Professor | Jinxin Che | Asia Growth Partners

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Name	Jinxin Che
Contact Information	chejx@zju.edu.cn
Language ability	Chinese, English
Province	Zhejiang

Upload Avatar (500 x 500)

Name

Jinxin Che

Contact Information

chejx@zju.edu.cn

Language ability

Chinese, English

Province

Zhejiang

University/Lab Affiliation and Title	Zhejiang University
Faculty	Pharmaceutical Sciences
Academic Background & Achievements	2013.9~2018.6 Medical Doctor: Zhejiang University School of Pharmacy 2009.9~2013.6 Bachelor of Science: China Pharmaceutical University School of Pharmacy Zhejiang Province Association for Science and Technology Youth Talent Support Project
Work Experience	2021.8~Present - Zhejiang University School of Pharmacy - Distinguished Researcher 2018.7~2021.7 - Zhejiang University School of Pharmacy - Postdoctoral Researcher
Awards	Zhejiang Province Pharmaceutical Association Science and Technology First Prize

University/Lab Affiliation and Title

Zhejiang University

Faculty

Pharmaceutical Sciences

Academic Background & Achievements

2013.9~2018.6 Medical Doctor: Zhejiang University School of Pharmacy
2009.9~2013.6 Bachelor of Science: China Pharmaceutical University School of Pharmacy
Zhejiang Province Association for Science and Technology Youth Talent Support Project

Work Experience

2021.8~Present - Zhejiang University School of Pharmacy - Distinguished Researcher
2018.7~2021.7 - Zhejiang University School of Pharmacy - Postdoctoral Researcher

