Professor | Yang Wang | Asia Growth Partners

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Name	Yang Wang
Contact Information	wangyang@shmu.edu.cn
Language ability	Chinese, English
Province	Shanghai

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Name

Yang Wang

Contact Information

wangyang@shmu.edu.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	Fudan University
Faculty	Pharmaceutical Sciences
Academic Background & Achievements	1985.09 – 1989.06 Bachelor: Zhengzhou University, Chemistry 1989.09 – 1992.06 Master: Zhengzhou University, Organic Chemistry 2001.09 – 2005.06 PhD: Fudan University, Pharmaceutical Chemistry
Work Experience	1992.07 – 1999.03 Zhengzhou University, Chemistry Department - Assistant, Lecturer (1995) 1993.09 – 1994.09 Ryukoku University, Japan - Visiting Scholar 1999.04 – Present Fudan University, School of Pharmacy, Department of Medicinal Chemistry - Associate Professor (2000), Professor (2010) 2006.01 – Present Director of the Pharmacy Experimental Teaching Center 2011.10 – Present Member of the Shanghai Pharmaceutical Association, Medicinal Chemistry Committee
Awards	2019: Shanghai Talent Award 2015: Baosteel Excellent Teacher Award 2013: Second Prize of Shanghai Teaching Achievement (Second Contributor) 2012: Fudan University 'Excellence in Teaching and Educating' Outstanding Communist Party Member

University/Lab Affiliation and Title

Fudan University

Faculty

Pharmaceutical Sciences

Academic Background & Achievements

1985.09 – 1989.06 Bachelor: Zhengzhou University, Chemistry
1989.09 – 1992.06 Master: Zhengzhou University, Organic Chemistry
2001.09 – 2005.06 PhD: Fudan University, Pharmaceutical Chemistry

Work Experience

1992.07 – 1999.03 Zhengzhou University, Chemistry Department - Assistant, Lecturer (1995)
1993.09 – 1994.09 Ryukoku University, Japan - Visiting Scholar
1999.04 – Present Fudan University, School of Pharmacy, Department of Medicinal Chemistry - Associate Professor (2000), Professor (2010)
2006.01 – Present Director of the Pharmacy Experimental Teaching Center
2011.10 – Present Member of the Shanghai Pharmaceutical Association, Medicinal Chemistry Committee

Awards

2019: Shanghai Talent Award
2015: Baosteel Excellent Teacher Award
2013: Second Prize of Shanghai Teaching Achievement (Second Contributor)
2012: Fudan University 'Excellence in Teaching and Educating' Outstanding Communist Party Member

Areas of Focus	Synthesis, structural modification, and druggability research of active natural products
Publications	Targeting the tumor microenvironment by an enzyme-responsive prodrug of tubulin destabilizer for triple-negative breast cancer therapy with high safety, Peng, Y.; Shi, Z.; Liang, Y.; Ding, K.; Wang, Y., 2022 Discovery of a 2,6-Diarylpyridine-Based Hydroxamic Acid Derivative as Novel Histone Deacetylase 8 and Tubulin Dual Inhibitor for the Treatment of Neuroblastoma, Tang, H.; Liang, Y.; Shen, H.; Cai, S.; Yu, M.; Fan, H.; Ding, K.; Wang, Y., 2022 Bifunctional Chiral Selenium-Containing 1,4-Diarylazetidin-2-ones with Potent Antitumor Activities by Disrupting Tubulin Polymerization and Inducing Reactive Oxygen Species Production, Tang, H.; Liang, Y.; Cheng, J.; Ding, K.; Wang, Y., 2021 Novel Diaryl-2H-azirines: Antitumor Hybrids for Dual-targeting Tubulin and DNA, Lin, S.; Liang, Y.; Cheng, J.; Pan, F.; Wang, Y., 2021 Design, Synthesis and Antitumor Evaluation of Novel Chiral Diaryl Substituted Azetidin-2-one Derivatives as Tubulin Polymerization Inhibitors, Liang, Y.; Zhang, M.; Zhou, P.; Liu, M.; Li, J.; Wang, Y., 2021 Design, Synthesis and Activity Evaluation of Novel Acyclic Nucleosides as Potential Anticancer Agents in Vitro and in Vivo, Hao, E.-J.; Li, G.-X.; Liang, Y.-R.; Xie, M.-S.; Wang, D.-C.; Jiang, X.-H.; Cheng, J.-Y.; Shi, Z.-X.; Wang, Y.; Guo, H.-M., 2021 Discovery of a Chiral Fluorinated Azetidin-2-one as a Tubulin Polymerisation Inhibitor with Potent Antitumour Efficacy, Tang, H.; Cheng, J.; Liang, Y.; Wang, Y., 2020 Discovery of Novel Aryl Carboxamide Derivatives as Hypoxia-Inducible Factor (HIF) 1α Signaling Inhibitors with Potent Activities of Anticancer Metastasis, Liu, M.; Liang, Y.; Zhu, Z.; Wang, J.; Cheng, X.; Cheng, J.; Xu, B.; Li, R.; Liu, X.; Wang, Y., 2019 Design, Synthesis, Antitumor Activities and Biological Studies of Novel Diaryl Substituted Fused Heterocycles as Dual Ligands Targeting Tubulin and Katanin, Gao, F.; Liang, Y.; Zhou, P.; Cheng, J.; Ding, K.; Wang, Y., 2019 Design, Synthesis, Biological Evaluation and Cocrystal Structures with Tubulin of Chiral β-Lactam Bridged Combretastatin A-4 Analogues as Potent Antitumor Agents, Zhou, P.; Liang, Y.; Zhang, H.; Jiang, H.; Feng, K.; Xu, P.; Wang, J.; Wang, X.; Ding, K.; Luo, C.; Liu, M.; Wang, Y., 2018 Design, Synthesis, and Biological Evaluation of Hydantoin Bridged Analogues of Combretastatin A-4 as Potential Anticancer Agents, Zhang M.; Liang, Y.-R.; Li, H.; Liu, M.-M.; Wang, Y., 2017 The Total Synthesis of (±)-Sanggenol F, Sheng, X.; Jia, X.-Y.; Tang, F.; Wang, Y.; Hou, A.-J., 2017 Potent Anti-tumor Activities and Structure Basis of the Chiral β-Lactam Bridged Analogue of Combretastatin A-4 Binding to Tubulin, Zhou, P.; Liu, Y.; Zhou, L.; Zhu, K.; Feng, K.; Zhang, H.; Liang, Y.; Jiang, H.; Luo, C.; Liu, M.; Wang, Y., 2016

