Professor | Xiaochun Yang | Asia Growth Partners

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Name	Xiaochun Yang
Contact Information	yangxiaochun@zju.edu.cn
Language ability	Chinese, English
Province	Zhejiang

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Name

Xiaochun Yang

Contact Information

yangxiaochun@zju.edu.cn

Language ability

Chinese, English

Province

Zhejiang

University/Lab Affiliation and Title	Zhejiang University
Faculty	Pharmaceutical Sciences
Academic Background & Achievements	Associate Professor at Zhejiang University Vice Director of the Drug Safety Evaluation Research Center at Zhejiang University Certified Toxicologist by the Chinese Society of Toxicology Published over 50 SCI papers Applied for 11 national invention patents Received 6 provincial and ministerial awards Completed over 300 non-clinical pharmacology and toxicology studies for new drugs
Awards	2009: First Prize of National Commercial Science and Technology Progress Award by China General Chamber of Commerce 2010: Second Prize of Zhejiang Provincial Science and Technology Progress Award 2014: Third Prize of Chinese Pharmaceutical Association Science and Technology Award 2017: Second Prize of Zhejiang Pharmaceutical Association Science and Technology Award 2018: Second Prize of Ministry of Education Natural Science Award

University/Lab Affiliation and Title

Zhejiang University

Faculty

Pharmaceutical Sciences

Academic Background & Achievements

Associate Professor at Zhejiang University
Vice Director of the Drug Safety Evaluation Research Center at Zhejiang University
Certified Toxicologist by the Chinese Society of Toxicology
Published over 50 SCI papers
Applied for 11 national invention patents
Received 6 provincial and ministerial awards
Completed over 300 non-clinical pharmacology and toxicology studies for new drugs

Awards

2009: First Prize of National Commercial Science and Technology Progress Award by China General Chamber of Commerce
2010: Second Prize of Zhejiang Provincial Science and Technology Progress Award
2014: Third Prize of Chinese Pharmaceutical Association Science and Technology Award
2017: Second Prize of Zhejiang Pharmaceutical Association Science and Technology Award
2018: Second Prize of Ministry of Education Natural Science Award