Awards

Zhejiang Province Pharmaceutical Association Science and Technology First Prize

Areas of Focus	Drug Repositioning Hybrid Drug Design Innovative Drug Research with Multi-Technology Integration
Publications	Discovery of New Phenyltetrazolium Derivatives as Ferroptosis Inhibitors for Treating Ischemic Stroke: An Example Development from Free Radical Scavengers, Lu, Y.; Shen, Z.; Xu, Y.; Lin, H.; Shen, L.; Jin, Y.; Guo, Y.; Lu, J.; Li, L.; Zhuang, Y.; Jin, Y.; Zhuang, W.; Dong, X.; Dai, H.; Che, J., 2024 Discovery of a Highly Potent and Selective BRD9 PROTAC Degrader Based on E3 Binder Investigation for the Treatment of Hematological Tumors, Duan, H.; Zhang, J.; Gui, R.; Lu, Y.; Pang, A.; Chen, B.; Shen, L.; Yu, H.; Li, J.; Xu, T.; Wang, Y.; Yao, X.; Zhang, B.; Lin, N.; Dong, X.; Zhou, Y.; Che, J., 2024 Cpd-A1 Alleviates Acute Kidney Injury by Inhibiting Ferroptosis, Chen, Y.; Wu, M.; Xie, M.; Lu, Y.; Li, C.; Xie, S.; Ma, W.; Ji, M.; Hou, R.; Dong, Z.; He, R.; Zhang, M.; Lu, H.; Gao, L.; Wen, J.; Jin, J.; Dong, X.; Che, J.; Meng, X., 2024 Rational Identification of Novel Antibody-Drug Conjugate with High Bystander Killing Effect against Heterogeneous Tumors, Guo, Y.; Shen, Z.; Zhao, W.; Lu, J.; Song, Y.; Shen, L.; Lu, Y.; Wu, M.; Shi, Q.; Zhuang, W.; Qiu, Y.; Sheng, J.; Zhou, Z.; Fang, L.; Che, J.; Dong, X., 2024 Discovery of N-(1-(6-Oxo-1,6-Dihydropyrimidine)-Pyrazole) Acetamide Derivatives as Novel Noncovalent DprE1 Inhibitors against Mycobacterium Tuberculosis, Yang, L.; Hu, X.; Lu, Y.; Xu, R.; Xu, Y.; Ma, W.; Alam, M. S.; Zhang, T.; Chai, X.; Lei, Y.; Ye, Q.; Dong, X.; Kang, Y.; Che, J.; Hou, T.; Li, D., 2024 Discovery of Novel Oxazepine Derivatives as Akt/Rock Inhibitors for Growth Arrest and Differentiation Induction in Neuroblastoma Treatment, Che, J.; Bing, S.; Lu, J.; Jin, Z.; Gao, J.; Sheng, H.; Li, D.; Yang, B.; He, Q.; Ying, M.; Dong, X., 2023 TransFoxMol: predicting molecular property with focused attention, Gao, J.; Shen, Z.; Xie, Y.; Lu, J.; Lu, Y.; Chen, S.; Bian, Q.; Guo, Y.; Shen, L.; Wu, J.; Zhou, B.; Hou, T.; He, Q.; Che, J.; Dong, X., 2023 ClusterX: a novel representation learning-based deep clustering framework for accurate visual inspection in virtual screening, Chen, S.; Gao, J.; Chen, J.; Xie, Y.; Shen, Z.; Xu, L.; Che, J.; Wu, J.; Dong, X., 2023 Structure-Based Identification of New Orally Bioavailable BRD9-PROTACs for Treating Acute Myelocytic Leukemia, Zhang, J.; Duan, H.; Gui, R.; Wu, M.; Shen, L.; Jin, Y.; Pang, A.; Yu, X.; Zeng, S.; Zhang, B.; Lin, N.; Huang, W.; Wang, Y.; Yao, X.; Li, J.; Dong, X.; Zhou, Y.; Che, J., 2023 Targeted Delivery of Cathepsin-Activatable near-Infrared Fluorescence Probe for Ultrahigh Specific Imaging of Peritoneal Metastasis, Lu, J.; Guo, Y.; Hao, H.; Ma, J.; Lu, Y.; Sun, Y.; Shi, Z.; Dong, X.; Zhang, B.; Fang, L.; Che, J., 2023 An Updated Patent Review of AKT Inhibitors (2020 – Present), Li, L.; Guo, Y.; Lu, Y.; Xu, Y.; Lu, Y.; Zhu, X.; Dong, X.; Che, J., 2023 Discovery of new macrophage M2 polarization modulators as multiple sclerosis treatment agents that enable the inflammation microenvironment