Professor | Xianghuo He | Asia Growth Partners

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Name	Xianghuo He
Contact Information	xhhe@fudan.edu.cn
Language ability	Chinese, English
Province	Shanghai

Upload Avatar (500 x 500)

Name

Xianghuo He

Contact Information

xhhe@fudan.edu.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	Fudan University
Faculty	Biomedical Sciences
Academic Background & Achievements	2000-2003 PhD: Fudan University, Shanghai Medical College 1995-1998 Master's: East China Normal University, Department of Biology 1991-1995 Bachelor's: East China Normal University, Department of Biology 2016 Young and Middle-aged Leading Talent in Scientific and Technological Innovation, Ministry of Science and Technology 2015 Leading Medical Talent in Shanghai, Shanghai Municipal Health Commission 2011 National Outstanding Youth Science Fund, National Natural Science Foundation 2011 Shanghai Outstanding Academic Leader, Shanghai Science and Technology Commission 2011 Shanghai Shuguang Scholar, Shanghai Municipal Education Commission 2011 Shanghai Municipal Health Commission Outstanding Discipline Leader, Shanghai Municipal Health Commission 2010 New Century Excellent Talent, Ministry of Education 2006 Pujiang Talent Program, Shanghai Science and Technology Commission
Work Experience	2014.01-Present - Fudan University, Institute of Biomedical Sciences and Affiliated Cancer Hospital - Researcher 2008.12-2013.12 - Shanghai Cancer Institute, State Key Laboratory of Oncogenes and Related Genes - Researcher 2006.04-2008.11 - Shanghai Cancer Institute, State Key Laboratory of Oncogenes and Related Genes - Associate Researcher 2003.08-2006.04 - UT MD Anderson Cancer Center, Department of Molecular and Cellular Oncology - Postdoctoral Fellow 1998.07-2000.08 - Shanghai Cancer Institute, Immunology Department - Assistant Researcher
Awards	2012 Second Prize in Natural Science (First Author), Ministry of Education 2011 Second Prize in Medical Science and Technology Award (First Author), Shanghai Medical Association 2011 First Prize in the Fifth Wu Mengchao Medical Science Award, Wu Mengchao Medical Science Foundation 2011 Second Prize in the Thirteenth Silver Snake Award, Shanghai Municipal Health Commission 2011 Excellence Award in Meiji Life Science Award, National Human Genome South Research Center

University/Lab Affiliation and Title

Fudan University

Faculty

Biomedical Sciences

Academic Background & Achievements

2000-2003 PhD: Fudan University, Shanghai Medical College
1995-1998 Master's: East China Normal University, Department of Biology
1991-1995 Bachelor's: East China Normal University, Department of Biology
2016 Young and Middle-aged Leading Talent in Scientific and Technological Innovation, Ministry of Science and Technology
2015 Leading Medical Talent in Shanghai, Shanghai Municipal Health Commission
2011 National Outstanding Youth Science Fund, National Natural Science Foundation
2011 Shanghai Outstanding Academic Leader, Shanghai Science and Technology Commission
2011 Shanghai Shuguang Scholar, Shanghai Municipal Education Commission
2011 Shanghai Municipal Health Commission Outstanding Discipline Leader, Shanghai Municipal Health Commission
2010 New Century Excellent Talent, Ministry of Education
2006 Pujiang Talent Program, Shanghai Science and Technology Commission

Work Experience

2014.01-Present - Fudan University, Institute of Biomedical Sciences and Affiliated Cancer Hospital - Researcher
2008.12-2013.12 - Shanghai Cancer Institute, State Key Laboratory of Oncogenes and Related Genes - Researcher
2006.04-2008.11 - Shanghai Cancer Institute, State Key Laboratory of Oncogenes and Related Genes - Associate Researcher
2003.08-2006.04 - UT MD Anderson Cancer Center, Department of Molecular and Cellular Oncology - Postdoctoral Fellow
1998.07-2000.08 - Shanghai Cancer Institute, Immunology Department - Assistant Researcher

Awards

2012 Second Prize in Natural Science (First Author), Ministry of Education
2011 Second Prize in Medical Science and Technology Award (First Author), Shanghai Medical Association
2011 First Prize in the Fifth Wu Mengchao Medical Science Award, Wu Mengchao Medical Science Foundation
2011 Second Prize in the Thirteenth Silver Snake Award, Shanghai Municipal Health Commission
2011 Excellence Award in Meiji Life Science Award, National Human Genome South Research Center

