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Hongbin Zou
Pharmaceutical Sciences
Zhejiang University
Zhejiang
Language: Chinese, English, German
Drug Discovery
Chemical Synthesis
Enzyme Mechanism
Biocatalysis
Natural Products
Chiral Drugs
High-Throughput Screening
Phenotypic Screening
Fluorescent Dyes
Neuroprotection
Areas of Focus
- Drug Chemistry
- Enzyme Catalysis
Work Experience
- 2007-2009 - Postdoctoral Researcher - Zhejiang University
- 2009-Present - Lecturer, Associate Professor - Zhejiang University
- 2013-2016 - Visiting Researcher - Scripps Institution of Oceanography, UC San Diego
Academic Background & Achievements
- 2002 - Bachelor's Degree: Zhejiang University
- 2007 - Doctorate: Zhejiang University
- Postdoctoral Research: Zhejiang University
- Visiting Research: University of Mainz, Germany
- Visiting Research: Scripps Institution of Oceanography, UC San Diego
Publications
- β-Methyltryptamine Provoking the Crucial Role of Strictosidine Synthase Tyr151-OH for Its Stereoselective Pictet−Spengler Reactions to Tryptoline-type Alkaloids, Haicheng Liu, Santosh Panjikar, Xiang Sheng, Yushi Futamura, Chenghua Zhang, Nana Shao, Hiroyuki Osada, Hongbin Zou, 2022
- C(sp3)–H Oxygenation via Alkoxypalladium(II) Species: an Update for the Mechanism, Shuaizhong Zhang, Jinquan Zhang, Hongbin Zou, 2022
- Privileged Biorenewable Secologanin-Based Diversity-Oriented Synthesis for Pseudo-Natural Alkaloids: Uncovering Novel Neuroprotective and Antimalarial Frameworks, Huajian Zhu, Yunrui Cai, Shijia Ma, Yushi Futamura, Jinbiao Li, Wen Zhong, Xiangnan Zhang, Hiroyuki Osada, Hongbin Zou, 2021
- Direct Transition-Metal Free Benzene C-H Functionalization by Intramolecular Non-Nitroarene Nucleophilic Aromatic Substitution of Hydrogen to Diverse AIEgens, Jinbiao Li, Shuaizhong Zhang, Hongbin Zou, 2021
- Acid- and Base-Switched Palladium-Catalyzed γ-C(sp3)–H Alkylation and Alkenylation of Neopentylamine, Jinquan Zhang, Shuaizhong Zhang, Hongbin Zou, 2021
- Discovery of 3-Cinnamamido-N-Substituted Benzamides as Potential Antimalarial Agents, Haicheng Liu, Yushi Futamura, Honghai Wu, Aki Ishiyama, Taotao Zhang, Tao Shi, Qunxiong Zheng, Masato Iwatsuki, Satoshi Ōmura, Hongbin Zou, Hiroyuki Osada, 2021
- Temperature-Modulated Selective C(sp3)–H or C(sp2)–H Arylation through Palladium Catalysis, Thirupathi Gogula, Jinquan Zhang, Madhava Reddy Lonka, Shuaizhong Zhang, Hongbin Zou, 2020
- Benign Synthesis of Unsymmetrical Arylurea Derivatives Using 3-Substituted Dioxazolones as Isocyanate Surrogates, Supakarn Chamni, Jinquan Zhang, Hongbin Zou, 2020
- Design, Synthesis and Antitumor Assessment of Phenylureas Bearing 5-Fluoroindolin-2-one Moiety, Yunrui Cai, Tong Chen, Huajian Zhu, Hongbin Zou, 2020
- Versatile Regioselective Deuteration of Indoles via Transition-Metal-Catalyzed H/D Exchange, Jinquan Zhang, Shuaizhong Zhang, Thirupathi Gogula, Hongbin Zou, 2020
- Water-Promoted Synthesis of Azepino[3,4,5-cd]indole Analogues via Pictet-Spengler Reaction, Shuaizhong Zhang, Yunrui Cai, Hongbin Zou, 2020
- One-Pot Chemoselective Domino Condensation to Form a Fused Pyrrolo–pyrazino–indolizine Framework: Discovery of Novel AIE Molecules, Jinbiao Li, Shuaizhong Zhang, Hongbin Zou, 2020
- Chameleon-like Behavior of the Directing Group in the Rh(III)-Catalyzed Regioselective C-H Amidation of Indole: An Experimental and Computational Study, Jinquan Zhang, Hujun Xie, Huajian Zhu, Shuaizhong Zhang, Madhava Reddy Lonka, Hongbin Zou, 2019
- Stereocomplementary Chemoenzymatic Pictet-Spengler Reactions for Formation of Rare Azepino-indole Frameworks: Discovery of Antimalarial Compounds, Yunrui Cai, Nana Shao, Hujun Xie, Yushi Futamura, Santosh Panjikar, Haicheng Liu, Huajian Zhu, Hiroyuki Osada, Hongbin Zou, 2019
