Professor | 孙莲莉 | 数字化转型顾问

	Upload Avatar (500 x 500)
Name	孙莲莉
Contact Information	sunlianli@zju.edu.cn
Language ability	中文, 德语, 英语
Province	浙江

Upload Avatar (500 x 500)

Name

孙莲莉

Contact Information

sunlianli@zju.edu.cn

Language ability

中文, 德语, 英语

Province

浙江

University/Lab Affiliation and Title	浙江大学
Faculty	Pharmaceutical Sciences
Academic Background & Achievements	2005.09-2008.06 生物制药专业博士: 德国美因茨大学 2003.09-2008.06 药物分析专业博士: 浙江大学 1999.09-2003.06 药学专业学士: 浙江大学
Work Experience	2014.06-至今 - 浙江大学药学院 - 副教授 2012.06-2014.5 - 浙江大学生仪学院 - 讲师 2009.05-2012.05 - 浙江大学药学院 - 博士后 2008.07-2009.04 - 德国美因茨大学药学院 - 博士后

University/Lab Affiliation and Title

浙江大学

Faculty

Pharmaceutical Sciences

Academic Background & Achievements

2005.09-2008.06 生物制药专业博士: 德国美因茨大学
2003.09-2008.06 药物分析专业博士: 浙江大学
1999.09-2003.06 药学专业学士: 浙江大学

Work Experience

2014.06-至今 - 浙江大学药学院 - 副教授
2012.06-2014.5 - 浙江大学生仪学院 - 讲师
2009.05-2012.05 - 浙江大学药学院 - 博士后
2008.07-2009.04 - 德国美因茨大学药学院 - 博士后

Areas of Focus	酶工程及其在药物合成的应用天然产物微生物合成
Publications	Switching the chemoselectivity of perakine reductase for selective reduction of α,β-unsaturated ketones by Arg127 mutation, Z Zhang, Y Zhou, H Zhao, Y Wu, L Sun, 2023 Characterization of a novel recombinant calcium-binding protein from Arca subcrenata and its anti-hepatoma activities in vitro and in vivo, H Shi, S Panjikar, C Li, X Ou, Y Zhou, K Zhang, L Song, R Yu, L Sun, J Zhu, 2023 MUC1 detection and in situ imaging method based on aptamer conformational switch and hybridization chain reaction, Z Song, Y Zhou, M Shen, D Zhao, H Hu, S Zeng, L Sun, S Cai, 2022 Correlation Between Crohn’s Disease Activity and Serum Selenium Concentration, Y Wu, M Wei, Z Song, L Huang, H Chen, Q Cao, L Sun, 2022 Metal-phenolic coated and prochloraz-loaded calcium carbonate carriers with pH responsiveness for environmentally-safe fungicide delivery, D Xiao, J Cheng, W Liang, L Sun, Jinhao Zhao, 2021 Enantioselective reduction of α,β-unsaturated ketones and aryl ketones by perakine reductase, S Cai, N Shao, Y Chen, A Li, J Pan, H Zhu, H Zou, S Zeng, L Sun, J Zhao, 2019 A conformational switch‐based aptasensor for the chemiluminescence detection of microRNA, S Cai, J Ye, AAA AL‐maskri, L Sun, S Zeng, 2019 Inter-isoform hetero-dimerization of human UDP-Glucuronosyltransferases (UGTs) 1A1, 1A9 and 2B7 and impacts on glucuronidation activity, L Yuan, Z Gao, H Sun, S Qian, Y Xiao, L Sun, S Zeng, 2016 Study on antitubercular constituents from the seeds of Nigella glandulifera, L Sun, M Luan, W Zhu, S Gao, Q Zhang, C Xu, X Lu, X Xu, J Tian, L Zhang, 2013 Crystal structure of perakine reductase, a founding member of a novel aldo-keto reductase (AKR) subfamily which undergoes unique conformational changes during NADPH binding, L Sun, Y Chen, C Rajendran, U Mueller, S Panjikar, M Wang, R Mindnich, C Rosenthal, TM Penning, J Stöckigt, 2012 Scaffold tailoring by a newly detected Pictet−Spenglerase activity of strictosidine synthase: from the common tryptoline skeleton to the rare piperazino-indole framework, F Wu, H Zhu, L Sun, C Rajendran, M Wang, X Ren, S Panjikar, A Cherkasov, H Zou, J Stöckigt, 2012 Proteomics analysis of UV-irradiated Lonicera japonica Thunb. with bioactive metabolites enhancement, L Zhang, X Li, W Zheng, Z Fu, W Li, L Ma, K Li, L Sun, J Tian, 2013 Comparative proteomic analysis of the sun- and freeze-dried earthworm Eisenia fetida with differentially thrombolytic activities, Z Fu, L Zhang, X Liu, Y Zhang, Q Zhang, X Li, W Zheng, L Sun, J Tian, 2013 Phytochemical investigation and cytotoxic evaluation of the components of the medicinal plant Ligularia atroviolace, X Wang, L Sun, K Huang, S Shi, L Zhang, J Xu, H Peng, X Sun, L Wang, X Wu, Y Zhao, X Li, J Stöckigt, J Qu, 2009 Purification, cloning, functional expression and characterization of perakine reductase: the first example from the AKR enzyme family, extending the alkaloidal network of the plant Rauvolfia, L Sun, M Ruppert, Y Sheludko, H Warzecha, Y Zhao, J Stöckigt, 2008

