1999-07--2000-06 Studied Chinese: National University of Singapore
1993-10--1996-06 PhD in Chemistry: University of Cambridge
1989-10--1992-06 Bachelor of Science in Chemistry: University of Cambridge
2015-09~Present - University of Chinese Academy of Sciences - Professor
2003-04~Present - Institute of Biophysics, Chinese Academy of Sciences - Head of Innovation Group
2000-10~2003-03 - Institute of Biophysics, Chinese Academy of Sciences - Visiting Scholar
1997-07~2000-09 - Sidney Sussex College, University of Cambridge - Research Fellow
1996-10~1997-09 - Department of Chemistry, University of Cambridge - Postdoctoral Researcher
1992-10~1993-09 - Department of Chemistry, University of Cambridge - Research Assistant
Fellow of the Royal Society of Chemistry (FRSC) (2017): National Level
International Cooperation Partner Award for Young Scientists, Chinese Academy of Sciences (2015): Institute Level
Order of the British Empire (OBE) (2015): National Level
Research
Protein folding, modification, and quality control Molecular mechanisms and applications of amyloid fiber assembly Nanomaterials with biological functions
Reversible Redox-Dependent Conformational Switch of the C-Terminal alpha-Helical Lid of Human Hsp70 Observed by In-Cell NMR, Liang, Qihui, Zhang, Yiying, Zhang, Hong, Wu, Si, Gong, Weibin, Sarah Perrett, 2023
Effect of evolution of the C-terminal region on chaperone activity of Hsp70, Zhang, Hong, Hu, Huimin, Wu, Si, Sarah Perrett, 2023
Interaction between Huntingtin exon 1 and HEAT repeat structure probed by chimeric model proteins, Sarah Perrett, Hong Zhang, Si Wu, Itzhaki, Laura S., 2023
Exploration of the cysteine reactivity of human inducible Hsp70 and cognate Hsc70, Hong, Zhouping, Gong, Weibin, Yang, Jie, Li, Sainan, Liu, Zhenyan, Sarah Perrett, Zhang, Hong, 2023
Methylene blue accelerates liquid-to-gel transition of tau condensates impacting tau function and pathology, Yongqi Huang, Jitao Wen, Lisa-Marie Ramirez, Eymen Gümüşdil, Pravin Pokhrel, Viet H. Man, Haiqiong Ye, Yue Han, Yunfei Liu, Ping Li, Zhengding Su, Junmei Wang, Hanbin Mao, Markus Zweckstetter, Sarah Perrett, Si Wu, Meng Gao, 2023
PES derivative PESA is a potent tool to globally profile cellular targets of PES, Yang, Jie, Liu, Zhenyan, Sarah Perrett, Zhang, Hong, Pan, Zhengying, 2022
蛋白质和多肽的检测与疾病诊疗, 柯莎, 朱笠, 2022
Resonance assignments for the tandem PWWP-ARID domains of human RBBP1 (vol 13, pg 177, 2019), Gong, Weibin, Yao, Xingzhe, Liang, Qihui, Tong, Yufeng, Sarah Perrett, Feng, Yingang, 2022
Exploration of the cysteine reactivity of human inducible Hsp70 and cognate Hsc70, Zhouping Hong, Weibin Gong, Jie Yang, Sainan Li, Zhenyan Liu, Sarah Perrett, Hong Zhang, 2022
蛋白质错误折叠相关疾病的多肽药物研究进展, 吴思, 张红, 柯莎, 2022
Peptide-based Strategies for Treatment of Protein Misfolding Diseases, Wu Si, Zhang Hong, 柯莎, 2022
Unravelling the microscopic characteristics of intrinsically disordered proteins upon liquid-liquid phase separation, Wu, Si, Wen, Jitao, 柯莎, 2022
Hsp70 in Redox Homeostasis, Hong Zhang, Weibin Gong, Si Wu, 柯莎, 2022
Distinct lipid membrane-mediated pathways of Tau assembly revealed by single-molecule analysis, Yao, Qiong-Qiong, Wen, Jitao, 柯莎, Wu, Si, 2022
Single Molecule Characterization of Amyloid Oligomers, Yang, Jie, Perrett, Sarah, Wu, Si, 2021
Mutational analysis of the Hsp70 substrate-binding domain: Correlating molecular-level changes with in vivo function, Xu, Linan, Zhang, Hong, Cuskelly, Daragh D, Doyle, Sean, Perrett, Sarah, Jones, Gary W., 2021
