Professor | Yujiang Geno Shi | Asia Growth Partners

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Name	Yujiang Geno Shi
Contact Information	shiyujiang@fudan.edu.cn
Language ability	English, Chinese
Province	Shanghai

Upload Avatar (500 x 500)

Name

Yujiang Geno Shi

Contact Information

shiyujiang@fudan.edu.cn

Language ability

English, Chinese

Province

Shanghai

University/Lab Affiliation and Title	Fudan University
Faculty	Biomedical Sciences
Academic Background & Achievements	2000 - PhD: University of Florida 1990 - Bachelor's: Wuhan University Discovered the first histone demethylase LSD1/KDM1A Published over 60 research papers
Work Experience	2023-present - Dual-appointed Professor, Zhongshan Hospital, Fudan University 2022-present - Distinguished Professor, Fudan University 2015-2022 - Associate Professor, Harvard Medical School & Brigham and Women's Hospital 2005-2015 - Assistant Professor, Harvard Medical School & Brigham and Women's Hospital 2000-2005 - Postdoctoral Fellow, Department of Pathology, Harvard Medical School
Awards	Pew Biomedical Scholar (2006-2010): Pew Foundation

University/Lab Affiliation and Title

Fudan University

Faculty

Biomedical Sciences

Academic Background & Achievements

2000 - PhD: University of Florida
1990 - Bachelor's: Wuhan University
Discovered the first histone demethylase LSD1/KDM1A
Published over 60 research papers

Work Experience

2023-present - Dual-appointed Professor, Zhongshan Hospital, Fudan University
2022-present - Distinguished Professor, Fudan University
2015-2022 - Associate Professor, Harvard Medical School & Brigham and Women's Hospital
2005-2015 - Assistant Professor, Harvard Medical School & Brigham and Women's Hospital
2000-2005 - Postdoctoral Fellow, Department of Pathology, Harvard Medical School

