ., Tanaka, T., Ferrucci, L., Fallin, MD., Feinberg, AP., 2014
Epigenome-wide association data implicate DNA methylation as an intermediary of generic risk in Rheumatoid Arthritis, Liu, Y., Aryee, MJ., Padyukov, L., Fallin, MD., Hesselberg, E., Runarsson, A., Reinius, L., Acevedo, N., Taub, M., Ronninger, M., Shchetynsky, K., Scheynius, A., Kere, J., Alfredsson, L., Klareskog, L., Ekstrom, TJ., Feinberg, AP., 2013
A Plant Homeodomain in RAG-2 that Binds Hypermethylated Lysine 4 of Histone H3 is Necessary For Efficient Antigen-Receptor-Gene Rearrangement, Liu, Y., Subrahmanyam, R., Chakraborty, T., Sen, R. and Desiderio, S., 2007

Dna Methylation Human Diseases Cancer Molecular Markers Precision Medicine Epigenetics Clinical Application Biomarkers Genetics Disease Mechanisms

Yan Sun - Peking University

Genze Shao - Peking University

Yang Chen - Peking University

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