Professor | Hongbin Zou | Asia Growth Partners

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Name	Hongbin Zou
Contact Information	zouhb@zju.edu.cn
Language ability	Chinese, English, German
Province	Zhejiang

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Name

Hongbin Zou

Contact Information

zouhb@zju.edu.cn

Language ability

Chinese, English, German

Province

Zhejiang

University/Lab Affiliation and Title	Zhejiang University
Faculty	Pharmaceutical Sciences
Academic Background & Achievements	2002 - Bachelor's Degree: Zhejiang University 2007 - Doctorate: Zhejiang University Postdoctoral Research: Zhejiang University Visiting Research: University of Mainz, Germany Visiting Research: Scripps Institution of Oceanography, UC San Diego
Work Experience	2007-2009 - Postdoctoral Researcher - Zhejiang University 2009-Present - Lecturer, Associate Professor - Zhejiang University 2013-2016 - Visiting Researcher - Scripps Institution of Oceanography, UC San Diego
Awards	2011 - Selected for Zhejiang Province Qianjiang Talent Plan

University/Lab Affiliation and Title

Zhejiang University

Faculty

Pharmaceutical Sciences

Academic Background & Achievements

2002 - Bachelor's Degree: Zhejiang University
2007 - Doctorate: Zhejiang University
Postdoctoral Research: Zhejiang University
Visiting Research: University of Mainz, Germany
Visiting Research: Scripps Institution of Oceanography, UC San Diego

Work Experience

2007-2009 - Postdoctoral Researcher - Zhejiang University
2009-Present - Lecturer, Associate Professor - Zhejiang University
2013-2016 - Visiting Researcher - Scripps Institution of Oceanography, UC San Diego

