Professor | Wuyuan Lu | Asia Growth Partners

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Name	Wuyuan Lu
Contact Information	luwuyuan@fudan.edu.cn
Language ability	English, Chinese
Province	Shanghai

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Name

Wuyuan Lu

Contact Information

luwuyuan@fudan.edu.cn

Language ability

English, Chinese

Province

Shanghai

University/Lab Affiliation and Title	Fudan University
Faculty	Basic Medical Sciences
Academic Background & Achievements	1980.09—1984.07 Bachelor's in Analytical Chemistry: Nanjing University 1987.09—1989.12 Master's in Biochemistry: Nanjing University 1992.02—1994.12 Graduate studies in Biochemistry: Purdue University
Work Experience	1984.07—1987.08 - Nanjing Institute of Dermatology - Assistant Researcher 1990.02—1992.01 - Purdue University - Research Assistant 1995.07—1996.12 - Scripps Research Institute - Postdoctoral Fellow 1997.01—1998.06 - Gryphon Sciences - Senior Scientist and Director of Protein Chemistry 1998.07—2000.06 - University of Chicago - Assistant Professor (Research) 2000.07—2007.06 - University of Maryland Biotechnology Institute - Assistant Professor, Associate Professor (Tenured) 2007.07—2009.06 - University of Maryland School of Medicine - Associate Professor (Tenured) 2009.07—2020.06 - University of Maryland School of Medicine - Professor (Tenured), Researcher at Institute of Human Virology, Researcher at Greenebaum Cancer Center 2012.01—2017.01 - Xi'an Jiaotong University - Distinguished Professor 2012.01—2015.04 - Xi'an Jiaotong University Institute of Frontier Science and Technology - Director of Translational Medicine Research Center 2013.06—2015.03 - Xi'an Jiaotong University School of Life Science and Technology - Vice Dean 2014.07—2020.06 - University of Maryland School of Medicine Institute of Human Virology - Director of Basic Science Division 2018.07—2020.06 - University of Maryland School of Medicine Institute of Human Virology - Deputy Director 2020.08—Present - Fudan University School of Basic Medical Sciences - Distinguished Professor
Awards	Ely Lilly Travel Award (1992): American Protein Society Ismail Interdisciplinary Doctoral Research Award (1993): Purdue University Special Lecturer Award (2007): Auburn University Research Scholar Award (2007): American Cancer Society Science and Technology Award Second Prize (2014): Chinese Pharmaceutical Association

University/Lab Affiliation and Title

Fudan University

Faculty

Basic Medical Sciences

Academic Background & Achievements

1980.09—1984.07 Bachelor's in Analytical Chemistry: Nanjing University
1987.09—1989.12 Master's in Biochemistry: Nanjing University
1992.02—1994.12 Graduate studies in Biochemistry: Purdue University

Work Experience

1984.07—1987.08 - Nanjing Institute of Dermatology - Assistant Researcher
1990.02—1992.01 - Purdue University - Research Assistant
1995.07—1996.12 - Scripps Research Institute - Postdoctoral Fellow
1997.01—1998.06 - Gryphon Sciences - Senior Scientist and Director of Protein Chemistry
1998.07—2000.06 - University of Chicago - Assistant Professor (Research)
2000.07—2007.06 - University of Maryland Biotechnology Institute - Assistant Professor, Associate Professor (Tenured)
2007.07—2009.06 - University of Maryland School of Medicine - Associate Professor (Tenured)
2009.07—2020.06 - University of Maryland School of Medicine - Professor (Tenured), Researcher at Institute of Human Virology, Researcher at Greenebaum Cancer Center
2012.01—2017.01 - Xi'an Jiaotong University - Distinguished Professor
2012.01—2015.04 - Xi'an Jiaotong University Institute of Frontier Science and Technology - Director of Translational Medicine Research Center
2013.06—2015.03 - Xi'an Jiaotong University School of Life Science and Technology - Vice Dean
2014.07—2020.06 - University of Maryland School of Medicine Institute of Human Virology - Director of Basic Science Division
2018.07—2020.06 - University of Maryland School of Medicine Institute of Human Virology - Deputy Director
2020.08—Present - Fudan University School of Basic Medical Sciences - Distinguished Professor

