Areas of Focus
- Research on anticancer drugs targeting one-carbon unit transferase inhibitors
Work Experience
- 2004-present - Peking University School of Pharmaceutical Sciences - Faculty Member
- 2010-2011 - University of Orléans, France - Researcher in Organic and Analytical Chemistry
Academic Background & Achievements
- 2004 - PhD in Medicinal Chemistry: Peking University
- Discovered lead compounds with good tumor cell inhibitory effects
- Published over 10 research papers in SCI and core journals
Publications
- Synthesis and neuroprotective effect of E-3,4-dihydroxy styryl aralkyl ketones derivatives against oxidative stress and inflammation, Xianling Ning, Ying Guo, Xiaoyan Ma, Renzong Zhu, Chao Tian, Xiaowei Wang, Zhizhong Ma, Zhili Zhang, Junyi Liu, 2013
- Mechanism-based design, synthesis and biological studies of N5-substituted tetrahydrofolate analogues as inhibitors of cobalamin-dependent methionine synthase and potential anticancer agents, Zhili Zhang, Chao Tian, Shouxin Zhou, Wei Wang, Ying Guo, Jie Xia, Zhenming Liu, Biao Wang, Xiaowei Wang, Junyi Liu, 2012
- Novel synthesis of 8-deaza-5,6,7,8-tetrahydroaminopterin analogues via an aziridine intermediate, Shouxin Zhou, Chao Tian, Chao Li, Ying Guo, Xiaowei Wang, Junyi Liu, Zhili Zhang, 2012
- Novel 8-deaza-5,6,7,8-tetrahydro aminopterin derivatives as dihydrofolate inhibitor: design, synthesis and antifolate activity, Zhili Zhang, Jun Wu, Fuxiang Ran, Ying Guo, Ran Tian, Shouxin Zhou, 2009
- Facile alternative synthesis of 1-alkyl-5-alkylamino-6-phenethyluracils, Zhili Zhang, Zhijian Cheng, Xiaoyan Ma, 2009
- Synthesis of 2-amino-4-hydroxyl-6-hydroxymethyl-5,6,7,8-tetrahydropyrido[3,2-d] pyrimidine from 2-amino-4-hydroxyl-6-methylpyrimidine, Zhili Zhang, Jie Liu, Weidong Liu, Xiaowei Wang, 2009
- Synthesis of 1-amino-6, 7-dihydro-7-(hydroxymethyl)-4-nitro-pyrrolo(1, 2-f) pyrimidin-3-(5H)-one from 2-amino-6-methylpyrimidin-3-one, Jie Liu, Weidong Liu, Zhili Zhang, Zhijian Cheng, Xiaoyan Ma, Xiaowei Wang, Junyi Liu, 2009
- Two newly synthesized 5-methyltetrahydrofolate-like compounds inhibit methionine synthase activity accompanied by cell cycle arrest in G1/S phase and apoptosis in vitro, Cai Tang, Zhili Zhang, Bo Xu, Min Li, Junyi Liu, Jingrong Cui, 2008
- Tetrabutylammon hydroxide: an efficient catalyst of N-alkylation of pyrimidines and purines, Zhili Zhang, Shouxin Zhou, Xiaowei Wang, Hongtao Wang, Yanli Chen, Junyi Liu, 2006
- The benzoylation of 6-methyluracil and 5-nitro-6-methyluracil, Zhili Zhang, Peng Han, Xiaoyan Ma, Jie Liu, Xiaowei Wang, Junyi Liu, 2005
Awards
- 2007: Peking University Health Science Center Outstanding Teacher
- 2009: First Prize in the Ninth Young Teachers Lecture Competition, Peking University School of Pharmaceutical Sciences
- 2011: Peking University Green Leaf Biomedical Outstanding Young Scholar Award