Areas of Focus	Molecular Mechanisms of Gastrointestinal Malignancies Non-coding RNA Functions and Molecular Mechanisms Abnormal RNA Splicing and Regulatory Mechanisms Transcriptional Reprogramming and Epigenetic Regulatory Mechanisms
Publications	CRISPR/Cas9 Screens Reveal that Hexokinase 2 Enhances Cancer Stemness and Tumorigenicity by Activating the ACSL4-Fatty Acid β-Oxidation Pathway, Li H, Song J, He Y, Liu Y, Liu Z, Sun W, Hu W, Lei Q, Hu X, Chen Z, He X., 2022 LncRNA RP11-295G20.2 regulates hepatocellular carcinoma cell growth and autophagy by targeting PTEN to lysosomal degradation, Liang L, Huan L, Wang J, Wu Y, Huang S, He X., 2021 Gain of LINC00624 Enhances Liver Cancer Progression by Disrupting the HDAC6-TRIM28-ZNF354C Corepressor Complex, Li Z, Lu X, Liu Y, Zhao J, Ma S, Yin H, Huang S, Zhao Y, He X., 2021 HNRNPL Circularizes ARHGAP35 to Produce an Oncogenic Protein, Li Y, Chen B, Zhao J, Li Q, Chen S, Guo T, Li C, Lai H, Chen Z, Meng Z, Guo W, He X., Huang S., 2021 Inflammation-induced LINC00665 increases the malignancy through activating PKR/NF-κB pathway in hepatocellular carcinoma, Ding J, Zhao J, Huan L, Liu Y, Qiao Y, Wang Z, Chen Z, Huang S, Zhao Y, He X., 2020 Splicing Regulator p54nrb/NONO Enhances Carcinogenesis via Oncogenic Isoform Switch of BIN1 in Hepatocellular Carcinoma, Hu Z, Dong L, Li S, Li Z, Qiao Y, Li Y, Ding J, Chen Z, Wu Y, Wang Z, Huang S, Gao Q, Zhao Y, He X., 2020 Tumor-Specific Transcripts Are Frequently Expressed in Hepatocellular Carcinoma With Clinical Implication and Potential Function, Zheng Q, Zhao J, Yu H, Zong H, He X, Zhao Y, Li Y, Wang Y, Bao Y, Li Y, Chen B, Guo W, Wang Y, Chen Z, Zhao Y, Wang Y, He X., Huang S., 2020 Transcriptome-Wide Analysis Reveals the Landscape of Aberrant Alternative Splicing Events in Liver Cancer, Li S, Hu Z, Zhao Y, Huang S, He X., 2019 The LINC01138 drives malignancies via activating arginine methyltransferase 5 in hepatocellular carcinoma, Li Z, Zhang J, Liu X, Li S, Wang Q, Chen D, Hu Z, Yu T, Ding J, Li J, Yao M, Fan J, Huang S, Gao Q, Zhao Y, He X., 2018 Long noncoding RNA TSLNC8 is a tumor suppressor that inactivates the interleukin-6/STAT3 signaling pathway, Zhang J, Li Z, Liu L, Wang Q, Li S, Chen D, Hu Z, Yu T, Ding J, Li J, Yao M, Huang S, Zhao Y, He X., 2018 Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs, Zheng Q, Bao C, Guo W, Li S, Chen J, Chen B, Luo Y, Lyu D, Li Y, Shi G, Liang L, Gu J, He X., Huang S., 2016 MicroRNA-124 reduces the pentose phosphate pathway and proliferation by targeting PRPS1 and RPIA mRNAs in human colorectal cancer cells, Qiu Z, Guo W, Wang Q, Chen Z, Huang S, Zhao F, Yao M, Zhao Y, He X., 2015 Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis, Li Y, Zheng Q, Bao C, Li S, Guo W, Zhao J, Chen D, Gu J, He X., Huang S., 2015 MiR-199a-5p is negatively associated with malignancies and regulates glycolysis and lactate production by targeting hexokinase 2 in liver cancer, Guo W, Qiu Z, Wang Z, Wang Q, Tan N, Chen T, Chen Z, Huang S, Gu J, Li J, Yao M, Zhao Y, He X., 2015 Exome sequencing of hepatoblastoma reveals novel mutations and cancer genes in the Wnt pathway and ubiquitin ligase complex, Jia D, Dong R, Jing Y, Xu D, Wang Q, Chen L, Li Q, Huang Y, Zhang Y, Zhang Z, Liu L, Zheng S, Xia Q, Wang H, Dong K, He X., 2014 Activating mutations in PTPN3 promote cholangiocarcinoma cell proliferation and migration and are associated with tumor recurrence in patients, Gao Q, Zhao YJ, Wang XY, Guo WJ, Gao S, Wei L, Shi JY, Shi GM, Wang ZC, Zhang YN, Shi YH, Ding J, Ding ZB, Ke AW, Dai Z, Wu FZ, Wang H, Qiu ZP, Chen ZA, Zhang ZF, Qiu SJ, Zhou J, He XH, Fan J., 2014 Amplification of MPZL1/PZR promotes tumor cell migration through Src-mediated phosphorylation of cortactin in hepatocellular carcinoma, Jia D, Jing Y, Zhang Z, Liu L, Ding J, Zhao F, Ge C, Wang Q, Chen T, Yao M, Li J, Gu J, He X., 2014 Genome-wide screening reveals that miR-195 targets the TNF-α/NF-κB pathway by down-regulating IκB kinase alpha and TAB3 in hepatocellular carcinoma, Ding J, Huang S, Wang Y, Tian Q, Zha R, Shi H, Wang Q, Ge C, Chen T, Zhao Y, Liang L, Li J, He X., 2013 Hypoxia-inducible microRNA-210 augments the metastatic potential of tumor cells by targeting vacuole membrane protein 1 in hepatocellular carcinoma, Ying Q, Liang L, Guo W, Zha R, Tian Q, Huang S, Yao J, Ding J, Bao M, Ge C, Yao M, Li J, He X., 2011 Genome-wide copy number analyses identified novel cancer genes in hepatocellular

