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Liming Shao
Pharmaceutical Sciences
Fudan University
Shanghai
Language: Chinese, Japanese, English
Central Nervous System
Drug Design
Synthesis
Therapeutic Drugs
Malignant Tumors
Drug Discovery
Synthetic Methods
Druggability
Structural Biology
Translational Medicine
Areas of Focus
- Rational design, synthesis, and research and development of diagnostic and therapeutic drugs for central nervous system diseases
- Research and development of therapeutic drugs for malignant tumors
- Research and development of new methods for drug discovery (new synthetic methods, druggability, structural biology)
- Exploration of translational medicine methods in drug research
Work Experience
- 1982.08 – 1987.05 WHO Human Reproduction Research Center/Shanghai Institute of Planned Parenthood Research, Assistant Researcher
- 1998.09 – 2010.10 Sepracor Inc., Drug Development and Preclinical Research Department (USA, Massachusetts)
- 2008-2010 Senior Director
- 2005-2008 Director
- 2001-2005 Associate Director
- 2000-2001 Senior Scientist
- 1998-2000 Scientist
- 2010.10 – 2012.05 Sunovion Inc., Preclinical Research and Translational Medicine Department (USA, Massachusetts), Senior Director
- 2012.06 – Present Fudan University School of Pharmacy, Professor
Academic Background & Achievements
- 1978.09 – 1982.07 Bachelor of Science in Organic Chemistry: Fudan University
- 1987.09 – 1990.03 Master of Engineering in Industrial Chemistry: University of Tokyo
- 1990.03 – 1993.03 Doctor of Engineering in Industrial Chemistry: University of Tokyo
- 1993.04 – 1996.08 Postdoctoral Researcher in Chemistry and Chemical Biology: Harvard University
- Led and participated in the research and development of various drugs, with 4 compounds approved by the US FDA for clinical trials
- Participated in the development of contraceptives, with one drug approved by the China FDA for market
Publications
- Discovery of Potent and Selective Transient Receptor Potential Vanilloid 1 (TRPV1) Agonists with Analgesic Effects In Vivo Based on the Functional Conversion Induced by Altering the Orientation of the Indazole Core, Liang, Q.Q.; Qiao, Z.; Zhou, Q.Q.; Xue, D.Q.; Wang, K.W.; Shao, L.M., 2022
- SLL-627 Is a Highly Selective and Potent Kappa Opioid Receptor (KOR) Agonist with an Unexpected Nonreduction in Locomotor Activity, Kong, L. H.; Shu, X. L.; Tang, S. Y.; Ye, R. R.; Sun, H. J.; Jiang, S.; Li, Z. X.; Chai, J. R.; Fang, Y.; Lan, Y. J.; Yu, L. Q.; Xie, Q.; Fu, W.; Wang, Y. J.; Li, W.; Qiu, Z. B.; Liu, J. G.; Shao, L. M., 2022
- Design and development of selective competitive fluorescent ligands for the detection and visualization of Kv7.2/7.3 in vitro, Qiao, Z.; Tang, S. Y.; Guan, J. L.; Yin, Z. J.; Zhu, C.; Zhou, Q. Q.; Shao, L. M., 2022
- Novel selective kappa agonists SLL-039 and SLL-1206 produce potent antinociception with fewer sedation and aversion, Wei, Y. Y.; Ma, Y.; Yao, S. Y.; Kong, L. H.; Liu, X.; Chai, J. R.; Chen, J.; Li, W.; Wang, Y. J.; Shao, L. M.; Liu, J. G., 2022
- Design and synthesis of novel alpha-aminoamides derivatives as Nav1.7 inhibitors for antinociception, Xue, D. Q.; Liu, Y. N.; Zheng, Y. L.; Niu, H. L.; Dong, L. Y.; Ouyang, X. S.; Song, S. Y.; Zhang, D. G.; Ge, Q. W.; Wang, K. W.; Shao, L. M., 2022
- A covalent modification strategy for di-alkyne tagged metal-organic frameworks to access efficient heterogeneous catalysts toward C-C bond formation, Liang, Q. Q.; Cheng, H.; Li, C. W.; Ning, L. M.; Shao, L. M., 2022
