Professor | Qunying Lei | Asia Growth Partners

	Upload Avatar (500 x 500)
Name	Qunying Lei
Contact Information	qlei@fudan.edu.cn
Language ability	Chinese, English
Province	Shanghai

Upload Avatar (500 x 500)

Name

Qunying Lei

Contact Information

qlei@fudan.edu.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	Fudan University
Faculty	Biomedical Sciences
Academic Background & Achievements	1999.09-2002.07 Ph.D.: Fudan University Shanghai Medical College, Department of Biochemistry and Molecular Biology 1996.09-1999.07 Master's: Suzhou University Suzhou Medical College, Department of Biochemistry and Molecular Biology 1988.09-1993.07 Bachelor's: Nanchang University Jiangxi Medical College, Preventive Medicine 2023 New Cornerstone Researcher 2014 Leading Talent in Science and Technology Innovation for Young and Middle-aged People, Ministry of Science and Technology 2013 Outstanding Academic Leader in Shanghai, Shanghai Science and Technology Commission 2012 National Outstanding Youth Science Fund, National Natural Science Foundation 2011 Dawn Scholar, Shanghai Municipal Education Commission 2011 Outstanding Academic Leader in Shanghai Health System, Shanghai Municipal Health Commission 2009 Excellent Talent of the New Century, Ministry of Education 2007 Pujiang Talent Program, Shanghai Science and Technology Commission
Work Experience	2017.01-Present - Fudan University, Cancer Hospital/Biomedical Research Institute - Professor 2009.11-2016.12 - Fudan University, School of Basic Medical Sciences/Biomedical Research Institute - Professor 2006.03-2009.10 - Fudan University, School of Basic Medical Sciences/Biomedical Research Institute - Associate Professor 2002.09-2006.01 - University of California, Los Angeles, Department of Molecular Pharmacology - Postdoctoral Fellow 1993.07-1996.08 - Jiangxi Jinxian CDC - Preventive Physician
Awards	Wu Jieping-Paul Janssen Medical and Pharmaceutical Award (2021): Detail Tang Prize for Life Science Innovation (2020): Tang Prize Foundation Shanghai Natural Science First Prize (2019): Shanghai Science and Technology Commission National March 8th Red Banner Holder (2017): All-China Women's Federation Shanghai March 8th Red Banner Pacesetter (2016): Shanghai Women's Federation Shanghai Natural Science Peony Award (2015): Shanghai Association for Science and Technology Five Continents Women's Science and Technology Award (2015): Chinese Medical Women's Association Second Prize in Natural Science (2014): Ministry of Education China Young Female Scientist Award (2013): UNESCO First Prize in Natural Science (2012): Ministry of Education Shanghai March 8th Red Banner Holder (2012): Shanghai Women's Federation Meiji Life Science Award (Outstanding Award) (2011): National Human Genome South Research Center

University/Lab Affiliation and Title

Fudan University

Faculty

Biomedical Sciences

Academic Background & Achievements

1999.09-2002.07 Ph.D.: Fudan University Shanghai Medical College, Department of Biochemistry and Molecular Biology
1996.09-1999.07 Master's: Suzhou University Suzhou Medical College, Department of Biochemistry and Molecular Biology
1988.09-1993.07 Bachelor's: Nanchang University Jiangxi Medical College, Preventive Medicine
2023 New Cornerstone Researcher
2014 Leading Talent in Science and Technology Innovation for Young and Middle-aged People, Ministry of Science and Technology
2013 Outstanding Academic Leader in Shanghai, Shanghai Science and Technology Commission
2012 National Outstanding Youth Science Fund, National Natural Science Foundation
2011 Dawn Scholar, Shanghai Municipal Education Commission
2011 Outstanding Academic Leader in Shanghai Health System, Shanghai Municipal Health Commission
2009 Excellent Talent of the New Century, Ministry of Education
2007 Pujiang Talent Program, Shanghai Science and Technology Commission

