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Wenning Wang
Biomedical Sciences
Fudan University
Shanghai
Language: Chinese, English
Structural Biology
Computational Biology
Membrane Protein
Conformational Dynamics
Post-Translational Modifications
Protein-Protein Interactions
Signal Transduction
Intrinsically Disordered Proteins
Nmr
X-Ray Crystallography
Areas of Focus
- Structural Biology and Computational Biology
- Membrane Protein Conformational Dynamics
- Post-translational Modifications
- Protein-Protein Interactions in Signal Transduction Pathways
- Conformational Dynamics and Functions of Intrinsically Disordered Proteins
Work Experience
- 2005.4-Present - Fudan University - Professor, Department of Chemistry
- 2002.2-2003.8 - Hong Kong University of Science and Technology - Visiting Scholar, Department of Biochemistry
- 2000.12-2005.4 - Fudan University - Associate Professor, Department of Chemistry
- 1996.4-2000.12 - Fudan University - Lecturer, Department of Chemistry
- 1995.12-1996.3 - National Institute for Molecular Science, Japan - Postdoctoral Researcher
Academic Background & Achievements
- 1990-1995 PhD: Fudan University, Department of Chemistry
- 1986-1990 Bachelor: Fudan University, Department of Chemistry
- 2004 Shuguang Scholar, Shanghai Municipal Education Commission
- 2003 Hong Kong Croucher Foundation Mainland Young Scholar
Publications
- LGN/mInsc and LGN/NuMA complexes structures suggest distinct functions in asymmetric cell division for the Par3/mInsc/LGN and Gai/LGN/NuMA pathways, Zhu, J., Wen, W., Zheng, Z., Shang, Y., Wei, Z., Xiao, Z., Pan, Z., Du Q.*, Wang W.*, Zhang M.*, 2011
- The structural basis of Miranda-mediated Staufen localization during Drosophila neuroblast asymmetric division, Jia, M., Shan, Z., Yang, Y., Liu, C., Li, J., Luo, Z., Zhang, M., Cai Y.*, Wen W.*, Wang W.*, 2015
- Creating conformational entropy by increasing inter-domain mobility in ligand binding regulation: a revisit to N-terminal tandem PDZ domains of PSD-95, Wang, W.*, Weng, J., Zhang, X., Liu, M., Zhang, M.*, 2009
- Conformational Dynamics of apo-GlnBP Revealed by Experimental and Computational Analysis, Feng, Y., Zhang, L., Wu, S., Gao, X., Liu, J.*, Huang, X.*, Wang, W.*, 2016
- The Dynamic Multisite Interactions between Two Intrinsically Disordered Proteins, Wu S., Wang D., Liu J., Feng Y., Weng J., Gao X., Liu J.*, Wang W.*, 2017
- Phosphorylated Peptides Functionalization of Lanthanide Upconversion Nanoparticles for Tuning the Nanomaterial-Cell Interaction, Yao, C., Wei, C., Huang, Z., Lu, Y., El-Toni, AM, Ju, D., Zhang, X., Wang, W.*, Zhang, F.*, 2016
- Phosphorylation of DCC by ERK2 is Facilitated by Direct Docking of the Receptor P1 Domain to the Kinase, Ma, W., Shang, Y., Wei, Z., Wen, W., Wang, W.*, Zhang, M.*, 2010
- An auto-inhibited conformation of LGN reveals a distinct interaction mode between GoLoco motifs and TPR motifs, Pan, Z., Zhu, J., Shang, Y., Wei, Z., Jia, M., Xia, C., Wen, W., Wang W.*, Zhang M.*, 2013
- The conformational transition pathway of ATP binding cassette transporter MsbA revealed by atomistic simulations, Weng, J., Fan, K. Wang, W.*, 2010
- Crystal Structures of the scaffolding protein LGN reveal the general mechanism by which GoLoco binding motifs inhibit the release of GDP from Gai subunits in G-coupled heterotrimeric proteins, Jia, M., Li, J., Zhu, J., Wen, W., Zhang, M., Wang, W.*, 2012
- Stepwise substrate translocation mechanism revealed by free energy calculations of doxorubicin in the multidrug transporter AcrB., Zuo, Z., Wang, B., Weng, J.*, Wang, W.*, 2015
- The Conformational Coupling and Translocation Mechanism of Vitamin B12 ATP-binding Cassette (ABC) Transporter BtuCD, Weng, J., Ma, J., Fan, KN, Wang, W.*, 2008
- Asymmetric conformational flexibility in the ATP-Binding Cassette transporter HI1470/1, Weng, J., Ma, J. Fan, K., and Wang, W.*, 2009
- Maltose Binding Protein Effectively Stabilizes the Partially Closed Conformation of the ATP-binding Cassette Transporter MalFGK2, Weng, J., Gu, S., Gao, X., Huang, X.*, Wang, W.*, 2017
- Substrate binding accelerates the conformational transitions and substrate dissociation in multidrug efflux transporter AcrB, Wang, B., Weng, J.*, Wang, W.*, 2015
- The Dynamic Multisite Interactions between Two Intrinsically Disordered Proteins, Wu S., Wang D., Liu J., Feng Y., Weng J., Gao X., Liu J.*, Wang W.*, 2017
Awards
- Shuguang Scholar (2004): Shanghai Municipal Education Commission
- Mainland Young Scholar (2003): Hong Kong Croucher Foundation