Areas of Focus	Pharmacology and Toxicology Non-clinical Safety Evaluation of New Drugs Research on Traditional Chinese Medicine and Health Products
Publications	An update on Alectinib: a first line treatment for ALK-positive advanced lung cancer, Zhou Y, Yin Y, Xu J, Xu Z, Yang B, He Q, Luo P, Yan H, Yang X, 2023 Crizotinib induces pulmonary toxicity by blocking autophagy flux in alveolar epithelial cells, Zhang Y, Gao Z, Pan Z, Fu H, Jiang F, Yan H, Yang B, He Q, Luo P, Xu Z, Yang X, 2023 Development and safety of PI3K inhibitors in cancer, Yu M, Chen J, Xu Z, Yang B, He Q, Luo P, Yan H, Yang X, 2023 Exploration of the Use of Natural Compounds in Combination with Chemotherapy Drugs for Tumor Treatment, Wu J, Li Y, He Q, Yang X, 2023 Potential of Compounds Originating from the Nature to Act in Hepatocellular Carcinoma Therapy by Targeting the Tumor Immunosuppressive Microenvironment: A Review, Li Y, Li H, He Q, Yang X, 2022 JAK-STAT signaling as an ARDS therapeutic target: Status and future trends, Zhang Y, Gao Z, Jiang F, Yan H, Yang B, He Q, Luo P, Xu Z, Yang X, 2022 Targeting Ubiquitin-Specific Protease 7 (USP7) in Cancer: A New Insight to Overcome Drug Resistance, Lu J, Zhao H, Yu C, Kang Y, Yang X, 2021 Protective effects and possible mechanisms of Centella asiatica (L.) urban extract against acute and chronic liver injury: Evidence from in vivo and in vitro studies, Lu J, Chen C, Gai R, Qiu H, Wu Y, He Q, Yang X, 2021 Dissipation behavior, residue dynamics, and dietary risk assessment of forchlorfenuron in postharvest kiwifruits during simulated cold chain logistics and store shelf life, Zhu D, Ping L, Qian R, Chen C, Hong Y, Tong Z, Yang X, 2021 Research Status and Outlook of PD-1/PD-L1 Inhibitors for Cancer Therapy, Ai L, Chen J, Yan H, He Q, Luo P, Xu Z, Yang X, 2020 A Comprehensive Review of Clinical Cardiotoxicity Incidence of FDA-Approved Small-Molecule Kinase Inhibitors, Jin Y, Xu Z, Yan H, He Q, Yang X, Luo P, 2020 Enhanced proliferation inhibition and apoptosis in glioma cells elicited by combination of irinotecan and imatinib, Lu J, Hu Y, Qian R, Zhang Y, Yang X, Luo P, 2020 ROS-dependent DNA damage contributes to crizotinib-induced hepatotoxicity via the apoptotic pathway, Yan H, Du J, Chen X, Yang B, He Q, Yang X, Luo P, 2019 HMGB1 contributes to adriamycin-induced cardiotoxicity via up-regulating autophagy, Luo P, Zhu Y, Chen M, Yan H, Yang B, Yang X, He Q, 2018 Interleukin-6 induced by YAP in hepatocellular carcinoma cells recruits tumor-associated macrophages, Zhou T, Zhou Y, Qian M, Fang Y, Ye S, Xin W, Yang X, Wu H, 2018 Autophagy protects against dasatinib-induced hepatotoxicity via p38 signaling, Yang X, Wang J, Dai J, Shao J, Ma J, Chen C, Ma S, He Q, Luo P, Yang B, 2015 Sequential treatment with aurora B inhibitors enhances cisplatin-mediated apoptosis via c-Myc, Ma Y, Cao H, Lou S, Shao X, Lv W, Qi X, Liu Y, Ying M, He Q, Yang X, 2015 GL3, a Novel 4β-Anilino-4'-O-Demethyl-4-Desoxypodophyllotoxin Analog, Traps Topoisomerase II Cleavage Complexes and Exerts Anticancer Activities, Yang X, Qian S, Wang L, Liao S, Cao J, Hu Y, He Q, Zhu H, Yang B, 2013 Retinoid-Regulated FGF8f Secretion by Osteoblasts Bypasses Retinoid Stimuli to Mediate Granulocytic Differentiation of Myeloid Leukemia Cells, Chaudhry P, Yang X, Wagner M, Jong A, Wu L, 2012 Oxidative stress is involved in Dasatinib-induced apoptosis in rat primary hepatocytes, Xue T, Luo P, Zhu H, Zhao Y, Wu H, Gai R, Wu Y, Yang B, Yang X, He Q, 2012 Antimetastatic activity of MONCPT in preclinical melanoma mice model, Yang X, Tu CX, Luo PH, Zhu H, Zhu DF, Wu HH, Zhou XL, Lu W, He QJ, Yang B*, 2010 Retinoid-suppressed phosphorylation of RARalpha mediates the differentiation pathway of osteosarcoma cells, Luo P, Yang X, Ying M, Chaudhry P, Wang A, Shimada H, May WA, Adams GB, Mock D, Triche TJ, He Q, Wu L, 2010 Antiproliferation in human EA.hy926 endothelial cells and inhibition of VEGF expression in PC-3 cells by topotecan, Yang X, Zhang C, Ying M, Yang B, He Q, 2007 Antiangiogenesis response of endothelial cells to the antitumour drug 10-methoxy-9-nitrocamptothecin, Yang X, Luo P, Yang B and He Q, 2006

Areas of Focus

Pharmacology and Toxicology
Non-clinical Safety Evaluation of New Drugs
Research on Traditional Chinese Medicine and Health Products

