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Li Fuzhuo
Pharmaceutical Sciences
Fudan University
Shanghai
Language: Chinese, English
Protein Evolution
Enzymatic Catalysis
Chemoenzymatic Synthesis
Bioactive Natural Products
Chiral Drugs
Structure-Activity Relationship
Mechanism Of Action
Green Chemistry
Synthetic Biology
Biocatalysis
Areas of Focus
- Directed evolution of proteins and development of novel enzymatic catalytic methodologies
- Application of chemoenzymatic strategies in the synthesis of bioactive natural products and chiral drugs
- Structure-activity relationship and mechanism of action studies of bioactive natural products
Work Experience
- 2022-present - Fudan University - Junior Researcher
- 2017-2022 - Scripps Research Institute - Postdoctoral Researcher
Academic Background & Achievements
- 2012-2017 Ph.D. in Chemistry: Peking University
- 2008-2012 B.Sc. in Chemistry: Lanzhou University
Publications
- Chemoenzymatic Approaches for Exploring Structure–Activity Relationship Studies of Bioactive Natural Products, Li, F.; Deng, H.; Renata, H., 2023
- Remote B-Ring Oxidation of Sclareol with an Engineered P450 Facilitates Divergent Access to Complex Terpenoids, Li, F.; Deng, H.; Renata, H., 2022
- A Chiral-Pool-Based Strategy to Access Trans-Syn-Fused Drimane Meroterpenoids: Chemoenzymatic Total Syntheses of Polysin, N-Acetyl-Polyveoline and the Chrodrimanins, Li, F.; Renata, H., 2021
- Stereoselective Synthesis of β-Branched α-Amino Acids via a Biocatalytic Dynamic Kinetic Resolution, Li, F.; Yang, L.-C.; Zhang, J.; Chen. J. S.; Renata, H., 2021
- Merging Chemoenzymatic and Radical-Based Retrosynthetic Logic for Rapid and Modular Synthesis of Oxidized Meroterpenoids, Li, J.; Li, F.; King-Smith, E.; Renata, H., 2020
- Enzymatic C–H Functionalizations for Natural Product Synthesis, Li, F.; Zhang, X.; Renata, H., 2019
- Bioinspired Asymmetric Synthesis of Hispidanin A, Li, F.; Tu, Q.; Chen. S.; Zhu, L.; Lan, Y.; Gong, J.; Yang, Z., 2017
- A Chiral Pool Approach for Asymmetric Syntheses of (-)-Antrocin, (+)-Asperolide C and (-)-trans-Ozic acid, Li, F.; Li, S.; Zhang, P.; Huang, Z.; Zhang, W.; Gong, J.-X.; Yang Z., 2016
- Palladium-Catalyzed Carbonylative Cyclization of Aryl Alkenes/Alkenols: A New Reaction Mode for the Synthesis of Electron-Rich Chromanes, Li, S.; Li, F.; Gong, J.; Yang. Z., 2015
- Asymmetric Total Synthesis of (-)-Maoecrystal V, Zhang, W.; Shao, W.; Li, F.; Gong, J., 2015
- Collective Synthesis of Humulanolides Using a Metathesis Cascade Reaction, Han, J.; Li, F.; Li, C.-C., 2014
- 牛樟芝素的制备方法, 李付琸; 张伟滨; 张鹏鹏; 黄智辉; 龚建贤; 曾耀铭; 杨震, 2017
Awards
- National Overseas High-Level Talent Introduction Youth Project (2024-2027)
- Shanghai Overseas High-Level Talent Introduction Program