Areas of Focus

Molecular Mechanisms of Gastrointestinal Malignancies
Non-coding RNA Functions and Molecular Mechanisms
Abnormal RNA Splicing and Regulatory Mechanisms
Transcriptional Reprogramming and Epigenetic Regulatory Mechanisms

Publications

CRISPR/Cas9 Screens Reveal that Hexokinase 2 Enhances Cancer Stemness and Tumorigenicity by Activating the ACSL4-Fatty Acid β-Oxidation Pathway, Li H, Song J, He Y, Liu Y, Liu Z, Sun W, Hu W, Lei Q, Hu X, Chen Z, He X., 2022
LncRNA RP11-295G20.2 regulates hepatocellular carcinoma cell growth and autophagy by targeting PTEN to lysosomal degradation, Liang L, Huan L, Wang J, Wu Y, Huang S, He X., 2021
Gain of LINC00624 Enhances Liver Cancer Progression by Disrupting the HDAC6-TRIM28-ZNF354C Corepressor Complex, Li Z, Lu X, Liu Y, Zhao J, Ma S, Yin H, Huang S, Zhao Y, He X., 2021
HNRNPL Circularizes ARHGAP35 to Produce an Oncogenic Protein, Li Y, Chen B, Zhao J, Li Q, Chen S, Guo T, Li C, Lai H, Chen Z, Meng Z, Guo W, He X., Huang S., 2021
Inflammation-induced LINC00665 increases the malignancy through activating PKR/NF-κB pathway in hepatocellular carcinoma, Ding J, Zhao J, Huan L, Liu Y, Qiao Y, Wang Z, Chen Z, Huang S, Zhao Y, He X., 2020
Splicing Regulator p54nrb/NONO Enhances Carcinogenesis via Oncogenic Isoform Switch of BIN1 in Hepatocellular Carcinoma, Hu Z, Dong L, Li S, Li Z, Qiao Y, Li Y, Ding J, Chen Z, Wu Y, Wang Z, Huang S, Gao Q, Zhao Y, He X., 2020
Tumor-Specific Transcripts Are Frequently Expressed in Hepatocellular Carcinoma With Clinical Implication and Potential Function, Zheng Q, Zhao J, Yu H, Zong H, He X, Zhao Y, Li Y, Wang Y, Bao Y, Li Y, Chen B, Guo W, Wang Y, Chen Z, Zhao Y, Wang Y, He X., Huang S., 2020
Transcriptome-Wide Analysis Reveals the Landscape of Aberrant Alternative Splicing Events in Liver Cancer, Li S, Hu Z, Zhao Y, Huang S, He X., 2019
The LINC01138 drives malignancies via activating arginine methyltransferase 5 in hepatocellular carcinoma, Li Z, Zhang J, Liu X, Li S, Wang Q, Chen D, Hu Z, Yu T, Ding J, Li J, Yao M, Fan J, Huang S, Gao Q, Zhao Y, He X., 2018
Long noncoding RNA TSLNC8 is a tumor suppressor that inactivates the interleukin-6/STAT3 signaling pathway, Zhang J, Li Z, Liu L, Wang Q, Li S, Chen D, Hu Z, Yu T, Ding J, Li J, Yao M, Huang S, Zhao Y, He X., 2018
Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs, Zheng Q, Bao C, Guo W, Li S, Chen J, Chen B, Luo Y, Lyu D, Li Y, Shi G, Liang L, Gu J, He X., Huang S., 2016
