Zuoyun Wang

wangzuoyun@fudan.edu.cn

Chinese, English

Shanghai

Fudan University

Basic Medical Sciences

• 2002.09—2006.07 Bachelor in Biological Sciences: Linyi University
• 2006.09—2009.07 Master in Biochemistry and Molecular Biology: Zhejiang Sci-Tech University
• 2010.09—2013.07 PhD in Cell Biology: Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences

• 2013.08—2017.07 - Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences - Postdoctoral Researcher
• 2017.08—2021.02 - Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences - Assistant Researcher and Associate Researcher
• 2021.03—Present - School of Basic Medical Sciences, Fudan University - Junior Researcher, Group Leader, Doctoral Supervisor

• 2010: Young Scientist Forum Award, Chinese Society of Biochemistry and Molecular Biology
• 2014: Outstanding Young Talent Award, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences
• 2020: Sanofi Outstanding Young Talent Award, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences
• 2021: Outstanding Young Scholar Award, Shanghai Society for Cell Biology

Analyzing the functions and molecular mechanisms of important signaling pathways in cell proliferation, differentiation, and apoptosis using biochemical, molecular, and cell biology techniques.
Using disease and tumor models in mice, combined with human clinical sample analysis, to reveal the functions and mechanisms of signaling networks such as Hippo in disease and tumorigenesis; screening small molecule compounds related to anti-tumor and immunity using cell and mouse disease models.

• VGLL4 promotes osteoblast differentiation by antagonizing TEADs-inhibited Runx2 transcriptions, Jinlong Suo, Xue Feng, Jiayi Li, Jinghui Wang, Zuoyun Wang, Lei Zhang, Weiguo Zou, 2020
• VGLL4 plays a critical role in heart valve development and homeostasis, Wei Yu, Xueyan Ma, Jinjin Xu, Zhaoliang Fei, Xue Feng, Xiaodong Wang, Kuo Liu, Jinhui Li, Guizhong Cui, Guangdun Peng, Hongbin Ji, Jinsong Li, Naihe Jing, Hai Song, Zhiqiang Lin, Yun Zhao, Zuoyun Wang, Bin Zhou, Lei Zhang, 2019
• Dual function of VGLL4 in muscle regeneration, Xue Feng, Zuoyun Wang, Fei Wang, Tiantian Lu, Jinjin Xu, Xueyan Ma, Jinhui Li, Lingli He, Wenxiang Zhang, Sheng Li, Wenjun Yang, Lili Han, Shu Zhang, Gaoxiang Ge, Yun Zhao, Ping Hu, Lei Zhang, 2019
• CBX4 exerts oncogenic properties in lung cancer through Wnt signalling pathway, Zuoyun Wang, Zhaoyuan Fang, Gaobin Chen, Bo Liu, Jinjin Xu, Fei Li, Fuming Li, Hongyan Liu, Haoen Zhang, Yihua Sun, Gang Tian, Haiquan Chen, Guoliang Xu, Lei Zhang, Liang Hu, Hongbin Ji, 2021
• Two co-existed germline mutations P53V157D and PMS2 R20Q promote tumorigenesis in a familial cancer syndrome, Zuoyun Wang, Yihua Sun, Bin Gao, Yi Lu, Rong Fang, Yijun Gao, Tian Xiao, Xin-Yuan Liu, William Pao, Yun Zhao, Haiquan Chen, Hongbin Ji, 2014
• Temporal dissection of K-rasG12D Mutant in vitro and in vivo using a regulatable K-rasG12D mouse allele, Zuoyun Wang, Yan Feng, Nabeel Bardessy, Kwok-kin Wong, Xin-Yuan Liu, Hongbin Ji, 2012
• Selective YAP activation in Procr cells is essential for ovarian stem/progenitor expansion and epithelium repair, Jingqiang Wang, Chunye Liu, Lingli He, Zhiyao Xie, Lanyue Bai, Wentao Yu, Zuoyun Wang, Yi Lu, Dong Gao, Junfen Fu, Lei Zhang, Yi Arial Zeng, 2022
• The Tumor Suppressor Interferon Regulatory Factor 2 Binding Protein 2 Regulates Hippo Pathway in Liver Cancer by a Feedback Loop in Mice, Xue Feng, Tiantian Lu, Jinhui Li, Ruizeng Yang, Liqiao Hu, Yi Ye, Feifei Mao, Lingli He, Jinjin Xu, Zuoyun Wang, Yingbin Liu, Yonglong Zhang, Hongbin Ji, Yun Zhao, Shuqun Cheng, Wei Tian, Lei Zhang, 2020
• Glucocorticoid receptor signaling activates TEAD4 to promote breast cancer progression, Lingli He, Liang Yuan, Yang Sun, Pingyang Wang, Hailin Zhang, Xue Feng, Zuoyun Wang, Wenxiang Zhang, Chuanyu Yang, Yi Arial Zeng, Yun Zhao, Ceshi Chen, Lei Zhang, 2019
• VGLL4 functions as a new tumor suppressor in lung cancer by negatively regulating the YAP-TEAD transcriptional complex, Wenjing Zhang, Yijun Gao, Peixue Li, Zhubing Shi, Tong Guo, Fei Li, Xiangkun Han, Yan Feng, Chao Zheng, Zuoyun Wang, Fuming Li, Haiquan Chen, Zhaocai Zhou, Lei Zhang, Hongbin Ji, 2014