Work Experience

2017.01-Present - Fudan University, Cancer Hospital/Biomedical Research Institute - Professor
2009.11-2016.12 - Fudan University, School of Basic Medical Sciences/Biomedical Research Institute - Professor
2006.03-2009.10 - Fudan University, School of Basic Medical Sciences/Biomedical Research Institute - Associate Professor
2002.09-2006.01 - University of California, Los Angeles, Department of Molecular Pharmacology - Postdoctoral Fellow
1993.07-1996.08 - Jiangxi Jinxian CDC - Preventive Physician

Awards

Wu Jieping-Paul Janssen Medical and Pharmaceutical Award (2021): Detail
Tang Prize for Life Science Innovation (2020): Tang Prize Foundation
Shanghai Natural Science First Prize (2019): Shanghai Science and Technology Commission
National March 8th Red Banner Holder (2017): All-China Women's Federation
Shanghai March 8th Red Banner Pacesetter (2016): Shanghai Women's Federation
Shanghai Natural Science Peony Award (2015): Shanghai Association for Science and Technology
Five Continents Women's Science and Technology Award (2015): Chinese Medical Women's Association
Second Prize in Natural Science (2014): Ministry of Education
China Young Female Scientist Award (2013): UNESCO
First Prize in Natural Science (2012): Ministry of Education
Shanghai March 8th Red Banner Holder (2012): Shanghai Women's Federation
Meiji Life Science Award (Outstanding Award) (2011): National Human Genome South Research Center

Areas of Focus	Metabolic abnormalities in cancer Nutritional regulation of tumor metabolism
Publications	Enhanced BCAT1 activity and BCAA metabolism promotes RhoC activity in cancer progression, Qian L#, Li N#, Lu XC#, Xu MD#, Liu Y, Li KY, Zhang Y, Hu KW, Qi YT, Yao J, Wu YL, Wen WY, Huang SL, Chen ZJ, Yin M, Lei QY, 2023 S-adenosyl-L-methionine supplementation alleviates damaged intestinal epithelium and inflammatory infiltration caused by Mat2a deficiency, Li ML#, Cao SY, Qu J, Zhang L, Gao Q, Wang X, Yin M, Liu Y, Lei MZ, Lei QY, 2023 BCAA-BCKA axis regulates WAT browning through acetylation of PRDM16, Ma QX#, Zhu WY, Lu XC, Jiang D, Xu F, Li JT, Zhang L, Wu YL, Chen ZJ, Yin M, Huang HY, Lei QY, 2022 AHCYL1 Senses SAH to Inhibit Autophagy through Interaction with PIK3C3 in an mTORC1-independent Manner, Huang W#, Li N#, Zhang Y, Wang X, Yin M, Lei QY, 2022 Dietary folate drives methionine metabolism to promote cancer development by