Areas of Focus

酶工程及其在药物合成的应用
天然产物微生物合成

Publications

Switching the chemoselectivity of perakine reductase for selective reduction of α,β-unsaturated ketones by Arg127 mutation, Z Zhang, Y Zhou, H Zhao, Y Wu, L Sun, 2023
Characterization of a novel recombinant calcium-binding protein from Arca subcrenata and its anti-hepatoma activities in vitro and in vivo, H Shi, S Panjikar, C Li, X Ou, Y Zhou, K Zhang, L Song, R Yu, L Sun, J Zhu, 2023
MUC1 detection and in situ imaging method based on aptamer conformational switch and hybridization chain reaction, Z Song, Y Zhou, M Shen, D Zhao, H Hu, S Zeng, L Sun, S Cai, 2022
Correlation Between Crohn’s Disease Activity and Serum Selenium Concentration, Y Wu, M Wei, Z Song, L Huang, H Chen, Q Cao, L Sun, 2022
Metal-phenolic coated and prochloraz-loaded calcium carbonate carriers with pH responsiveness for environmentally-safe fungicide delivery, D Xiao, J Cheng, W Liang, L Sun, Jinhao Zhao, 2021
Enantioselective reduction of α,β-unsaturated ketones and aryl ketones by perakine reductase, S Cai, N Shao, Y Chen, A Li, J Pan, H Zhu, H Zou, S Zeng, L Sun, J Zhao, 2019
A conformational switch‐based aptasensor for the chemiluminescence detection of microRNA, S Cai, J Ye, AAA AL‐maskri, L Sun, S Zeng, 2019
Inter-isoform hetero-dimerization of human UDP-Glucuronosyltransferases (UGTs) 1A1, 1A9 and 2B7 and impacts on glucuronidation activity, L Yuan, Z Gao, H Sun, S Qian, Y Xiao, L Sun, S Zeng, 2016
Study on antitubercular constituents from the seeds of Nigella glandulifera, L Sun, M Luan, W Zhu, S Gao, Q Zhang, C Xu, X Lu, X Xu, J Tian, L Zhang, 2013
Crystal structure of perakine reductase, a founding member of a novel aldo-keto reductase (AKR) subfamily which undergoes unique conformational changes during NADPH binding, L Sun, Y Chen, C Rajendran, U Mueller, S Panjikar, M Wang, R Mindnich, C Rosenthal, TM Penning, J Stöckigt, 2012
Scaffold tailoring by a newly detected Pictet−Spenglerase activity of strictosidine synthase: from the common tryptoline skeleton to the rare piperazino-indole framework, F Wu, H Zhu, L Sun, C Rajendran, M Wang, X Ren, S Panjikar, A Cherkasov, H Zou, J Stöckigt, 2012
Proteomics analysis of UV-irradiated Lonicera japonica Thunb. with bioactive metabolites enhancement, L Zhang, X Li, W Zheng, Z Fu, W Li, L Ma, K Li, L Sun, J Tian, 2013
Comparative proteomic analysis of the sun- and freeze-dried earthworm Eisenia fetida with differentially thrombolytic activities, Z Fu, L Zhang, X Liu, Y Zhang, Q Zhang, X Li, W Zheng, L Sun, J Tian, 2013
Phytochemical investigation and cytotoxic evaluation of the components of the medicinal plant Ligularia atroviolace, X Wang, L Sun, K Huang, S Shi, L Zhang, J Xu, H Peng, X Sun, L Wang, X Wu, Y Zhao, X Li, J Stöckigt, J Qu, 2009
Purification, cloning, functional expression and characterization of perakine reductase: the first example from the AKR enzyme family, extending the alkaloidal network of the plant Rauvolfia, L Sun, M Ruppert, Y Sheludko, H Warzecha, Y Zhao, J Stöckigt, 2008

酶工程药物合成微生物合成天然产物合成生物学基于三维结构的酶设计定向进化化学选择性手性醇合成生物催化

李付琸 - 复旦大学

麻光磊 - 浙江大学

Area of Focus
生物合成 | 天然产物 | 药用 | 酶 | 催化 | 中药 | 基因组学 | 先导结构 | 合成生物学 | 制造

马明 - 北京大学

View All

Personal Information

Academic Information

Research

联系我们

还未创建账户?

Personal Information

Academic Information

Research

联系我们