remodeling, Che, J.; Li, D.; Hong, W.; Wang, L.; Guo, Y.; Wu, M.; Lu, J.; Tong, L.; Weng, Q.; Wang, J.; Dong, X., 2022 Structural Feature Analyzation Strategies toward Discovery of Orally Bioavailable PROTACs of Bruton's Tyrosine Kinase for the Treatment of Lymphoma, Zhang, J.; Che, J.; Luo, X.; Wu, M.; Kan, W.; Jin, Y.; Wang, H.; Pang, A.; Li, C.; Huang, W.; Zeng, S.; Zhuang, W.; Wu, Y.; Xu, Y.; Zhou, Y.; Li, J.; Dong, X., 2022 Altered pathways and targeted therapy in double hit lymphoma, Zhuang, Y.; Che, J.; Wu, M.; Guo, Y.; Xu, Y.; Dong, X.; Yang, H., 2022 Discovery of seneciobipyrrolidine derivatives for the amelioration of glucose homeostasis disorders through 4E-BP1/Akt/AMPK signaling activation, Che, J.; Ma, C.; Lu, J.; Chen, B.; Shi, Q.; Jin, X.; Song, R.; Xu, F.; Gan, L.; Li, J.; Hu, Y.; Dong, X., 2022 Discovery of N-((3S,4S)-4-(3,4-Difluorophenyl)Piperidin-3-yl)-2-Fluoro-4-(1-Methyl-1H-Pyrazol-5-yl)Benzamide (Hu7691), a Potent and Selective Akt Inhibitor that Enables Decrease of Cutaneous Toxicity, Che, J.; Dai, X.; Gao, J.; Sheng, H.; Zhan, W.; Lu, Y.; Li, D.; Gao, Z.; Jin, Z.; Chen, B.; Luo, P.; Yang, B.; Hu, Y.; He, Q.; Weng, Q.; Dong, X., 2021 Discovery of 5,6-Bis(4-Methoxy-3-Methylphenyl)Pyridin-2-Amine as a WSB1 Degrader to Inhibit Cancer Cell Metastasis, Che, J.; Jin, Z.; Yan, F.; You, J.; Xie, J.; Chen, B.; Zhu, H.; He, Q.; Hu, Y.; Yang, B.; Cao, J.; Dong, X., 2021 Discovery of phenyl-linked symmetric small molecules as inhibitors of the programmed cell death-1/programmed cell death-ligand 1 interaction, Wu, Y.; Zhang, Y.; Guo, Y.; Pan, Z.; Zhong, S.; Jin, X.; Zhuang, W.; Chen, S.; Gao, J.; Huang, W.; Dong, X.; Che, J., 2021 Inhibiting Ferroptosis: A Novel Approach for Stroke Therapeutics, Jin, Y.; Zhuang, Y.; Liu, M.; Che, J.; Dong, X., 2021 Structure-based design, synthesis and bioactivity evaluation of macrocyclic inhibitors of mutant isocitrate dehydrogenase 2 (IDH2) displaying activity in acute myeloid leukemia cells, Che, J.; Huang, F.; Zhang, M.; Xu, G.; Qu, B.; Gao, J.; Chen, B.; Zhang, J.; Ying, H.; Hu, Y.; Hu, X.; Zhou, Y.; Gao, A.; Li, J.; Dong, X., 2020 Development of differentiation modulators and targeted agents for treating neuroblastoma, Jin, Z.; Lu, Y.; Wu, Y.; Che, J.; Dong, X., 2020 Targeting CXCR1/2: The medicinal potential as cancer immunotherapy agents, antagonists research highlights and challenges ahead, Che, J.; Song, R.; Chen, B.; Dong, X., 2020 Discovery of pyrazole-thiophene derivatives as highly Potent, orally active Akt inhibitors, Zhan, W.; Che, J.; Xu, L.; Wu, Y.; Hu, X.; Zhou, Y.; Cheng, G.; Hu, Y.; Dong, X.; Li, J., 2019 Phenotypic Screening-Based Identification of 3,4-Disubstituted Piperidine Derivatives as Macrophage M2 Polarization Modulators: An Opportunity for Treating Multiple Sclerosis, Weng, Q.; Che, J.; Zhang, Z.; Zheng, J.; Zhan, W.; Ling, S.; Tian, T.; Wang, J.; Gai, R.; Hu, Y.; Yang, B.; He, Q.; Dong, X., 2019 Visible-light-mediated guest trapping in a photosensitizing porous coordination network: metal-free C-C bond-forming modification of metal-organic frameworks for aqueous-phase herbicide adsorption, Yang, Y.; Che, J.; Wang, B.; Wu, Y.; Chen, B.; Gao, L.; Dong, X.; Zhao, J., 2019

