Professor | Tie-Shan Tang | Asia Growth Partners

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Name	Tie-Shan Tang
Contact Information	tangtsh@ioz.ac.cn
Language ability	Chinese, English
Province	Beijing

Upload Avatar (500 x 500)

Name

Tie-Shan Tang

Contact Information

tangtsh@ioz.ac.cn

Language ability

Chinese, English

Province

Beijing

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Academic Background & Achievements	1994-09 to 1998-06: Ph.D. from Institute of Developmental Biology, Chinese Academy of Sciences 1986-09 to 1994-07: Bachelor's and Master's from Northwest Agricultural University
Work Experience	2009-02 to Present: Researcher at Institute of Zoology, Chinese Academy of Sciences 2006-07 to 2009-02: Lecturer at University of Texas Southwestern Medical Center 2004-07 to 2006-07: Assistant Lecturer at University of Texas Southwestern Medical Center 2000-07 to 2004-07: Postdoctoral Researcher at University of Texas Southwestern Medical Center 1998-07 to 2000-07: Assistant Researcher at Institute of Developmental Biology, Chinese Academy of Sciences

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Academic Background & Achievements

1994-09 to 1998-06: Ph.D. from Institute of Developmental Biology, Chinese Academy of Sciences
1986-09 to 1994-07: Bachelor's and Master's from Northwest Agricultural University

Work Experience

2009-02 to Present: Researcher at Institute of Zoology, Chinese Academy of Sciences
2006-07 to 2009-02: Lecturer at University of Texas Southwestern Medical Center
2004-07 to 2006-07: Assistant Lecturer at University of Texas Southwestern Medical Center
2000-07 to 2004-07: Postdoctoral Researcher at University of Texas Southwestern Medical Center
1998-07 to 2000-07: Assistant Researcher at Institute of Developmental Biology, Chinese Academy of Sciences

