Professor | Zhenghong Yuan | Asia Growth Partners

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Name	Zhenghong Yuan
Contact Information	zhyuan@shmu.edu.cn
Language ability	Chinese, English
Province	Shanghai

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Name

Zhenghong Yuan

Contact Information

zhyuan@shmu.edu.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	Fudan University
Faculty	Basic Medical Sciences
Work Experience	2006-present - Chinese Society for Microbiology Virology Committee - Director, Chairman 2014-2016 - Chinese Medical Association Medical Virology Branch - Chairman 2002-2010 - Shanghai Medical Association Medical Virology Branch - Chairman 2019-present - Shanghai Society for Microbiology - President 2011-present - Emerging Microbes and Infections - Deputy Editor 2000-present - Key Laboratory of Medical Molecular Virology - Director
Awards	Ministry of Education China University Technology Invention Award (2001): Construction and application of HBV antigen-antibody-recombinant plasmid DNA complex in hepatitis B, First Prize Ministry of Education Natural Science Award (2012): Mechanism study of immunotherapy for HBV infection with antigen-antibody complex, First Prize Chinese Preventive Medicine Association Science and Technology Award (2013): Application of proteomics technology in the prevention and treatment of major infectious diseases and liver and lung cancer, First Prize Ministry of Education Natural Science Award (2015): New mechanism of interaction between HBV and type I interferon system, First Prize Chinese Medical Science and Technology Award (2015): Discovery and etiological study of human infection with novel H7N9 avian influenza virus, First Prize National Science and Technology Progress Award (2017): Major innovations and technological breakthroughs in the prevention and control system of new emerging infectious diseases such as H7N9 avian influenza in China, Special Prize Shanghai Natural Science Award (2019): Research on multiple mechanisms and treatment strategies for chronic hepatitis B, First Prize

University/Lab Affiliation and Title

Fudan University

Faculty

Basic Medical Sciences

Work Experience

2006-present - Chinese Society for Microbiology Virology Committee - Director, Chairman
2014-2016 - Chinese Medical Association Medical Virology Branch - Chairman
2002-2010 - Shanghai Medical Association Medical Virology Branch - Chairman
2019-present - Shanghai Society for Microbiology - President
2011-present - Emerging Microbes and Infections - Deputy Editor
2000-present - Key Laboratory of Medical Molecular Virology - Director

Awards

Ministry of Education China University Technology Invention Award (2001): Construction and application of HBV antigen-antibody-recombinant plasmid DNA complex in hepatitis B, First Prize
Ministry of Education Natural Science Award (2012): Mechanism study of immunotherapy for HBV infection with antigen-antibody complex, First Prize
Chinese Preventive Medicine Association Science and Technology Award (2013): Application of proteomics technology in the prevention and treatment of major infectious diseases and liver and lung cancer, First Prize
Ministry of Education Natural Science Award (2015): New mechanism of interaction between HBV and type I interferon system, First Prize
Chinese Medical Science and Technology Award (2015): Discovery and etiological study of human infection with novel H7N9 avian influenza virus, First Prize
National Science and Technology Progress Award (2017): Major innovations and technological breakthroughs in the prevention and control system of new emerging infectious diseases such as H7N9 avian influenza in China, Special Prize
Shanghai Natural Science Award (2019): Research on multiple mechanisms and treatment strategies for chronic hepatitis B, First Prize

