Professor | Wei Li | Asia Growth Partners

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Name	Wei Li
Contact Information	wei-li@fudan.edu.cn
Language ability	Chinese, English
Province	Shanghai

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Name

Wei Li

Contact Information

wei-li@fudan.edu.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	Fudan University
Faculty	Pharmaceutical Sciences
Academic Background & Achievements	1998.9-2002.7 Bachelor's Degree in Pharmacy: Fudan University 2002.9-2004.7 Master's Degree in Medicinal Chemistry: Fudan University 2004.9-2007.7 Ph.D. in Medicinal Chemistry: Fudan University
Work Experience	2016.12 – Present - Fudan University, Department of Medicinal Chemistry - Associate Professor 2012.10–2013.10 - Medicinal Chemistry Laboratory, Alcohol and Drug Abuse Research Center, McLean Hospital \| Psychiatric affiliate of Harvard Medical School - Visiting Scholar 2007.7 – 2016.11 - Fudan University, Department of Medicinal Chemistry - Lecturer

University/Lab Affiliation and Title

Fudan University

Faculty

Pharmaceutical Sciences

Academic Background & Achievements

1998.9-2002.7 Bachelor's Degree in Pharmacy: Fudan University
2002.9-2004.7 Master's Degree in Medicinal Chemistry: Fudan University
2004.9-2007.7 Ph.D. in Medicinal Chemistry: Fudan University

Work Experience

2016.12 – Present - Fudan University, Department of Medicinal Chemistry - Associate Professor
2012.10–2013.10 - Medicinal Chemistry Laboratory, Alcohol and Drug Abuse Research Center, McLean Hospital | Psychiatric affiliate of Harvard Medical School - Visiting Scholar
2007.7 – 2016.11 - Fudan University, Department of Medicinal Chemistry - Lecturer

