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Jianhua Li
Basic Medical Sciences
Fudan University
Shanghai
Language: Chinese, English
T Cell Activation
B Cell Activation
Differentiation Niches
Viral Infection
Hbv
Hbsag
Cccdna
Immune Response
Emerging Infectious Diseases
Vaccine Design
Areas of Focus
- Systematic revelation of the physical and functional structures of T and B cell activation and differentiation niches during viral infection, and the mechanisms of T and B cell differentiation fate determination
- Systematic elucidation of the immune panorama and mechanisms of HBV, HBsAg, cccDNA clearance and tolerance, exploring cure strategies and methods
- Immune response mechanisms of emerging infectious diseases and the design of new vaccines
Work Experience
- 2016-present - Fudan University, School of Basic Medical Sciences, Department of Pathogen Biology - Researcher
- 2014-2016 - University of California, San Francisco, Department of Immunology/Howard Hughes Medical Institute (HHMI) - Postdoctoral Researcher
- 2013-2016 - Fudan University, School of Basic Medical Sciences, Department of Pathogen Biology - Associate Researcher
- 2012-2013 - Fudan University, School of Basic Medical Sciences, Department of Pathogen Biology - Lecturer
- 2010-2012 - Fudan University, School of Basic Medical Sciences, Department of Pathogen Biology - Postdoctoral Researcher
Academic Background & Achievements
- 2007-2010 PhD: Fudan University, School of Basic Medical Sciences, Department of Pathogen Biology
- 2004-2007 Master's: Central South University, Xiangya School of Medicine, Department of Medical Microbiology
- 1999-2004 Bachelor's: University of South China, School of Public Health, Department of Health Inspection
Publications
- Exosomes exploit the virus entry machinery and pathway to transmit IFN-α-induced antiviral activity, Yao Z, Qiao Y, Li X, Chen J, Ding J, Bai L, Shen F, Shi B, Liu J, Peng L, Li J*, Yuan Z*, 2018
- EBI2 augments Tfh cell fate by promoting interaction with IL2-quenching dendritic cells, Li, J., E. Lu, T. Yi, and Cyster JG, 2016
- Splenic Dendritic Cells Survey Red Blood Cells for Missing Self-CD47 to Trigger Adaptive Immune Responses, Yi T., Li J, Chen H, Wu J, An J, Xu Y, Hu Y, Lowell CA, Cyster JG, 2015
- Exosomes mediate the cell-to-cell transmission of IFN-α-induced antiviral activity, Li, J., K. Liu, Y. Liu, Y. Xu, F. Zhang, H. Yang, J. Liu, T. Pan, J. Chen, M. Wu, X. Zhou, and Z. Yuan, 2013
- Association between adverse clinical outcome in human disease caused by novel influenza A H7N9 virus and sustained viral shedding and emergence of antiviral resistance, Hu, Y*., S. Lu*, Z. Song*, W. Wang*, P. Hao*, J. Li*, X. Zhang*, H. L. Yen, M. Peiris, and Z. Yuan, 2013
Awards
- 2014: First Prize in Natural Science Award by the Ministry of Education, ranked second
- 2020: First Prize in Shanghai Natural Science Award, ranked fourth