- Rhodium(III)-Catalyzed Cascade Reactions of Benzoic Acids with Dioxazolones: Discovery of 2,5-Substituted Benzoxazinones as AIE Molecules, Jinbiao Li, Shuaizhong Zhang, Madhava Reddy Lonka, Jinquan Zhang, Hongbin Zou, 2019
- Rhodium(III)-Catalyzed Regioselective C(sp2)-H Functionalization of 7-Arylpyrazolo[1,5-a]pyrimidines with Dioxazolones as Amidating Agents, Thirupathi Gogula, Jinquan Zhang, Hongbin Zou, 2019
- Copper(I)-Catalyzed Benzylation of Triazolopyridine through Direct C–H Functionalization, Madhava Reddy Lonka, Jinquan Zhang, Thirupathi Gogula, Hongbin Zou, 2019
- Functionalized N-Containing Heterocyclic Scaffolds Derived from N-Substituted Pyrroles via Inter- and Intramolecular Annulations, Nana Shao, Jinbiao Li, Huajian Zhu, Shuaizhong Zhang, Hongbin Zou, 2018
- Strictosidine Synthase Triggered Enantioselective Synthesis of N-substituted (S)-3,14,18,19-Tetrahydroangustines as novel Top1 Inhibitors, Yunrui Cai, Huajian Zhu, Zaccary Alperstein, Wenjun Yu, Artem Cherkasov, Hongbin Zou, 2017
- “One-pot” Cascade Approach to 5,6-Dihydroindolizines and Indolizines from Pyrrole-2-carbaldehydes and Nitroethylenes, Wen Zhong, Huajian Zhu, Hongbin Zou, 2017
- Methanol Facilitated Synthesis of 7-Methoxy-2-thioxo-2,3-dihydro-1H-1,3-diazepin-4(7H)-ones from Nitroallylic Acetates and Thiourea, Taotao Zhang, Nana Shao, Huajian Zhu, Tong Chen, Qunxiong Zheng, Hongbin Zou, 2014
- Generation of Insulin-Producing Cells from Rat Mesenchymal Stem Cells Using an Aminopyrrole Derivative XW4.4, Jingfeng Ouyang, Wei Huang, Wanwan Yu, Wei Xiong, Ramanjaneya V.R. Mula, Hongbin Zou, Yongping Yu, 2014
- Cascade Regioselective Synthesis of Pyrazoles from Nitroallylic Acetates and N-Tosyl Hydrazine, Nana Shao, Tong Chen, Taotao Zhang, Huajian Zhu, Qunxiong Zheng, Hongbin Zou, 2014
- Functionalized Heterocyclic Scaffolds Derived from Morita–Baylis–Hillman Acetates, Huajian Zhu, Nana Shao, Tong Chen, Hongbin Zou, 2013
- Cascade Reaction for 3-Pyrrolines and Pyrroles from Nitroallylic Acetates and N-Mesyl 2-Aminoethanones, Tong Chen, Nana Shao, Huajian Zhu, Boya Zhang, Hongbin Zou, 2013
- Scaffold Tailoring by a Newly Detected Pictet-Spenglerase Activity of Strictosidine Synthase: From the Common Tryptoline Skeleton to the Rare Piperazino-indole Framework, Fangrui Wu, Huajian Zhu, Lianli Sun, Chitra Rajendran, Meitian Wang, Xin Ren, Santosh Panjikar, Artem Cherkasov, Hongbin Zou, Joachim Stoeckigt, 2012
- Hepatic Differentiation of Rat Mesenchymal Stem Cells by a Small Molecule, Jingfeng Ouyang, Jiaan Shao, Hongbin Zou, Yijia Lou, Yongping Yu, 2012
- Synthesis and Biological Evaluation of 2-Indolinone Derivatives as Potential Antitumor Agents, Hongbin Zou, Liang Zhang, Jingfeng Ouyang, Marc A. Giulianotti, Yongping Yu, 2011
- A Facile Approach to Polysubstituted Pyrazoles from Hydrazonyl Chlorides and Vinyl Azides, Hongbin Zou, Huajian Zhu, Jiaan Shao, Jianwei Wu, Wenteng Chen, Marc A. Giulianotti, Yongping Yu, 2011
- “One-Pot” Multicomponent Approach to Indolizines and Pyrido[1,2-a]indoles, Huajian Zhu, Joachim Stöckigt, Yongping Yu, Hongbin Zou, 2011
- Synthesis and structure-activity relationship studies of cytotoxic cinnamic alcohol derivatives, Hongbin Zou, Liang Zhang, Leixiang Yang, Liuqing Yang, Yu Zhao, Yongping Yu, Joachim Stöckigt, 2011
- A Facile Chemoenzymatic Approach: One-Step Syntheses of Monoterpenoid Indole Alkaloids, Hongbin Zou, Huajian Zhu, Liang Zhang, Liuqing Yang, Yongping Yu, Joachim Stöckigt, 2010
- Synthesis, Biological Evaluation, and Structure–Activity Relationship Study of Novel Cytotoxic Aza-Caffeic Acid Derivatives, Hongbin Zou, Hao Wu, Xiangnan Zhang, Yu Zhao, Joachim Stöckigt, Yijia Lou, Yongping Yu, 2010
- Improved Expression of His6-Tagged Strictosidine Synthase cDNA for Chemo-Enzymatic Alkaloid Diversification, Liuqing Yang, Hongbin Zou, Huajian Zhu, Martin Ruppert, Jingxu Gong, Joachim Stöckigt, 2010
- Dom
Awards
- 2011 - Selected for Zhejiang Province Qianjiang Talent Plan