stabilizing MAT IIA, Li JT#, Yang H#, Lei MZ#, Zhu WP#, Su Y, Li KY, Zhu WY, Wang J, Zhang L, Qu J, Lv L, Lu HJ, Chen ZJ, Wang L, Yin M, Lei QY, 2022 Palmitoylation of MDH2 by ZDHHC18 activates mitochondrial respiration and accelerates ovarian cancer growth, Pei X#, Li KY, Shen Y, Li JT, Lei MZ, Fang CY, Lu HJ, Yang HJ, Wen W, Yin M, Qu J, Lei QY, 2022 Diet High in Branched-chain Amino Acid Promotes PDAC Development by USP1-mediated BCAT2 Stabilization, Li JT#, Li KY#, Su Y, Shen Y, Lei MZ, Zhang F, Yin M, Chen ZJ, Wen WY, Hu WG, Su D, Qu J, Lei QY, 2021 BCAT2-mediated BCAA Catabolism is Critical for Development of Pancreatic Ductal Adenocarcinoma, Li JT#, Yin M#, Wang D#, Wang J, Lei MZ, Zhang Y, Liu Y, Zhang L, Zou SW, Hu LP, Zhang ZG, Wang YP, Wen WY, Lu HJ, Chen ZJ, Su D, Lei QY, 2020 Acetylation promotes BCAT2 degradation to suppress BCAA catabolism and pancreatic cancer growth, Lei, M.-Z. #, Li, X.-X., Zhang, Y., Li, J.-T., Zhang, F., Wang, Y.-P., Yin, M., Qu, J. , and Lei, QY., 2020 Nuclear Lactate Dehydrogenase A Senses ROS to Produce a-Hydroxybutyrate for HPV-Induced Cervical Tumor Growth, Liu Y#, Guo JZ#, Liu Y#, Wang K, Ding WC, Wang H, Liu X, Zhou ST, Lu XC, Yang HB, Xu CY, Gao W, Zhou L, Wang YP, Hu WG, Wei YQ, Huang CH, Lei QY, 2018 CARM1 Methylates GAPDH to Regulate Glucose Metabolism and Is Suppressed in Liver Cancer, Zhong XY#, Yuan XM, Xu YY, Yin M, Yan WW, Zou SW, Wei LM, Lu HJ, Wang YP, Lei QY, 2018 Prevention of Dietary-Fat-Fueled Ketogenesis Attenuates BRAF V600E Tumor Growth, Xia S#, Lin R#, Jin L, Zhao L, Kang HB, Pan Y, Liu S, Qian G, Qian Z, Konstantakou E, Zhang B, Dong JT, Chung YR, Abdel-Wahab O, Merghoub T, Zhou L, Kudchadkar RR, Lawson DH, Khoury HJ, Lee BH, Pollack BP, Arbiser JL, Fan J, Lei QY, Chen J, 2017 Acetylation Targets HSD17B4 for Degradation via CMA Pathway in Response to E1, Zhang Y#, Xu YY#, Zhao XN, Li JT, Yang HB, Zhang M, Li, Yao CB, Yin M, Chen J, Lei QY, 2017 Arginine Methylation of MDH1 by CARM1 Inhibits Non-canonical Glutamine Metabolism and Suppresses Pancreatic Cancer, Wang YP，Wang J，Gao X, Xu YY, Cheng JK, Lei QY, 2016 Acetate Functions as an Epigenetic Metabolite to Promote Lipid Synthesis under Hypoxia, Gao X#, Lin SH#，Ren F, Li1 JT, Chen JJ, Yao CB,Yang HB,Jiang SX, Yan GQ, Wang D，Wang Y, Liu Y, Cai Z, Xu YY, Chen J, Yu W, Yang YP, Lei QY*, 2016 Acetylation of MAT IIα represses tumour cell growth

