Professor | Yu Lei Zhao | Asia Growth Partners

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Name	Yu Lei Zhao
Contact Information	zhaoyl@fudan.edu.cn
Language ability	English, Chinese
Province	Shanghai

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Name

Yu Lei Zhao

Contact Information

zhaoyl@fudan.edu.cn

Language ability

English, Chinese

Province

Shanghai

University/Lab Affiliation and Title	Fudan University
Faculty	Basic Medical Sciences
Academic Background & Achievements	2011.09-2016.06 Ph.D. in Pathology and Molecular Medicine: Queen's University, Canada 2006.09-2011.06 Dual Bachelor's in Science and Medicine: Jilin University, China
Work Experience	2022.12-Present - Fudan University - Young Researcher, Doctoral Supervisor 2018.10-2022.11 - Sloan Kettering Cancer Center, USA - Research Associate 2016.08-2018.08 - Queen's University, Canada - Postdoctoral Researcher 2010.05-2011.05 - National Institute of Biological Sciences, Beijing - Undergraduate Thesis Intern
Awards	2022: TDI ResMed Scholar 2021: Charles H. Revson Senior Biomedical Research Scholar 2021: MSK Society Scholar 2016: CIHR/Terry Fox Foundation Interdisciplinary Award 2016: Queen's University Outstanding Ph.D. Thesis 2015: Queen's University Principal's Award 2015: CIHR Research Competition Gold Medal 2014: Chinese Government Award for Outstanding Self-financed Students Abroad 2011-2015: Canadian Government Scholarship 2013: Robert Kisilevsky Academic Presentation Award 2011: Robert Kisilevsky Research Fund 2008-2009: National Scholarship 2007-2008: National Scholarship 2008: National College English Competition Special Prize 2009-2010: National Inspirational Scholarship 2006-2007: National Inspirational Scholarship 2006-2007: Jilin University First-Class Scholarship 2006-2010: Jilin University Outstanding Student

University/Lab Affiliation and Title

Fudan University

Faculty

Basic Medical Sciences

Academic Background & Achievements

2011.09-2016.06 Ph.D. in Pathology and Molecular Medicine: Queen's University, Canada
2006.09-2011.06 Dual Bachelor's in Science and Medicine: Jilin University, China

Work Experience

2022.12-Present - Fudan University - Young Researcher, Doctoral Supervisor
2018.10-2022.11 - Sloan Kettering Cancer Center, USA - Research Associate
2016.08-2018.08 - Queen's University, Canada - Postdoctoral Researcher
2010.05-2011.05 - National Institute of Biological Sciences, Beijing - Undergraduate Thesis Intern

Awards

2022: TDI ResMed Scholar
2021: Charles H. Revson Senior Biomedical Research Scholar
2021: MSK Society Scholar
2016: CIHR/Terry Fox Foundation Interdisciplinary Award
2016: Queen's University Outstanding Ph.D. Thesis
2015: Queen's University Principal's Award
2015: CIHR Research Competition Gold Medal
2014: Chinese Government Award for Outstanding Self-financed Students Abroad
2011-2015: Canadian Government Scholarship
2013: Robert Kisilevsky Academic Presentation Award
2011: Robert Kisilevsky Research Fund
2008-2009: National Scholarship
2007-2008: National Scholarship
2008: National College English Competition Special Prize
2009-2010: National Inspirational Scholarship
2006-2007: National Inspirational Scholarship
2006-2007: Jilin University First-Class Scholarship
2006-2010: Jilin University Outstanding Student

Areas of Focus	Mechanisms of cell-autonomous and non-autonomous regulation in cancer development and drug resistance Screening and identification of drug targets for cancer therapy Development of small molecule drugs based on targets
Publications	Chemical remodeling of a cellular chaperone to target the active state of mutant KRAS, Schulze CJ, Seamon KJ, Zhao Y* (co-first author), Yang YC, Cregg J, et al., 2023 Diverse alterations associated with resistance to KRAS(G12C) inhibition, Zhao Y, Murciano-Goroff YR, J. Russell Lipford^, Bob T. Li^ and Piro Lito^, 2021 Rapid non-uniform adaptation to conformation-specific KRASG12C inhibition, Xue J, Zhao Y (co-first author), Aronowitz J, Vides A, Qeriqi B, Kim DS, Stanchina E, Riely G, Mazutis L, Risso D and Lito P, 2020 Suppressing nucleotide exchange to inhibit KRAS-mutant tumors, Zhao Y, Xue J, Lito P, 2021 Pan-KRAS inhibitor disables oncogenic signalling and tumour growth, Kim D, Herdeis L, Rudolph D*, Zhao Y, Böttcher J, Vides A, et al., 2023 KRAS oncoprotein inactivation through enhanced GTPase activity, Li C, Vides A, Kim DS, Xue J, Zhao Y, Lito P, 2021 YAP-induced resistance of cancer cells to antitubulin drugs is modulated by a Hippo-independent pathway, Zhao Y, Khanal P, Savage P, She Y, Cyr TD, Yang X, 2014

Areas of Focus

Mechanisms of cell-autonomous and non-autonomous regulation in cancer development and drug resistance
Screening and identification of drug targets for cancer therapy
Development of small molecule drugs based on targets

Publications

Chemical remodeling of a cellular chaperone to target the active state of mutant KRAS, Schulze CJ*, Seamon KJ*, Zhao Y* (co-first author), Yang YC, Cregg J, et al., 2023
Diverse alterations associated with resistance to KRAS(G12C) inhibition, Zhao Y*, Murciano-Goroff YR*, J. Russell Lipford^, Bob T. Li^ and Piro Lito^, 2021
Rapid non-uniform adaptation to conformation-specific KRASG12C inhibition, Xue J*, Zhao Y* (co-first author), Aronowitz J, Vides A, Qeriqi B, Kim DS, Stanchina E, Riely G, Mazutis L, Risso D and Lito P, 2020
Suppressing nucleotide exchange to inhibit KRAS-mutant tumors, Zhao Y, Xue J, Lito P, 2021
Pan-KRAS inhibitor disables oncogenic signalling and tumour growth, Kim D*, Herdeis L*, Rudolph D*, Zhao Y, Böttcher J, Vides A, et al., 2023
KRAS oncoprotein inactivation through enhanced GTPase activity, Li C, Vides A, Kim DS, Xue J, Zhao Y, Lito P, 2021
YAP-induced resistance of cancer cells to antitubulin drugs is modulated by a Hippo-independent pathway, Zhao Y, Khanal P, Savage P, She Y, Cyr TD, Yang X, 2014

Cancer Drug Resistance Cell-Autonomous Non-Autonomous Regulation Drug Targets Screening Identification Small Molecule Drugs Development

Ying Zhao - Peking University

Jing Liang - Peking University

Kailong Li - Peking University

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