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Lianli Sun
Pharmaceutical Sciences
Zhejiang University
Zhejiang
Language: Chinese, German, English
Enzyme Engineering
Drug Synthesis
Microbial Synthesis
Natural Products
Synthetic Biology
3D Structure-Based Enzyme Design
Directed Evolution
Chemoselectivity
Chiral Alcohol Synthesis
Biocatalysis
Areas of Focus
- Enzyme Engineering and its Application in Drug Synthesis
- Microbial Synthesis of Natural Products
Work Experience
- 2014.06-present - Zhejiang University, College of Pharmaceutical Sciences - Associate Professor
- 2012.06-2014.5 - Zhejiang University, College of Biomedical Engineering - Lecturer
- 2009.05-2012.05 - Zhejiang University, College of Pharmaceutical Sciences - Postdoctoral Researcher
- 2008.07-2009.04 - University of Mainz, College of Pharmaceutical Sciences - Postdoctoral Researcher
Academic Background & Achievements
- 2005.09-2008.06 Ph.D. in Biopharmaceuticals: University of Mainz
- 2003.09-2008.06 Ph.D. in Pharmaceutical Analysis: Zhejiang University
- 1999.09-2003.06 Bachelor's in Pharmacy: Zhejiang University
Publications
- Switching the chemoselectivity of perakine reductase for selective reduction of α,β-unsaturated ketones by Arg127 mutation, Z Zhang, Y Zhou, H Zhao, Y Wu, L Sun, 2023
- Characterization of a novel recombinant calcium-binding protein from Arca subcrenata and its anti-hepatoma activities in vitro and in vivo, H Shi, S Panjikar, C Li, X Ou, Y Zhou, K Zhang, L Song, R Yu, L Sun, J Zhu, 2023
- MUC1 detection and in situ imaging method based on aptamer conformational switch and hybridization chain reaction, Z Song, Y Zhou, M Shen, D Zhao, H Hu, S Zeng, L Sun, S Cai, 2022
- Correlation Between Crohn’s Disease Activity and Serum Selenium Concentration, Y Wu, M Wei, Z Song, L Huang, H Chen, Q Cao, L Sun, 2022
- Metal-phenolic coated and prochloraz-loaded calcium carbonate carriers with pH responsiveness for environmentally-safe fungicide delivery, D Xiao, J Cheng, W Liang, L Sun, Jinhao Zhao, 2021
- Enantioselective reduction of α,β-unsaturated ketones and aryl ketones by perakine reductase, S Cai, N Shao, Y Chen, A Li, J Pan, H Zhu, H Zou, S Zeng, L Sun, J Zhao, 2019
- A conformational switch‐based aptasensor for the chemiluminescence detection of microRNA, S Cai, J Ye, AAA AL‐maskri, L Sun, S Zeng, 2019
- Inter-isoform hetero-dimerization of human UDP-Glucuronosyltransferases (UGTs) 1A1, 1A9 and 2B7 and impacts on glucuronidation activity, L Yuan, Z Gao, H Sun, S Qian, Y Xiao, L Sun, S Zeng, 2016
- Study on antitubercular constituents from the seeds of Nigella glandulifera, L Sun, M Luan, W Zhu, S Gao, Q Zhang, C Xu, X Lu, X Xu, J Tian, L Zhang, 2013
- Crystal structure of perakine reductase, a founding member of a novel aldo-keto reductase (AKR) subfamily which undergoes unique conformational changes during NADPH binding, L Sun, Y Chen, C Rajendran, U Mueller, S Panjikar, M Wang, R Mindnich, C Rosenthal, TM Penning, J Stöckigt, 2012
- Scaffold tailoring by a newly detected Pictet−Spenglerase activity of strictosidine synthase: from the common tryptoline skeleton to the rare piperazino-indole framework, F Wu, H Zhu, L Sun, C Rajendran, M Wang, X Ren, S Panjikar, A Cherkasov, H Zou, J Stöckigt, 2012
- Proteomics analysis of UV-irradiated Lonicera japonica Thunb. with bioactive metabolites enhancement, L Zhang, X Li, W Zheng, Z Fu, W Li, L Ma, K Li, L Sun, J Tian, 2013
- Comparative proteomic analysis of the sun- and freeze-dried earthworm Eisenia fetida with differentially thrombolytic activities, Z Fu, L Zhang, X Liu, Y Zhang, Q Zhang, X Li, W Zheng, L Sun, J Tian, 2013
- Phytochemical investigation and cytotoxic evaluation of the components of the medicinal plant Ligularia atroviolace, X Wang, L Sun, K Huang, S Shi, L Zhang, J Xu, H Peng, X Sun, L Wang, X Wu, Y Zhao, X Li, J Stöckigt, J Qu, 2009
- Purification, cloning, functional expression and characterization of perakine reductase: the first example from the AKR enzyme family, extending the alkaloidal network of the plant Rauvolfia, L Sun, M Ruppert, Y Sheludko, H Warzecha, Y Zhao, J Stöckigt, 2008