Areas of Focus

Metabolic abnormalities in cancer
Nutritional regulation of tumor metabolism

Publications

Enhanced BCAT1 activity and BCAA metabolism promotes RhoC activity in cancer progression, Qian L#, Li N#, Lu XC#, Xu MD#, Liu Y, Li KY, Zhang Y, Hu KW, Qi YT, Yao J, Wu YL, Wen WY, Huang SL, Chen ZJ, Yin M, Lei QY*, 2023
S-adenosyl-L-methionine supplementation alleviates damaged intestinal epithelium and inflammatory infiltration caused by Mat2a deficiency, Li ML#, Cao SY, Qu J, Zhang L, Gao Q, Wang X, Yin M, Liu Y, Lei MZ*, Lei QY*, 2023
BCAA-BCKA axis regulates WAT browning through acetylation of PRDM16, Ma QX#, Zhu WY, Lu XC, Jiang D, Xu F, Li JT, Zhang L, Wu YL, Chen ZJ, Yin M*, Huang HY*, Lei QY*, 2022
AHCYL1 Senses SAH to Inhibit Autophagy through Interaction with PIK3C3 in an mTORC1-independent Manner, Huang W#, Li N#, Zhang Y, Wang X, Yin M, Lei QY*, 2022
Dietary folate drives methionine metabolism to promote cancer development by stabilizing MAT IIA, Li JT#, Yang H#, Lei MZ#, Zhu WP#, Su Y, Li KY, Zhu WY, Wang J, Zhang L, Qu J, Lv L, Lu HJ, Chen ZJ, Wang L*, Yin M*, Lei QY*, 2022
Palmitoylation of MDH2 by ZDHHC18 activates mitochondrial respiration and accelerates ovarian cancer growth, Pei X#, Li KY, Shen Y, Li JT, Lei MZ, Fang CY, Lu HJ, Yang HJ, Wen W, Yin M, Qu J*, Lei QY*, 2022
Diet High in Branched-chain Amino Acid Promotes PDAC Development by USP1-mediated BCAT2 Stabilization, Li JT#, Li KY#, Su Y, Shen Y, Lei MZ, Zhang F, Yin M, Chen ZJ, Wen WY, Hu WG, Su D*, Qu J*, Lei QY*, 2021
BCAT2-mediated BCAA Catabolism is Critical for Development of Pancreatic Ductal Adenocarcinoma, Li JT#, Yin M#, Wang D#, Wang J, Lei MZ, Zhang Y, Liu Y, Zhang L, Zou SW, Hu LP, Zhang ZG, Wang YP, Wen WY, Lu HJ, Chen ZJ, Su D, Lei QY*, 2020
Acetylation promotes BCAT2 degradation to suppress BCAA catabolism and pancreatic cancer growth, Lei, M.-Z. #, Li, X.-X., Zhang, Y., Li, J.-T., Zhang, F., Wang, Y.-P., Yin, M., Qu, J. *, and Lei, QY.*, 2020
Nuclear Lactate Dehydrogenase A Senses ROS to Produce a-Hydroxybutyrate for HPV-Induced Cervical Tumor Growth, Liu Y#, Guo JZ#, Liu Y#, Wang K, Ding WC, Wang H, Liu X, Zhou ST, Lu XC, Yang HB, Xu CY, Gao W, Zhou L, Wang YP, Hu WG, Wei YQ, Huang CH*, Lei QY*, 2018
CARM1 Methylates GAPDH to Regulate Glucose Metabolism and Is Suppressed in Liver Cancer, Zhong XY#, Yuan XM, Xu YY, Yin M, Yan WW, Zou SW, Wei LM, Lu HJ, Wang YP*, Lei QY*, 2018
Prevention of Dietary-Fat-Fueled Ketogenesis Attenuates BRAF V600E Tumor Growth, Xia S#, Lin R#, Jin L, Zhao L, Kang HB, Pan Y, Liu S, Qian G, Qian Z, Konstantakou E, Zhang B, Dong JT, Chung YR, Abdel-Wahab O, Merghoub T, Zhou L, Kudchadkar RR, Lawson DH, Khoury HJ, Lee BH, Pollack BP, Arbiser JL, Fan J*, Lei QY*, Chen J*, 2017
Acetylation Targets HSD17B4 for Degradation via CMA Pathway in Response to E1, Zhang Y#, Xu YY#, Zhao XN, Li JT, Yang HB, Zhang M, Li, Yao CB, Yin M*, Chen J*, Lei QY*, 2017
Arginine Methylation of MDH1 by CARM1 Inhibits Non-canonical Glutamine Metabolism and Suppresses Pancreatic Cancer, Wang YP*，Wang J，Gao X, Xu YY, Cheng JK*, Lei QY*, 2016
Acetate Functions as an Epigenetic Metabolite to Promote Lipid Synthesis under Hypoxia, Gao X#, Lin SH#，Ren F, Li1 JT, Chen JJ, Yao CB,Yang HB,Jiang SX, Yan GQ, Wang D，Wang Y, Liu Y, Cai Z, Xu YY, Chen J, Yu W, Yang YP*, Lei QY*, 2016
Acetylation of MAT IIα represses tumour cell growth

Metabolism Cancer Warburg Effect Genomics Nutritional Components Enzymes Epigenetics Post-Translational Modifications Pancreatic Cancer Metabolic Targeting

Fei Chen - Fudan University

Xianghuo He - Fudan University

Yujiang Geno Shi - Fudan University

View All

Personal Information

Academic Information

Research

Contact us

No account yet?

Personal Information

Academic Information

Research

Contact us