Professor | Zhengren Xu | Asia Growth Partners

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Name	Zhengren Xu
Contact Information	zhengrenxu@bjmu.edu.cn
Language ability	Chinese, English
Province	Beijing

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Name

Zhengren Xu

Contact Information

zhengrenxu@bjmu.edu.cn

Language ability

Chinese, English

Province

Beijing

University/Lab Affiliation and Title	Peking University
Faculty	Pharmaceutical Sciences
Academic Background & Achievements	2001-2005 Bachelor: Pharmacy, Peking University School of Pharmaceutical Sciences 2005-2007 Master: Pharmacognosy, Peking University School of Pharmaceutical Sciences (Supervisor: Professor Pengfei Tu) 2007-2011 PhD: Chemical Biology, Peking University School of Pharmaceutical Sciences (Supervisors: Professor Yanxing Jia, Professor Lihe Zhang)
Work Experience	2011-10 to 2014-09 - Postdoctoral Researcher - Swiss Federal Institute of Technology Lausanne (Supervisor: Professor Jieping Zhu) 2014-10 to 2018-03 - Postdoctoral Researcher - The Scripps Research Institute (Supervisor: Professor Ben Shen) 2018-04 to Present - Assistant Professor - Department of Natural Medicinal Chemistry, Peking University School of Pharmaceutical Sciences

University/Lab Affiliation and Title

Peking University

Faculty

Pharmaceutical Sciences

Academic Background & Achievements

2001-2005 Bachelor: Pharmacy, Peking University School of Pharmaceutical Sciences
2005-2007 Master: Pharmacognosy, Peking University School of Pharmaceutical Sciences (Supervisor: Professor Pengfei Tu)
2007-2011 PhD: Chemical Biology, Peking University School of Pharmaceutical Sciences (Supervisors: Professor Yanxing Jia, Professor Lihe Zhang)

Work Experience

2011-10 to 2014-09 - Postdoctoral Researcher - Swiss Federal Institute of Technology Lausanne (Supervisor: Professor Jieping Zhu)
2014-10 to 2018-03 - Postdoctoral Researcher - The Scripps Research Institute (Supervisor: Professor Ben Shen)
2018-04 to Present - Assistant Professor - Department of Natural Medicinal Chemistry, Peking University School of Pharmaceutical Sciences