Awards

Pew Biomedical Scholar (2006-2010): Pew Foundation

Areas of Focus	Epigenetics Diabetes, Obesity, and Cancer Epigenetic Mechanisms Phenotypic Genomics and Epigenetic Mechanisms of Aging and Longevity Anti-aging Computational Biology and New Longevity & Aging Model Organisms
Publications	Coordinated histone modifications mediated by a CtBP co-repressor complex, Shi YJ, Sawada J, Sui G, Affar el B, Whetstine JR, Lan F, Ogawa H, Luke MP, Nakatani Y, Shi Y, 2003 Histone demethylation mediated by the nuclear amine oxidase homolog LSD1, Shi YJ, Lan F, Matson C, Mulligan P, Whetstine JR, Cole PA, Casero RA, Shi Y, 2004 Yin Yang 1 is a negative regulator of p53, Sui G, Affar EB, Shi YJ, Brignone C, Wall NR, Yin P, Donohoe P, Calvo P, Luke MP, Grossman SR, Shi Y, 2004 Regulation of LSD1 Histone Demethylase Activity by Its Associated Factors, Shi YJ, Matson C, Lan F, Iwase S, Baba T, Shi Y, 2005 The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation, Tahiliani M, Mei P, Fang R, Leonor T, Rutenberg M, Shimizu F, Li J, Rao A and Shi YJ, 2007 Human LSD2/KDM1b/AOF1 regulates gene transcription by modulating intragenic H3K4me2 methylation, Fang R, Barbera AJ, Xu Y, Rutenberg M, Leonor T, Bi Q, Lan F, Mei P, Yuan GC, Lian C, Peng J, Cheng D, Sui G, Kaiser UB, Shi YJ, 2010 TET1 is a DNA-binding protein that modulates DNA methylation and gene transcription via hydroxylation of 5-methylcytosine, Zhang H, Zhang X, Clark E, Mulcahey M, Huang S, Shi YJ, 2010 Genome-wide Regulation of 5hmC, 5mC, and Gene Expression by Tet1 Hydroxylase in Mouse Embryonic Stem Cells, Xu Y, Wu F, Tan L, Kong L, Xiong L, Deng J, Barbera AJ, Shi YJ, 2011 Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma, Lian CG, Xu Y, Ceol C, Wu F, Larson A, Dresser K, Xu W, Tan L, Hu Y, Zhan Q, Lee CW, Hu D, Lian BQ, Kleffel S, Yang Y, Neiswender J, Khorasani AJ, Fang R, Lezcano C, Duncan LM, Scolyer RA, Thompson JF, Kakavand H, Houvras Y, Zon LI, Mihm MC Jr, Kaiser UB, Schatton T, Woda BA, Murphy GF, Shi YJ, 2012 Tet3 CXXC domain and dioxygenase activity cooperatively regulate key genes for Xenopus eye and neural development, Xu Y, Xu C, Kato A, Tempel W, Abreu JG, Bian C, Hu Y, Hu D, Zhao B, Cerovina T, Diao J, Wu F, He HH, Cui Q, Clark E, Ma C, Barbara A, Veenstra GJ, Xu G, Kaiser UB, Liu XS, Sugrue SP, He X, Min J, Kato Y, Shi YJ, 2012 LSD2/KDM1B and its cofactor NPAC/GLYR1 endow a structural and molecular model for regulation of H3K4 demethylation, Fang R, Chen F, Dong Z, Hu D, Barbera AJ, Clark EA, Fang J, Yang Y, Mei P, Rutenberg M, Li Z, Zhang Y, Xu Y, Yang H, Wang P, Simon MD, Zhou Q, Li J, Marynick MP, Li X, Lu H, Kaiser UB, Kingston RE, Xu Y, Shi YJ, 2013 Genome-wide comparison of DNA hydroxymethylation in mouse embryonic stem cells and neural progenitor cells by a new comparative hMeDIP-seq method, Tan L, Xiong L, Xu W, Wu F, Huang N, Xu Y, Kong L, Zheng L, Schwartz L, Shi Y, Shi YJ, 2013 A primary role of TET proteins in establishment and maintenance of De Novo bivalency at CpG islands, Kong L, Tan L, Lv R, Shi Z, Xiong L, Wu F, Rabidou K, Smith M, He C, Zhang L, Qian Y, Ma D, Lan F, Shi Y, Shi YJ, 2016 The Glucose/AMPK/TET2/5hmC axis constitutes a new pathway linking diabetes to cancer, Di W, Di H, Hao C, Shi G, Fetahu IS, Wu F, Rabidou K, Fang R, Tan L, Xu S, Liu H, Argueta C, Zhang L, Mao F, Yan G, Chen J, Dong Z, Lv R, Xu Y, Wang M, Ye Y, Zhang S, Duquette D, Geng S, Guo C, Murphy GF, Adler G, Garg R, Lynch L, Yang P, Li Y, Lan F, Fan J, Shi Y, Shi YJ, 2018 TET2 stabilization by 14-3-3 binding to the phosphorylated Serine 99 is deregulated by mutations in cancer, Chen H, Yu D, Fang R, Rabidou K, Wu D, Hu D, Jia P, Zhao Z, Wu Z, Peng J, Shi Y, Shi YJ, 2019 GR and LSD1/KDM1A- Targeted Gene Activation Requires Selective H3K4me2 Demethylation at Enhancers, Clark EA, Wu F, Chen Y, Kang P, Kaiser UB, Fang R, Shi YJ, 2019 Epigenetic Signatures of methylated DNA Cytosine in Alzheimer’s Disease, Fetahu IS, Ma D, Rabidou K, Argueta C, Smith M, Liu H, Wu F, Shi YJ, 2019 Nono deficiency compromises TET1 chromatin association and impedes neuronal differentiation of mouse embryonic stem cells, Li W, Karwacki-Neisius V, Ma C, Tan L, Shi Y, Wu F, Shi YJ, 2020 The fusiform gyrus exhibits an epigenetic signature for Alzheimer's disease, Ma D, Fetahu IS, Wang M, Fang R, Li J, Liu H, Gramyk T, Iwanicki I, Gu S, Xu W, Tan L, Wu F, Shi YJ, 2020 TET2 promotes anti-tumor immunity by governing G-MDSCs and CD8+ T-cell numbers, Li S, Feng J, Wu F, Cai J, Zhang X, Wang H, Fetahu IS, Iwanicki I, Ma D, Hu T, Liu H, Wang B, Shi G, Tan L, Shi YJ, 2020

Areas of Focus

Epigenetics
Diabetes, Obesity, and Cancer Epigenetic Mechanisms
Phenotypic Genomics and Epigenetic Mechanisms of Aging and Longevity
Anti-aging Computational Biology and New Longevity & Aging Model Organisms

