Professor | Zhili Zhang | Asia Growth Partners

Name	Zhili Zhang
Contact Information	lilybmu@bjmu.edu.cn
Language ability	Chinese, English, French
Province	Beijing

Name

Zhili Zhang

Contact Information

lilybmu@bjmu.edu.cn

Language ability

Chinese, English, French

Province

Beijing

University/Lab Affiliation and Title	Peking University
Faculty	Pharmaceutical Sciences
Academic Background & Achievements	2004 - PhD in Medicinal Chemistry: Peking University Discovered lead compounds with good tumor cell inhibitory effects Published over 10 research papers in SCI and core journals
Work Experience	2004-present - Peking University School of Pharmaceutical Sciences - Faculty Member 2010-2011 - University of Orléans, France - Researcher in Organic and Analytical Chemistry
Awards	2007: Peking University Health Science Center Outstanding Teacher 2009: First Prize in the Ninth Young Teachers Lecture Competition, Peking University School of Pharmaceutical Sciences 2011: Peking University Green Leaf Biomedical Outstanding Young Scholar Award

University/Lab Affiliation and Title

Peking University

Faculty

Pharmaceutical Sciences

Academic Background & Achievements

2004 - PhD in Medicinal Chemistry: Peking University
Discovered lead compounds with good tumor cell inhibitory effects
Published over 10 research papers in SCI and core journals

Work Experience

2004-present - Peking University School of Pharmaceutical Sciences - Faculty Member
2010-2011 - University of Orléans, France - Researcher in Organic and Analytical Chemistry

Awards

2007: Peking University Health Science Center Outstanding Teacher
2009: First Prize in the Ninth Young Teachers Lecture Competition, Peking University School of Pharmaceutical Sciences
2011: Peking University Green Leaf Biomedical Outstanding Young Scholar Award

Areas of Focus	Research on anticancer drugs targeting one-carbon unit transferase inhibitors
Publications	Synthesis and neuroprotective effect of E-3,4-dihydroxy styryl aralkyl ketones derivatives against oxidative stress and inflammation, Xianling Ning, Ying Guo, Xiaoyan Ma, Renzong Zhu, Chao Tian, Xiaowei Wang, Zhizhong Ma, Zhili Zhang, Junyi Liu, 2013 Mechanism-based design, synthesis and biological studies of N5-substituted tetrahydrofolate analogues as inhibitors of cobalamin-dependent methionine synthase and potential anticancer agents, Zhili Zhang, Chao Tian, Shouxin Zhou, Wei Wang, Ying Guo, Jie Xia, Zhenming Liu, Biao Wang, Xiaowei Wang, Junyi Liu, 2012 Novel synthesis of 8-deaza-5,6,7,8-tetrahydroaminopterin analogues via an aziridine intermediate, Shouxin Zhou, Chao Tian, Chao Li, Ying Guo, Xiaowei Wang, Junyi Liu, Zhili Zhang, 2012 Novel 8-deaza-5,6,7,8-tetrahydro aminopterin derivatives as dihydrofolate inhibitor: design, synthesis and antifolate activity, Zhili Zhang, Jun Wu, Fuxiang Ran, Ying Guo, Ran Tian, Shouxin Zhou, 2009 Facile alternative synthesis of 1-alkyl-5-alkylamino-6-phenethyluracils, Zhili Zhang, Zhijian Cheng, Xiaoyan Ma, 2009 Synthesis of 2-amino-4-hydroxyl-6-hydroxymethyl-5,6,7,8-tetrahydropyrido[3,2-d] pyrimidine from 2-amino-4-hydroxyl-6-methylpyrimidine, Zhili Zhang, Jie Liu, Weidong Liu, Xiaowei Wang, 2009 Synthesis of 1-amino-6, 7-dihydro-7-(hydroxymethyl)-4-nitro-pyrrolo(1, 2-f) pyrimidin-3-(5H)-one from 2-amino-6-methylpyrimidin-3-one, Jie Liu, Weidong Liu, Zhili Zhang, Zhijian Cheng, Xiaoyan Ma, Xiaowei Wang, Junyi Liu, 2009 Two newly synthesized 5-methyltetrahydrofolate-like compounds inhibit methionine synthase activity accompanied by cell cycle arrest in G1/S phase and apoptosis in vitro, Cai Tang, Zhili Zhang, Bo Xu, Min Li, Junyi Liu, Jingrong Cui, 2008 Tetrabutylammon hydroxide: an efficient catalyst of N-alkylation of pyrimidines and purines, Zhili Zhang, Shouxin Zhou, Xiaowei Wang, Hongtao Wang, Yanli Chen, Junyi Liu, 2006 The benzoylation of 6-methyluracil and 5-nitro-6-methyluracil, Zhili Zhang, Peng Han, Xiaoyan Ma, Jie Liu, Xiaowei Wang, Junyi Liu, 2005