MicroRNA-124 reduces the pentose phosphate pathway and proliferation by targeting PRPS1 and RPIA mRNAs in human colorectal cancer cells, Qiu Z, Guo W, Wang Q, Chen Z, Huang S, Zhao F, Yao M, Zhao Y, He X., 2015
Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis, Li Y, Zheng Q, Bao C, Li S, Guo W, Zhao J, Chen D, Gu J, He X., Huang S., 2015
MiR-199a-5p is negatively associated with malignancies and regulates glycolysis and lactate production by targeting hexokinase 2 in liver cancer, Guo W, Qiu Z, Wang Z, Wang Q, Tan N, Chen T, Chen Z, Huang S, Gu J, Li J, Yao M, Zhao Y, He X., 2015
Exome sequencing of hepatoblastoma reveals novel mutations and cancer genes in the Wnt pathway and ubiquitin ligase complex, Jia D, Dong R, Jing Y, Xu D, Wang Q, Chen L, Li Q, Huang Y, Zhang Y, Zhang Z, Liu L, Zheng S, Xia Q, Wang H, Dong K, He X., 2014
Activating mutations in PTPN3 promote cholangiocarcinoma cell proliferation and migration and are associated with tumor recurrence in patients, Gao Q, Zhao YJ, Wang XY, Guo WJ, Gao S, Wei L, Shi JY, Shi GM, Wang ZC, Zhang YN, Shi YH, Ding J, Ding ZB, Ke AW, Dai Z, Wu FZ, Wang H, Qiu ZP, Chen ZA, Zhang ZF, Qiu SJ, Zhou J, He XH, Fan J., 2014
Amplification of MPZL1/PZR promotes tumor cell migration through Src-mediated phosphorylation of cortactin in hepatocellular carcinoma, Jia D, Jing Y, Zhang Z, Liu L, Ding J, Zhao F, Ge C, Wang Q, Chen T, Yao M, Li J, Gu J, He X., 2014
Genome-wide screening reveals that miR-195 targets the TNF-α/NF-κB pathway by down-regulating IκB kinase alpha and TAB3 in hepatocellular carcinoma, Ding J, Huang S, Wang Y, Tian Q, Zha R, Shi H, Wang Q, Ge C, Chen T, Zhao Y, Liang L, Li J, He X., 2013
Hypoxia-inducible microRNA-210 augments the metastatic potential of tumor cells by targeting vacuole membrane protein 1 in hepatocellular carcinoma, Ying Q, Liang L, Guo W, Zha R, Tian Q, Huang S, Yao J, Ding J, Bao M, Ge C, Yao M, Li J, He X., 2011
Genome-wide copy number analyses identified novel cancer genes in hepatocellular

Gastrointestinal Malignancies Molecular Mechanisms Non-Coding Rna Rna Splicing Regulatory Mechanisms Transcriptional Reprogramming Epigenetics Cancer Tumorigenesis

Min Luo - Fudan University

Qunying Lei - Fudan University

Yujiang Geno Shi - Fudan University

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