Upload Avatar (500 x 500)
Xinsheng Lei
Pharmaceutical Sciences
Fudan University
Shanghai
Language: Chinese, English
Synthesis
Methodology
Drug
Process
Research
Marine
Natural
Products
New
Areas of Focus
- Synthetic Methodology and Drug Synthesis Process Research
- New Drug Research Based on Marine Natural Products
Work Experience
- 1999.09 – 2001.07 Postdoctoral Fellow: Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
- 2001.11 – 2003.12 Postdoctoral Fellow: INSA de Rouen, France
- 2004.01 – 2007.06 Researcher: Shanghai Hengrui Pharmaceutical Technology Co., Ltd., R&D Center
- 2007.07 – 2020.11 Associate Researcher and Master's Supervisor: Department of Medicinal Chemistry, School of Pharmacy, Fudan University
- 2012.06 – 2012.07 Visiting Professor: INSA de Rouen, France
- 2020.12 – Present Professor and Doctoral Supervisor: Department of Medicinal Chemistry, School of Pharmacy, Fudan University
Academic Background & Achievements
- 1986.09 – 1990.06 Bachelor: Nankai University, Department of Chemistry
- 1990.09 – 1993.06 Master: Nankai University, Department of Chemistry
- 1996.09 – 1999.08 PhD: Peking Union Medical College & Chinese Academy of Medical Sciences, Institute of Materia Medica
Publications
- Unexpected Enhancement of HDACs Inhibition by MeS Substitution at C-2 Position of Fluoro Largazole, Bingbing Zhang, Zhu-Wei Ruan, Dongdong Luo, Yueyue Zhu, Tingbo Ding, Qiang Sui and Xinsheng Lei, 2020
- Ru-Catalyzed cascade reaction of α,ω-alkynoic acids and arylethylamines towards the synthesis of aryl-fused heterocycles, Yinying Zheng, Jiami Liu and Xinsheng Lei, 2020
- A fluorine scan on the Zn2+-binding thiolate side chain of HDAC inhibitor largazole: synthesis, biological evaluation, and molecular modeling, Bingbing Zhang; Jiami Liu; Dingding Gao; Xiaolin Yu; Jinlei Wang; Xinsheng Lei, 2019
- Synthesis and Preliminary Biological Evaluation of Two Fluoroolefin Analogs of Largazole Inspired by the Structural Similarity of the Side Chain Unit in Psammaplin A, Bingbing Zhang, Guangsheng Shan, Yinying Zheng, Xiaolin Yu, Zhu-Wei Ruan, Yang Li, Xinsheng Lei, 2019
- Discovery, synthesis, biological evaluation and molecular docking study of (R)-5-methylmellein and its analogs as selective monoamine oxidase A inhibitors, Chao Huang, Juan Xiong, Hui-Da Guan, Chang-Hong Wang, Xinsheng Lei, Jin-Feng Hu, 2019
- A highly enantioselective synthetic method towards the α2c-adrenoceptor antagonist ORM-10921, Qiaoning Ma, Xiaodi Yang, Xinsheng Lei, Guo-Qiang Lin, 2019
- Practical and scalable preparation of Minodronic acid and Zolpidem from 2-chloroimidazole[1,2-a]pyridines, Yuheng Wang, Bingbing Zhang, Yinying Zheng, Qiaoning Ma, Qiang Sui, Xinsheng Lei, 2019
- Cs2CO3-promoted defluorination and functionalization of a-CF3 carbonyl compounds in the presence of N-, O-, and/or S-nucleophiles, Yue Wu, Bingbing Zhang, Yinying Zheng, Yuheng Wang, Xinsheng Lei, 2018
- Synthesis of the molecular hybrid inspired by Largazole and Psammaplin A, Xiaoling Yu, Bingbing Zhang, Guangsheng Shan, Yue Wu, Feng-Ling Yang, Xinsheng Lei, 2018