Awards

2011 - Selected for Zhejiang Province Qianjiang Talent Plan

Areas of Focus	Drug Chemistry Enzyme Catalysis
Publications	β-Methyltryptamine Provoking the Crucial Role of Strictosidine Synthase Tyr151-OH for Its Stereoselective Pictet−Spengler Reactions to Tryptoline-type Alkaloids, Haicheng Liu, Santosh Panjikar, Xiang Sheng, Yushi Futamura, Chenghua Zhang, Nana Shao, Hiroyuki Osada, Hongbin Zou, 2022 C(sp3)–H Oxygenation via Alkoxypalladium(II) Species: an Update for the Mechanism, Shuaizhong Zhang, Jinquan Zhang, Hongbin Zou, 2022 Privileged Biorenewable Secologanin-Based Diversity-Oriented Synthesis for Pseudo-Natural Alkaloids: Uncovering Novel Neuroprotective and Antimalarial Frameworks, Huajian Zhu, Yunrui Cai, Shijia Ma, Yushi Futamura, Jinbiao Li, Wen Zhong, Xiangnan Zhang, Hiroyuki Osada, Hongbin Zou, 2021 Direct Transition-Metal Free Benzene C-H Functionalization by Intramolecular Non-Nitroarene Nucleophilic Aromatic Substitution of Hydrogen to Diverse AIEgens, Jinbiao Li, Shuaizhong Zhang, Hongbin Zou, 2021 Acid- and Base-Switched Palladium-Catalyzed γ-C(sp3)–H Alkylation and Alkenylation of Neopentylamine, Jinquan Zhang, Shuaizhong Zhang, Hongbin Zou, 2021 Discovery of 3-Cinnamamido-N-Substituted Benzamides as Potential Antimalarial Agents, Haicheng Liu, Yushi Futamura, Honghai Wu, Aki Ishiyama, Taotao Zhang, Tao Shi, Qunxiong Zheng, Masato Iwatsuki, Satoshi Ōmura, Hongbin Zou, Hiroyuki Osada, 2021 Temperature-Modulated Selective C(sp3)–H or C(sp2)–H Arylation through Palladium Catalysis, Thirupathi Gogula, Jinquan Zhang, Madhava Reddy Lonka, Shuaizhong Zhang, Hongbin Zou, 2020 Benign Synthesis of Unsymmetrical Arylurea Derivatives Using 3-Substituted Dioxazolones as Isocyanate Surrogates, Supakarn Chamni, Jinquan Zhang, Hongbin Zou, 2020 Design, Synthesis and Antitumor Assessment of Phenylureas Bearing 5-Fluoroindolin-2-one Moiety, Yunrui Cai, Tong Chen, Huajian Zhu, Hongbin Zou, 2020 Versatile Regioselective Deuteration of Indoles via Transition-Metal-Catalyzed H/D Exchange, Jinquan Zhang, Shuaizhong Zhang, Thirupathi Gogula, Hongbin Zou, 2020 Water-Promoted Synthesis of Azepino[3,4,5-cd]indole Analogues via Pictet-Spengler Reaction, Shuaizhong Zhang, Yunrui Cai, Hongbin Zou, 2020 One-Pot Chemoselective Domino Condensation to Form a Fused Pyrrolo–pyrazino–indolizine Framework: Discovery of Novel AIE Molecules, Jinbiao Li, Shuaizhong Zhang, Hongbin Zou, 2020 Chameleon-like Behavior of the Directing Group in the Rh(III)-Catalyzed Regioselective C-H Amidation of Indole: An Experimental and Computational Study, Jinquan Zhang, Hujun Xie, Huajian Zhu, Shuaizhong Zhang, Madhava Reddy Lonka, Hongbin Zou, 2019 Stereocomplementary Chemoenzymatic Pictet-Spengler Reactions for Formation of Rare Azepino-indole Frameworks: Discovery of Antimalarial Compounds, Yunrui Cai, Nana Shao, Hujun Xie, Yushi Futamura, Santosh Panjikar, Haicheng Liu, Huajian Zhu, Hiroyuki Osada, Hongbin Zou, 2019 Rhodium(III)-Catalyzed Cascade Reactions of Benzoic Acids with Dioxazolones: Discovery of 2,5-Substituted Benzoxazinones as AIE Molecules, Jinbiao Li, Shuaizhong Zhang, Madhava Reddy Lonka, Jinquan Zhang, Hongbin Zou, 2019 Rhodium(III)-Catalyzed Regioselective C(sp2)-H Functionalization of 7-Arylpyrazolo[1,5-a]pyrimidines with Dioxazolones as Amidating Agents, Thirupathi Gogula, Jinquan Zhang, Hongbin Zou, 2019 Copper(I)-Catalyzed Benzylation of