Professor | 李付琸 | 数字化转型顾问

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Name	李付琸
Contact Information	lifuzhuo@fudan.edu.cn
Language ability	中文, 英语
Province	上海

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Name

李付琸

Contact Information

lifuzhuo@fudan.edu.cn

Language ability

中文, 英语

Province

上海

University/Lab Affiliation and Title	复旦大学
Faculty	Pharmaceutical Sciences
Academic Background & Achievements	2012-2017 理学博士: 北京大学 2008-2012 理学学士: 兰州大学
Work Experience	2022至今 - 复旦大学 - 青年研究员 2017-2022 - Scripps研究所 - 博士后
Awards	国家海外高层次人才引进青年项目 (2024-2027) 上海海外高层次人才引进计划

University/Lab Affiliation and Title

复旦大学

Faculty

Pharmaceutical Sciences

Academic Background & Achievements

2012-2017 理学博士: 北京大学
2008-2012 理学学士: 兰州大学

Work Experience

2022至今 - 复旦大学 - 青年研究员
2017-2022 - Scripps研究所 - 博士后

Awards

国家海外高层次人才引进青年项目 (2024-2027)
上海海外高层次人才引进计划

Areas of Focus	蛋白质定向进化和新型酶催化反应方法学的开发化学酶法策略在活性天然产物和手性药物合成中的应用活性天然产物的构效关系与作用机制研究
Publications	Chemoenzymatic Approaches for Exploring Structure–Activity Relationship Studies of Bioactive Natural Products, Li, F.; Deng, H.; Renata, H., 2023 Remote B-Ring Oxidation of Sclareol with an Engineered P450 Facilitates Divergent Access to Complex Terpenoids, Li, F.; Deng, H.; Renata, H., 2022 A Chiral-Pool-Based Strategy to Access Trans-Syn-Fused Drimane Meroterpenoids: Chemoenzymatic Total Syntheses of Polysin, N-Acetyl-Polyveoline and the Chrodrimanins, Li, F.; Renata, H., 2021 Stereoselective Synthesis of β-Branched α-Amino Acids via a Biocatalytic Dynamic Kinetic Resolution, Li, F.; Yang, L.-C.; Zhang, J.; Chen. J. S.; Renata, H., 2021 Merging Chemoenzymatic and Radical-Based Retrosynthetic Logic for Rapid and Modular Synthesis of Oxidized Meroterpenoids, Li, J.; Li, F.; King-Smith, E.; Renata, H., 2020 Enzymatic C–H Functionalizations for Natural Product Synthesis, Li, F.; Zhang, X.; Renata, H., 2019 Bioinspired Asymmetric Synthesis of Hispidanin A, Li, F.; Tu, Q.; Chen. S.; Zhu, L.; Lan, Y.; Gong, J.; Yang, Z., 2017 A Chiral Pool Approach for Asymmetric Syntheses of (-)-Antrocin, (+)-Asperolide C and (-)-trans-Ozic acid, Li, F.; Li, S.; Zhang, P.; Huang, Z.; Zhang, W.; Gong, J.-X.; Yang Z., 2016 Palladium-Catalyzed Carbonylative Cyclization of Aryl Alkenes/Alkenols: A New Reaction Mode for the Synthesis of Electron-Rich Chromanes, Li, S.; Li, F.; Gong, J.; Yang. Z., 2015 Asymmetric Total Synthesis of (-)-Maoecrystal V, Zhang, W.; Shao, W.; Li, F.; Gong, J., 2015 Collective Synthesis of Humulanolides Using a Metathesis Cascade Reaction, Han, J.; Li, F.; Li, C.-C., 2014 牛樟芝素的制备方法, 李付琸; 张伟滨; 张鹏鹏; 黄智辉; 龚建贤; 曾耀铭; 杨震, 2017

Areas of Focus

蛋白质定向进化和新型酶催化反应方法学的开发
化学酶法策略在活性天然产物和手性药物合成中的应用
活性天然产物的构效关系与作用机制研究

Publications

Chemoenzymatic Approaches for Exploring Structure–Activity Relationship Studies of Bioactive Natural Products, Li, F.; Deng, H.; Renata, H., 2023
Remote B-Ring Oxidation of Sclareol with an Engineered P450 Facilitates Divergent Access to Complex Terpenoids, Li, F.; Deng, H.; Renata, H., 2022
A Chiral-Pool-Based Strategy to Access Trans-Syn-Fused Drimane Meroterpenoids: Chemoenzymatic Total Syntheses of Polysin, N-Acetyl-Polyveoline and the Chrodrimanins, Li, F.; Renata, H., 2021
Stereoselective Synthesis of β-Branched α-Amino Acids via a Biocatalytic Dynamic Kinetic Resolution, Li, F.; Yang, L.-C.; Zhang, J.; Chen. J. S.; Renata, H., 2021
Merging Chemoenzymatic and Radical-Based Retrosynthetic Logic for Rapid and Modular Synthesis of Oxidized Meroterpenoids, Li, J.; Li, F.; King-Smith, E.; Renata, H., 2020
Enzymatic C–H Functionalizations for Natural Product Synthesis, Li, F.; Zhang, X.; Renata, H., 2019
Bioinspired Asymmetric Synthesis of Hispidanin A, Li, F.; Tu, Q.; Chen. S.; Zhu, L.; Lan, Y.; Gong, J.; Yang, Z., 2017
A Chiral Pool Approach for Asymmetric Syntheses of (-)-Antrocin, (+)-Asperolide C and (-)-trans-Ozic acid, Li, F.; Li, S.; Zhang, P.; Huang, Z.; Zhang, W.; Gong, J.-X.; Yang Z., 2016
Palladium-Catalyzed Carbonylative Cyclization of Aryl Alkenes/Alkenols: A New Reaction Mode for the Synthesis of Electron-Rich Chromanes, Li, S.; Li, F.; Gong, J.; Yang. Z., 2015
Asymmetric Total Synthesis of (-)-Maoecrystal V, Zhang, W.; Shao, W.; Li, F.; Gong, J., 2015
Collective Synthesis of Humulanolides Using a Metathesis Cascade Reaction, Han, J.; Li, F.; Li, C.-C., 2014
牛樟芝素的制备方法, 李付琸; 张伟滨; 张鹏鹏; 黄智辉; 龚建贤; 曾耀铭; 杨震, 2017

蛋白质进化酶催化化学酶法合成活性天然产物手性药物构效关系作用机制绿色化学合成生物学生物催化

孙莲莉 - 浙江大学

马明 - 北京大学

邹宏斌 - 浙江大学

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