Areas of Focus

Drug Repositioning
Hybrid Drug Design
Innovative Drug Research with Multi-Technology Integration

Publications

Discovery of New Phenyltetrazolium Derivatives as Ferroptosis Inhibitors for Treating Ischemic Stroke: An Example Development from Free Radical Scavengers, Lu, Y.; Shen, Z.; Xu, Y.; Lin, H.; Shen, L.; Jin, Y.; Guo, Y.; Lu, J.; Li, L.; Zhuang, Y.; Jin, Y.; Zhuang, W.; Dong, X.; Dai, H.; Che, J., 2024
Discovery of a Highly Potent and Selective BRD9 PROTAC Degrader Based on E3 Binder Investigation for the Treatment of Hematological Tumors, Duan, H.; Zhang, J.; Gui, R.; Lu, Y.; Pang, A.; Chen, B.; Shen, L.; Yu, H.; Li, J.; Xu, T.; Wang, Y.; Yao, X.; Zhang, B.; Lin, N.; Dong, X.; Zhou, Y.; Che, J., 2024
Cpd-A1 Alleviates Acute Kidney Injury by Inhibiting Ferroptosis, Chen, Y.; Wu, M.; Xie, M.; Lu, Y.; Li, C.; Xie, S.; Ma, W.; Ji, M.; Hou, R.; Dong, Z.; He, R.; Zhang, M.; Lu, H.; Gao, L.; Wen, J.; Jin, J.; Dong, X.; Che, J.; Meng, X., 2024
Rational Identification of Novel Antibody-Drug Conjugate with High Bystander Killing Effect against Heterogeneous Tumors, Guo, Y.; Shen, Z.; Zhao, W.; Lu, J.; Song, Y.; Shen, L.; Lu, Y.; Wu, M.; Shi, Q.; Zhuang, W.; Qiu, Y.; Sheng, J.; Zhou, Z.; Fang, L.; Che, J.; Dong, X., 2024
Discovery of N-(1-(6-Oxo-1,6-Dihydropyrimidine)-Pyrazole) Acetamide Derivatives as Novel Noncovalent DprE1 Inhibitors against Mycobacterium Tuberculosis, Yang, L.; Hu, X.; Lu, Y.; Xu, R.; Xu, Y.; Ma, W.; Alam, M. S.; Zhang, T.; Chai, X.; Lei, Y.; Ye, Q.; Dong, X.; Kang, Y.; Che, J.; Hou, T.; Li, D., 2024
Discovery of Novel Oxazepine Derivatives as Akt/Rock Inhibitors for Growth Arrest and Differentiation Induction in Neuroblastoma Treatment, Che, J.; Bing, S.; Lu, J.; Jin, Z.; Gao, J.; Sheng, H.; Li, D.; Yang, B.; He, Q.; Ying, M.; Dong, X., 2023
TransFoxMol: predicting molecular property with focused attention, Gao, J.; Shen, Z.; Xie, Y.; Lu, J.; Lu, Y.; Chen, S.; Bian, Q.; Guo, Y.; Shen, L.; Wu, J.; Zhou, B.; Hou, T.; He, Q.; Che, J.; Dong, X., 2023
ClusterX: a novel representation learning-based deep clustering framework for accurate visual inspection in virtual screening, Chen, S.; Gao, J.; Chen, J.; Xie, Y.; Shen, Z.; Xu, L.; Che, J.; Wu, J.; Dong, X., 2023
Structure-Based Identification of New Orally Bioavailable BRD9-PROTACs for Treating Acute Myelocytic Leukemia, Zhang, J.; Duan, H.; Gui, R.; Wu, M.; Shen, L.; Jin, Y.; Pang, A.; Yu, X.; Zeng, S.; Zhang, B.; Lin, N.; Huang, W.; Wang, Y.; Yao, X.; Li, J.; Dong, X.; Zhou, Y.; Che, J., 2023
Targeted Delivery of Cathepsin-Activatable near-Infrared Fluorescence Probe for Ultrahigh Specific Imaging of Peritoneal Metastasis, Lu, J.; Guo, Y.; Hao, H.; Ma, J.; Lu, Y.; Sun, Y.; Shi, Z.; Dong, X.; Zhang, B.; Fang, L.; Che, J., 2023
An Updated Patent Review of AKT Inhibitors (2020 – Present), Li, L.; Guo, Y.; Lu, Y.; Xu, Y.; Lu, Y.; Zhu, X.; Dong, X.; Che, J., 2023
Discovery of new macrophage M2 polarization modulators as multiple sclerosis treatment agents that enable the inflammation microenvironment remodeling, Che, J.; Li, D.; Hong, W.; Wang, L.; Guo, Y.; Wu, M.; Lu, J.; Tong, L.; Weng, Q.; Wang, J.; Dong, X., 2022
