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Yu Lei Zhao
Basic Medical Sciences
Fudan University
Shanghai
Language: English, Chinese
Cancer
Drug Resistance
Cell-Autonomous
Non-Autonomous
Regulation
Drug Targets
Screening
Identification
Small Molecule Drugs
Development
Areas of Focus
- Mechanisms of cell-autonomous and non-autonomous regulation in cancer development and drug resistance
- Screening and identification of drug targets for cancer therapy
- Development of small molecule drugs based on targets
Work Experience
- 2022.12-Present - Fudan University - Young Researcher, Doctoral Supervisor
- 2018.10-2022.11 - Sloan Kettering Cancer Center, USA - Research Associate
- 2016.08-2018.08 - Queen's University, Canada - Postdoctoral Researcher
- 2010.05-2011.05 - National Institute of Biological Sciences, Beijing - Undergraduate Thesis Intern
Academic Background & Achievements
- 2011.09-2016.06 Ph.D. in Pathology and Molecular Medicine: Queen's University, Canada
- 2006.09-2011.06 Dual Bachelor's in Science and Medicine: Jilin University, China
Publications
- Chemical remodeling of a cellular chaperone to target the active state of mutant KRAS, Schulze CJ*, Seamon KJ*, Zhao Y* (co-first author), Yang YC, Cregg J, et al., 2023
- Diverse alterations associated with resistance to KRAS(G12C) inhibition, Zhao Y*, Murciano-Goroff YR*, J. Russell Lipford^, Bob T. Li^ and Piro Lito^, 2021
- Rapid non-uniform adaptation to conformation-specific KRASG12C inhibition, Xue J*, Zhao Y* (co-first author), Aronowitz J, Vides A, Qeriqi B, Kim DS, Stanchina E, Riely G, Mazutis L, Risso D and Lito P, 2020
- Suppressing nucleotide exchange to inhibit KRAS-mutant tumors, Zhao Y, Xue J, Lito P, 2021
- Pan-KRAS inhibitor disables oncogenic signalling and tumour growth, Kim D*, Herdeis L*, Rudolph D*, Zhao Y, Böttcher J, Vides A, et al., 2023
- KRAS oncoprotein inactivation through enhanced GTPase activity, Li C, Vides A, Kim DS, Xue J, Zhao Y, Lito P, 2021
- YAP-induced resistance of cancer cells to antitubulin drugs is modulated by a Hippo-independent pathway, Zhao Y, Khanal P, Savage P, She Y, Cyr TD, Yang X, 2014
Awards
- 2022: TDI ResMed Scholar
- 2021: Charles H. Revson Senior Biomedical Research Scholar
- 2021: MSK Society Scholar
- 2016: CIHR/Terry Fox Foundation Interdisciplinary Award
- 2016: Queen's University Outstanding Ph.D. Thesis
- 2015: Queen's University Principal's Award
- 2015: CIHR Research Competition Gold Medal
- 2014: Chinese Government Award for Outstanding Self-financed Students Abroad
- 2011-2015: Canadian Government Scholarship
- 2013: Robert Kisilevsky Academic Presentation Award
- 2011: Robert Kisilevsky Research Fund
- 2008-2009: National Scholarship
- 2007-2008: National Scholarship
- 2008: National College English Competition Special Prize
- 2009-2010: National Inspirational Scholarship
- 2006-2007: National Inspirational Scholarship
- 2006-2007: Jilin University First-Class Scholarship
- 2006-2010: Jilin University Outstanding Student
