Professor | Xiaoyan Shen | Asia Growth Partners

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Name	Xiaoyan Shen
Contact Information	shxiaoy@fudan.edu.cn
Language ability	Chinese, English
Province	Shanghai

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Name

Xiaoyan Shen

Contact Information

shxiaoy@fudan.edu.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	Fudan University
Faculty	Pharmaceutical Sciences
Academic Background & Achievements	1986/09-1991/07: Bachelor, Nanjing University of Chinese Medicine 1996/09-1999/06: Master, Guangzhou University of Chinese Medicine 1999/09-2002/06: PhD, Guangzhou University of Chinese Medicine
Work Experience	1991/08-1996/08: Resident Physician, Tongzhou Hospital of Traditional Chinese Medicine, Jiangsu Province 2000/05-2002/02: Visiting Scholar, Shimane Medical University, Japan 2002/07-2003/08: Attending Physician, First Affiliated Hospital of Guangzhou University of Chinese Medicine 2003/09-2008/08: Postdoctoral Fellow, National Heart, Lung, and Blood Institute (NHLBI), NIH, USA 2009/01-2013/09: Professor and Doctoral Supervisor, School of Pharmacy, Sun Yat-sen University 2013/10-Present: Professor and Doctoral Supervisor, Department of Pharmacology, School of Pharmacy, Fudan University
Awards	2018: First Prize in Natural Science Award, Ministry of Education, China (Second Place), Discipline: Pharmacology of Traditional Chinese Medicine, Project: Research on New Mechanisms of Inhibiting Abnormal Cell Proliferation and Differentiation 2005: Second Prize in Science and Technology Progress Award, Guangdong Provincial Science and Technology Commission (Third Place)

University/Lab Affiliation and Title

Fudan University

Faculty

Pharmaceutical Sciences

Academic Background & Achievements

1986/09-1991/07: Bachelor, Nanjing University of Chinese Medicine
1996/09-1999/06: Master, Guangzhou University of Chinese Medicine
1999/09-2002/06: PhD, Guangzhou University of Chinese Medicine

Work Experience

1991/08-1996/08: Resident Physician, Tongzhou Hospital of Traditional Chinese Medicine, Jiangsu Province
2000/05-2002/02: Visiting Scholar, Shimane Medical University, Japan
2002/07-2003/08: Attending Physician, First Affiliated Hospital of Guangzhou University of Chinese Medicine
2003/09-2008/08: Postdoctoral Fellow, National Heart, Lung, and Blood Institute (NHLBI), NIH, USA
2009/01-2013/09: Professor and Doctoral Supervisor, School of Pharmacy, Sun Yat-sen University
2013/10-Present: Professor and Doctoral Supervisor, Department of Pharmacology, School of Pharmacy, Fudan University

Awards

2018: First Prize in Natural Science Award, Ministry of Education, China (Second Place), Discipline: Pharmacology of Traditional Chinese Medicine, Project: Research on New Mechanisms of Inhibiting Abnormal Cell Proliferation and Differentiation
2005: Second Prize in Science and Technology Progress Award, Guangdong Provincial Science and Technology Commission (Third Place)

