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Liu Yun
Basic Medical Sciences
Fudan University
Shanghai
Language: English, Chinese
Dna Methylation
Human Diseases
Cancer
Molecular Markers
Precision Medicine
Epigenetics
Clinical Application
Biomarkers
Genetics
Disease Mechanisms
Areas of Focus
- Mechanisms of DNA methylation in common human diseases and cancer
- Clinical application of DNA methylation as molecular markers in precision medicine
Work Experience
- 2014/06-Present - Fudan University - Researcher, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences
- 2009/10-2014/05 - Johns Hopkins University - Postdoctoral Fellow, Epigenetics Center, School of Medicine
Academic Background & Achievements
- 2003/09-2009/09 Ph.D.: Johns Hopkins University, School of Medicine, Department of Molecular Biology and Genetics
- 2007/09-2009/09 M.S.: Johns Hopkins University, School of Public Health, Department of Biostatistics
- 1999/09-2003/07 B.S.: Fudan University, School of Life Sciences
Publications
- Genotype-dependent epigenetic regulation of DLGAP2 in alcohol use and dependence, Meng, W., Sjöholm, LK., Kononenko, O., Tay, N., Zhang, D., Sarkisyan, D., Geske, JR., Ing, A., Qiu, W., Watanabe, H., Almamoun, R., Frieling, H., Bleich, S., Cui, D., Biernacka, JM., Mayfield, RD., Dang, Y., Karpyak, VM., Schumann, G.; IMAGEN Consortium, Bakalkin, G., Ekström, TJ., Rüegg, J., Liu, Y., 2021
- Determination of local chromatin interactions using a combined CRISPR and peroxidase APEX2 system, Qiu, W., Xu, Z., Zhang, M., Zhang, D., Fan, H., Li, T., Wang, Q., Liu, P., Zhu, Z., Du, D., Tan, M., Wen, B., Liu, Y., 2019
- Allele-Specific Methylation of SPDEF: A Novel Moderator of Psychosocial Stress and Substance Abuse, Tay N, Macare C, Liu Y, Ruggeri B, Jia T, Chu C, Biondo F, Ing A, Luo Q, Sarkysian D, Banaschewski T, Barker GJ, Bokde ALW, Bromberg U, Büchel C, Quinlan EB, Desrivières S, Flor H, Frouin V, Garavan H, Gowland P, Heinz A, Ittermann B, Martinot JL, Artiges E, Nees F, Orfanos DP, Paus T, Poustka L, Hohmann S, Fröhner JH, Smolka MN, Walter H, Whelan R, Frieling H, Bleich S, Barker ED, Syvänen AC, Rüegg J, Ekström TJ, Bakalkin G, Schumann G.; IMAGEN Consortium, 2019
- DNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in multiple sclerosis, Kular L, Liu Y, Ruhrmann S, Zheleznyakova G, Marabita F, Gomez-Cabrero D, James T, Ewing E, Lindén M, Górnikiewicz B, Aeinehband S, Stridh P, Link J, Andlauer TFM, Gasperi C, Wiendl H, Zipp F, Gold R, Tackenberg B, Weber F, Hemmer B, Strauch K, Heilmann-Heimbach S, Rawal R, Schminke U, Schmidt CO, Kacprowski T, Franke A, Laudes M, Dilthey AT, Celius EG, Søndergaard HB, Tegnér J, Harbo HF, Oturai AB, Olafsson S, Eggertsson HP, Halldorsson BV, Hjaltason H, Olafsson E, Jonsdottir I, Stefansson K, Olsson T, Piehl F, Ekström TJ, Kockum I, Feinberg AP, Jagodic M., 2018
- DNA hypomethylation of a transcription factor binding site within the promoter of a gout risk gene NRBP1 upregulates its expression by inhibition of TFAP2A binding, Zhu, Z., Meng, W., Liu, P., Zhu, X., Liu, Y., Zou, H., 2017
- DNA methylation mediates genotype and smoking interaction in the development of anti-citrullinated peptide antibody-positive rheumatoid arthritis, Meng, W., Zhu, Z., Jiang, X., Too, CL., Uebe, S., Jagodic, M., Kockum, I., Murad, S., Ferrucci, L., Alfredsson, L., Zou, H., Klareskog, L., Feinberg, AP., Ekström, TJ., Padyukov, L., Liu, Y., 2017
- Oestrogen receptor β regulates epigenetic patterns at specific genomic loci through interaction with thymine DNA glycosylase, Liu, Y., Duong, W., Krawczyk, C., Bretschneider, N., Borbely, G., Varshney, M., Zinser, C., Schar, P., Ruegg, J., 2016
- GeMes: Clusters of DNA methylation under genetic control can inform genetic and epigenetic analysis of disease, Liu, Y., Li, X., Aryee, MJ., Ekstrom, TJ., Padyukov, L., Klareskog, L., Vandiver, A., Moore, AZ., Tanaka, T., Ferrucci, L., Fallin, MD., Feinberg, AP., 2014
- Epigenome-wide association data implicate DNA methylation as an intermediary of generic risk in Rheumatoid Arthritis, Liu, Y., Aryee, MJ., Padyukov, L., Fallin, MD., Hesselberg, E., Runarsson, A., Reinius, L., Acevedo, N., Taub, M., Ronninger, M., Shchetynsky, K., Scheynius, A., Kere, J., Alfredsson, L., Klareskog, L., Ekstrom, TJ., Feinberg, AP., 2013
- A Plant Homeodomain in RAG-2 that Binds Hypermethylated Lysine 4 of Histone H3 is Necessary For Efficient Antigen-Receptor-Gene Rearrangement, Liu, Y., Subrahmanyam, R., Chakraborty, T., Sen, R. and Desiderio, S., 2007
Awards
- 2020: Shanghai Outstanding Academic Leader (Youth)
- 2014: National High-Level Talent Program