Areas of Focus

Research on anticancer drugs targeting one-carbon unit transferase inhibitors

Publications

Synthesis and neuroprotective effect of E-3,4-dihydroxy styryl aralkyl ketones derivatives against oxidative stress and inflammation, Xianling Ning, Ying Guo, Xiaoyan Ma, Renzong Zhu, Chao Tian, Xiaowei Wang, Zhizhong Ma, Zhili Zhang, Junyi Liu, 2013
Mechanism-based design, synthesis and biological studies of N5-substituted tetrahydrofolate analogues as inhibitors of cobalamin-dependent methionine synthase and potential anticancer agents, Zhili Zhang, Chao Tian, Shouxin Zhou, Wei Wang, Ying Guo, Jie Xia, Zhenming Liu, Biao Wang, Xiaowei Wang, Junyi Liu, 2012
Novel synthesis of 8-deaza-5,6,7,8-tetrahydroaminopterin analogues via an aziridine intermediate, Shouxin Zhou, Chao Tian, Chao Li, Ying Guo, Xiaowei Wang, Junyi Liu, Zhili Zhang, 2012
Novel 8-deaza-5,6,7,8-tetrahydro aminopterin derivatives as dihydrofolate inhibitor: design, synthesis and antifolate activity, Zhili Zhang, Jun Wu, Fuxiang Ran, Ying Guo, Ran Tian, Shouxin Zhou, 2009
Facile alternative synthesis of 1-alkyl-5-alkylamino-6-phenethyluracils, Zhili Zhang, Zhijian Cheng, Xiaoyan Ma, 2009
Synthesis of 2-amino-4-hydroxyl-6-hydroxymethyl-5,6,7,8-tetrahydropyrido[3,2-d] pyrimidine from 2-amino-4-hydroxyl-6-methylpyrimidine, Zhili Zhang, Jie Liu, Weidong Liu, Xiaowei Wang, 2009
Synthesis of 1-amino-6, 7-dihydro-7-(hydroxymethyl)-4-nitro-pyrrolo(1, 2-f) pyrimidin-3-(5H)-one from 2-amino-6-methylpyrimidin-3-one, Jie Liu, Weidong Liu, Zhili Zhang, Zhijian Cheng, Xiaoyan Ma, Xiaowei Wang, Junyi Liu, 2009
Two newly synthesized 5-methyltetrahydrofolate-like compounds inhibit methionine synthase activity accompanied by cell cycle arrest in G1/S phase and apoptosis in vitro, Cai Tang, Zhili Zhang, Bo Xu, Min Li, Junyi Liu, Jingrong Cui, 2008
Tetrabutylammon hydroxide: an efficient catalyst of N-alkylation of pyrimidines and purines, Zhili Zhang, Shouxin Zhou, Xiaowei Wang, Hongtao Wang, Yanli Chen, Junyi Liu, 2006
The benzoylation of 6-methyluracil and 5-nitro-6-methyluracil, Zhili Zhang, Peng Han, Xiaoyan Ma, Jie Liu, Xiaowei Wang, Junyi Liu, 2005

Anticancer Drugs One-Carbon Unit Transferase Inhibitors Methionine Synthase Cobalamin-Dependent Lead Compounds Tumor Cell Inhibition Synthesis Biological Studies Drug Development

Jie Wang - Fudan University

Bang-Guo Wei - Fudan University

Wenteng Chen - Zhejiang University

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