Structural basis for the DNA-binding activity of human ARID4B Tudor domain, Jie Ren, Hongwei Yao, Wanhui Hu, Sarah Perrett, Weibin Gong, Yingang Feng, 2021
Structural Insight into Chromatin Recognition by Multiple Domains of the Tumor Suppressor RBBP1, Gong, Weibin, Liang, Qihui, Tong, Yufeng, Perrett, Sarah, Feng, Yingang, 2021
PES inhibits human-inducible Hsp70 by covalent targeting of cysteine residues in the substrate-binding domain, Yang, Jie, Gong, Weibin, Wu, Si, Zhang, Hong, Perrett, Sarah, 2021
Conformational Expansion of Tau in Condensates Promotes Irreversible Aggregation, Wen, Jitao, Hong, Liu, Krainer, Georg, Yao, QiongQiong, Knowles, Tuomas P J, Wu, Si, Perrett, Sarah, 柯莎, 2021
Studying protein folding in health and disease using biophysical approaches, 柯莎, 2021
Discovery and mechanism of a pH-dependent dual-binding-site switch in the interaction of a pair of protein modules, Yao, Xingzhe, Chen, Chao, Wang, Yefei, Dong, Sheng, Liu, YaJun, Li, Yifei, Cui, Zhenling, Gong, Weibin, Perrett, Sarah, Yao, Lishan, Lamed, Raphael, Bayer, Edward A, Cui, Qiu, Feng, Yingang, 2020
S-Glutathionylation of human inducible Hsp70 reveals a regulatory mechanism involving the C-terminal α-helical lid, Jie Yang, Hong Zhang, Weibin Gong, Zhenyan Liu, Huiwen Wu, Wanhui Hu, Xinxin Chen, Lei Wang, Si Wu, Chang Chen, Sarah Perrett, 2020
Distinct microscopic mechanisms for the accelerated aggregation of pathogenic Tau mutants revealed by kinetic analysis, Yao, QiongQiong, Hong, Liu, Wu, Si, Perrett, Sarah, 2020
Kinetic diversity of amyloid oligomers, Dear, Alexander J, Michaels, Thomas C T, Meisl, Georg, Klenerman, David, Wu, Si, Perrett, Sarah, Linse, Sara, Dobson, Christopher M, Knowles, Tuomas P J, 2020
Kinetics of the conformational cycle of Hsp70 reveals the importance of the dynamic and heterogeneous nature of Hsp70 for its function, Wu, Si, Hong, Liu, Wang, Yuqing, Yu, Jieqiong, Yang, Jie, Yang, Jie, Zhang, Hong, Perrett, Sarah, 柯莎, 2020
Amelioration of aggregate cytotoxicity by catalytic conversion of protein oligomers into amyloid fibrils, Yang, Jie, Dear, Alexander J, Yao, QiongQiong, Liu, Zhenyan, Dobson, Christopher M, Knowles, Tuomas P J, Wu, Si, Perrett, Sarah, 柯莎, 2020
A kinetic view of the conformational cycle of Hsp70 reveals the importance of the dynamic and heterogeneous nature of Hsp70 for its function, 柯莎, 2020
Resonance assignments for the tandem PWWP-ARID domains of human RBBP1, Gong, Weibin, Yao, Xingzhe, Liang, Qihui, Tong, Yufeng, Perrett, Sarah, Feng, Yingang, 2019
Rapid acetylation of yeast Hsp70 mediates the cellular response to heat stress, 柯莎, 2019
Rapid deacetylation of yeast Hsp70 mediates the cellular response to heat stress, Xu, Linan, Nitika, Hasin, Naushaba, Cuskelly, Daragh D, Wolfgeher, Donald, Doyle, Sean, Moynagh, Paul, Perrett, Sarah, Jones, Gary W, Truman, Andrew W., 2019
Protein Microgels from Amyloid Fibril Networks, Roode, Lianne W Y, Shimanovich, Ulyana, Wu, Si, Perrett, Sarah, Knowles, Tuomas P J, Perrett, S, Buell, AK, Knowles, TPJ, 2019
The same but different: the role of Hsp70 in heat shock response and prion propagation, Xu, Linan, Gong, Weibin, Zhang, Hong, Perrett, Sarah, Jones, Gary W., 2018
Direct Observation of Oligomerization by Single Molecule Fluorescence Reveals a Multistep Aggregation Mechanism for the Yeast Prion Protein Ure2, Yang, Jie, Dear, Alexander J, Yao, QiongQiong, Liu, Zhenyan, Dobson, Christopher M, Knowles,
Keywords
Protein FoldingProtein ModificationQuality ControlAmyloid FibersMolecular MechanismsNanomaterialsBiological FunctionsProtein AssemblyBiophysicsChemical Biology