Areas of Focus	Opioid receptor ligands and their applications in the diagnosis and treatment of related diseases Construction of diverse compound libraries and their applications in drug discovery for central nervous system diseases
Publications	SLL-627 is a highly selective and potent κ opioid receptor (KOR) agonist with an unexpected non-reduction in locomotor activity., Linghui Kong, Xuelian Shu, Siyuan Tang, Rongrong Ye, Huijiao Sun, Shuang Jiang, Zixiang Li, Jingrui Chai, Yun Fang, Yinjie Lan, Linqian Yu, Qiong Xie, Wei Fu, Yujun Wang, Wei Li, Zhuibai Qiu, Jinggen Liu, Liming Shao, 2022 Novel selective κ agonists SLL-039 and SLL-1206 produce potent antinociception with fewer sedation and aversion., Yuanyuan Wei, Yan Ma, Songyu Yao, Linghui Kong, Xiao Liu, Jingrui Chai, Jing Chen, Wei Li, Yujun Wang, Liming Shao, Jinggen Liu, 2022 Discovery of an m‑substituted N‑cyclopropylmethyl-7α-phenyl-6,14-endoethanotetrahydro northebaine as a selective, potent, and orally active κ‑opioid receptor agonist with an improved central nervous system safety profile., Qian He, Yuanyuan Wei, Xiao Liu, Rongrong Ye, Linghui Kong, Zixiang Li, Shuang Jiang, Linqian Yu, Jingrui Chai, Qiong Xie, Wei Fu, Yujun Wang, Wei Li, Zhuibai Qiu, Jinggen Liu, Liming Shao, 2021 Discovery, Structure–Activity Relationship, and Mechanistic Studies of 1-((3R,4S)-3- ((Dimethylamino)methyl)-4-hydroxy-4-(3-methoxyphenyl)piperidin-1-yl)-2-(2,4,5-trifluorophenyl)ethan-1-one as a Novel Potent Analgesic., Huoming Huang, Xueping Li, Peng Xie, Xinwei Li, XueJun Xu, Yuanyuan Qian, Congmin Yuan, Xiangguo Meng, JingRui Chai, Jing Chen, Jing Liu, Wenli Wang, Wei Li, YuJun Wang, Wei Fu, Jinggen Liu, 2021 An Exploration of the SAR Connection Between Morphinan and Arylacetamide-based κ Opioid Receptor (κOR) Agonists using the Strategy of Bridging., Xiao Liu, Shuang Jiang, Linghui Kong, Rongrong Ye, Li Xiao, Xuejun Xu, Qian He, Yuanyuan Wei, Zixiang Li, Huijiao Sun, Qiong Xie, Xu Xu, Yan Lu, Yujun Wang, Wei Li, Wei Fu, Zhuibai Qiu, Jinggen Liu, Liming Shao, 2021 The Use of Computational Approaches in the Discovery and Mechanism Study of Opioid Analgesics., Bangyi Zhao, Wei Li, Lijie Sun, Wei Fu, 2020 Discovery of 3-((dimethylamino)methyl)-4-hydroxy-4-(3-methoxyphenyl)-N-phenylpiperidine-1-carboxamide as novel potent analgesic., Huoming Huang, Wenli Wanga, Xuejun Xu, Chen Zhu, Yujun Wang, Jinggen Liu, Wei Li, Wei Fu, 2020 Discovery of a highly selective and potent kappa opioid receptor agonist from N-cyclopropylmethyl-7α-phenyl-6,14-endoethano-tetrahydronorthebaines with reduced central nervous system (CNS) side effects navigated by the message-address concept., Li Xiao, Yujun Wang, Mumei Zhang, Weiwei Wu, Linghui Kong, Yan Ma, Xuejun Xu, Xiao Liu, Qian He, Yuanyuan Qian, Huijiao Sun, Haihao Wu, Cheng Lin, Huoming Huang, Rongrong Ye, Shuang Jiang, Rufeng Ye, Congmin Yuan, Shengyang Fang, Dengqi Xue, Xicheng Yang, Hao Chen, Yilin Zheng, Linqian Yu, Qiong Xie, Lan Zheng, Wei Fu, Wei Li, Zhuibai Qiu, Jinggen Liu, Liming Shao, 2019 7β-methyl substituent is a structural locus associated with activity cliff for nepenthone analogues., Huijiao Sun, Yuhua Wang, Congmin Yuan, Linghui Kong, Xuejun Xu, Yujun Wang, Haihao Wu, Cheng Lin, Yuanyuan Qian, Huoming Huang, Li Xiao, Xiao Liu, Qian He, Shengyang Fang, Dengqi Xue, Xicheng Yanga, Hao Chen, Yilin Zheng, Lan Zheng, Linqian Yu, Qiong Xie, Wei Fu, Wei Li, Jinggen Liu, Zhuibai Qiu, Liming Shao, 2018 The Pharmacological Heterogeneity of Nepenthone Analogs in Conferring Highly Selective and Potent kappa-Opioid Agonistic Activities., Wei Li, Jiandong Long, Yuanyuan Qian, Yu Long, Xuejun Xu, Yujun Wang, Qing Shen, Zuoneng Wang, Xicheng Yang, Li Xiao, Hongpeng Sun, Yulong Xu, Yiyi Chen, Qiong Xie, Yonghui Wang, Liming Shao, Jinggen Liu, Zhuibai Qiu, Wei Fu, 2017

Areas of Focus

Opioid receptor ligands and their applications in the diagnosis and treatment of related diseases
Construction of diverse compound libraries and their applications in drug discovery for central nervous system diseases

