Professor | Minfeng Shu | Asia Growth Partners

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Name	Minfeng Shu
Contact Information	minfeng_shu@fudan.edu.cn
Language ability	Chinese, English
Province	Shanghai

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Name

Minfeng Shu

Contact Information

minfeng_shu@fudan.edu.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	Fudan University
Faculty	Basic Medical Sciences
Academic Background & Achievements	2001.09—2006.09 Bachelor's Degree in Clinical Medicine: Wannan Medical College 2006.09—2011.07 Ph.D. in Pharmacology: Sun Yat-sen University
Work Experience	2011.10—2017.10 - University of Chicago - Postdoctoral Researcher 2017.11—Present - Fudan University - Junior Researcher
Awards	2019: Shanghai 'Oriental Scholar' Distinguished Professor, Shanghai Municipal Education Commission

University/Lab Affiliation and Title

Fudan University

Faculty

Basic Medical Sciences

Academic Background & Achievements

2001.09—2006.09 Bachelor's Degree in Clinical Medicine: Wannan Medical College
2006.09—2011.07 Ph.D. in Pharmacology: Sun Yat-sen University

Work Experience

2011.10—2017.10 - University of Chicago - Postdoctoral Researcher
2017.11—Present - Fudan University - Junior Researcher

Awards

2019: Shanghai 'Oriental Scholar' Distinguished Professor, Shanghai Municipal Education Commission

Areas of Focus	Research on the role of RNA stability in the development of malignant tumors and innate immunity Development of gene therapy drugs for tumors based on viral vectors
Publications	The role of Activating Transcription Factor 3 in the synthesis of LAT and maintenance of HSV-1 in latent state in ganglia, Minfeng Shu, Te Du, Guoying Zhou and Bernard Roizman, 2015 Tristetraprolin recruits the herpes simplex virion host shutoff RNase to the A-U rich elements in stress response mRNAs to enable their cleavage, Minfeng Shu, Brunella Taddeo and Bernard Roizman, 2015 Selective degradation of mRNAs by the HSV host shutoff RNase is regulated by the UL47 tegument protein, Minfeng Shu, Brunella Taddeo, Weiran Zhang and Bernard Roizman, 2013 The nuclear-cytoplasmic shuttling of virion host shutoff RNase is enabled by pUL47 and an embedded nuclear export signal and defines the sites of degradation of AU-rich and stable cellular mRNAs, Minfeng Shu, Brunella Taddeo and Bernard Roizman, 2013 MicroRNA 335 is required for differentiation of malignant glioma cells induced by activation of cAMP/protein kinase A pathway, Minfeng Shu, Yuehan Zhou, Wenbo Zhu, Haipeng Zhang, Sihan Wu, Jingkao Chen,and Guangmei Yan, 2012 Targeting oncogenic miR-335 inhibits growth and invasion of malignant astrocytoma cells, Minfeng Shu, Xiaoke Zheng , Sihan Wu, Huimin Lu, Tiandong Leng, Wenbo Zhu, Yuehan Zhou, Yanqiu Ou, Xi Lin, Yuan Lin, Dong Xu, Yuxi Zhou and Guangmei Yan, 2011 miR-221/222 suppression induced by activation of the cAMP/PKA/CREB1 pathway is required for cAMP-induced bidirectional differentiation of glioma cells, Qian Liu , Ruotong Tian , Panpan Yu and Minfeng Shu, 2021 Identification and Validation of an Immune-Associated RNA-Binding Proteins Signature to Predict Clinical Outcomes and Therapeutic Responses in Glioma Patients, Ruotong Tian, Yimin Li, Qian Liu and Minfeng Shu, 2021 Circadian Regulation Patterns With Distinct Immune Landscapes in Gliomas Aid in the Development of a Risk Model to Predict Prognosis and Therapeutic Response, Ruotong Tian, Yimin Li and Minfeng Shu, 2022 Therapeutic targeting m6A-guided miR-146a-5p signaling contributes to the melittin-induced selective suppression of bladder cancer, Rucheng Yan, Weiwei Dai, Ruixin Wu, Houbao Huang and Minfeng Shu, 2022

Areas of Focus

Research on the role of RNA stability in the development of malignant tumors and innate immunity
Development of gene therapy drugs for tumors based on viral vectors

Publications

The role of Activating Transcription Factor 3 in the synthesis of LAT and maintenance of HSV-1 in latent state in ganglia, Minfeng Shu, Te Du, Guoying Zhou and Bernard Roizman, 2015
Tristetraprolin recruits the herpes simplex virion host shutoff RNase to the A-U rich elements in stress response mRNAs to enable their cleavage, Minfeng Shu, Brunella Taddeo and Bernard Roizman, 2015
Selective degradation of mRNAs by the HSV host shutoff RNase is regulated by the UL47 tegument protein, Minfeng Shu, Brunella Taddeo, Weiran Zhang and Bernard Roizman, 2013
The nuclear-cytoplasmic shuttling of virion host shutoff RNase is enabled by pUL47 and an embedded nuclear export signal and defines the sites of degradation of AU-rich and stable cellular mRNAs, Minfeng Shu, Brunella Taddeo and Bernard Roizman, 2013
MicroRNA 335 is required for differentiation of malignant glioma cells induced by activation of cAMP/protein kinase A pathway, Minfeng Shu, Yuehan Zhou, Wenbo Zhu, Haipeng Zhang, Sihan Wu, Jingkao Chen,and Guangmei Yan, 2012
Targeting oncogenic miR-335 inhibits growth and invasion of malignant astrocytoma cells, Minfeng Shu, Xiaoke Zheng , Sihan Wu, Huimin Lu, Tiandong Leng, Wenbo Zhu, Yuehan Zhou, Yanqiu Ou, Xi Lin, Yuan Lin, Dong Xu, Yuxi Zhou and Guangmei Yan, 2011
miR-221/222 suppression induced by activation of the cAMP/PKA/CREB1 pathway is required for cAMP-induced bidirectional differentiation of glioma cells, Qian Liu , Ruotong Tian , Panpan Yu and Minfeng Shu, 2021
Identification and Validation of an Immune-Associated RNA-Binding Proteins Signature to Predict Clinical Outcomes and Therapeutic Responses in Glioma Patients, Ruotong Tian, Yimin Li, Qian Liu and Minfeng Shu, 2021
Circadian Regulation Patterns With Distinct Immune Landscapes in Gliomas Aid in the Development of a Risk Model to Predict Prognosis and Therapeutic Response, Ruotong Tian, Yimin Li and Minfeng Shu, 2022
Therapeutic targeting m6A-guided miR-146a-5p signaling contributes to the melittin-induced selective suppression of bladder cancer, Rucheng Yan, Weiwei Dai, Ruixin Wu, Houbao Huang and Minfeng Shu, 2022

Rna Stability Malignant Tumors Innate Immunity Gene Therapy Viral Vectors Cancer Research Tumor Development Rna-Binding Proteins Immunotherapy Oncology

Yanhui Yin - Peking University

Shi Feng - Central South University

Yongguang Tao - Central South University

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