Professor | Chang-Mei Si | Asia Growth Partners

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Name	Chang-Mei Si
Contact Information	sicm@fudan.edu.cn
Language ability	Chinese, English
Province	Shanghai

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Name

Chang-Mei Si

Contact Information

sicm@fudan.edu.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	Fudan University
Faculty	Pharmaceutical Sciences
Academic Background & Achievements	2007.09 – 2011.06 Bachelor: Northwest A&F University, Applied Chemistry 2011.09 – 2016.06 PhD: Northwest A&F University, Chemical Biology
Work Experience	2016.07 – 2018.12 - Fudan University, School of Pharmacy - Postdoctoral Researcher 2019.01 – Present - Fudan University, School of Pharmacy - Assistant Researcher

University/Lab Affiliation and Title

Fudan University

Faculty

Pharmaceutical Sciences

Academic Background & Achievements

2007.09 – 2011.06 Bachelor: Northwest A&F University, Applied Chemistry
2011.09 – 2016.06 PhD: Northwest A&F University, Chemical Biology

Work Experience

2016.07 – 2018.12 - Fudan University, School of Pharmacy - Postdoctoral Researcher
2019.01 – Present - Fudan University, School of Pharmacy - Assistant Researcher

Areas of Focus	Asymmetric synthesis and structural modification of active components in traditional Chinese medicine
Publications	Synthesis of 1,4- and 1,5-Amino Alcohols via Nucleophilic Addition of Semicyclic N,O-Acetal with Organozinc Reagents, Xue-Mei Wang, Yi-Wen Liu, Rui-Jun Ma, Chang-Mei Si, Bang-Guo Wei, 2019 A divergent method to key unit of tubulysin V through one-pot diastereoselective Mannich process of N,O-acetal with ketone, Xue-Mei Wang, Yi-Wen Liu, Qiao-E Wang, Zhu Zhou, Chang-Mei Si, Bang-Guo Wei, 2019 Approach to Chiral 1-Substituted Isoquinolone and 3-Substituted Isoindolin-1-one by Addition-Cyclization Process, Wen Zhou, Yan-Xue Zhang, Xiao-Di Nie, Chang-Mei Si, Xun Sun, Bang-Guo Wei, 2018 Regio- and Stereoselective Cascades via Aldol Condensation and 1,3-Dipolar Cycloaddition for Construction of Functional Pyrrolizidine Derivatives, Zhuo-Ya Mao, Yi-Wen Liu, Pan Han, Han-Qing Dong, Chang-Mei Si, Bang-Guo Wei, Guo-Qiang Lin, 2018 Asymmetric Synthesis of Rupestonic Acid and Pechueloic Acid, Pan Han, Zhu Zhou, Chang-Mei Si, Xian-Yi Sha, Zheng-Yi Gu, Bang-Guo Wei, Guo-Qiang Lin, 2017 A practical approach to asymmetric synthesis of dolastatin 10, Wen Zhou, Xiao-Di Nie, Yu Zhang, Chang-Mei Si, Zhu Zhou, Xun Sun, Bang-Guo Wei, 2017 Asymmetric syntheses of epohelmins A and B by In-mediated allylation, Yi-Wen Liu, Pan Han, Wen Zhou, Zhuo-Ya Mao, Chang-Mei Si, Bang-Guo Wei, 2016 Diastereoconvergent Synthesis of trans-5-Hydroxy-6-Substituted-2-Piperidinones by Addition-Cyclization-Deprotection Process, Chang-Mei Si, Wei Huang, Zhen-Ting Du, Bang-Guo Wei, Guo-Qiang Lin, 2014 Divergent Method to trans-5-Hydroxy-6-alkynyl/alkenyl-2-piperidinones: Syntheses of (-)-Epiquinamide and (+)-Swainsonine, Chang-Mei Si, Zhuo-Ya Mao, Han-Qing Dong, Zhen-Ting Du, Bang-Guo Wei, Guo-Qiang Lin, 2015 Stereoselective Formation of Chiral trans-4-Hydroxy-5-Substituted 2-Pyrrolidinones: Syntheses of Streptopyrrolidine and 3-epi-Epohelmin A, Chang-Mei Si, Zhuo-Ya Mao, Yi-Wen Liu, Zhen-Ting Du, Bang-Guo Wei, Guo-Qiang Lin, 2015 An efficient approach to trans-4-hydroxy-5-substituted 2-pyrrolidinones through a stereoselective tandem Barbier process: divergent syntheses of (3R,4S)-statines, (+)-preussin and (-)-hapalosin, Chang-Mei Si, Lu-Ping Shao, Zhuo-Ya Mao, Wen Zhou, Bang-Guo Wei, 2017 Synthesis and structure revision of symplocin A, Lu-Ping Shao, Chang-Mei Si, Zhuo-Ya Mao, Wen Zhou, Tadeusz F. Molinski, Bang-Guo Wei, Guo-Qiang Lin, 2017