Areas of Focus

Synthesis, structural modification, and druggability research of active natural products

Publications

Targeting the tumor microenvironment by an enzyme-responsive prodrug of tubulin destabilizer for triple-negative breast cancer therapy with high safety, Peng, Y.; Shi, Z.; Liang, Y.; Ding, K.; Wang, Y., 2022
Discovery of a 2,6-Diarylpyridine-Based Hydroxamic Acid Derivative as Novel Histone Deacetylase 8 and Tubulin Dual Inhibitor for the Treatment of Neuroblastoma, Tang, H.; Liang, Y.; Shen, H.; Cai, S.; Yu, M.; Fan, H.; Ding, K.; Wang, Y., 2022
Bifunctional Chiral Selenium-Containing 1,4-Diarylazetidin-2-ones with Potent Antitumor Activities by Disrupting Tubulin Polymerization and Inducing Reactive Oxygen Species Production, Tang, H.; Liang, Y.; Cheng, J.; Ding, K.; Wang, Y., 2021
Novel Diaryl-2H-azirines: Antitumor Hybrids for Dual-targeting Tubulin and DNA, Lin, S.; Liang, Y.; Cheng, J.; Pan, F.; Wang, Y., 2021
Design, Synthesis and Antitumor Evaluation of Novel Chiral Diaryl Substituted Azetidin-2-one Derivatives as Tubulin Polymerization Inhibitors, Liang, Y.; Zhang, M.; Zhou, P.; Liu, M.; Li, J.; Wang, Y., 2021
Design, Synthesis and Activity Evaluation of Novel Acyclic Nucleosides as Potential Anticancer Agents in Vitro and in Vivo, Hao, E.-J.; Li, G.-X.; Liang, Y.-R.; Xie, M.-S.; Wang, D.-C.; Jiang, X.-H.; Cheng, J.-Y.; Shi, Z.-X.; Wang, Y.; Guo, H.-M., 2021
Discovery of a Chiral Fluorinated Azetidin-2-one as a Tubulin Polymerisation Inhibitor with Potent Antitumour Efficacy, Tang, H.; Cheng, J.; Liang, Y.; Wang, Y., 2020
Discovery of Novel Aryl Carboxamide Derivatives as Hypoxia-Inducible Factor (HIF) 1α Signaling Inhibitors with Potent Activities of Anticancer Metastasis, Liu, M.; Liang, Y.; Zhu, Z.; Wang, J.; Cheng, X.; Cheng, J.; Xu, B.; Li, R.; Liu, X.; Wang, Y., 2019
Design, Synthesis, Antitumor Activities and Biological Studies of Novel Diaryl Substituted Fused Heterocycles as Dual Ligands Targeting Tubulin and Katanin, Gao, F.; Liang, Y.; Zhou, P.; Cheng, J.; Ding, K.; Wang, Y., 2019
Design, Synthesis, Biological Evaluation and Cocrystal Structures with Tubulin of Chiral β-Lactam Bridged Combretastatin A-4 Analogues as Potent Antitumor Agents, Zhou, P.; Liang, Y.; Zhang, H.; Jiang, H.; Feng, K.; Xu, P.; Wang, J.; Wang, X.; Ding, K.; Luo, C.; Liu, M.; Wang, Y., 2018
Design, Synthesis, and Biological Evaluation of Hydantoin Bridged Analogues of Combretastatin A-4 as Potential Anticancer Agents, Zhang M.; Liang, Y.-R.; Li, H.; Liu, M.-M.; Wang, Y., 2017
The Total Synthesis of (±)-Sanggenol F, Sheng, X.; Jia, X.-Y.; Tang, F.; Wang, Y.; Hou, A.-J., 2017
Potent Anti-tumor Activities and Structure Basis of the Chiral β-Lactam Bridged Analogue of Combretastatin A-4 Binding to Tubulin, Zhou, P.; Liu, Y.; Zhou, L.; Zhu, K.; Feng, K.; Zhang, H.; Liang, Y.; Jiang, H.; Luo, C.; Liu, M.; Wang, Y., 2016

Synthesis Structural Modification Druggability Active Natural Products Pharmaceutical Chemistry Organic Synthesis Medicinal Chemistry Natural Products Drug Discovery Bioactive Compounds

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