Professor | Wenning Wang | Asia Growth Partners

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Name	Wenning Wang
Contact Information	wnwang@fudan.edu.cn
Language ability	Chinese, English
Province	Shanghai

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Name

Wenning Wang

Contact Information

wnwang@fudan.edu.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	Fudan University
Faculty	Biomedical Sciences
Academic Background & Achievements	1990-1995 PhD: Fudan University, Department of Chemistry 1986-1990 Bachelor: Fudan University, Department of Chemistry 2004 Shuguang Scholar, Shanghai Municipal Education Commission 2003 Hong Kong Croucher Foundation Mainland Young Scholar
Work Experience	2005.4-Present - Fudan University - Professor, Department of Chemistry 2002.2-2003.8 - Hong Kong University of Science and Technology - Visiting Scholar, Department of Biochemistry 2000.12-2005.4 - Fudan University - Associate Professor, Department of Chemistry 1996.4-2000.12 - Fudan University - Lecturer, Department of Chemistry 1995.12-1996.3 - National Institute for Molecular Science, Japan - Postdoctoral Researcher
Awards	Shuguang Scholar (2004): Shanghai Municipal Education Commission Mainland Young Scholar (2003): Hong Kong Croucher Foundation

University/Lab Affiliation and Title

Fudan University

Faculty

Biomedical Sciences

Academic Background & Achievements

1990-1995 PhD: Fudan University, Department of Chemistry
1986-1990 Bachelor: Fudan University, Department of Chemistry
2004 Shuguang Scholar, Shanghai Municipal Education Commission
2003 Hong Kong Croucher Foundation Mainland Young Scholar

Work Experience

2005.4-Present - Fudan University - Professor, Department of Chemistry
2002.2-2003.8 - Hong Kong University of Science and Technology - Visiting Scholar, Department of Biochemistry
2000.12-2005.4 - Fudan University - Associate Professor, Department of Chemistry
1996.4-2000.12 - Fudan University - Lecturer, Department of Chemistry
1995.12-1996.3 - National Institute for Molecular Science, Japan - Postdoctoral Researcher

Awards

Shuguang Scholar (2004): Shanghai Municipal Education Commission
Mainland Young Scholar (2003): Hong Kong Croucher Foundation

Areas of Focus	Structural Biology and Computational Biology Membrane Protein Conformational Dynamics Post-translational Modifications Protein-Protein Interactions in Signal Transduction Pathways Conformational Dynamics and Functions of Intrinsically Disordered Proteins
Publications	LGN/mInsc and LGN/NuMA complexes structures suggest distinct functions in asymmetric cell division for the Par3/mInsc/LGN and Gai/LGN/NuMA pathways, Zhu, J., Wen, W., Zheng, Z., Shang, Y., Wei, Z., Xiao, Z., Pan, Z., Du Q., Wang W., Zhang M., 2011 The structural basis of Miranda-mediated Staufen localization during Drosophila neuroblast asymmetric division, Jia, M., Shan, Z., Yang, Y., Liu, C., Li, J., Luo, Z., Zhang, M., Cai Y., Wen W., Wang W., 2015 Creating conformational entropy by increasing inter-domain mobility in ligand binding regulation: a revisit to N-terminal tandem PDZ domains of PSD-95, Wang, W., Weng, J., Zhang, X., Liu, M., Zhang, M., 2009 Conformational Dynamics of apo-GlnBP Revealed by Experimental and Computational Analysis, Feng, Y., Zhang, L., Wu, S., Gao, X., Liu, J., Huang, X., Wang, W., 2016 The Dynamic Multisite Interactions between Two Intrinsically Disordered Proteins, Wu S., Wang D., Liu J., Feng Y., Weng J., Gao X., Liu J., Wang W., 2017 Phosphorylated Peptides Functionalization of Lanthanide Upconversion Nanoparticles for Tuning the Nanomaterial-Cell Interaction, Yao, C., Wei, C., Huang, Z., Lu, Y., El-Toni, AM, Ju, D., Zhang, X., Wang, W., Zhang, F., 2016 Phosphorylation of DCC by ERK2 is Facilitated by Direct Docking of the Receptor P1 Domain to the Kinase, Ma, W., Shang, Y., Wei, Z., Wen, W., Wang, W., Zhang, M., 2010 An auto-inhibited conformation of LGN reveals a distinct interaction mode between GoLoco motifs and TPR motifs, Pan, Z., Zhu, J., Shang, Y., Wei, Z., Jia, M., Xia, C., Wen, W., Wang W., Zhang M., 2013 The conformational transition pathway of ATP binding cassette transporter MsbA revealed by atomistic simulations, Weng, J., Fan, K. Wang, W., 2010 Crystal Structures of the scaffolding protein LGN reveal the general mechanism by which GoLoco binding motifs inhibit the release of GDP from Gai subunits in G-coupled heterotrimeric proteins, Jia, M., Li, J., Zhu, J., Wen, W., Zhang, M., Wang, W., 2012 Stepwise substrate translocation mechanism revealed by free energy calculations of doxorubicin in the multidrug transporter AcrB., Zuo, Z., Wang, B., Weng, J., Wang, W., 2015 The Conformational Coupling and Translocation Mechanism of Vitamin B12 ATP-binding Cassette (ABC) Transporter BtuCD, Weng, J., Ma, J., Fan, KN, Wang, W., 2008 Asymmetric conformational flexibility in the ATP-Binding Cassette transporter HI1470/1, Weng, J., Ma, J. Fan, K., and Wang, W., 2009 Maltose Binding Protein Effectively Stabilizes the Partially Closed Conformation of the ATP-binding Cassette Transporter MalFGK2, Weng, J., Gu, S., Gao, X., Huang, X., Wang, W., 2017 Substrate binding accelerates the conformational transitions and substrate dissociation in multidrug efflux transporter AcrB, Wang, B., Weng, J., Wang, W., 2015 The Dynamic Multisite Interactions between Two Intrinsically Disordered Proteins, Wu S., Wang D., Liu J., Feng Y., Weng J., Gao X., Liu J., Wang W.*, 2017