Triazolopyridine through Direct C–H Functionalization, Madhava Reddy Lonka, Jinquan Zhang, Thirupathi Gogula, Hongbin Zou, 2019 Functionalized N-Containing Heterocyclic Scaffolds Derived from N-Substituted Pyrroles via Inter- and Intramolecular Annulations, Nana Shao, Jinbiao Li, Huajian Zhu, Shuaizhong Zhang, Hongbin Zou, 2018 Strictosidine Synthase Triggered Enantioselective Synthesis of N-substituted (S)-3,14,18,19-Tetrahydroangustines as novel Top1 Inhibitors, Yunrui Cai, Huajian Zhu, Zaccary Alperstein, Wenjun Yu, Artem Cherkasov, Hongbin Zou, 2017 “One-pot” Cascade Approach to 5,6-Dihydroindolizines and Indolizines from Pyrrole-2-carbaldehydes and Nitroethylenes, Wen Zhong, Huajian Zhu, Hongbin Zou, 2017 Methanol Facilitated Synthesis of 7-Methoxy-2-thioxo-2,3-dihydro-1H-1,3-diazepin-4(7H)-ones from Nitroallylic Acetates and Thiourea, Taotao Zhang, Nana Shao, Huajian Zhu, Tong Chen, Qunxiong Zheng, Hongbin Zou, 2014 Generation of Insulin-Producing Cells from Rat Mesenchymal Stem Cells Using an Aminopyrrole Derivative XW4.4, Jingfeng Ouyang, Wei Huang, Wanwan Yu, Wei Xiong, Ramanjaneya V.R. Mula, Hongbin Zou, Yongping Yu, 2014 Cascade Regioselective Synthesis of Pyrazoles from Nitroallylic Acetates and N-Tosyl Hydrazine, Nana Shao, Tong Chen, Taotao Zhang, Huajian Zhu, Qunxiong Zheng, Hongbin Zou, 2014 Functionalized Heterocyclic Scaffolds Derived from Morita–Baylis–Hillman Acetates, Huajian Zhu, Nana Shao, Tong Chen, Hongbin Zou, 2013 Cascade Reaction for 3-Pyrrolines and Pyrroles from Nitroallylic Acetates and N-Mesyl 2-Aminoethanones, Tong Chen, Nana Shao, Huajian Zhu, Boya Zhang, Hongbin Zou, 2013 Scaffold Tailoring by a Newly Detected Pictet-Spenglerase Activity of Strictosidine Synthase: From the Common Tryptoline Skeleton to the Rare Piperazino-indole Framework, Fangrui Wu, Huajian Zhu, Lianli Sun, Chitra Rajendran, Meitian Wang, Xin Ren, Santosh Panjikar, Artem Cherkasov, Hongbin Zou, Joachim Stoeckigt, 2012 Hepatic Differentiation of Rat Mesenchymal Stem Cells by a Small Molecule, Jingfeng Ouyang, Jiaan Shao, Hongbin Zou, Yijia Lou, Yongping Yu, 2012 Synthesis and Biological Evaluation of 2-Indolinone Derivatives as Potential Antitumor Agents, Hongbin Zou, Liang Zhang, Jingfeng Ouyang, Marc A. Giulianotti, Yongping Yu, 2011 A Facile Approach to Polysubstituted Pyrazoles from Hydrazonyl Chlorides and Vinyl Azides, Hongbin Zou, Huajian Zhu, Jiaan Shao, Jianwei Wu, Wenteng Chen, Marc A. Giulianotti, Yongping Yu, 2011 “One-Pot” Multicomponent Approach to Indolizines and Pyrido[1,2-a]indoles, Huajian Zhu, Joachim Stöckigt, Yongping Yu, Hongbin Zou, 2011 Synthesis and structure-activity relationship studies of cytotoxic cinnamic alcohol derivatives, Hongbin Zou, Liang Zhang, Leixiang Yang, Liuqing Yang, Yu Zhao, Yongping Yu, Joachim Stöckigt, 2011 A Facile Chemoenzymatic Approach: One-Step Syntheses of Monoterpenoid Indole Alkaloids, Hongbin Zou, Huajian Zhu, Liang Zhang, Liuqing Yang, Yongping Yu, Joachim Stöckigt, 2010 Synthesis, Biological Evaluation, and Structure–Activity Relationship Study of Novel Cytotoxic Aza-Caffeic Acid Derivatives, Hongbin Zou, Hao Wu, Xiangnan Zhang, Yu Zhao, Joachim Stöckigt, Yijia Lou, Yongping Yu, 2010 Improved Expression of His6-Tagged Strictosidine Synthase cDNA for Chemo-Enzymatic Alkaloid Diversification, Liuqing Yang, Hongbin Zou, Huajian Zhu, Martin Ruppert, Jingxu Gong, Joachim Stöckigt, 2010 Dom