Publications

SLL-627 is a highly selective and potent κ opioid receptor (KOR) agonist with an unexpected non-reduction in locomotor activity., Linghui Kong, Xuelian Shu, Siyuan Tang, Rongrong Ye, Huijiao Sun, Shuang Jiang, Zixiang Li, Jingrui Chai, Yun Fang, Yinjie Lan, Linqian Yu, Qiong Xie, Wei Fu, Yujun Wang, Wei Li, Zhuibai Qiu, Jinggen Liu, Liming Shao, 2022
Novel selective κ agonists SLL-039 and SLL-1206 produce potent antinociception with fewer sedation and aversion., Yuanyuan Wei, Yan Ma, Songyu Yao, Linghui Kong, Xiao Liu, Jingrui Chai, Jing Chen, Wei Li, Yujun Wang, Liming Shao, Jinggen Liu, 2022
Discovery of an m‑substituted N‑cyclopropylmethyl-7α-phenyl-6,14-endoethanotetrahydro northebaine as a selective, potent, and orally active κ‑opioid receptor agonist with an improved central nervous system safety profile., Qian He, Yuanyuan Wei, Xiao Liu, Rongrong Ye, Linghui Kong, Zixiang Li, Shuang Jiang, Linqian Yu, Jingrui Chai, Qiong Xie, Wei Fu, Yujun Wang, Wei Li, Zhuibai Qiu, Jinggen Liu, Liming Shao, 2021
Discovery, Structure–Activity Relationship, and Mechanistic Studies of 1-((3R,4S)-3- ((Dimethylamino)methyl)-4-hydroxy-4-(3-methoxyphenyl)piperidin-1-yl)-2-(2,4,5-trifluorophenyl)ethan-1-one as a Novel Potent Analgesic., Huoming Huang, Xueping Li, Peng Xie, Xinwei Li, XueJun Xu, Yuanyuan Qian, Congmin Yuan, Xiangguo Meng, JingRui Chai, Jing Chen, Jing Liu, Wenli Wang, Wei Li, YuJun Wang, Wei Fu, Jinggen Liu, 2021
An Exploration of the SAR Connection Between Morphinan and Arylacetamide-based κ Opioid Receptor (κOR) Agonists using the Strategy of Bridging., Xiao Liu, Shuang Jiang, Linghui Kong, Rongrong Ye, Li Xiao, Xuejun Xu, Qian He, Yuanyuan Wei, Zixiang Li, Huijiao Sun, Qiong Xie, Xu Xu, Yan Lu, Yujun Wang, Wei Li, Wei Fu, Zhuibai Qiu, Jinggen Liu, Liming Shao, 2021
The Use of Computational Approaches in the Discovery and Mechanism Study of Opioid Analgesics., Bangyi Zhao, Wei Li, Lijie Sun, Wei Fu, 2020
Discovery of 3-((dimethylamino)methyl)-4-hydroxy-4-(3-methoxyphenyl)-N-phenylpiperidine-1-carboxamide as novel potent analgesic., Huoming Huang, Wenli Wanga, Xuejun Xu, Chen Zhu, Yujun Wang, Jinggen Liu, Wei Li, Wei Fu, 2020
Discovery of a highly selective and potent kappa opioid receptor agonist from N-cyclopropylmethyl-7α-phenyl-6,14-endoethano-tetrahydronorthebaines with reduced central nervous system (CNS) side effects navigated by the message-address concept., Li Xiao, Yujun Wang, Mumei Zhang, Weiwei Wu, Linghui Kong, Yan Ma, Xuejun Xu, Xiao Liu, Qian He, Yuanyuan Qian, Huijiao Sun, Haihao Wu, Cheng Lin, Huoming Huang, Rongrong Ye, Shuang Jiang, Rufeng Ye, Congmin Yuan, Shengyang Fang, Dengqi Xue, Xicheng Yang, Hao Chen, Yilin Zheng, Linqian Yu, Qiong Xie, Lan Zheng, Wei Fu, Wei Li, Zhuibai Qiu, Jinggen Liu, Liming Shao, 2019
7β-methyl substituent is a structural locus associated with activity cliff for nepenthone analogues., Huijiao Sun, Yuhua Wang, Congmin Yuan, Linghui Kong, Xuejun Xu, Yujun Wang, Haihao Wu, Cheng Lin, Yuanyuan Qian, Huoming Huang, Li Xiao, Xiao Liu, Qian He, Shengyang Fang, Dengqi Xue, Xicheng Yanga, Hao Chen, Yilin Zheng, Lan Zheng, Linqian Yu, Qiong Xie, Wei Fu, Wei Li, Jinggen Liu, Zhuibai Qiu, Liming Shao, 2018
The Pharmacological Heterogeneity of Nepenthone Analogs in Conferring Highly Selective and Potent kappa-Opioid Agonistic Activities., Wei Li, Jiandong Long, Yuanyuan Qian, Yu Long, Xuejun Xu, Yujun Wang, Qing Shen, Zuoneng Wang, Xicheng Yang, Li Xiao, Hongpeng Sun, Yulong Xu, Yiyi Chen, Qiong Xie, Yonghui Wang, Liming Shao, Jinggen Liu, Zhuibai Qiu, Wei Fu, 2017

Opioid Receptor Ligands Diagnosis Treatment Diseases Compound Libraries Central Nervous System Drug Discovery Applications Medicinal Chemistry

Liming Shao - Fudan University

Jianjia Huang - Fudan University

Tang Xinjing - Peking University

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