Professor | Lu Zhou | Asia Growth Partners

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Name	Lu Zhou
Contact Information	zhoulu@fudan.edu.cn
Language ability	Chinese, English
Province	Shanghai

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Name

Lu Zhou

Contact Information

zhoulu@fudan.edu.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	Fudan University
Faculty	Pharmaceutical Sciences
Academic Background & Achievements	2001.9–2006.7 PhD: Peking University, College of Chemistry and Molecular Engineering 1997.9–2001.7 Bachelor's: Peking University, College of Chemistry and Molecular Engineering Published over 70 research and teaching papers in domestic and international academic journals First author or corresponding author of more than 20 SCI papers Three papers with IF>20 (Cancer Cell 2012, Nature Chemistry 2014, Cell Metabolism 2019) Applied for 6 national invention patents, 4 of which have been authorized Applied for and obtained patent authorizations in the USA, Japan, and other countries and regions
Work Experience	2019.12-Present - Fudan University, School of Pharmacy - Professor 2013.12-2019.11 - Fudan University, School of Pharmacy - Associate Professor 2010.9-2012.7 - University of Chicago, Department of Chemistry - Visiting Scholar 2008.7-2013.11 - Fudan University, School of Pharmacy - Lecturer 2006.7-2008.7 - Peking University, College of Chemistry and Molecular Engineering - Postdoctoral Researcher
Awards	Shanghai Youth Science and Technology Star Program (2015-2018) Fudan University's First 'Zhuoxue' Program

University/Lab Affiliation and Title

Fudan University

Faculty

Pharmaceutical Sciences

Academic Background & Achievements

2001.9–2006.7 PhD: Peking University, College of Chemistry and Molecular Engineering
1997.9–2001.7 Bachelor's: Peking University, College of Chemistry and Molecular Engineering
Published over 70 research and teaching papers in domestic and international academic journals
First author or corresponding author of more than 20 SCI papers
Three papers with IF>20 (Cancer Cell 2012, Nature Chemistry 2014, Cell Metabolism 2019)
Applied for 6 national invention patents, 4 of which have been authorized
Applied for and obtained patent authorizations in the USA, Japan, and other countries and regions

Work Experience

2019.12-Present - Fudan University, School of Pharmacy - Professor
2013.12-2019.11 - Fudan University, School of Pharmacy - Associate Professor
2010.9-2012.7 - University of Chicago, Department of Chemistry - Visiting Scholar
2008.7-2013.11 - Fudan University, School of Pharmacy - Lecturer
2006.7-2008.7 - Peking University, College of Chemistry and Molecular Engineering - Postdoctoral Researcher

Awards

Shanghai Youth Science and Technology Star Program (2015-2018)
Fudan University's First 'Zhuoxue' Program

