Professor | 雷新胜 | 数字化转型顾问

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Name	雷新胜
Contact Information	leixs@fudan.edu.cn
Language ability	中文, 英语
Province	上海

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Name

雷新胜

Contact Information

leixs@fudan.edu.cn

Language ability

中文, 英语

Province

上海

University/Lab Affiliation and Title	复旦大学
Faculty	Pharmaceutical Sciences
Academic Background & Achievements	1986.09 – 1990.06 学士: 南开大学化学系 1990.09 – 1993.06 硕士: 南开大学化学系 1996.09 – 1999.08 博士: 中国协和医科大学&中国医学科学院药物研究所
Work Experience	1999.09 – 2001.07 博士后: 中国科学院上海有机化学研究所 2001.11 – 2003.12 博士后: 法国国立应用科学研究院（INSA de Rouen） 2004.01 – 2007.06 研究员: 上海恒瑞医药科技有限公司，研发中心 2007.07 – 2020.11 副研究员，硕士生导师: 复旦大学药学院药化教研室 2012.06 – 2012.07 访问教授: 法国国立应用科学研究院（INSA de Rouen） 2020.12 – 至今教授，博士生导师: 复旦大学药学院药化系

University/Lab Affiliation and Title

复旦大学

Faculty

Pharmaceutical Sciences

Academic Background & Achievements

1986.09 – 1990.06 学士: 南开大学化学系
1990.09 – 1993.06 硕士: 南开大学化学系
1996.09 – 1999.08 博士: 中国协和医科大学&中国医学科学院药物研究所

Work Experience

1999.09 – 2001.07 博士后: 中国科学院上海有机化学研究所
2001.11 – 2003.12 博士后: 法国国立应用科学研究院（INSA de Rouen）
2004.01 – 2007.06 研究员: 上海恒瑞医药科技有限公司，研发中心
2007.07 – 2020.11 副研究员，硕士生导师: 复旦大学药学院药化教研室
2012.06 – 2012.07 访问教授: 法国国立应用科学研究院（INSA de Rouen）
2020.12 – 至今教授，博士生导师: 复旦大学药学院药化系

Areas of Focus	合成方法学及药物合成工艺研究基于海洋天然产物的新药研究
Publications	Unexpected Enhancement of HDACs Inhibition by MeS Substitution at C-2 Position of Fluoro Largazole, Bingbing Zhang, Zhu-Wei Ruan, Dongdong Luo, Yueyue Zhu, Tingbo Ding, Qiang Sui and Xinsheng Lei, 2020 Ru-Catalyzed cascade reaction of α,ω-alkynoic acids and arylethylamines towards the synthesis of aryl-fused heterocycles, Yinying Zheng, Jiami Liu and Xinsheng Lei, 2020 A fluorine scan on the Zn2+-binding thiolate side chain of HDAC inhibitor largazole: synthesis, biological evaluation, and molecular modeling, Bingbing Zhang; Jiami Liu; Dingding Gao; Xiaolin Yu; Jinlei Wang; Xinsheng Lei, 2019 Synthesis and Preliminary Biological Evaluation of Two Fluoroolefin Analogs of Largazole Inspired by the Structural Similarity of the Side Chain Unit in Psammaplin A, Bingbing Zhang, Guangsheng Shan, Yinying Zheng, Xiaolin Yu, Zhu-Wei Ruan, Yang Li, Xinsheng Lei, 2019 Discovery, synthesis, biological evaluation and molecular docking study of (R)-5-methylmellein and its analogs as selective monoamine oxidase A inhibitors, Chao Huang, Juan Xiong, Hui-Da Guan, Chang-Hong Wang, Xinsheng Lei, Jin-Feng Hu, 2019 A highly enantioselective synthetic method towards the α2c-adrenoceptor antagonist ORM-10921, Qiaoning Ma, Xiaodi Yang, Xinsheng Lei, Guo-Qiang Lin, 2019 Practical and scalable preparation of Minodronic acid and Zolpidem from 2-chloroimidazole[1,2-a]pyridines, Yuheng Wang, Bingbing Zhang, Yinying Zheng, Qiaoning Ma, Qiang Sui, Xinsheng Lei, 2019 Cs2CO3-promoted defluorination and functionalization of a-CF3 carbonyl compounds in the presence of N-, O-, and/or S-nucleophiles, Yue Wu, Bingbing Zhang, Yinying Zheng, Yuheng Wang, Xinsheng Lei, 2018 Synthesis of the molecular hybrid inspired by Largazole and Psammaplin A, Xiaoling Yu, Bingbing Zhang, Guangsheng Shan, Yue Wu, Feng-Ling Yang, Xinsheng Lei, 2018

Areas of Focus

合成方法学及药物合成工艺研究
基于海洋天然产物的新药研究

Publications

Unexpected Enhancement of HDACs Inhibition by MeS Substitution at C-2 Position of Fluoro Largazole, Bingbing Zhang, Zhu-Wei Ruan, Dongdong Luo, Yueyue Zhu, Tingbo Ding, Qiang Sui and Xinsheng Lei, 2020
Ru-Catalyzed cascade reaction of α,ω-alkynoic acids and arylethylamines towards the synthesis of aryl-fused heterocycles, Yinying Zheng, Jiami Liu and Xinsheng Lei, 2020
A fluorine scan on the Zn2+-binding thiolate side chain of HDAC inhibitor largazole: synthesis, biological evaluation, and molecular modeling, Bingbing Zhang; Jiami Liu; Dingding Gao; Xiaolin Yu; Jinlei Wang; Xinsheng Lei, 2019
Synthesis and Preliminary Biological Evaluation of Two Fluoroolefin Analogs of Largazole Inspired by the Structural Similarity of the Side Chain Unit in Psammaplin A, Bingbing Zhang, Guangsheng Shan, Yinying Zheng, Xiaolin Yu, Zhu-Wei Ruan, Yang Li, Xinsheng Lei, 2019
Discovery, synthesis, biological evaluation and molecular docking study of (R)-5-methylmellein and its analogs as selective monoamine oxidase A inhibitors, Chao Huang, Juan Xiong, Hui-Da Guan, Chang-Hong Wang, Xinsheng Lei, Jin-Feng Hu, 2019
A highly enantioselective synthetic method towards the α2c-adrenoceptor antagonist ORM-10921, Qiaoning Ma, Xiaodi Yang, Xinsheng Lei, Guo-Qiang Lin, 2019
Practical and scalable preparation of Minodronic acid and Zolpidem from 2-chloroimidazole[1,2-a]pyridines, Yuheng Wang, Bingbing Zhang, Yinying Zheng, Qiaoning Ma, Qiang Sui, Xinsheng Lei, 2019
Cs2CO3-promoted defluorination and functionalization of a-CF3 carbonyl compounds in the presence of N-, O-, and/or S-nucleophiles, Yue Wu, Bingbing Zhang, Yinying Zheng, Yuheng Wang, Xinsheng Lei, 2018
Synthesis of the molecular hybrid inspired by Largazole and Psammaplin A, Xiaoling Yu, Bingbing Zhang, Guangsheng Shan, Yue Wu, Feng-Ling Yang, Xinsheng Lei, 2018

合成方法学药物工艺研究海洋天然产物新

戴惠芳 - 复旦大学

丁宁 - 复旦大学

Area of Focus
糖类 | 药物 | 海洋 | 制药 | 化学 | 研究 | 合成 | 评估 | 生物 | 治疗

王洁 - 复旦大学

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