Publications

Coordinated histone modifications mediated by a CtBP co-repressor complex, Shi YJ, Sawada J, Sui G, Affar el B, Whetstine JR, Lan F, Ogawa H, Luke MP, Nakatani Y, Shi Y, 2003
Histone demethylation mediated by the nuclear amine oxidase homolog LSD1, Shi YJ, Lan F, Matson C, Mulligan P, Whetstine JR, Cole PA, Casero RA, Shi Y, 2004
Yin Yang 1 is a negative regulator of p53, Sui G, Affar EB*, Shi YJ*, Brignone C, Wall NR, Yin P, Donohoe P, Calvo P, Luke MP, Grossman SR, Shi Y, 2004
Regulation of LSD1 Histone Demethylase Activity by Its Associated Factors, Shi YJ, Matson C, Lan F, Iwase S, Baba T, Shi Y, 2005
The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation, Tahiliani M, Mei P, Fang R, Leonor T, Rutenberg M, Shimizu F, Li J, Rao A and Shi YJ, 2007
Human LSD2/KDM1b/AOF1 regulates gene transcription by modulating intragenic H3K4me2 methylation, Fang R, Barbera AJ, Xu Y, Rutenberg M, Leonor T, Bi Q, Lan F, Mei P, Yuan GC, Lian C, Peng J, Cheng D, Sui G, Kaiser UB, Shi YJ, 2010
TET1 is a DNA-binding protein that modulates DNA methylation and gene transcription via hydroxylation of 5-methylcytosine, Zhang H, Zhang X, Clark E, Mulcahey M, Huang S, Shi YJ, 2010
Genome-wide Regulation of 5hmC, 5mC, and Gene Expression by Tet1 Hydroxylase in Mouse Embryonic Stem Cells, Xu Y, Wu F, Tan L, Kong L, Xiong L, Deng J, Barbera AJ, Shi YJ, 2011
Loss of 5-hydroxymethylcytosine is an epigenetic hallmark of melanoma, Lian CG, Xu Y, Ceol C, Wu F, Larson A, Dresser K, Xu W, Tan L, Hu Y, Zhan Q, Lee CW, Hu D, Lian BQ, Kleffel S, Yang Y, Neiswender J, Khorasani AJ, Fang R, Lezcano C, Duncan LM, Scolyer RA, Thompson JF, Kakavand H, Houvras Y, Zon LI, Mihm MC Jr, Kaiser UB, Schatton T, Woda BA, Murphy GF, Shi YJ, 2012
Tet3 CXXC domain and dioxygenase activity cooperatively regulate key genes for Xenopus eye and neural development, Xu Y, Xu C, Kato A, Tempel W, Abreu JG, Bian C, Hu Y, Hu D, Zhao B, Cerovina T, Diao J, Wu F, He HH, Cui Q, Clark E, Ma C, Barbara A, Veenstra GJ, Xu G, Kaiser UB, Liu XS, Sugrue SP, He X, Min J, Kato Y, Shi YJ, 2012
LSD2/KDM1B and its cofactor NPAC/GLYR1 endow a structural and molecular model for regulation of H3K4 demethylation, Fang R, Chen F, Dong Z, Hu D, Barbera AJ, Clark EA, Fang J, Yang Y, Mei P, Rutenberg M, Li Z, Zhang Y, Xu Y, Yang H, Wang P, Simon MD, Zhou Q, Li J, Marynick MP, Li X, Lu H, Kaiser UB, Kingston RE, Xu Y, Shi YJ, 2013
Genome-wide comparison of DNA hydroxymethylation in mouse embryonic stem cells and neural progenitor cells by a new comparative hMeDIP-seq method, Tan L, Xiong L, Xu W, Wu F, Huang N, Xu Y, Kong L, Zheng L, Schwartz L, Shi Y, Shi YJ, 2013
A primary role of TET proteins in establishment and maintenance of De Novo bivalency at CpG islands, Kong L, Tan L, Lv R, Shi Z, Xiong L, Wu F, Rabidou K, Smith M, He C, Zhang L, Qian Y, Ma D, Lan F, Shi Y, Shi YJ, 2016
The Glucose/AMPK/TET2/5hmC axis constitutes a new pathway linking diabetes to cancer, Di W, Di H, Hao C, Shi G, Fetahu IS, Wu F, Rabidou K, Fang R, Tan L, Xu S, Liu H, Argueta C, Zhang L, Mao F, Yan G, Chen J, Dong Z, Lv R, Xu Y, Wang M, Ye Y, Zhang S, Duquette D, Geng S, Guo C, Murphy GF, Adler G, Garg R, Lynch L, Yang P, Li Y, Lan F, Fan J, Shi Y, Shi YJ, 2018
TET2 stabilization by 14-3-3 binding to the phosphorylated Serine 99 is deregulated by mutations in cancer, Chen H, Yu D, Fang R, Rabidou K, Wu D, Hu D, Jia P, Zhao Z, Wu Z, Peng J, Shi Y, Shi YJ, 2019
GR and LSD1/KDM1A- Targeted Gene Activation Requires Selective H3K4me2 Demethylation at Enhancers, Clark EA, Wu F, Chen Y, Kang P, Kaiser UB, Fang R, Shi YJ, 2019
Epigenetic Signatures of methylated DNA Cytosine in Alzheimer’s Disease, Fetahu IS, Ma D, Rabidou K, Argueta C, Smith M, Liu H, Wu F, Shi YJ, 2019
Nono deficiency compromises TET1 chromatin association and impedes neuronal differentiation of mouse embryonic stem cells, Li W, Karwacki-Neisius V, Ma C, Tan L, Shi Y, Wu F, Shi YJ, 2020
The fusiform gyrus exhibits an epigenetic signature for Alzheimer's disease, Ma D, Fetahu IS, Wang M, Fang R, Li J, Liu H, Gramyk T, Iwanicki I, Gu S, Xu W, Tan L, Wu F, Shi YJ, 2020
TET2 promotes anti-tumor immunity by governing G-MDSCs and CD8+ T-cell numbers, Li S, Feng J, Wu F, Cai J, Zhang X, Wang H, Fetahu IS, Iwanicki I, Ma D, Hu T, Liu H, Wang B, Shi G, Tan L, Shi YJ, 2020

Epigenetics Histone Demethylation Lsd1 Kdm1A Tet Proteins Dna Methylation Stem Cells Cancer Aging Longevity

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