Areas of Focus	Research on new targets and new drugs for the treatment of inflammatory and immune diseases Discovery of targets and molecular pharmacological mechanisms of natural drugs Preclinical pharmacodynamic evaluation and pharmacological mechanism research of new drugs
Publications	Inhibiting sorting nexin 10 promotes mucosal healing through SREBP2-mediated stemness restoration of intestinal stem cells, Bao W, You Y, Ni J, Hou H, Lyu J, Feng G, Wang Y, You K, Zhang S, Zhang L, Cao X, Wang X, Li H, Li H, Xu J, Liu C, Luo X, Du P, Chen D, Shen X, 2023 A potent PGK1 antagonist reveals PGK1 regulates the production of IL-1β and IL-6, Liao L, Dang W, Lin T, Yu J, Liu T, Li W, Xiao S, Feng L, Huang J, Fu R, Li J, Liu L, Wang M, Tao H, Jiang H, Chen K, Diao X, Zhou B, Shen X, Luo C, 2022 Paeoniflorin prevents aberrant proliferation and differentiation of intestinal stem cells by controlling C1q release from macrophages in chronic colitis, Wang Y, You K, You Y, Li Q, Feng G, Ni J, Cao X, Zhang X, Wang Y, Bao W, Wang X, Chen T, Li H, Huang Y, Lyu J, Yu S, Li H, Xu S, Zeng K, Shen X, 2022 Discovery of First-in-Class TAK1-MKK3 Protein-Protein Interaction (PPI) Inhibitor (R)-STU104 for the Treatment of Ulcerative Colitis through Modulating TNF-α Production, Tang ML, Li H, Ning JF, Shen X, Sun X, 2022 Dephosphorylation of AMP-activated kinase exacerbates ischemia/reperfusion-induced acute kidney injury via mitochondrial dysfunction, Ma H, Guo X, Cui S, Wu Y, Zhang Y, Shen X, Xie C, Li J, 2022 SNX10-mediated LPS sensing causes intestinal barrier dysfunction via a caspase-5-dependent signaling cascade, Wang X, Ni J, You Y, Feng G, Zhang S, Bao W, Hou H, Li H, Liu L, Zheng M, Wang Y, Zhou H, Shen W, Shen X, 2021 Targeting sorting nexin 10 improves mouse colitis via inhibiting PIKfyve-mediated TBK1/c-Rel signaling activation, Bao W, Liu X, You Y, Hou H, Wang X, Zhang S, Li H, Feng G, Cao X, Jiang H, Zheng M, Shen X, 2021 Sorting Nexin 10 Mediates Metabolic Reprogramming of Macrophages in Atherosclerosis Through the Lyn-dependent TFEB Signaling Pathway, You Y, Bao WL, Zhang S, Li HD, Li H, Dang WZ, Zou SI, Cao XY, Wang X, Liu LX, Jiang H, Qu L, Zheng M, Shen X, 2020 BIG1 controls macrophage pro-inflammatory responses through ARF3-mediated PI(4,5)P2 synthesis, Liu L, Zhang S, Wang Y, Bao W, Zhou Y, Dang W, Wang X, Li H, Cao X, You Y, Fang H, Shen X, 2020 SNX10 (sorting nexin 10) inhibits colorectal cancer initiation and progression by controlling autophagic degradation of SRC, Zhang S, Yang Z, Bao W, Liu L, You Y, Wang X, Shao L, Fu W, Kou X, Shen W, Yuan C, Hu B, Dang W, Nandakumar KS, Jiang H, Zheng M, Shen X, 2020 SNX10 mediates alcohol-induced liver injury and steatosis by regulating the activation of chaperone-mediated autophagy, You Y, Li WZ, Zhang S, Hu B, Li YX, Li HD, Tang HH, Li QW, Guan YY, Liu LX, Bao WL, Shen X, 2018 Deficiency of sorting nexin 10 prevents bone erosion in collagen-induced mouse arthritis through promoting NFATc1 degradation, Zhou C, You Y, Shen W, Zhu YZ, Peng J, Feng HT, Wang Y, Li D, Shao WW, Li CX, Li WZ, Xu J, Shen X, 2016 BIG1, a brefeldin A-inhibited guanine nucleotide-exchange protein modulates ABCA1 trafficking and function, Lin S, Zhou C, Neufeld E, Wang YH, Xu SW, Lu L, Wang Y, Liu ZP, Li D, Li C, Chen S, Le K, Huang H, Liu P, Moss J, Vaughan M, Shen X, 2013

Areas of Focus

Research on new targets and new drugs for the treatment of inflammatory and immune diseases
Discovery of targets and molecular pharmacological mechanisms of natural drugs
Preclinical pharmacodynamic evaluation and pharmacological mechanism research of new drugs