Structural Feature Analyzation Strategies toward Discovery of Orally Bioavailable PROTACs of Bruton's Tyrosine Kinase for the Treatment of Lymphoma, Zhang, J.; Che, J.; Luo, X.; Wu, M.; Kan, W.; Jin, Y.; Wang, H.; Pang, A.; Li, C.; Huang, W.; Zeng, S.; Zhuang, W.; Wu, Y.; Xu, Y.; Zhou, Y.; Li, J.; Dong, X., 2022
Altered pathways and targeted therapy in double hit lymphoma, Zhuang, Y.; Che, J.; Wu, M.; Guo, Y.; Xu, Y.; Dong, X.; Yang, H., 2022
Discovery of seneciobipyrrolidine derivatives for the amelioration of glucose homeostasis disorders through 4E-BP1/Akt/AMPK signaling activation, Che, J.; Ma, C.; Lu, J.; Chen, B.; Shi, Q.; Jin, X.; Song, R.; Xu, F.; Gan, L.; Li, J.; Hu, Y.; Dong, X., 2022
Discovery of N-((3S,4S)-4-(3,4-Difluorophenyl)Piperidin-3-yl)-2-Fluoro-4-(1-Methyl-1H-Pyrazol-5-yl)Benzamide (Hu7691), a Potent and Selective Akt Inhibitor that Enables Decrease of Cutaneous Toxicity, Che, J.; Dai, X.; Gao, J.; Sheng, H.; Zhan, W.; Lu, Y.; Li, D.; Gao, Z.; Jin, Z.; Chen, B.; Luo, P.; Yang, B.; Hu, Y.; He, Q.; Weng, Q.; Dong, X., 2021
Discovery of 5,6-Bis(4-Methoxy-3-Methylphenyl)Pyridin-2-Amine as a WSB1 Degrader to Inhibit Cancer Cell Metastasis, Che, J.; Jin, Z.; Yan, F.; You, J.; Xie, J.; Chen, B.; Zhu, H.; He, Q.; Hu, Y.; Yang, B.; Cao, J.; Dong, X., 2021
Discovery of phenyl-linked symmetric small molecules as inhibitors of the programmed cell death-1/programmed cell death-ligand 1 interaction, Wu, Y.; Zhang, Y.; Guo, Y.; Pan, Z.; Zhong, S.; Jin, X.; Zhuang, W.; Chen, S.; Gao, J.; Huang, W.; Dong, X.; Che, J., 2021
Inhibiting Ferroptosis: A Novel Approach for Stroke Therapeutics, Jin, Y.; Zhuang, Y.; Liu, M.; Che, J.; Dong, X., 2021
Structure-based design, synthesis and bioactivity evaluation of macrocyclic inhibitors of mutant isocitrate dehydrogenase 2 (IDH2) displaying activity in acute myeloid leukemia cells, Che, J.; Huang, F.; Zhang, M.; Xu, G.; Qu, B.; Gao, J.; Chen, B.; Zhang, J.; Ying, H.; Hu, Y.; Hu, X.; Zhou, Y.; Gao, A.; Li, J.; Dong, X., 2020
Development of differentiation modulators and targeted agents for treating neuroblastoma, Jin, Z.; Lu, Y.; Wu, Y.; Che, J.; Dong, X., 2020
Targeting CXCR1/2: The medicinal potential as cancer immunotherapy agents, antagonists research highlights and challenges ahead, Che, J.; Song, R.; Chen, B.; Dong, X., 2020
Discovery of pyrazole-thiophene derivatives as highly Potent, orally active Akt inhibitors, Zhan, W.; Che, J.; Xu, L.; Wu, Y.; Hu, X.; Zhou, Y.; Cheng, G.; Hu, Y.; Dong, X.; Li, J., 2019
Phenotypic Screening-Based Identification of 3,4-Disubstituted Piperidine Derivatives as Macrophage M2 Polarization Modulators: An Opportunity for Treating Multiple Sclerosis, Weng, Q.; Che, J.; Zhang, Z.; Zheng, J.; Zhan, W.; Ling, S.; Tian, T.; Wang, J.; Gai, R.; Hu, Y.; Yang, B.; He, Q.; Dong, X., 2019
Visible-light-mediated guest trapping in a photosensitizing porous coordination network: metal-free C-C bond-forming modification of metal-organic frameworks for aqueous-phase herbicide adsorption, Yang, Y.; Che, J.; Wang, B.; Wu, Y.; Chen, B.; Gao, L.; Dong, X.; Zhao, J., 2019

Drug Repositioning Hybrid Drug Design Innovative Drug Research Multi-Technology Integration Candidate Molecules Drug Discovery Target Identification Therapeutic Development Pharmaceutical Chemistry Biomedical Research

Ke-Wu Zeng - Peking University

Xiaoyan Liu - Peking University

Yang Wang - Fudan University

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