Professor | Xiaobo Li | Asia Growth Partners

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Name	Xiaobo Li
Contact Information	xbli@fudan.edu.cn
Language ability	Chinese, English
Province	Shanghai

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Name

Xiaobo Li

Contact Information

xbli@fudan.edu.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	Fudan University
Faculty	Basic Medical Sciences
Academic Background & Achievements	2002.09-2007.07 Ph.D. in Pathology and Pathophysiology: Fudan University 2005.07-2007.05 Joint Ph.D. Student: Virginia Commonwealth University 1997.09-2002.07 Bachelor's in Clinical Medicine: Shanxi Medical University
Work Experience	2013.12-Present - Fudan University - Associate Professor 2013.06-2014.06 - Harvard University School of Public Health - Visiting Scholar 2007.07-2013.12 - Fudan University - Lecturer
Awards	2023: Fudan University Shanghai Medical College 'Young Medical Teacher Cultivation Project' Funding 2020: First Prize in the Third Course Ideological and Political Teaching Plan Competition of Shanghai Medical College 2019: Third Prize in the MBBS Program Young Teacher English Teaching Competition of Fudan University Shanghai Medical College 2018: Second Prize in the Young Teacher Teaching Competition of Fudan University

University/Lab Affiliation and Title

Fudan University

Faculty

Basic Medical Sciences

Academic Background & Achievements

2002.09-2007.07 Ph.D. in Pathology and Pathophysiology: Fudan University
2005.07-2007.05 Joint Ph.D. Student: Virginia Commonwealth University
1997.09-2002.07 Bachelor's in Clinical Medicine: Shanxi Medical University

Work Experience

2013.12-Present - Fudan University - Associate Professor
2013.06-2014.06 - Harvard University School of Public Health - Visiting Scholar
2007.07-2013.12 - Fudan University - Lecturer

Awards

2023: Fudan University Shanghai Medical College 'Young Medical Teacher Cultivation Project' Funding
2020: First Prize in the Third Course Ideological and Political Teaching Plan Competition of Shanghai Medical College
2019: Third Prize in the MBBS Program Young Teacher English Teaching Competition of Fudan University Shanghai Medical College
2018: Second Prize in the Young Teacher Teaching Competition of Fudan University

Areas of Focus	Biological significance of lipid small molecule metabolites in maintaining liver-intestinal homeostasis and communication between digestive organs Drug-induced liver injury
Publications	Cholesterol sulfate alleviates ulcerative colitis by promoting cholesterol biosynthesis in colonic epithelial cells, Xu D, Ma R, Ju Y, Song X, Niu B, Hong W, Wang R, Yang Q, Zhao Z, Zhang Y, Zheng Y, Bai Q, Lv M, Sun N, Li X, 2022 β-Hydroxybutyrate Inhibits Ferroptosis-mediated Pancreatic Damage in Acute Liver Failure through the Increase of H3K9bhb, Zheng Y, Sun W, Shan C, Li B, Liu J, Xing H, Xu Q, Cui B, Zhu W, Chen J, Liu L, Yang T, Sun N, Li X, 2022 Single-cell RNA sequencing reveals that HSD17B2 in cancer-associated fibroblasts promotes the development and progression of castration-resistant prostate cancer, Zhang Y, Fan A, Li Y, Liu Z, Yu L, Guo J, Hou J, Li X, Chen W, 2023 Single-cell RNA sequencing to reveal non-parenchymal cell heterogeneity and immune network of acetaminophen-induced liver injury in mice, Li X, Zhi Y, Li J, Lei X, Ju Y, Zhang Y, Zheng Y, Kong X, Xue F, Zhong W, Chen X, Tang J, Li X, Mao Y, 2023 Activation of Pancreatic Acinar FXR Protects against Pancreatitis via Osgin1-Mediated Restoration of Efficient Autophagy, Zheng Y, Sun W, Wang Z, Liu J, Shan C, He C, Li B, Hu X, Zhu W, Liu L, Lan F, Jiang C, Zhao C, Li X, Sun N, 2022 Protecting mitochondria via inhibiting VDAC1 oligomerization alleviates ferroptosis in acetaminophen-induced acute liver injury, Niu B, Lei X, Xu Q, Ju Y, Xu D, Mao L, Li J, Zheng Y, Sun N, Zhang X, Mao Y, Li X, 2022 Egr1 confers protection against acetaminophen induced hepatotoxicity via transcriptional upregulating of Acaa2, Lei X, Xu Q, Li C, Niu B, Ming Y, Li J, Tang Y, Li X, Tang J, Wu J, Ju Y, Yao L, Wang B, Miao Q, Zhong W, Zhi Y, Xu L, Li C, Li X, Mao Y, 2022 Vitamin A and retinoic acid accelerate the attenuation of intestinal adaptability upon feeding induced by high-fat diet in mice, Hong W, Xu D, Song X, Niu B, Zhuang Z, Lu Y, Lei X, Ma R, Lu C, Sun N, Mao Y, Li X, 2021 Potential Crosstalk between Liver and Extra-liver Organs in Mouse Models of Acute Liver Injury, Zheng Y, Cui B, Sun W, Wang S, Huang X, Gao H, Gao F, Cheng Q, Lu L, An Y, Li X, Sun N, 2020 GADD45α alleviates acetaminophen-induced hepatotoxicity by promoting AMPK activation, Li C, Ming Y, Wang Z, Xu Q, Yao L, Xu D, Tang Y, Lei X, Li X, Mao Y, 2019 HIC-5 in cancer-associated fibroblasts contributes to esophageal squamous cell carcinoma progression, Du X, Xu Q, Pan D, Xu D, Niu B, Hong W, Zhang R, Li X, Chen S, 2019 Turnover of bile acids in liver, serum and caecal content by high-fat diet feeding affects hepatic steatosis in rats, Tang Y, Zhang J, Li J, Lei X, Xu D, Wang Y, Li C, Li X, Mao Y, 2019 Upregulation of hydroxysteroid sulfotransferase 2B1b promotes hepatic oval cell proliferation by modulating oxysterol-induced LXR activation in a mouse model of liver injury, Wang Z, Yang X, Chen L, Zhi X, Lu H, Ning Y, Yeong J, Chen S, Yin L, Wang X, Li X, 2017

