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Yang Wang
Pharmaceutical Sciences
Fudan University
Shanghai
Language: Chinese, English
Synthesis
Structural Modification
Druggability
Active Natural Products
Pharmaceutical Chemistry
Organic Synthesis
Medicinal Chemistry
Natural Products
Drug Discovery
Bioactive Compounds
Areas of Focus
- Synthesis, structural modification, and druggability research of active natural products
Work Experience
- 1992.07 – 1999.03 Zhengzhou University, Chemistry Department - Assistant, Lecturer (1995)
- 1993.09 – 1994.09 Ryukoku University, Japan - Visiting Scholar
- 1999.04 – Present Fudan University, School of Pharmacy, Department of Medicinal Chemistry - Associate Professor (2000), Professor (2010)
- 2006.01 – Present Director of the Pharmacy Experimental Teaching Center
- 2011.10 – Present Member of the Shanghai Pharmaceutical Association, Medicinal Chemistry Committee
Academic Background & Achievements
- 1985.09 – 1989.06 Bachelor: Zhengzhou University, Chemistry
- 1989.09 – 1992.06 Master: Zhengzhou University, Organic Chemistry
- 2001.09 – 2005.06 PhD: Fudan University, Pharmaceutical Chemistry
Publications
- Targeting the tumor microenvironment by an enzyme-responsive prodrug of tubulin destabilizer for triple-negative breast cancer therapy with high safety, Peng, Y.; Shi, Z.; Liang, Y.; Ding, K.; Wang, Y., 2022
- Discovery of a 2,6-Diarylpyridine-Based Hydroxamic Acid Derivative as Novel Histone Deacetylase 8 and Tubulin Dual Inhibitor for the Treatment of Neuroblastoma, Tang, H.; Liang, Y.; Shen, H.; Cai, S.; Yu, M.; Fan, H.; Ding, K.; Wang, Y., 2022
- Bifunctional Chiral Selenium-Containing 1,4-Diarylazetidin-2-ones with Potent Antitumor Activities by Disrupting Tubulin Polymerization and Inducing Reactive Oxygen Species Production, Tang, H.; Liang, Y.; Cheng, J.; Ding, K.; Wang, Y., 2021
- Novel Diaryl-2H-azirines: Antitumor Hybrids for Dual-targeting Tubulin and DNA, Lin, S.; Liang, Y.; Cheng, J.; Pan, F.; Wang, Y., 2021
- Design, Synthesis and Antitumor Evaluation of Novel Chiral Diaryl Substituted Azetidin-2-one Derivatives as Tubulin Polymerization Inhibitors, Liang, Y.; Zhang, M.; Zhou, P.; Liu, M.; Li, J.; Wang, Y., 2021
- Design, Synthesis and Activity Evaluation of Novel Acyclic Nucleosides as Potential Anticancer Agents in Vitro and in Vivo, Hao, E.-J.; Li, G.-X.; Liang, Y.-R.; Xie, M.-S.; Wang, D.-C.; Jiang, X.-H.; Cheng, J.-Y.; Shi, Z.-X.; Wang, Y.; Guo, H.-M., 2021
- Discovery of a Chiral Fluorinated Azetidin-2-one as a Tubulin Polymerisation Inhibitor with Potent Antitumour Efficacy, Tang, H.; Cheng, J.; Liang, Y.; Wang, Y., 2020
- Discovery of Novel Aryl Carboxamide Derivatives as Hypoxia-Inducible Factor (HIF) 1α Signaling Inhibitors with Potent Activities of Anticancer Metastasis, Liu, M.; Liang, Y.; Zhu, Z.; Wang, J.; Cheng, X.; Cheng, J.; Xu, B.; Li, R.; Liu, X.; Wang, Y., 2019
- Design, Synthesis, Antitumor Activities and Biological Studies of Novel Diaryl Substituted Fused Heterocycles as Dual Ligands Targeting Tubulin and Katanin, Gao, F.; Liang, Y.; Zhou, P.; Cheng, J.; Ding, K.; Wang, Y., 2019
- Design, Synthesis, Biological Evaluation and Cocrystal Structures with Tubulin of Chiral β-Lactam Bridged Combretastatin A-4 Analogues as Potent Antitumor Agents, Zhou, P.; Liang, Y.; Zhang, H.; Jiang, H.; Feng, K.; Xu, P.; Wang, J.; Wang, X.; Ding, K.; Luo, C.; Liu, M.; Wang, Y., 2018
- Design, Synthesis, and Biological Evaluation of Hydantoin Bridged Analogues of Combretastatin A-4 as Potential Anticancer Agents, Zhang M.; Liang, Y.-R.; Li, H.; Liu, M.-M.; Wang, Y., 2017
- The Total Synthesis of (±)-Sanggenol F, Sheng, X.; Jia, X.-Y.; Tang, F.; Wang, Y.; Hou, A.-J., 2017
- Potent Anti-tumor Activities and Structure Basis of the Chiral β-Lactam Bridged Analogue of Combretastatin A-4 Binding to Tubulin, Zhou, P.; Liu, Y.; Zhou, L.; Zhu, K.; Feng, K.; Zhang, H.; Liang, Y.; Jiang, H.; Luo, C.; Liu, M.; Wang, Y., 2016
Awards
- 2019: Shanghai Talent Award
- 2015: Baosteel Excellent Teacher Award
- 2013: Second Prize of Shanghai Teaching Achievement (Second Contributor)
- 2012: Fudan University 'Excellence in Teaching and Educating' Outstanding Communist Party Member