Areas of Focus	Drug Chemical Biology Design and synthesis of small molecule drugs targeting new targets
Publications	Site-Selective Phosphoglycerate Mutase 1 Acetylation by a Small Molecule, Zhang XD, Jiang, LlL, Huang K, Fang CT, Li J, Yang JT, Li HT, Ruan XX, Wang PH, Mo MG, Wu P, Xu YH, Peng C, Uesugi M, Ye DY, Yu FX, Zhou L, 2020 An allosteric PGAM1 inhibitor effectively suppresses pancreatic ductal adenocarcinoma, Wen CL, Huang K, Jiang LL, Lu XX, Dai YT, Shi MM, Tang XM, Wang QB, Zhang XD, Wang PH, Li HT, Ruan XX, Wang LW, Wang XJ, Wang Q, Lu W, Xiang XQ, Sun X, Xu YH, Lai LH, Zhan Q, Li HW, Peng CH, Chen J, Huang JY, Ye DY, Chen SJ, Chen Z, Li M, Fang Y, Shen BY, Zhou L, 2019 A Novel Allosteric Inhibitor of Phosphoglycerate Mutase 1 Suppresses Growth and Metastasis of Non-Small-Cell Lung Cancer, Huang K, Liang Q, Zhou Y, Jiang LL, Gu WM, Luo MY, Tang YB, Wang Y, Lu W, Huang M, Zhang SZ, Zhuang GL, Dai Q, Shen QC, Zhang J, Lei HM, Zhu L, Ye DY, Chen HZ, Zhou L, Shen Y, 2019 Development of Anthraquinone Analogues as Phosphoglycerate Mutase 1 Inhibitors, Huang K, Jiang L, Li H, Ye D, Zhou L, 2019 Synthesis and biological evaluation of anthraquinone derivatives as allosteric phosphoglycerate mutase 1 inhibitors for cancer treatment, Huang K, Jiang L, Liang R, Li H, Ruan X, Shan C, Ye D, Zhou L, 2019 Discovery, synthesis and anti-atherosclerotic activities of a novel selective sphingomyelin synthase 2 inhibitor, Li Y, Huang T, Lou B, Ye D, Qi X, Li X, Hu S, Ding T, Chen Y, Cao Y, Mo M, Dong J, Wei M, Chu Y, Li H, Jiang XC, Cheng N, Zhou L, 2019 Discovery, cocrystallization and biological evaluation of novel piperidine derivatives as high affinity Ls-AChBP ligands possessing α7 nAChR activities, Yang X, Shen J, Jiang L, Li W, Yu M, Pan G, Yan Y, Zhang C, Jia W, Xiao L, Yu H, Chen H, Zheng Y, Yu L, Xie Q, Zhou L, Shao L, 2018 Discovery of 4-Benzyloxybenzo[ d]isoxazole-3-amine Derivatives as Highly Selective and Orally Efficacious Human Sphingomyelin Synthase 2 Inhibitors that Reduce Chronic Inflammation in db/ db Mice, Mo M, Yang J, Jiang XC, Cao Y, Fei J, Chen Y, Qi X, Chu Y, Zhou L, Ye D, 2018 The Design and Synthesis of N-Xanthone Benzenesulfonamides as Novel Phosphoglycerate Mutase 1 (PGAM1) Inhibitors, Wang P, Jiang L, Cao Y, Ye D, Zhou L, 2018 Xanthone derivatives as phosphoglycerate mutase 1 inhibitors: Design, synthesis, and biological evaluation, Wang P, Jiang L, Cao Y, Zhang X, Chen B, Zhang S, Huang K, Ye D, Zhou L, 2018 Conformation and dynamics of the C-terminal region in human phosphoglycerate mutase 1, Liu SE, Hu JC, Zhang H, Xu P, Wan W, Zheng MY, Yu KQ, Ding H, Jiang HL, Zhou L, Luo C, 2017 Selective non-zinc binding MMP-2 inhibitors: Novel benzamide Ilomastat analogs with anti-tumor metastasis, Song J, Peng P, Chang J, Liu MM, Yu JM, Zhou L, Sun X, 2016 A protein engineered to bind uranyl selectively and with femtomolar affinity, Zhou L, Bosscher M, Zhang C, Ozçubukçu S, Zhang L, Zhang W, Li CJ, Liu J, Jensen MP, Lai L, He C, 2014 Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation, Hitosugi T, Zhou L, Fan J, Elf S, Zhang L, Xie J, Wang Y, Gu TL, Alečković M, LeRoy G, Kang Y, Kang HB, Seo JH, Shan C, Jin P, Gong W, Lonial S, Arellano ML, Khoury HJ, Chen GZ, Shin DM, Khuri FR, Boggon TJ, Kang S, He C, Chen J, 2013 Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth, Hitosugi T, Zhou L, Elf S, Fan J, Kang HB, Seo JH, Shan C, Dai Q, Zhang L, Xie J, Gu TL, Jin P, Alečković M, LeRoy G, Kang Y, Sudderth JA, DeBerardinis RJ, Luan CH, Chen GZ, Muller S, Shin DM, Owonikoko TK, Lonial S, Arellano ML, Khoury HJ, Khuri FR, Lee BH, Ye K, Boggon TJ, Kang S, He C, Chen J, 2012

Areas of Focus

Drug Chemical Biology
Design and synthesis of small molecule drugs targeting new targets