Areas of Focus	Molecular mechanisms of neurodevelopmental and neurodegenerative diseases Neurodevelopment, aging, and neuroregeneration
Publications	RAD18 O-GlcNAcylation promotes translesion DNA synthesis and homologous recombination repair., Xiaolu Ma, Hui Fu, Chenyi Sun, Wei Wu, Wenya Hou, Zibin Zhou, Hui Zheng, Yifei Gong, Honglin Wu, Junying Qin, Huiqiang Lou, Jing Li, Tie-Shan Tang, Caixia Guo, 2024 Agomirs upregulating carboxypeptidase E expression rescue hippocampal neurogenesis and memory deficits in Alzheimer’s disease., Dongfang Jiang, Hongmei Liu, Tingting Li, Song Zhao, Keyan Yang, Fuwen Yao, Bo Zhou, Haiping Feng, Sijia Wang, Jiaqi Shen, Jinglan Tang, Yu-Xin Zhang, Yun Wang, Caixia Guo, Tie-Shan Tang, 2024 TBC1D23 mediates Golgi-specific LKB1 signaling., Tu Y, Yang Q, Tang M, Gao L, Wang Y, Wang J, Liu Z, Li X, Mao L, Jia RZ, Wang Yuan, Tang TS, Xu P, Liu Y, Dai L, Jia D, 2024 ER Ca 2+ overload activates the IRE1α signaling and promotes cell survival., Song Zhao, Haiping Feng, Dongfang Jiang, Keyan Yang, Si-Tong Wang, Yu-Xin Zhang, Yun Wang, Hongmei Liu, Caixia Guo, Tie-Shan Tang, 2023 Cyclin-dependent kinase 5 negatively regulates antiviral immune response by disrupting myeloid differentiation primary response protein 88 self-association., Ren, JianPing, Cong, HaoLong, Gao, LiJie, Jiang, DongFang, Li, XinTong, Wang, Yun, Wang, JiuQiang, Tang, Tie-Shan, 2023 Human neural stem cells., Wang, YuKai, Yu, Juan, Zhang, TingTing, Ma, AiJin, Hao, Jie, Chen, YueJun, Liu, ChangMei, Liu, Yan, Wang, ChangLin, Zhai, PeiJun, Xiang, Andy Peng, Li, TianQing, Tang, Tie-Shan, Chen, Hong, Bao, XinJie, Wang, YanLin, He, WenYan, Fan, Jing, Teng, ZhaoQian, Wang, Liu, Zhou, JiaXi, Fu, BoQiang, Fu, Yu Vincent, Feng, Lin, Cao, JiaNi, Liang, LingMin, Wang, Lei, Zhou, Qi, Zhang, Yu, Hu, BaoYang, Zhao, TongBiao, 2023 Small molecule modulators of chromatin remodeling: from neurodevelopment to neurodegeneration., Dongfang Jiang, Tingting Li, Caixia Guo, Tie-Shan Tang, Hongmei Liu, 2023 Ca2+ homeostasis maintained by TMCO1 underlies corpus callosum development via ERK signaling., Yang, KeYan, Zhao, Song, Feng, Haiping, Shen, Jiaqi, Chen, Yuwei, Wang, SiTong, Wang, SiJia, Zhang, YuXin, Wang, Yun, Guo, Caixia, Liu, Hongmei, Tang, TieShan, 2022 DNA polymerase η promotes nonhomologous end joining upon etoposide exposure dependent on the scaffolding protein Kap1., Xiaolu Ma, Chen Wang, Bo Zhou, Zina Cheng, Zhiyong Mao, TieShan Tang, Caixia Guo, 2022 Polymerases and DNA Repair in Neurons: Implications in Neuronal Survival and Neurodegenerative Diseases., Li, Xiaoling, Cao, Guanghui, Liu, Xiaokang, Tang, TieShan, Guo, Caixia, Liu, Hongmei, 2022 iASPP suppresses Gp78-mediated TMCO1 degradation to maintain Ca2+ homeostasis and control tumor growth and drug resistance., Zheng, Shanliang, Zhao, Dong, Hou, Guixue, Zhao, Song, Zhang, Wenxin, Wang, Xingwen, Li, Li, Lin, Liang, Tang, TieShan, Hu, Ying, 2022 Micropeptide PACMP inhibition elicits synthetic lethal effects by decreasing CtIP and poly(ADP-ribosyl)ation., Zhang, Chuanchao, Zhou, Bo, Gu, Feng, Liu, Hongmei, Wu, Honglin, Yao, Fuwen, Zheng, Hui, Fu, Hui, Chong, Wei, Cai, Shurui, Huang, Min, Ma, Xiaolu, Guo, Zhifang, Li, Tingting, Deng, Wenyuan, Zheng, Meiwen, Ji, Qiao, Zhao, Yongliang, Ma, Yongjie, Wang, QiEn, Tang, TieShan, Guo, Caixia, 2022 VDAC1 negatively regulates melanogenesis through the Ca2+-calcineurin-CRTC1-MITF pathway., Wang, Jianli, Gong, Juanjuan, Wang, Qiaochu, 唐铁山, Li, Wei, 2022 BMP4 Exerts Anti-Neurogenic Effect via Inducing Id3 during Aging., Tingting Li, Hongmei Liu, Dongfang Jiang, Keyan Yang, Jiaqi Shen, Haiping Feng, Sijia Wang, Yuxin Zhang, Yun Wang, TieShan Tang, 2022 Mitochondrial outer membrane protein FUNDC2 promotes ferroptosis and contributes to doxorubicin-induced cardiomyopathy., Ta, Na, Qu, Chuanren, Wu, Hao, Zhang, Di, Sun, Tiantian, Li, Yanjun, Wang, Jun, Wang, Xiaohui, Tang, TieShan, Chen, Quan, Liu, Lei, 2022 Mutations and clinical significance of calcium voltage-gated channel subunit alpha 1E (CACNA1E) in non-small cell lung cancer., Gao, SanHui, Wang, GuiZhen, Wang, LiPeng, Feng, Lin, Zhou, YongChun, Yu, XianJun, Liang, Fan, Yang, FuYing, Wang, Zheng, Sun, BeiBei, Wang, Di, Liang, LiJun, Xie, DaWei, Zhao, Song, Feng, HaiPing, Li, Xueqing, Li, Keqin Kathy, Tang, TieShan, Huang, YunChao, Wang, ShiQiang, Zhou, GuangBiao, 2022 Maternal EHMT2 is essential for homologous chromosome segregation by regulating Cyclin B3 transcription in oocyte meiosis., Meng, TieGang, Lei, WenLong, Lu, Xukun, Liu, XiaoYu, Ma, XueShan, Nie, XiaoQing, Zhao, ZhengHui, Li, QianNan, Huang, Lin, Hou, Yi, Ouyang, YingChun, Li, Lei, Tang, TieShan, Schatten, Heide, Xie, Wei, Gao, ShaoRong, Ou, XiangHong, Wang, ZhenBo, Sun, QingYuan, 2022 GUIDELINES FOR THE USE AND INTERPRETATION OF ASSAYS FOR MONITORING AUTOPHAGY (4TH EDITION)., Daniel J Klionsky, Amal Kamal AbdelAziz, TieShan Tang, 2021 Rescue of premature aging defects in Cockayne syndrome stem cells by CRISPR/Cas9-mediated gene correction., Si Wang, Zheying Min, Qianzhao Ji, Lingling Geng, Yao Su, Zunpeng Liu, Huifang Hu, Lixia Wang, Weiqi Zhang, Keiichiro Suzuiki, Yu Huang, Puyao Zhang, TieShan Tang, Jing Qu, Yang Yu, GuangHui Liu, Jie Qiao, 2020 Regulation of translesion DNA synthesis in mammalian cells., Ma, Xiaolu, Tang, TieShan, Guo, Caixia, 2020 Determining the Fate of Neurons in SCA3: ATX3, a Rising Decision Maker in Response to DNA Stresses and Beyond., Tu, Yingfeng, Li, Xiaoling, Zhu, Xuefei, Liu, Xiaokang, Guo, Caixia, Jia, Da, Tang, TieShan, 2020 Miro2 supplies a platform for Parkin translocation to damaged mitochondria., Wang, JiuQiang, Zhu, Shu, Wang, Yihan, Wang, Fengli, An, Chaoqiang, Jiang, Dongfang, Gao, Lijie, Tu, Yingfeng, Zhu, Xuefei, Wang, Yun, Liu, Hongmei, Gong, Juanjuan, Sun, Zhongshuai, Wang, Xi, Liu, Leimei, Yang, Keyan, Guo, Caixia, Tang, TieShan, 2019 ER stress mediated degradation of diacylglycerol acyltransferase impairs mitochondrial functions in TMCO1 deficient cells., Wang, Xi, Wang, QiaoChu, Sun, Zhongshuai, Li, Tingting, Yang, Keyan, An, Chaoqiang, Guo, Caixia, Tan, TieShan, 2019 多聚谷氨酰胺神经疾病的表观谱., 唐铁山, 2018 TMCO1 is essential for ovarian follicle development by regulating ER Ca2+ store of granulosa cells., Sun, Zhongshuai, Zhang, Hui, Wang, Xi, Wang, QiaoChu, Zhang, Chuanchao, Wang, JiuQiang, Wang, YiHan, An, ChaoQiang, Yang, KeYan, Wang, Yun, Gao, Fei, Guo, Caixia, Tang, TieShan, 2018 EB1 traps STIM1 and regulates local store-operated Ca2+ entry., Wang, QiaoChu, Wang, Xi, Tang, TieShan, 2018 RNA-splicing factor SART3 regulates translesion DNA synthesis., Huang, Min, Zhou, Bo, Gong, Juanjuan, Xing, Lingyu, Ma, Xiaolu, Wang, Fengli, Wu, Wei, Shen, Hongyan, Sun, Chenyi, Zhu, Xuefei, Yang, Yeran, Sun, Yazhou, Liu, Yang, Tang, TieShan, Guo, Caixia, 2018 DNA Damage Response and The Pathogenesis of