Areas of Focus	Chemical-Enzymatic Synthesis of Natural Products Novel Enzyme-Catalyzed Reactions Natural Product Medicinal Chemistry
Publications	Biomimetic total synthesis of the spiroindimicin family of natural products, Zheng, X.; Li, Y.; Guan, M.; Wang, L.; Wei, S.; Li, Y.-C.; Chang, C.-Y.; Xu, Z., 2022 Characterization of enzymes catalyzing the formation of the nonproteinogenic amino acid L-Dap in capreomycin biosynthesis, Hsu, S.-H.; Zhang, S.; Huang, S.-C.; Wu, T.-K.; Xu, Z.; Chang, C.-Y., 2021 Cascade cyclization reaction initiated by benzylic carbocation of indole: scope and mechanistic insights, Gao, Z.; Wang, Y.; Song, H.; Xu, Z.; Jia, Y., 2021 Discovery of kirromycins with anti-Wolbachia activity from Streptomyces sp. CB00686, Xu, Z.; Fang, S.-M.; Bakowski, M. A.; Rateb, M. E.; Yang, D.; Zhu, X.; Huang, Y.; Zhao, L.-X.; Jiang, Y.; Duan, Y.; Hull, M. V.; McNamara, C. W.; Shen, B., 2019 Discovery and characterization of 1-aminocyclopropane-1-carboxylic acid synthase of bacterial origin, Xu, Z.; Pan, G.; Zhou, H.; Shen, B., 2018 Metamorphosis of cycloalkenes for the divergent total synthesis of polycyclic indole alkaloids, Xu, Z.; Wang, Q.; Zhu, J., 2018 Discovery of the leinamycin family of natural products by mining actinobacterial genomes, Pan, G.; Xu, Z.; Guo, Z.; Hindra; Ma, M.; Yang, D.; Zhou, H.; Gansemans, Y.; Zhu, X.; Huang, Y.; Zhao, L.-X.; Jiang, Y.; Cheng, J.; Nieuwerburgh, F. V.; Suh, J.-W.; Duan, Y.; Shen, B., 2017 A long-range acting dehydratase domain as the missing link for C17-dehydration in iso-migrastatin biosynthesis, Zhang, B.; Xu, Z.; Teng, Q.; Pan, G.; Ma, M.; Shen, B., 2017 An enantioselective total synthesis of (-)-isoschizogamine, Xu, Z.; Bao, X.; Wang, Q.; Zhu, J., 2015 Aqueous titanium trichloride-promoted reductive cyclization of o-nitrostyrenes to indoles: development and application to the synthesis of rizatriptan and aspidospermidine, Tong, S.; Xu, Z.; Mamboury, M.; Wang, Q.; Zhu, J., 2015 Total syntheses of (-)-mersicarpine, (-)-scholarisine G, (+)-melodinine E, (-)-leuconoxine, (-)-leuconolam, (-)-leuconodine A, (+)-leuconodine F, and (-)-leuconodine C: self-induced diastereomeric anisochronism (SIDA) phenomenon for scholarisine G and leuconodine A and C, Xu, Z.; Wang, Q.; Zhu, J., 2015 Enantioselective total syntheses of leuconolam-leuconoxine- mersicarpine group monoterpene indole alkaloids, Xu, Z.; Wang, Q.; Zhu, J., 2013 Palladium-catalyzed decarboxylative vinylation of potassium nitrophenyl acetate: application to the total synthesis of (±)-goniomitine, Xu, Z.; Wang, Q.; Zhu, J., 2013 Total synthesis of (-)-indolactam V, Xu, Z.; Zhang, F.; Zhang, L.; Jia, Y., 2011 Total synthesis of clavicipitic acid and aurantioclavine: stereochemistry of clavicipitic acid revisitied, Xu, Z.; Hu, W.; Liu, Q.; Zhang, L.; Jia, Y., 2010 Efficient total synthesis of (-)-cis-clavicipitic acid, Xu, Z.; Li, Q.; Zhang, L.; Jia, Y., 2009 Palladium-catalyzed indole and azaindole synthesis by direct annulation of electron-poor o-chloroanilines and o-chloroaminopyridines with aldehydes, Xu, Z.; Hu, W.; Zhang, F.; Li, Q.; Lü, Z.; Zhang, L.; Jia, Y., 2008 Xylocosides A-G, phenolic glucosides from the stems of Xylosma controversum, Xu, Z.-R.; Chai, X.-Y.; Bai, C.-C.; Ren, H.-Y.; Lu, Y.-N.; Shi, H.-M.; Tu, P.-F., 2008 Chemical constituents from Xylosma controversum, Xu, Z.-R.; Lu, Y.-N.; Chai, X.-Y.; Ren, H.-Y.; Tu, P.-F., 2007

Areas of Focus

Chemical-Enzymatic Synthesis of Natural Products
Novel Enzyme-Catalyzed Reactions
Natural Product Medicinal Chemistry

