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Chang-Mei Si
Pharmaceutical Sciences
Fudan University
Shanghai
Language: Chinese, English
Asymmetric Synthesis
Structural Modification
Traditional Chinese Medicine
Active Components
Bioactivity Evaluation
Natural Products
Pharmacology
Organic Chemistry
Medicinal Chemistry
Drug Discovery
Areas of Focus
- Asymmetric synthesis and structural modification of active components in traditional Chinese medicine
Work Experience
- 2016.07 – 2018.12 - Fudan University, School of Pharmacy - Postdoctoral Researcher
- 2019.01 – Present - Fudan University, School of Pharmacy - Assistant Researcher
Academic Background & Achievements
- 2007.09 – 2011.06 Bachelor: Northwest A&F University, Applied Chemistry
- 2011.09 – 2016.06 PhD: Northwest A&F University, Chemical Biology
Publications
- Synthesis of 1,4- and 1,5-Amino Alcohols via Nucleophilic Addition of Semicyclic N,O-Acetal with Organozinc Reagents, Xue-Mei Wang, Yi-Wen Liu, Rui-Jun Ma, Chang-Mei Si, Bang-Guo Wei, 2019
- A divergent method to key unit of tubulysin V through one-pot diastereoselective Mannich process of N,O-acetal with ketone, Xue-Mei Wang, Yi-Wen Liu, Qiao-E Wang, Zhu Zhou, Chang-Mei Si, Bang-Guo Wei, 2019
- Approach to Chiral 1-Substituted Isoquinolone and 3-Substituted Isoindolin-1-one by Addition-Cyclization Process, Wen Zhou, Yan-Xue Zhang, Xiao-Di Nie, Chang-Mei Si, Xun Sun, Bang-Guo Wei, 2018
- Regio- and Stereoselective Cascades via Aldol Condensation and 1,3-Dipolar Cycloaddition for Construction of Functional Pyrrolizidine Derivatives, Zhuo-Ya Mao, Yi-Wen Liu, Pan Han, Han-Qing Dong, Chang-Mei Si, Bang-Guo Wei, Guo-Qiang Lin, 2018
- Asymmetric Synthesis of Rupestonic Acid and Pechueloic Acid, Pan Han, Zhu Zhou, Chang-Mei Si, Xian-Yi Sha, Zheng-Yi Gu, Bang-Guo Wei, Guo-Qiang Lin, 2017
- A practical approach to asymmetric synthesis of dolastatin 10, Wen Zhou, Xiao-Di Nie, Yu Zhang, Chang-Mei Si, Zhu Zhou, Xun Sun, Bang-Guo Wei, 2017
- Asymmetric syntheses of epohelmins A and B by In-mediated allylation, Yi-Wen Liu, Pan Han, Wen Zhou, Zhuo-Ya Mao, Chang-Mei Si, Bang-Guo Wei, 2016
- Diastereoconvergent Synthesis of trans-5-Hydroxy-6-Substituted-2-Piperidinones by Addition-Cyclization-Deprotection Process, Chang-Mei Si, Wei Huang, Zhen-Ting Du, Bang-Guo Wei, Guo-Qiang Lin, 2014
- Divergent Method to trans-5-Hydroxy-6-alkynyl/alkenyl-2-piperidinones: Syntheses of (-)-Epiquinamide and (+)-Swainsonine, Chang-Mei Si, Zhuo-Ya Mao, Han-Qing Dong, Zhen-Ting Du, Bang-Guo Wei, Guo-Qiang Lin, 2015
- Stereoselective Formation of Chiral trans-4-Hydroxy-5-Substituted 2-Pyrrolidinones: Syntheses of Streptopyrrolidine and 3-epi-Epohelmin A, Chang-Mei Si, Zhuo-Ya Mao, Yi-Wen Liu, Zhen-Ting Du, Bang-Guo Wei, Guo-Qiang Lin, 2015
- An efficient approach to trans-4-hydroxy-5-substituted 2-pyrrolidinones through a stereoselective tandem Barbier process: divergent syntheses of (3R,4S)-statines, (+)-preussin and (-)-hapalosin, Chang-Mei Si, Lu-Ping Shao, Zhuo-Ya Mao, Wen Zhou, Bang-Guo Wei, 2017
- Synthesis and structure revision of symplocin A, Lu-Ping Shao, Chang-Mei Si, Zhuo-Ya Mao, Wen Zhou, Tadeusz F. Molinski, Bang-Guo Wei, Guo-Qiang Lin, 2017