Areas of Focus

Structural Biology and Computational Biology
Membrane Protein Conformational Dynamics
Post-translational Modifications
Protein-Protein Interactions in Signal Transduction Pathways
Conformational Dynamics and Functions of Intrinsically Disordered Proteins

Publications

LGN/mInsc and LGN/NuMA complexes structures suggest distinct functions in asymmetric cell division for the Par3/mInsc/LGN and Gai/LGN/NuMA pathways, Zhu, J., Wen, W., Zheng, Z., Shang, Y., Wei, Z., Xiao, Z., Pan, Z., Du Q.*, Wang W.*, Zhang M.*, 2011
The structural basis of Miranda-mediated Staufen localization during Drosophila neuroblast asymmetric division, Jia, M., Shan, Z., Yang, Y., Liu, C., Li, J., Luo, Z., Zhang, M., Cai Y.*, Wen W.*, Wang W.*, 2015
Creating conformational entropy by increasing inter-domain mobility in ligand binding regulation: a revisit to N-terminal tandem PDZ domains of PSD-95, Wang, W.*, Weng, J., Zhang, X., Liu, M., Zhang, M.*, 2009
Conformational Dynamics of apo-GlnBP Revealed by Experimental and Computational Analysis, Feng, Y., Zhang, L., Wu, S., Gao, X., Liu, J.*, Huang, X.*, Wang, W.*, 2016
The Dynamic Multisite Interactions between Two Intrinsically Disordered Proteins, Wu S., Wang D., Liu J., Feng Y., Weng J., Gao X., Liu J.*, Wang W.*, 2017
Phosphorylated Peptides Functionalization of Lanthanide Upconversion Nanoparticles for Tuning the Nanomaterial-Cell Interaction, Yao, C., Wei, C., Huang, Z., Lu, Y., El-Toni, AM, Ju, D., Zhang, X., Wang, W.*, Zhang, F.*, 2016
Phosphorylation of DCC by ERK2 is Facilitated by Direct Docking of the Receptor P1 Domain to the Kinase, Ma, W., Shang, Y., Wei, Z., Wen, W., Wang, W.*, Zhang, M.*, 2010
An auto-inhibited conformation of LGN reveals a distinct interaction mode between GoLoco motifs and TPR motifs, Pan, Z., Zhu, J., Shang, Y., Wei, Z., Jia, M., Xia, C., Wen, W., Wang W.*, Zhang M.*, 2013
The conformational transition pathway of ATP binding cassette transporter MsbA revealed by atomistic simulations, Weng, J., Fan, K. Wang, W.*, 2010
Crystal Structures of the scaffolding protein LGN reveal the general mechanism by which GoLoco binding motifs inhibit the release of GDP from Gai subunits in G-coupled heterotrimeric proteins, Jia, M., Li, J., Zhu, J., Wen, W., Zhang, M., Wang, W.*, 2012
Stepwise substrate translocation mechanism revealed by free energy calculations of doxorubicin in the multidrug transporter AcrB., Zuo, Z., Wang, B., Weng, J.*, Wang, W.*, 2015
The Conformational Coupling and Translocation Mechanism of Vitamin B12 ATP-binding Cassette (ABC) Transporter BtuCD, Weng, J., Ma, J., Fan, KN, Wang, W.*, 2008
Asymmetric conformational flexibility in the ATP-Binding Cassette transporter HI1470/1, Weng, J., Ma, J. Fan, K., and Wang, W.*, 2009
Maltose Binding Protein Effectively Stabilizes the Partially Closed Conformation of the ATP-binding Cassette Transporter MalFGK2, Weng, J., Gu, S., Gao, X., Huang, X.*, Wang, W.*, 2017
Substrate binding accelerates the conformational transitions and substrate dissociation in multidrug efflux transporter AcrB, Wang, B., Weng, J.*, Wang, W.*, 2015
The Dynamic Multisite Interactions between Two Intrinsically Disordered Proteins, Wu S., Wang D., Liu J., Feng Y., Weng J., Gao X., Liu J.*, Wang W.*, 2017

Structural Biology Computational Biology Membrane Protein Conformational Dynamics Post-Translational Modifications Protein-Protein Interactions Signal Transduction Intrinsically Disordered Proteins Nmr X-Ray Crystallography

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