Awards

Ely Lilly Travel Award (1992): American Protein Society
Ismail Interdisciplinary Doctoral Research Award (1993): Purdue University
Special Lecturer Award (2007): Auburn University
Research Scholar Award (2007): American Cancer Society
Science and Technology Award Second Prize (2014): Chinese Pharmaceutical Association

Areas of Focus	Structure, function, and molecular mechanism of antimicrobial peptides—defensins Discovery of anti-tumor and anti-infection drugs Pathogen infection and pathogenic mechanisms Total chemical synthesis and post-translational modification of proteins
Publications	Engineering disulfide bridges to dissect antimicrobial and chemotactic activities of human beta-defensin 3, Wu, Z., et al., 2003 Productive folding of human neutrophil alpha-defensins in vitro without the pro-peptide, Wu, Z., R. Powell, and W. Lu, 2003 Total chemical synthesis of N-myristoylated HIV-1 matrix protein p17: structural and mechanistic implications of p17 myristoylation, Wu, Z., et al., 2004 Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX, Pazgier, M., et al., 2009 D-peptide inhibitors of the p53-MDM2 interaction for targeted molecular therapy of malignant neoplasms, Liu, M., et al., 2010 A left-handed solution to peptide inhibition of the p53-MDM2 interaction, Liu, M., et al., 2010 Human alpha-defensin 6 promotes mucosal innate immunity through self-assembled peptide nanonets, Chu, H., et al., 2012 Human enteric alpha-defensin 5 promotes Shigella infection by enhancing bacterial adhesion and invasion, Xu, D., et al., 2018 Tanshinones: first-in-class inhibitors of the biogenesis of the type 3 secretion system needle of Pseudomonas aeruginosa for antibiotic therapy, Feng, C., et al., 2019 Design of ultrahigh-affinity and dual-specificity peptide antagonists of MDM2 and MDMX for p53 activation and tumor suppression, Li, X., et al., 2021

Areas of Focus

Structure, function, and molecular mechanism of antimicrobial peptides—defensins
Discovery of anti-tumor and anti-infection drugs
Pathogen infection and pathogenic mechanisms
Total chemical synthesis and post-translational modification of proteins

Publications

Engineering disulfide bridges to dissect antimicrobial and chemotactic activities of human beta-defensin 3, Wu, Z., et al., 2003
Productive folding of human neutrophil alpha-defensins in vitro without the pro-peptide, Wu, Z., R. Powell, and W. Lu, 2003
Total chemical synthesis of N-myristoylated HIV-1 matrix protein p17: structural and mechanistic implications of p17 myristoylation, Wu, Z., et al., 2004
Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX, Pazgier, M., et al., 2009
D-peptide inhibitors of the p53-MDM2 interaction for targeted molecular therapy of malignant neoplasms, Liu, M., et al., 2010
A left-handed solution to peptide inhibition of the p53-MDM2 interaction, Liu, M., et al., 2010
Human alpha-defensin 6 promotes mucosal innate immunity through self-assembled peptide nanonets, Chu, H., et al., 2012
Human enteric alpha-defensin 5 promotes Shigella infection by enhancing bacterial adhesion and invasion, Xu, D., et al., 2018
Tanshinones: first-in-class inhibitors of the biogenesis of the type 3 secretion system needle of Pseudomonas aeruginosa for antibiotic therapy, Feng, C., et al., 2019
Design of ultrahigh-affinity and dual-specificity peptide antagonists of MDM2 and MDMX for p53 activation and tumor suppression, Li, X., et al., 2021

Antimicrobial Peptides Defensins Structure Function Molecular Mechanism Anti-Tumor Anti-Infection Pathogen Chemical Synthesis Post-Translational Modification

Xihui Gao - Fudan University

Erxia Shen - Guangzhou Medical University

Pang Wei - China Medical University

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