Areas of Focus

Asymmetric synthesis and structural modification of active components in traditional Chinese medicine

Publications

Synthesis of 1,4- and 1,5-Amino Alcohols via Nucleophilic Addition of Semicyclic N,O-Acetal with Organozinc Reagents, Xue-Mei Wang, Yi-Wen Liu, Rui-Jun Ma, Chang-Mei Si, Bang-Guo Wei, 2019
A divergent method to key unit of tubulysin V through one-pot diastereoselective Mannich process of N,O-acetal with ketone, Xue-Mei Wang, Yi-Wen Liu, Qiao-E Wang, Zhu Zhou, Chang-Mei Si, Bang-Guo Wei, 2019
Approach to Chiral 1-Substituted Isoquinolone and 3-Substituted Isoindolin-1-one by Addition-Cyclization Process, Wen Zhou, Yan-Xue Zhang, Xiao-Di Nie, Chang-Mei Si, Xun Sun, Bang-Guo Wei, 2018
Regio- and Stereoselective Cascades via Aldol Condensation and 1,3-Dipolar Cycloaddition for Construction of Functional Pyrrolizidine Derivatives, Zhuo-Ya Mao, Yi-Wen Liu, Pan Han, Han-Qing Dong, Chang-Mei Si, Bang-Guo Wei, Guo-Qiang Lin, 2018
Asymmetric Synthesis of Rupestonic Acid and Pechueloic Acid, Pan Han, Zhu Zhou, Chang-Mei Si, Xian-Yi Sha, Zheng-Yi Gu, Bang-Guo Wei, Guo-Qiang Lin, 2017
A practical approach to asymmetric synthesis of dolastatin 10, Wen Zhou, Xiao-Di Nie, Yu Zhang, Chang-Mei Si, Zhu Zhou, Xun Sun, Bang-Guo Wei, 2017
Asymmetric syntheses of epohelmins A and B by In-mediated allylation, Yi-Wen Liu, Pan Han, Wen Zhou, Zhuo-Ya Mao, Chang-Mei Si, Bang-Guo Wei, 2016
Diastereoconvergent Synthesis of trans-5-Hydroxy-6-Substituted-2-Piperidinones by Addition-Cyclization-Deprotection Process, Chang-Mei Si, Wei Huang, Zhen-Ting Du, Bang-Guo Wei, Guo-Qiang Lin, 2014
Divergent Method to trans-5-Hydroxy-6-alkynyl/alkenyl-2-piperidinones: Syntheses of (-)-Epiquinamide and (+)-Swainsonine, Chang-Mei Si, Zhuo-Ya Mao, Han-Qing Dong, Zhen-Ting Du, Bang-Guo Wei, Guo-Qiang Lin, 2015
Stereoselective Formation of Chiral trans-4-Hydroxy-5-Substituted 2-Pyrrolidinones: Syntheses of Streptopyrrolidine and 3-epi-Epohelmin A, Chang-Mei Si, Zhuo-Ya Mao, Yi-Wen Liu, Zhen-Ting Du, Bang-Guo Wei, Guo-Qiang Lin, 2015
An efficient approach to trans-4-hydroxy-5-substituted 2-pyrrolidinones through a stereoselective tandem Barbier process: divergent syntheses of (3R,4S)-statines, (+)-preussin and (-)-hapalosin, Chang-Mei Si, Lu-Ping Shao, Zhuo-Ya Mao, Wen Zhou, Bang-Guo Wei, 2017
Synthesis and structure revision of symplocin A, Lu-Ping Shao, Chang-Mei Si, Zhuo-Ya Mao, Wen Zhou, Tadeusz F. Molinski, Bang-Guo Wei, Guo-Qiang Lin, 2017

Asymmetric Synthesis Structural Modification Traditional Chinese Medicine Active Components Bioactivity Evaluation Natural Products Pharmacology Organic Chemistry Medicinal Chemistry Drug Discovery

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Yi-Zhun Zhu - Fudan University

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