Upload Avatar (500 x 500)
Wuyuan Lu
Basic Medical Sciences
Fudan University
Shanghai
Language: English, Chinese
Antimicrobial Peptides
Defensins
Structure
Function
Molecular Mechanism
Anti-Tumor
Anti-Infection
Pathogen
Chemical Synthesis
Post-Translational Modification
Areas of Focus
- Structure, function, and molecular mechanism of antimicrobial peptides—defensins
- Discovery of anti-tumor and anti-infection drugs
- Pathogen infection and pathogenic mechanisms
- Total chemical synthesis and post-translational modification of proteins
Work Experience
- 1984.07—1987.08 - Nanjing Institute of Dermatology - Assistant Researcher
- 1990.02—1992.01 - Purdue University - Research Assistant
- 1995.07—1996.12 - Scripps Research Institute - Postdoctoral Fellow
- 1997.01—1998.06 - Gryphon Sciences - Senior Scientist and Director of Protein Chemistry
- 1998.07—2000.06 - University of Chicago - Assistant Professor (Research)
- 2000.07—2007.06 - University of Maryland Biotechnology Institute - Assistant Professor, Associate Professor (Tenured)
- 2007.07—2009.06 - University of Maryland School of Medicine - Associate Professor (Tenured)
- 2009.07—2020.06 - University of Maryland School of Medicine - Professor (Tenured), Researcher at Institute of Human Virology, Researcher at Greenebaum Cancer Center
- 2012.01—2017.01 - Xi'an Jiaotong University - Distinguished Professor
- 2012.01—2015.04 - Xi'an Jiaotong University Institute of Frontier Science and Technology - Director of Translational Medicine Research Center
- 2013.06—2015.03 - Xi'an Jiaotong University School of Life Science and Technology - Vice Dean
- 2014.07—2020.06 - University of Maryland School of Medicine Institute of Human Virology - Director of Basic Science Division
- 2018.07—2020.06 - University of Maryland School of Medicine Institute of Human Virology - Deputy Director
- 2020.08—Present - Fudan University School of Basic Medical Sciences - Distinguished Professor
Academic Background & Achievements
- 1980.09—1984.07 Bachelor's in Analytical Chemistry: Nanjing University
- 1987.09—1989.12 Master's in Biochemistry: Nanjing University
- 1992.02—1994.12 Graduate studies in Biochemistry: Purdue University
Publications
- Engineering disulfide bridges to dissect antimicrobial and chemotactic activities of human beta-defensin 3, Wu, Z., et al., 2003
- Productive folding of human neutrophil alpha-defensins in vitro without the pro-peptide, Wu, Z., R. Powell, and W. Lu, 2003
- Total chemical synthesis of N-myristoylated HIV-1 matrix protein p17: structural and mechanistic implications of p17 myristoylation, Wu, Z., et al., 2004
- Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX, Pazgier, M., et al., 2009
- D-peptide inhibitors of the p53-MDM2 interaction for targeted molecular therapy of malignant neoplasms, Liu, M., et al., 2010
- A left-handed solution to peptide inhibition of the p53-MDM2 interaction, Liu, M., et al., 2010
- Human alpha-defensin 6 promotes mucosal innate immunity through self-assembled peptide nanonets, Chu, H., et al., 2012
- Human enteric alpha-defensin 5 promotes Shigella infection by enhancing bacterial adhesion and invasion, Xu, D., et al., 2018
- Tanshinones: first-in-class inhibitors of the biogenesis of the type 3 secretion system needle of Pseudomonas aeruginosa for antibiotic therapy, Feng, C., et al., 2019
- Design of ultrahigh-affinity and dual-specificity peptide antagonists of MDM2 and MDMX for p53 activation and tumor suppression, Li, X., et al., 2021
Awards
- Ely Lilly Travel Award (1992): American Protein Society
- Ismail Interdisciplinary Doctoral Research Award (1993): Purdue University
- Special Lecturer Award (2007): Auburn University
- Research Scholar Award (2007): American Cancer Society
- Science and Technology Award Second Prize (2014): Chinese Pharmaceutical Association