Areas of Focus

Biological significance of lipid small molecule metabolites in maintaining liver-intestinal homeostasis and communication between digestive organs
Drug-induced liver injury

Publications

Cholesterol sulfate alleviates ulcerative colitis by promoting cholesterol biosynthesis in colonic epithelial cells, Xu D, Ma R, Ju Y, Song X, Niu B, Hong W, Wang R, Yang Q, Zhao Z, Zhang Y, Zheng Y, Bai Q, Lv M, Sun N, Li X, 2022
β-Hydroxybutyrate Inhibits Ferroptosis-mediated Pancreatic Damage in Acute Liver Failure through the Increase of H3K9bhb, Zheng Y, Sun W, Shan C, Li B, Liu J, Xing H, Xu Q, Cui B, Zhu W, Chen J, Liu L, Yang T, Sun N, Li X, 2022
Single-cell RNA sequencing reveals that HSD17B2 in cancer-associated fibroblasts promotes the development and progression of castration-resistant prostate cancer, Zhang Y, Fan A, Li Y, Liu Z, Yu L, Guo J, Hou J, Li X, Chen W, 2023
Single-cell RNA sequencing to reveal non-parenchymal cell heterogeneity and immune network of acetaminophen-induced liver injury in mice, Li X, Zhi Y, Li J, Lei X, Ju Y, Zhang Y, Zheng Y, Kong X, Xue F, Zhong W, Chen X, Tang J, Li X, Mao Y, 2023
Activation of Pancreatic Acinar FXR Protects against Pancreatitis via Osgin1-Mediated Restoration of Efficient Autophagy, Zheng Y, Sun W, Wang Z, Liu J, Shan C, He C, Li B, Hu X, Zhu W, Liu L, Lan F, Jiang C, Zhao C, Li X, Sun N, 2022
Protecting mitochondria via inhibiting VDAC1 oligomerization alleviates ferroptosis in acetaminophen-induced acute liver injury, Niu B, Lei X, Xu Q, Ju Y, Xu D, Mao L, Li J, Zheng Y, Sun N, Zhang X, Mao Y, Li X, 2022
Egr1 confers protection against acetaminophen induced hepatotoxicity via transcriptional upregulating of Acaa2, Lei X, Xu Q, Li C, Niu B, Ming Y, Li J, Tang Y, Li X, Tang J, Wu J, Ju Y, Yao L, Wang B, Miao Q, Zhong W, Zhi Y, Xu L, Li C, Li X, Mao Y, 2022
Vitamin A and retinoic acid accelerate the attenuation of intestinal adaptability upon feeding induced by high-fat diet in mice, Hong W, Xu D, Song X, Niu B, Zhuang Z, Lu Y, Lei X, Ma R, Lu C, Sun N, Mao Y, Li X, 2021
Potential Crosstalk between Liver and Extra-liver Organs in Mouse Models of Acute Liver Injury, Zheng Y, Cui B, Sun W, Wang S, Huang X, Gao H, Gao F, Cheng Q, Lu L, An Y, Li X, Sun N, 2020
GADD45α alleviates acetaminophen-induced hepatotoxicity by promoting AMPK activation, Li C, Ming Y, Wang Z, Xu Q, Yao L, Xu D, Tang Y, Lei X, Li X, Mao Y, 2019
HIC-5 in cancer-associated fibroblasts contributes to esophageal squamous cell carcinoma progression, Du X, Xu Q, Pan D, Xu D, Niu B, Hong W, Zhang R, Li X, Chen S, 2019
Turnover of bile acids in liver, serum and caecal content by high-fat diet feeding affects hepatic steatosis in rats, Tang Y, Zhang J, Li J, Lei X, Xu D, Wang Y, Li C, Li X, Mao Y, 2019
Upregulation of hydroxysteroid sulfotransferase 2B1b promotes hepatic oval cell proliferation by modulating oxysterol-induced LXR activation in a mouse model of liver injury, Wang Z, Yang X, Chen L, Zhi X, Lu H, Ning Y, Yeong J, Chen S, Yin L, Wang X, Li X, 2017

Lipid Metabolism Liver Intestine Homeostasis Communication Digestive Organs Drug-Induced Liver Injury Biological Significance Metabolites

Tao Shen - Peking University

Liu Yi - Fudan University

Tao Zhuang - Fudan University

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