Professor | Xinsheng Lei | Asia Growth Partners

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Name	Xinsheng Lei
Contact Information	leixs@fudan.edu.cn
Language ability	Chinese, English
Province	Shanghai

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Name

Xinsheng Lei

Contact Information

leixs@fudan.edu.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	Fudan University
Faculty	Pharmaceutical Sciences
Academic Background & Achievements	1986.09 – 1990.06 Bachelor: Nankai University, Department of Chemistry 1990.09 – 1993.06 Master: Nankai University, Department of Chemistry 1996.09 – 1999.08 PhD: Peking Union Medical College & Chinese Academy of Medical Sciences, Institute of Materia Medica
Work Experience	1999.09 – 2001.07 Postdoctoral Fellow: Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences 2001.11 – 2003.12 Postdoctoral Fellow: INSA de Rouen, France 2004.01 – 2007.06 Researcher: Shanghai Hengrui Pharmaceutical Technology Co., Ltd., R&D Center 2007.07 – 2020.11 Associate Researcher and Master's Supervisor: Department of Medicinal Chemistry, School of Pharmacy, Fudan University 2012.06 – 2012.07 Visiting Professor: INSA de Rouen, France 2020.12 – Present Professor and Doctoral Supervisor: Department of Medicinal Chemistry, School of Pharmacy, Fudan University

University/Lab Affiliation and Title

Fudan University

Faculty

Pharmaceutical Sciences

Academic Background & Achievements

1986.09 – 1990.06 Bachelor: Nankai University, Department of Chemistry
1990.09 – 1993.06 Master: Nankai University, Department of Chemistry
1996.09 – 1999.08 PhD: Peking Union Medical College & Chinese Academy of Medical Sciences, Institute of Materia Medica

Work Experience

1999.09 – 2001.07 Postdoctoral Fellow: Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
2001.11 – 2003.12 Postdoctoral Fellow: INSA de Rouen, France
2004.01 – 2007.06 Researcher: Shanghai Hengrui Pharmaceutical Technology Co., Ltd., R&D Center
2007.07 – 2020.11 Associate Researcher and Master's Supervisor: Department of Medicinal Chemistry, School of Pharmacy, Fudan University
2012.06 – 2012.07 Visiting Professor: INSA de Rouen, France
2020.12 – Present Professor and Doctoral Supervisor: Department of Medicinal Chemistry, School of Pharmacy, Fudan University

Areas of Focus	Synthetic Methodology and Drug Synthesis Process Research New Drug Research Based on Marine Natural Products
Publications	Unexpected Enhancement of HDACs Inhibition by MeS Substitution at C-2 Position of Fluoro Largazole, Bingbing Zhang, Zhu-Wei Ruan, Dongdong Luo, Yueyue Zhu, Tingbo Ding, Qiang Sui and Xinsheng Lei, 2020 Ru-Catalyzed cascade reaction of α,ω-alkynoic acids and arylethylamines towards the synthesis of aryl-fused heterocycles, Yinying Zheng, Jiami Liu and Xinsheng Lei, 2020 A fluorine scan on the Zn2+-binding thiolate side chain of HDAC inhibitor largazole: synthesis, biological evaluation, and molecular modeling, Bingbing Zhang; Jiami Liu; Dingding Gao; Xiaolin Yu; Jinlei Wang; Xinsheng Lei, 2019 Synthesis and Preliminary Biological Evaluation of Two Fluoroolefin Analogs of Largazole Inspired by the Structural Similarity of the Side Chain Unit in Psammaplin A, Bingbing Zhang, Guangsheng Shan, Yinying Zheng, Xiaolin Yu, Zhu-Wei Ruan, Yang Li, Xinsheng Lei, 2019 Discovery, synthesis, biological evaluation and molecular docking study of (R)-5-methylmellein and its analogs as selective monoamine oxidase A inhibitors, Chao Huang, Juan Xiong, Hui-Da Guan, Chang-Hong Wang, Xinsheng Lei, Jin-Feng Hu, 2019 A highly enantioselective synthetic method towards the α2c-adrenoceptor antagonist ORM-10921, Qiaoning Ma, Xiaodi Yang, Xinsheng Lei, Guo-Qiang Lin, 2019 Practical and scalable preparation of Minodronic acid and Zolpidem from 2-chloroimidazole[1,2-a]pyridines, Yuheng Wang, Bingbing Zhang, Yinying Zheng, Qiaoning Ma, Qiang Sui, Xinsheng Lei, 2019 Cs2CO3-promoted defluorination and functionalization of a-CF3 carbonyl compounds in the presence of N-, O-, and/or S-nucleophiles, Yue Wu, Bingbing Zhang, Yinying Zheng, Yuheng Wang, Xinsheng Lei, 2018 Synthesis of the molecular hybrid inspired by Largazole and Psammaplin A, Xiaoling Yu, Bingbing Zhang, Guangsheng Shan, Yue Wu, Feng-Ling Yang, Xinsheng Lei, 2018

Areas of Focus

Synthetic Methodology and Drug Synthesis Process Research
New Drug Research Based on Marine Natural Products

Publications

Unexpected Enhancement of HDACs Inhibition by MeS Substitution at C-2 Position of Fluoro Largazole, Bingbing Zhang, Zhu-Wei Ruan, Dongdong Luo, Yueyue Zhu, Tingbo Ding, Qiang Sui and Xinsheng Lei, 2020
Ru-Catalyzed cascade reaction of α,ω-alkynoic acids and arylethylamines towards the synthesis of aryl-fused heterocycles, Yinying Zheng, Jiami Liu and Xinsheng Lei, 2020
A fluorine scan on the Zn2+-binding thiolate side chain of HDAC inhibitor largazole: synthesis, biological evaluation, and molecular modeling, Bingbing Zhang; Jiami Liu; Dingding Gao; Xiaolin Yu; Jinlei Wang; Xinsheng Lei, 2019
Synthesis and Preliminary Biological Evaluation of Two Fluoroolefin Analogs of Largazole Inspired by the Structural Similarity of the Side Chain Unit in Psammaplin A, Bingbing Zhang, Guangsheng Shan, Yinying Zheng, Xiaolin Yu, Zhu-Wei Ruan, Yang Li, Xinsheng Lei, 2019
Discovery, synthesis, biological evaluation and molecular docking study of (R)-5-methylmellein and its analogs as selective monoamine oxidase A inhibitors, Chao Huang, Juan Xiong, Hui-Da Guan, Chang-Hong Wang, Xinsheng Lei, Jin-Feng Hu, 2019
A highly enantioselective synthetic method towards the α2c-adrenoceptor antagonist ORM-10921, Qiaoning Ma, Xiaodi Yang, Xinsheng Lei, Guo-Qiang Lin, 2019
Practical and scalable preparation of Minodronic acid and Zolpidem from 2-chloroimidazole[1,2-a]pyridines, Yuheng Wang, Bingbing Zhang, Yinying Zheng, Qiaoning Ma, Qiang Sui, Xinsheng Lei, 2019
Cs2CO3-promoted defluorination and functionalization of a-CF3 carbonyl compounds in the presence of N-, O-, and/or S-nucleophiles, Yue Wu, Bingbing Zhang, Yinying Zheng, Yuheng Wang, Xinsheng Lei, 2018
Synthesis of the molecular hybrid inspired by Largazole and Psammaplin A, Xiaoling Yu, Bingbing Zhang, Guangsheng Shan, Yue Wu, Feng-Ling Yang, Xinsheng Lei, 2018

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