Areas of Focus

Drug Chemistry
Enzyme Catalysis

Publications

β-Methyltryptamine Provoking the Crucial Role of Strictosidine Synthase Tyr151-OH for Its Stereoselective Pictet−Spengler Reactions to Tryptoline-type Alkaloids, Haicheng Liu, Santosh Panjikar, Xiang Sheng, Yushi Futamura, Chenghua Zhang, Nana Shao, Hiroyuki Osada, Hongbin Zou, 2022
C(sp3)–H Oxygenation via Alkoxypalladium(II) Species: an Update for the Mechanism, Shuaizhong Zhang, Jinquan Zhang, Hongbin Zou, 2022
Privileged Biorenewable Secologanin-Based Diversity-Oriented Synthesis for Pseudo-Natural Alkaloids: Uncovering Novel Neuroprotective and Antimalarial Frameworks, Huajian Zhu, Yunrui Cai, Shijia Ma, Yushi Futamura, Jinbiao Li, Wen Zhong, Xiangnan Zhang, Hiroyuki Osada, Hongbin Zou, 2021
Direct Transition-Metal Free Benzene C-H Functionalization by Intramolecular Non-Nitroarene Nucleophilic Aromatic Substitution of Hydrogen to Diverse AIEgens, Jinbiao Li, Shuaizhong Zhang, Hongbin Zou, 2021
Acid- and Base-Switched Palladium-Catalyzed γ-C(sp3)–H Alkylation and Alkenylation of Neopentylamine, Jinquan Zhang, Shuaizhong Zhang, Hongbin Zou, 2021
Discovery of 3-Cinnamamido-N-Substituted Benzamides as Potential Antimalarial Agents, Haicheng Liu, Yushi Futamura, Honghai Wu, Aki Ishiyama, Taotao Zhang, Tao Shi, Qunxiong Zheng, Masato Iwatsuki, Satoshi Ōmura, Hongbin Zou, Hiroyuki Osada, 2021
Temperature-Modulated Selective C(sp3)–H or C(sp2)–H Arylation through Palladium Catalysis, Thirupathi Gogula, Jinquan Zhang, Madhava Reddy Lonka, Shuaizhong Zhang, Hongbin Zou, 2020
Benign Synthesis of Unsymmetrical Arylurea Derivatives Using 3-Substituted Dioxazolones as Isocyanate Surrogates, Supakarn Chamni, Jinquan Zhang, Hongbin Zou, 2020
Design, Synthesis and Antitumor Assessment of Phenylureas Bearing 5-Fluoroindolin-2-one Moiety, Yunrui Cai, Tong Chen, Huajian Zhu, Hongbin Zou, 2020
Versatile Regioselective Deuteration of Indoles via Transition-Metal-Catalyzed H/D Exchange, Jinquan Zhang, Shuaizhong Zhang, Thirupathi Gogula, Hongbin Zou, 2020
Water-Promoted Synthesis of Azepino[3,4,5-cd]indole Analogues via Pictet-Spengler Reaction, Shuaizhong Zhang, Yunrui Cai, Hongbin Zou, 2020
One-Pot Chemoselective Domino Condensation to Form a Fused Pyrrolo–pyrazino–indolizine Framework: Discovery of Novel AIE Molecules, Jinbiao Li, Shuaizhong Zhang, Hongbin Zou, 2020
Chameleon-like Behavior of the Directing Group in the Rh(III)-Catalyzed Regioselective C-H Amidation of Indole: An Experimental and Computational Study, Jinquan Zhang, Hujun Xie, Huajian Zhu, Shuaizhong Zhang, Madhava Reddy Lonka, Hongbin Zou, 2019
Stereocomplementary Chemoenzymatic Pictet-Spengler Reactions for Formation of Rare Azepino-indole Frameworks: Discovery of Antimalarial Compounds, Yunrui Cai, Nana Shao, Hujun Xie, Yushi Futamura, Santosh Panjikar, Haicheng Liu, Huajian Zhu, Hiroyuki Osada, Hongbin Zou, 2019
Rhodium(III)-Catalyzed Cascade Reactions of Benzoic Acids with Dioxazolones: Discovery of 2,5-Substituted Benzoxazinones as AIE Molecules, Jinbiao Li, Shuaizhong Zhang, Madhava Reddy Lonka, Jinquan Zhang, Hongbin Zou, 2019
Rhodium(III)-Catalyzed Regioselective C(sp2)-H Functionalization of 7-Arylpyrazolo[1,5-a]pyrimidines with Dioxazolones as Amidating Agents, Thirupathi Gogula, Jinquan Zhang, Hongbin Zou, 2019
Copper(I)-Catalyzed Benzylation of Triazolopyridine through Direct C–H Functionalization, Madhava Reddy Lonka, Jinquan Zhang, Thirupathi Gogula, Hongbin Zou, 2019
