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Zhengren Xu
Pharmaceutical Sciences
Peking University
Beijing
Language: Chinese, English
Natural Products
Chemical Synthesis
Enzymatic Synthesis
Enzyme Catalysis
Medicinal Chemistry
Biocatalysis
Pharmacognosy
Chemical Biology
Drug Discovery
Organic Chemistry
Areas of Focus
- Chemical-Enzymatic Synthesis of Natural Products
- Novel Enzyme-Catalyzed Reactions
- Natural Product Medicinal Chemistry
Work Experience
- 2011-10 to 2014-09 - Postdoctoral Researcher - Swiss Federal Institute of Technology Lausanne (Supervisor: Professor Jieping Zhu)
- 2014-10 to 2018-03 - Postdoctoral Researcher - The Scripps Research Institute (Supervisor: Professor Ben Shen)
- 2018-04 to Present - Assistant Professor - Department of Natural Medicinal Chemistry, Peking University School of Pharmaceutical Sciences
Academic Background & Achievements
- 2001-2005 Bachelor: Pharmacy, Peking University School of Pharmaceutical Sciences
- 2005-2007 Master: Pharmacognosy, Peking University School of Pharmaceutical Sciences (Supervisor: Professor Pengfei Tu)
- 2007-2011 PhD: Chemical Biology, Peking University School of Pharmaceutical Sciences (Supervisors: Professor Yanxing Jia, Professor Lihe Zhang)
Publications
- Biomimetic total synthesis of the spiroindimicin family of natural products, Zheng, X.; Li, Y.; Guan, M.; Wang, L.; Wei, S.; Li, Y.-C.; Chang, C.-Y.; Xu, Z., 2022
- Characterization of enzymes catalyzing the formation of the nonproteinogenic amino acid L-Dap in capreomycin biosynthesis, Hsu, S.-H.; Zhang, S.; Huang, S.-C.; Wu, T.-K.; Xu, Z.; Chang, C.-Y., 2021
- Cascade cyclization reaction initiated by benzylic carbocation of indole: scope and mechanistic insights, Gao, Z.; Wang, Y.; Song, H.; Xu, Z.; Jia, Y., 2021
- Discovery of kirromycins with anti-Wolbachia activity from Streptomyces sp. CB00686, Xu, Z.; Fang, S.-M.; Bakowski, M. A.; Rateb, M. E.; Yang, D.; Zhu, X.; Huang, Y.; Zhao, L.-X.; Jiang, Y.; Duan, Y.; Hull, M. V.; McNamara, C. W.; Shen, B., 2019
- Discovery and characterization of 1-aminocyclopropane-1-carboxylic acid synthase of bacterial origin, Xu, Z.; Pan, G.; Zhou, H.; Shen, B., 2018
- Metamorphosis of cycloalkenes for the divergent total synthesis of polycyclic indole alkaloids, Xu, Z.; Wang, Q.; Zhu, J., 2018
- Discovery of the leinamycin family of natural products by mining actinobacterial genomes, Pan, G.; Xu, Z.; Guo, Z.; Hindra; Ma, M.; Yang, D.; Zhou, H.; Gansemans, Y.; Zhu, X.; Huang, Y.; Zhao, L.-X.; Jiang, Y.; Cheng, J.; Nieuwerburgh, F. V.; Suh, J.-W.; Duan, Y.; Shen, B., 2017
- A long-range acting dehydratase domain as the missing link for C17-dehydration in iso-migrastatin biosynthesis, Zhang, B.; Xu, Z.; Teng, Q.; Pan, G.; Ma, M.; Shen, B., 2017
- An enantioselective total synthesis of (-)-isoschizogamine, Xu, Z.; Bao, X.; Wang, Q.; Zhu, J., 2015
- Aqueous titanium trichloride-promoted reductive cyclization of o-nitrostyrenes to indoles: development and application to the synthesis of rizatriptan and aspidospermidine, Tong, S.; Xu, Z.; Mamboury, M.; Wang, Q.; Zhu, J., 2015
- Total syntheses of (-)-mersicarpine, (-)-scholarisine G, (+)-melodinine E, (-)-leuconoxine, (-)-leuconolam, (-)-leuconodine A, (+)-leuconodine F, and (-)-leuconodine C: self-induced diastereomeric anisochronism (SIDA) phenomenon for scholarisine G and leuconodine A and C, Xu, Z.; Wang, Q.; Zhu, J., 2015
- Enantioselective total syntheses of leuconolam-leuconoxine- mersicarpine group monoterpene indole alkaloids, Xu, Z.; Wang, Q.; Zhu, J., 2013
- Palladium-catalyzed decarboxylative vinylation of potassium nitrophenyl acetate: application to the total synthesis of (±)-goniomitine, Xu, Z.; Wang, Q.; Zhu, J., 2013
- Total synthesis of (-)-indolactam V, Xu, Z.; Zhang, F.; Zhang, L.; Jia, Y., 2011
- Total synthesis of clavicipitic acid and aurantioclavine: stereochemistry of clavicipitic acid revisitied, Xu, Z.; Hu, W.; Liu, Q.; Zhang, L.; Jia, Y., 2010
- Efficient total synthesis of (-)-cis-clavicipitic acid, Xu, Z.; Li, Q.; Zhang, L.; Jia, Y., 2009
- Palladium-catalyzed indole and azaindole synthesis by direct annulation of electron-poor o-chloroanilines and o-chloroaminopyridines with aldehydes, Xu, Z.; Hu, W.; Zhang, F.; Li, Q.; Lü, Z.; Zhang, L.; Jia, Y., 2008
- Xylocosides A-G, phenolic glucosides from the stems of Xylosma controversum, Xu, Z.-R.; Chai, X.-Y.; Bai, C.-C.; Ren, H.-Y.; Lu, Y.-N.; Shi, H.-M.; Tu, P.-F., 2008
- Chemical constituents from Xylosma controversum, Xu, Z.-R.; Lu, Y.-N.; Chai, X.-Y.; Ren, H.-Y.; Tu, P.-F., 2007