Publications

Site-Selective Phosphoglycerate Mutase 1 Acetylation by a Small Molecule, Zhang XD, Jiang, LlL, Huang K, Fang CT, Li J, Yang JT, Li HT, Ruan XX, Wang PH, Mo MG, Wu P, Xu YH, Peng C, Uesugi M, Ye DY, Yu FX, Zhou L, 2020
An allosteric PGAM1 inhibitor effectively suppresses pancreatic ductal adenocarcinoma, Wen CL, Huang K, Jiang LL, Lu XX, Dai YT, Shi MM, Tang XM, Wang QB, Zhang XD, Wang PH, Li HT, Ruan XX, Wang LW, Wang XJ, Wang Q, Lu W, Xiang XQ, Sun X, Xu YH, Lai LH, Zhan Q, Li HW, Peng CH, Chen J, Huang JY, Ye DY, Chen SJ, Chen Z, Li M, Fang Y, Shen BY, Zhou L, 2019
A Novel Allosteric Inhibitor of Phosphoglycerate Mutase 1 Suppresses Growth and Metastasis of Non-Small-Cell Lung Cancer, Huang K, Liang Q, Zhou Y, Jiang LL, Gu WM, Luo MY, Tang YB, Wang Y, Lu W, Huang M, Zhang SZ, Zhuang GL, Dai Q, Shen QC, Zhang J, Lei HM, Zhu L, Ye DY, Chen HZ, Zhou L, Shen Y, 2019
Development of Anthraquinone Analogues as Phosphoglycerate Mutase 1 Inhibitors, Huang K, Jiang L, Li H, Ye D, Zhou L, 2019
Synthesis and biological evaluation of anthraquinone derivatives as allosteric phosphoglycerate mutase 1 inhibitors for cancer treatment, Huang K, Jiang L, Liang R, Li H, Ruan X, Shan C, Ye D, Zhou L, 2019
Discovery, synthesis and anti-atherosclerotic activities of a novel selective sphingomyelin synthase 2 inhibitor, Li Y, Huang T, Lou B, Ye D, Qi X, Li X, Hu S, Ding T, Chen Y, Cao Y, Mo M, Dong J, Wei M, Chu Y, Li H, Jiang XC, Cheng N, Zhou L, 2019
Discovery, cocrystallization and biological evaluation of novel piperidine derivatives as high affinity Ls-AChBP ligands possessing α7 nAChR activities, Yang X, Shen J, Jiang L, Li W, Yu M, Pan G, Yan Y, Zhang C, Jia W, Xiao L, Yu H, Chen H, Zheng Y, Yu L, Xie Q, Zhou L, Shao L, 2018
Discovery of 4-Benzyloxybenzo[ d]isoxazole-3-amine Derivatives as Highly Selective and Orally Efficacious Human Sphingomyelin Synthase 2 Inhibitors that Reduce Chronic Inflammation in db/ db Mice, Mo M, Yang J, Jiang XC, Cao Y, Fei J, Chen Y, Qi X, Chu Y, Zhou L, Ye D, 2018
The Design and Synthesis of N-Xanthone Benzenesulfonamides as Novel Phosphoglycerate Mutase 1 (PGAM1) Inhibitors, Wang P, Jiang L, Cao Y, Ye D, Zhou L, 2018
Xanthone derivatives as phosphoglycerate mutase 1 inhibitors: Design, synthesis, and biological evaluation, Wang P, Jiang L, Cao Y, Zhang X, Chen B, Zhang S, Huang K, Ye D, Zhou L, 2018
Conformation and dynamics of the C-terminal region in human phosphoglycerate mutase 1, Liu SE, Hu JC, Zhang H, Xu P, Wan W, Zheng MY, Yu KQ, Ding H, Jiang HL, Zhou L, Luo C, 2017
Selective non-zinc binding MMP-2 inhibitors: Novel benzamide Ilomastat analogs with anti-tumor metastasis, Song J, Peng P, Chang J, Liu MM, Yu JM, Zhou L, Sun X, 2016
A protein engineered to bind uranyl selectively and with femtomolar affinity, Zhou L, Bosscher M, Zhang C, Ozçubukçu S, Zhang L, Zhang W, Li CJ, Liu J, Jensen MP, Lai L, He C, 2014
Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation, Hitosugi T, Zhou L, Fan J, Elf S, Zhang L, Xie J, Wang Y, Gu TL, Alečković M, LeRoy G, Kang Y, Kang HB, Seo JH, Shan C, Jin P, Gong W, Lonial S, Arellano ML, Khoury HJ, Chen GZ, Shin DM, Khuri FR, Boggon TJ, Kang S, He C, Chen J, 2013
Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth, Hitosugi T, Zhou L, Elf S, Fan J, Kang HB, Seo JH, Shan C, Dai Q, Zhang L, Xie J, Gu TL, Jin P, Alečković M, LeRoy G, Kang Y, Sudderth JA, DeBerardinis RJ, Luan CH, Chen GZ, Muller S, Shin DM, Owonikoko TK, Lonial S, Arellano ML, Khoury HJ, Khuri FR, Lee BH, Ye K, Boggon TJ, Kang S, He C, Chen J, 2012

Drug Design Chemical Biology Small Molecules Cancer Research Pgam1 Inhibitors Hif-1Α Mechanism Study New Drug Targets Synthesis Biological Activity

Jia-Yu Liao - Zhejiang University

Xin Wang - Peking University

Shuchun Li - Peking University

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