Areas of Focus	Research on the basics and countermeasures of important persistent and emerging viral infections Mechanism and countermeasures of interaction between HBV and the body's innate immune system Formation, regulation mechanism, and clearance strategy of HBV cccDNA Identification technology and etiological research of important emerging infectious disease viruses
Publications	Hepatitis B Virus Polymerase Disrupts K63-Linked Ubiquitination of STING To Block Innate Cytosolic DNA-Sensing Pathways, Liu Y, Li J, Chen J, Li Y, Wang W, Du X, Song W, Zhang W, Lin L, Yuan Z, 2015 Hepatitis B virus polymerase impairs interferon-alpha-induced STAT activation through inhibition of importin-alpha5 and protein kinase C-delta, Wu M, Zhang X, Zhang W, Zhang Z, Chen L, He J, Zheng Y, Chen C, Wang F, Hu Y, Zhou X, Wang C, Xu Y, Lu M, Yuan Z, 2013 Hepatitis B Virus Surface Antigen Selectively Inhibits TLR2 Ligand-Induced IL-12 Production in Monocytes/Macrophages by Interfering with JNK Activation, Wang S, Chen Z, Hu C, Qian F, Cheng Y, Wu M, Shi B, Chen J, Hu Y, Yuan Z, 2013 Exosomes mediate the cell-to-cell transmission of IFN-alpha-induced antiviral activity, Liu K, Liu Y, Xu Y, Zhang F, Yang H, Liu J, Pan T, Chen J, Wu M, Zhou X, Yuan Z, 2013 In situ analysis of intrahepatic virological events in chronic hepatitis B virus infection, Zhang X, Lu W, Zheng Y, Wang W, Bai L, Chen L, Feng Y, Zhang Z, Yuan Z, 2016 Long-term functional maintenance of primary human hepatocytes in vitro, Xiang C, Du Y, Meng G, Soon Yi L, Sun S, Song N, Zhang X, Xiao Y, Wang J, Yi Z, Liu Y, Xie B, Wu M, Shu J, Sun D, Jia J, Liang Z, Sun D, Huang Y, Shi Y, Xu J, Lu F, Li C, Xiang K, Yuan Z, Lu S, Deng H, 2019 PRMT5 restricts hepatitis B virus replication through epigenetic repression of covalently closed circular DNA transcription and interference with pregenomic RNA encapsidation, Zhang W, Chen J, Wu M, Zhang X, Zhang M, Yue L, Li Y, Liu J, Li B, Shen F, Wang Y, Bai L, Protzer U, Levrero M, Yuan Z, 2017 An efficient antiviral strategy for targeting hepatitis B virus genome using transcription activator-like effector nucleases, Chen J, Zhang W, Lin J, Wang F, Wu M, Chen C, Zheng Y, Peng X, Li J, Yuan Z, 2014 Human infection with a novel avian-origin influenza A (H7N9) virus, Gao R, Cao B, Hu Y, Feng Z, Wang D, Hu W, Chen J, Jie Z, Qiu H, Xu K, Xu X, Lu H, Zhu W, Gao Z, Xiang N, Shen Y, He Z, Gu Y, Zhang Z, Yang Y, Zhao X, Zhou L, Li X, Zou S, Zhang Y, Li X, Yang L, Guo J, Dong J, Li Q, Dong L, Zhu Y, Bai T, Wang S, Hao P, Yang W, Zhang Y, Han J, Yu H, Li D, Gao GF, Wu G, Wang Y, Yuan Z, Shu Y, 2013 Association between adverse clinical outcome in human disease caused by novel influenza A H7N9 virus and sustained viral shedding and emergence of antiviral resistance, Hu Y, Lu S, Song Z, Wang W, Hao P, Li J, Zhang X, Yen HL, Shi B, Li T, Guan W, Xu L, Liu Y, Wang S, Zhang X, Tian D, Zhu Z, He J, Huang K, Chen H, Zheng L, Li X, Ping J, Kang B, Xi X, Zha L, Li Y, Zhang Z, Peiris M, Yuan Z, 2013 Medical Microbiology, Zhenghong Yuan, 2013 Research Techniques for Pathogen Variation in Infectious Disease Syndromes, Zhenghong Yuan, Yu Chen, 2016

Areas of Focus

Research on the basics and countermeasures of important persistent and emerging viral infections
Mechanism and countermeasures of interaction between HBV and the body's innate immune system
Formation, regulation mechanism, and clearance strategy of HBV cccDNA
Identification technology and etiological research of important emerging infectious disease viruses