Functionalized N-Containing Heterocyclic Scaffolds Derived from N-Substituted Pyrroles via Inter- and Intramolecular Annulations, Nana Shao, Jinbiao Li, Huajian Zhu, Shuaizhong Zhang, Hongbin Zou, 2018
Strictosidine Synthase Triggered Enantioselective Synthesis of N-substituted (S)-3,14,18,19-Tetrahydroangustines as novel Top1 Inhibitors, Yunrui Cai, Huajian Zhu, Zaccary Alperstein, Wenjun Yu, Artem Cherkasov, Hongbin Zou, 2017
“One-pot” Cascade Approach to 5,6-Dihydroindolizines and Indolizines from Pyrrole-2-carbaldehydes and Nitroethylenes, Wen Zhong, Huajian Zhu, Hongbin Zou, 2017
Methanol Facilitated Synthesis of 7-Methoxy-2-thioxo-2,3-dihydro-1H-1,3-diazepin-4(7H)-ones from Nitroallylic Acetates and Thiourea, Taotao Zhang, Nana Shao, Huajian Zhu, Tong Chen, Qunxiong Zheng, Hongbin Zou, 2014
Generation of Insulin-Producing Cells from Rat Mesenchymal Stem Cells Using an Aminopyrrole Derivative XW4.4, Jingfeng Ouyang, Wei Huang, Wanwan Yu, Wei Xiong, Ramanjaneya V.R. Mula, Hongbin Zou, Yongping Yu, 2014
Cascade Regioselective Synthesis of Pyrazoles from Nitroallylic Acetates and N-Tosyl Hydrazine, Nana Shao, Tong Chen, Taotao Zhang, Huajian Zhu, Qunxiong Zheng, Hongbin Zou, 2014
Functionalized Heterocyclic Scaffolds Derived from Morita–Baylis–Hillman Acetates, Huajian Zhu, Nana Shao, Tong Chen, Hongbin Zou, 2013
Cascade Reaction for 3-Pyrrolines and Pyrroles from Nitroallylic Acetates and N-Mesyl 2-Aminoethanones, Tong Chen, Nana Shao, Huajian Zhu, Boya Zhang, Hongbin Zou, 2013
Scaffold Tailoring by a Newly Detected Pictet-Spenglerase Activity of Strictosidine Synthase: From the Common Tryptoline Skeleton to the Rare Piperazino-indole Framework, Fangrui Wu, Huajian Zhu, Lianli Sun, Chitra Rajendran, Meitian Wang, Xin Ren, Santosh Panjikar, Artem Cherkasov, Hongbin Zou, Joachim Stoeckigt, 2012
Hepatic Differentiation of Rat Mesenchymal Stem Cells by a Small Molecule, Jingfeng Ouyang, Jiaan Shao, Hongbin Zou, Yijia Lou, Yongping Yu, 2012
Synthesis and Biological Evaluation of 2-Indolinone Derivatives as Potential Antitumor Agents, Hongbin Zou, Liang Zhang, Jingfeng Ouyang, Marc A. Giulianotti, Yongping Yu, 2011
A Facile Approach to Polysubstituted Pyrazoles from Hydrazonyl Chlorides and Vinyl Azides, Hongbin Zou, Huajian Zhu, Jiaan Shao, Jianwei Wu, Wenteng Chen, Marc A. Giulianotti, Yongping Yu, 2011
“One-Pot” Multicomponent Approach to Indolizines and Pyrido[1,2-a]indoles, Huajian Zhu, Joachim Stöckigt, Yongping Yu, Hongbin Zou, 2011
Synthesis and structure-activity relationship studies of cytotoxic cinnamic alcohol derivatives, Hongbin Zou, Liang Zhang, Leixiang Yang, Liuqing Yang, Yu Zhao, Yongping Yu, Joachim Stöckigt, 2011
A Facile Chemoenzymatic Approach: One-Step Syntheses of Monoterpenoid Indole Alkaloids, Hongbin Zou, Huajian Zhu, Liang Zhang, Liuqing Yang, Yongping Yu, Joachim Stöckigt, 2010
Synthesis, Biological Evaluation, and Structure–Activity Relationship Study of Novel Cytotoxic Aza-Caffeic Acid Derivatives, Hongbin Zou, Hao Wu, Xiangnan Zhang, Yu Zhao, Joachim Stöckigt, Yijia Lou, Yongping Yu, 2010
Improved Expression of His6-Tagged Strictosidine Synthase cDNA for Chemo-Enzymatic Alkaloid Diversification, Liuqing Yang, Hongbin Zou, Huajian Zhu, Martin Ruppert, Jingxu Gong, Joachim Stöckigt, 2010
Dom

Drug Discovery Chemical Synthesis Enzyme Mechanism Biocatalysis Natural Products Chiral Drugs High-Throughput Screening Phenotypic Screening Fluorescent Dyes Neuroprotection

Chun Lei - Fudan University

Li Fuzhuo - Fudan University

Lianli Sun - Zhejiang University

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