Publications

Inhibiting sorting nexin 10 promotes mucosal healing through SREBP2-mediated stemness restoration of intestinal stem cells, Bao W, You Y, Ni J, Hou H, Lyu J, Feng G, Wang Y, You K, Zhang S, Zhang L, Cao X, Wang X, Li H, Li H, Xu J, Liu C, Luo X, Du P, Chen D, Shen X, 2023
A potent PGK1 antagonist reveals PGK1 regulates the production of IL-1β and IL-6, Liao L, Dang W, Lin T, Yu J, Liu T, Li W, Xiao S, Feng L, Huang J, Fu R, Li J, Liu L, Wang M, Tao H, Jiang H, Chen K, Diao X, Zhou B, Shen X, Luo C, 2022
Paeoniflorin prevents aberrant proliferation and differentiation of intestinal stem cells by controlling C1q release from macrophages in chronic colitis, Wang Y, You K, You Y, Li Q, Feng G, Ni J, Cao X, Zhang X, Wang Y, Bao W, Wang X, Chen T, Li H, Huang Y, Lyu J, Yu S, Li H, Xu S, Zeng K, Shen X, 2022
Discovery of First-in-Class TAK1-MKK3 Protein-Protein Interaction (PPI) Inhibitor (R)-STU104 for the Treatment of Ulcerative Colitis through Modulating TNF-α Production, Tang ML, Li H, Ning JF, Shen X, Sun X, 2022
Dephosphorylation of AMP-activated kinase exacerbates ischemia/reperfusion-induced acute kidney injury via mitochondrial dysfunction, Ma H, Guo X, Cui S, Wu Y, Zhang Y, Shen X, Xie C, Li J, 2022
SNX10-mediated LPS sensing causes intestinal barrier dysfunction via a caspase-5-dependent signaling cascade, Wang X, Ni J, You Y, Feng G, Zhang S, Bao W, Hou H, Li H, Liu L, Zheng M, Wang Y, Zhou H, Shen W, Shen X, 2021
Targeting sorting nexin 10 improves mouse colitis via inhibiting PIKfyve-mediated TBK1/c-Rel signaling activation, Bao W, Liu X, You Y, Hou H, Wang X, Zhang S, Li H, Feng G, Cao X, Jiang H, Zheng M, Shen X, 2021
Sorting Nexin 10 Mediates Metabolic Reprogramming of Macrophages in Atherosclerosis Through the Lyn-dependent TFEB Signaling Pathway, You Y, Bao WL, Zhang S, Li HD, Li H, Dang WZ, Zou SI, Cao XY, Wang X, Liu LX, Jiang H, Qu L, Zheng M, Shen X, 2020
BIG1 controls macrophage pro-inflammatory responses through ARF3-mediated PI(4,5)P2 synthesis, Liu L, Zhang S, Wang Y, Bao W, Zhou Y, Dang W, Wang X, Li H, Cao X, You Y, Fang H, Shen X, 2020
SNX10 (sorting nexin 10) inhibits colorectal cancer initiation and progression by controlling autophagic degradation of SRC, Zhang S, Yang Z, Bao W, Liu L, You Y, Wang X, Shao L, Fu W, Kou X, Shen W, Yuan C, Hu B, Dang W, Nandakumar KS, Jiang H, Zheng M, Shen X, 2020
SNX10 mediates alcohol-induced liver injury and steatosis by regulating the activation of chaperone-mediated autophagy, You Y, Li WZ, Zhang S, Hu B, Li YX, Li HD, Tang HH, Li QW, Guan YY, Liu LX, Bao WL, Shen X, 2018
Deficiency of sorting nexin 10 prevents bone erosion in collagen-induced mouse arthritis through promoting NFATc1 degradation, Zhou C, You Y, Shen W, Zhu YZ, Peng J, Feng HT, Wang Y, Li D, Shao WW, Li CX, Li WZ, Xu J, Shen X, 2016
BIG1, a brefeldin A-inhibited guanine nucleotide-exchange protein modulates ABCA1 trafficking and function, Lin S, Zhou C, Neufeld E, Wang YH, Xu SW, Lu L, Wang Y, Liu ZP, Li D, Li C, Chen S, Le K, Huang H, Liu P, Moss J, Vaughan M, Shen X, 2013

Inflammatory Diseases Immune Diseases New Drug Targets Natural Drugs Molecular Pharmacology Preclinical Evaluation Pharmacodynamics Rheumatoid Arthritis Ulcerative Colitis Atherosclerosis

Yan You - Fudan University

Yicheng Mao - Fudan University

Feng Xu - Peking University

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