Publications

An update on Alectinib: a first line treatment for ALK-positive advanced lung cancer, Zhou Y, Yin Y, Xu J, Xu Z, Yang B, He Q, Luo P, Yan H*, Yang X*, 2023
Crizotinib induces pulmonary toxicity by blocking autophagy flux in alveolar epithelial cells, Zhang Y, Gao Z, Pan Z, Fu H, Jiang F, Yan H, Yang B, He Q, Luo P, Xu Z*, Yang X*, 2023
Development and safety of PI3K inhibitors in cancer, Yu M, Chen J, Xu Z, Yang B, He Q, Luo P, Yan H*, Yang X*, 2023
Exploration of the Use of Natural Compounds in Combination with Chemotherapy Drugs for Tumor Treatment, Wu J, Li Y, He Q, Yang X*, 2023
Potential of Compounds Originating from the Nature to Act in Hepatocellular Carcinoma Therapy by Targeting the Tumor Immunosuppressive Microenvironment: A Review, Li Y, Li H, He Q, Yang X*, 2022
JAK-STAT signaling as an ARDS therapeutic target: Status and future trends, Zhang Y, Gao Z, Jiang F, Yan H, Yang B, He Q, Luo P, Xu Z*, Yang X*, 2022
Targeting Ubiquitin-Specific Protease 7 (USP7) in Cancer: A New Insight to Overcome Drug Resistance, Lu J, Zhao H, Yu C, Kang Y, Yang X*, 2021
Protective effects and possible mechanisms of Centella asiatica (L.) urban extract against acute and chronic liver injury: Evidence from in vivo and in vitro studies, Lu J, Chen C, Gai R, Qiu H, Wu Y, He Q, Yang X*, 2021
Dissipation behavior, residue dynamics, and dietary risk assessment of forchlorfenuron in postharvest kiwifruits during simulated cold chain logistics and store shelf life, Zhu D, Ping L, Qian R, Chen C, Hong Y, Tong Z, Yang X*, 2021
Research Status and Outlook of PD-1/PD-L1 Inhibitors for Cancer Therapy, Ai L, Chen J, Yan H, He Q, Luo P, Xu Z*, Yang X*, 2020
A Comprehensive Review of Clinical Cardiotoxicity Incidence of FDA-Approved Small-Molecule Kinase Inhibitors, Jin Y, Xu Z, Yan H, He Q, Yang X*, Luo P*, 2020
Enhanced proliferation inhibition and apoptosis in glioma cells elicited by combination of irinotecan and imatinib, Lu J, Hu Y, Qian R, Zhang Y, Yang X*, Luo P*, 2020
ROS-dependent DNA damage contributes to crizotinib-induced hepatotoxicity via the apoptotic pathway, Yan H, Du J, Chen X, Yang B, He Q, Yang X*, Luo P*, 2019
HMGB1 contributes to adriamycin-induced cardiotoxicity via up-regulating autophagy, Luo P, Zhu Y, Chen M, Yan H, Yang B, Yang X*, He Q*, 2018
Interleukin-6 induced by YAP in hepatocellular carcinoma cells recruits tumor-associated macrophages, Zhou T, Zhou Y, Qian M, Fang Y, Ye S, Xin W, Yang X*, Wu H*, 2018
Autophagy protects against dasatinib-induced hepatotoxicity via p38 signaling, Yang X, Wang J, Dai J, Shao J, Ma J, Chen C, Ma S, He Q, Luo P, Yang B, 2015
Sequential treatment with aurora B inhibitors enhances cisplatin-mediated apoptosis via c-Myc, Ma Y, Cao H, Lou S, Shao X, Lv W, Qi X, Liu Y, Ying M, He Q, Yang X*, 2015
GL3, a Novel 4β-Anilino-4'-O-Demethyl-4-Desoxypodophyllotoxin Analog, Traps Topoisomerase II Cleavage Complexes and Exerts Anticancer Activities, Yang X, Qian S, Wang L, Liao S, Cao J, Hu Y, He Q, Zhu H*, Yang B*, 2013
Retinoid-Regulated FGF8f Secretion by Osteoblasts Bypasses Retinoid Stimuli to Mediate Granulocytic Differentiation of Myeloid Leukemia Cells, Chaudhry P, Yang X, Wagner M, Jong A, Wu L*, 2012
Oxidative stress is involved in Dasatinib-induced apoptosis in rat primary hepatocytes, Xue T, Luo P, Zhu H, Zhao Y, Wu H, Gai R, Wu Y, Yang B, Yang X*, He Q*, 2012
Antimetastatic activity of MONCPT in preclinical melanoma mice model, Yang X, Tu CX, Luo PH, Zhu H, Zhu DF, Wu HH, Zhou XL, Lu W, He QJ*, Yang B*, 2010
Retinoid-suppressed phosphorylation of RARalpha mediates the differentiation pathway of osteosarcoma cells, Luo P, Yang X, Ying M, Chaudhry P, Wang A, Shimada H, May WA, Adams GB, Mock D, Triche TJ, He Q, Wu L, 2010
Antiproliferation in human EA.hy926 endothelial cells and inhibition of VEGF expression in PC-3 cells by topotecan, Yang X, Zhang C, Ying M, Yang B, He Q, 2007
Antiangiogenesis response of endothelial cells to the antitumour drug 10-methoxy-9-nitrocamptothecin, Yang X, Luo P, Yang B and He Q, 2006

Pharmacology Toxicology Safety Evaluation New Drugs Traditional Chinese Medicine Health Products Non-Clinical Studies Drug Development Toxicologist Research

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