Publications

Biomimetic total synthesis of the spiroindimicin family of natural products, Zheng, X.; Li, Y.; Guan, M.; Wang, L.; Wei, S.; Li, Y.-C.; Chang, C.-Y.; Xu, Z., 2022
Characterization of enzymes catalyzing the formation of the nonproteinogenic amino acid L-Dap in capreomycin biosynthesis, Hsu, S.-H.; Zhang, S.; Huang, S.-C.; Wu, T.-K.; Xu, Z.; Chang, C.-Y., 2021
Cascade cyclization reaction initiated by benzylic carbocation of indole: scope and mechanistic insights, Gao, Z.; Wang, Y.; Song, H.; Xu, Z.; Jia, Y., 2021
Discovery of kirromycins with anti-Wolbachia activity from Streptomyces sp. CB00686, Xu, Z.; Fang, S.-M.; Bakowski, M. A.; Rateb, M. E.; Yang, D.; Zhu, X.; Huang, Y.; Zhao, L.-X.; Jiang, Y.; Duan, Y.; Hull, M. V.; McNamara, C. W.; Shen, B., 2019
Discovery and characterization of 1-aminocyclopropane-1-carboxylic acid synthase of bacterial origin, Xu, Z.; Pan, G.; Zhou, H.; Shen, B., 2018
Metamorphosis of cycloalkenes for the divergent total synthesis of polycyclic indole alkaloids, Xu, Z.; Wang, Q.; Zhu, J., 2018
Discovery of the leinamycin family of natural products by mining actinobacterial genomes, Pan, G.; Xu, Z.; Guo, Z.; Hindra; Ma, M.; Yang, D.; Zhou, H.; Gansemans, Y.; Zhu, X.; Huang, Y.; Zhao, L.-X.; Jiang, Y.; Cheng, J.; Nieuwerburgh, F. V.; Suh, J.-W.; Duan, Y.; Shen, B., 2017
A long-range acting dehydratase domain as the missing link for C17-dehydration in iso-migrastatin biosynthesis, Zhang, B.; Xu, Z.; Teng, Q.; Pan, G.; Ma, M.; Shen, B., 2017
An enantioselective total synthesis of (-)-isoschizogamine, Xu, Z.; Bao, X.; Wang, Q.; Zhu, J., 2015
Aqueous titanium trichloride-promoted reductive cyclization of o-nitrostyrenes to indoles: development and application to the synthesis of rizatriptan and aspidospermidine, Tong, S.; Xu, Z.; Mamboury, M.; Wang, Q.; Zhu, J., 2015
Total syntheses of (-)-mersicarpine, (-)-scholarisine G, (+)-melodinine E, (-)-leuconoxine, (-)-leuconolam, (-)-leuconodine A, (+)-leuconodine F, and (-)-leuconodine C: self-induced diastereomeric anisochronism (SIDA) phenomenon for scholarisine G and leuconodine A and C, Xu, Z.; Wang, Q.; Zhu, J., 2015
Enantioselective total syntheses of leuconolam-leuconoxine- mersicarpine group monoterpene indole alkaloids, Xu, Z.; Wang, Q.; Zhu, J., 2013
Palladium-catalyzed decarboxylative vinylation of potassium nitrophenyl acetate: application to the total synthesis of (±)-goniomitine, Xu, Z.; Wang, Q.; Zhu, J., 2013
Total synthesis of (-)-indolactam V, Xu, Z.; Zhang, F.; Zhang, L.; Jia, Y., 2011
Total synthesis of clavicipitic acid and aurantioclavine: stereochemistry of clavicipitic acid revisitied, Xu, Z.; Hu, W.; Liu, Q.; Zhang, L.; Jia, Y., 2010
Efficient total synthesis of (-)-cis-clavicipitic acid, Xu, Z.; Li, Q.; Zhang, L.; Jia, Y., 2009
Palladium-catalyzed indole and azaindole synthesis by direct annulation of electron-poor o-chloroanilines and o-chloroaminopyridines with aldehydes, Xu, Z.; Hu, W.; Zhang, F.; Li, Q.; Lü, Z.; Zhang, L.; Jia, Y., 2008
Xylocosides A-G, phenolic glucosides from the stems of Xylosma controversum, Xu, Z.-R.; Chai, X.-Y.; Bai, C.-C.; Ren, H.-Y.; Lu, Y.-N.; Shi, H.-M.; Tu, P.-F., 2008
Chemical constituents from Xylosma controversum, Xu, Z.-R.; Lu, Y.-N.; Chai, X.-Y.; Ren, H.-Y.; Tu, P.-F., 2007

Natural Products Chemical Synthesis Enzymatic Synthesis Enzyme Catalysis Medicinal Chemistry Biocatalysis Pharmacognosy Chemical Biology Drug Discovery Organic Chemistry

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