Publications

Hepatitis B Virus Polymerase Disrupts K63-Linked Ubiquitination of STING To Block Innate Cytosolic DNA-Sensing Pathways, Liu Y, Li J, Chen J, Li Y, Wang W, Du X, Song W, Zhang W, Lin L, Yuan Z, 2015
Hepatitis B virus polymerase impairs interferon-alpha-induced STAT activation through inhibition of importin-alpha5 and protein kinase C-delta, Wu M, Zhang X, Zhang W, Zhang Z, Chen L, He J, Zheng Y, Chen C, Wang F, Hu Y, Zhou X, Wang C, Xu Y, Lu M, Yuan Z, 2013
Hepatitis B Virus Surface Antigen Selectively Inhibits TLR2 Ligand-Induced IL-12 Production in Monocytes/Macrophages by Interfering with JNK Activation, Wang S, Chen Z, Hu C, Qian F, Cheng Y, Wu M, Shi B, Chen J, Hu Y, Yuan Z, 2013
Exosomes mediate the cell-to-cell transmission of IFN-alpha-induced antiviral activity, Liu K, Liu Y, Xu Y, Zhang F, Yang H, Liu J, Pan T, Chen J, Wu M, Zhou X, Yuan Z, 2013
In situ analysis of intrahepatic virological events in chronic hepatitis B virus infection, Zhang X, Lu W, Zheng Y, Wang W, Bai L, Chen L, Feng Y, Zhang Z, Yuan Z, 2016
Long-term functional maintenance of primary human hepatocytes in vitro, Xiang C, Du Y, Meng G, Soon Yi L, Sun S, Song N, Zhang X, Xiao Y, Wang J, Yi Z, Liu Y, Xie B, Wu M, Shu J, Sun D, Jia J, Liang Z, Sun D, Huang Y, Shi Y, Xu J, Lu F, Li C, Xiang K, Yuan Z, Lu S, Deng H, 2019
PRMT5 restricts hepatitis B virus replication through epigenetic repression of covalently closed circular DNA transcription and interference with pregenomic RNA encapsidation, Zhang W, Chen J, Wu M, Zhang X, Zhang M, Yue L, Li Y, Liu J, Li B, Shen F, Wang Y, Bai L, Protzer U, Levrero M, Yuan Z, 2017
An efficient antiviral strategy for targeting hepatitis B virus genome using transcription activator-like effector nucleases, Chen J, Zhang W, Lin J, Wang F, Wu M, Chen C, Zheng Y, Peng X, Li J, Yuan Z, 2014
Human infection with a novel avian-origin influenza A (H7N9) virus, Gao R, Cao B, Hu Y, Feng Z, Wang D, Hu W, Chen J, Jie Z, Qiu H, Xu K, Xu X, Lu H, Zhu W, Gao Z, Xiang N, Shen Y, He Z, Gu Y, Zhang Z, Yang Y, Zhao X, Zhou L, Li X, Zou S, Zhang Y, Li X, Yang L, Guo J, Dong J, Li Q, Dong L, Zhu Y, Bai T, Wang S, Hao P, Yang W, Zhang Y, Han J, Yu H, Li D, Gao GF, Wu G, Wang Y, Yuan Z, Shu Y, 2013
Association between adverse clinical outcome in human disease caused by novel influenza A H7N9 virus and sustained viral shedding and emergence of antiviral resistance, Hu Y, Lu S, Song Z, Wang W, Hao P, Li J, Zhang X, Yen HL, Shi B, Li T, Guan W, Xu L, Liu Y, Wang S, Zhang X, Tian D, Zhu Z, He J, Huang K, Chen H, Zheng L, Li X, Ping J, Kang B, Xi X, Zha L, Li Y, Zhang Z, Peiris M, Yuan Z, 2013
Medical Microbiology, Zhenghong Yuan, 2013
Research Techniques for Pathogen Variation in Infectious Disease Syndromes, Zhenghong Yuan, Yu Chen, 2016

Viral Infections Persistent Infections Emerging Infections Hbv Innate Immune System Cccdna Regulation Mechanism Clearance Strategy Identification Technology Etiological Research

Jianhua Li - Fudan University

Jiangxia Liu - Fudan University

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