- Iron-catalyzed radical cascade cyclization of oxime esters with isocyanides: synthesis of 1-cyanoalkyl isoquinolines and 6-cyanoalkyl phenanthridines, Xue, D. Q.; Liu, R. Q.; Zhang, D. G.; Li, N.; Xue, Y. J.; Ge, Q. W.; Shao, L. M., 2021
- Nickel- alkyne-functionalized metal-organic frameworks: An efficient and reusable catalyst, Chen, H.; N., L.M.; Liao, S. Y.; Li, W.; Tang, S. Y.; Li, J. L.; Chen, H. X.; Liu, X.; Shao, L. M., 2021
- Exploration of the SAR Connection between Morphinan- and Arylacetamide-Based kappa Opioid Receptor (kappa OR) Agonists Using the Strategy of Bridging, Liu, X.; Jiang, S.; Kong, L. H.; Ye, R. R.; Xiao, L.; Xu, X. J.; He, Q.; Wei, Y. Y.; Li, Z. X.; Sun, H. J.; Xie, Q.; Xu, X.; Lu, Y.; Wang, Y. J.; Li, W.; Fu, W.; Qiu, Z. B.; Liu, J. G.; Shao, L. M., 2021
- Discovery of an M-Substituted N-Cyclopropylmethyl-7alpha-phenyl-6,14-endoethanotetrahydronorthebaine as a Selective, Potent, and Orally Active kappa-Opioid Receptor Agonist with an Improved Central Nervous System Safety Profile, He, Q.; Wei, Y.; Liu, X.; Ye, R.; Kong, L.; Li, Z.; Jiang, S.; Yu, L.; Chai, J.; Xie, Q.; Fu, W.; Wang, Y.J.; Li, W.; Qiu, Z.; Liu, J.G.; Shao, L.M., 2021
- Inhibition of Nav1.7 channel by a novel blocker QLS-81 for alleviation of neuropathic pain, Niu, H. L.; Liu, Y. N.; Xue, D. Q.; Dong, L. Y.; Liu, H. J.; Wang, J.; Zheng, Y. L.; Zou, A. R.; Shao, L. M.; Wang, K. W., 2021
- Additive-Free Radical Cascade Reaction of Oxime Esters: Synthesis of Pyrroline-Functionalized Phenanthridines, Xue, Y. J.; Xue, D. Q.; He, Q.; Ge, Q. W.; Li, W.; Shao, L. M., 2020
- Palladium-Catalyzed Synthesis of beta,beta-Diaryl alpha,beta-Unsaturated Ketones, Zheng, Y. L.; Xiao, L.; Xie, Q.; Shao, L. M., 2019
- Metal-Free Radical Cyclization of Vinyl Isocyanides with Alkanes: Synthesis of 1-Alkylisoquinolines, Xue, D. Q.; Xue, Y. J.; Yu, H. H.; Shao, L. M., 2019
- Discovery of a Highly Selective and Potent kappa Opioid Receptor Agonist from N-Cyclopropylmethyl-7alpha-phenyl-6,14-endoethanotetrahydronorthebaines with Reduced Central Nervous System (CNS) Side Effects Navigated by the Message-Address Concept, Xiao, L.; Wang, Y.J.; Zhang, M.M.; Wu, W.; Kong, L.; Ma, Y.; Xu, X.; Liu, X.; He, Q.; Qian, Y.; Sun, H.; Wu, H.; Lin, C.; Huang, H.; Ye, R.; Jiang, S.; Ye, R. F.; Yuan, C.; Fang, S.; Xue, D.; Yang, X.; Chen, H.; Zheng, Y.; Yu, L.; Xie, Q.; Zheng, L.; Fu, W.; Li, W.; Qiu, Z.B.; Liu, J.G.; Shao, L.M., 2019
- Nickel-Catalyzed Construction of 2,4-Disubstituted Imidazoles via C-C Coupling and C-N Condensation Cascade Reactions, Fang, S. Y.; Yu, H. H.; Yang, X. C.; Li, J. Q.; Shao, L. M., 2019
- Discovery, cocrystallization and biological evaluation of novel piperidine derivatives as high affinity Ls-AChBP ligands possessing alpha 7 nAChR activities, Yang, X. C.; Shen, J.; Jiang, L. L.; Li, W.; Yu, M. C.; Pan, G. X.; Yan, Y. R.; Zhang, C. H.; Jia, W. W.; Xiao, L.; Yu, H. H.; Chen, H.; Zheng, Y. L.; Yu, L. Q.; Xie, Q.; Zhou, L.; Shao, L. M., 2018
- Regioselective Access to 3-Aryl-1-aminoisoquinolines via Nickel(I)-Catalyzed C-C and C-N Cascade Coupling Reactions from the Substituted 2-(Cyanomethyl)benzonitriles, Yang, X.; Yu, H.; Xu, Y.; Shao, L.M., 2018
- Discovery of novel 20S proteasome inhibitors by rational topology-based scaffold hopping of bortezomib