Areas of Focus

Molecular mechanisms of neurodevelopmental and neurodegenerative diseases
Neurodevelopment, aging, and neuroregeneration

Publications

RAD18 O-GlcNAcylation promotes translesion DNA synthesis and homologous recombination repair., Xiaolu Ma, Hui Fu, Chenyi Sun, Wei Wu, Wenya Hou, Zibin Zhou, Hui Zheng, Yifei Gong, Honglin Wu, Junying Qin, Huiqiang Lou, Jing Li, Tie-Shan Tang, Caixia Guo, 2024
Agomirs upregulating carboxypeptidase E expression rescue hippocampal neurogenesis and memory deficits in Alzheimer’s disease., Dongfang Jiang, Hongmei Liu, Tingting Li, Song Zhao, Keyan Yang, Fuwen Yao, Bo Zhou, Haiping Feng, Sijia Wang, Jiaqi Shen, Jinglan Tang, Yu-Xin Zhang, Yun Wang, Caixia Guo, Tie-Shan Tang, 2024
TBC1D23 mediates Golgi-specific LKB1 signaling., Tu Y, Yang Q, Tang M, Gao L, Wang Y, Wang J, Liu Z, Li X, Mao L, Jia RZ, Wang Yuan, Tang TS, Xu P, Liu Y, Dai L, Jia D, 2024
ER Ca 2+ overload activates the IRE1α signaling and promotes cell survival., Song Zhao, Haiping Feng, Dongfang Jiang, Keyan Yang, Si-Tong Wang, Yu-Xin Zhang, Yun Wang, Hongmei Liu, Caixia Guo, Tie-Shan Tang, 2023
Cyclin-dependent kinase 5 negatively regulates antiviral immune response by disrupting myeloid differentiation primary response protein 88 self-association., Ren, JianPing, Cong, HaoLong, Gao, LiJie, Jiang, DongFang, Li, XinTong, Wang, Yun, Wang, JiuQiang, Tang, Tie-Shan, 2023
Human neural stem cells., Wang, YuKai, Yu, Juan, Zhang, TingTing, Ma, AiJin, Hao, Jie, Chen, YueJun, Liu, ChangMei, Liu, Yan, Wang, ChangLin, Zhai, PeiJun, Xiang, Andy Peng, Li, TianQing, Tang, Tie-Shan, Chen, Hong, Bao, XinJie, Wang, YanLin, He, WenYan, Fan, Jing, Teng, ZhaoQian, Wang, Liu, Zhou, JiaXi, Fu, BoQiang, Fu, Yu Vincent, Feng, Lin, Cao, JiaNi, Liang, LingMin, Wang, Lei, Zhou, Qi, Zhang, Yu, Hu, BaoYang, Zhao, TongBiao, 2023
Small molecule modulators of chromatin remodeling: from neurodevelopment to neurodegeneration., Dongfang Jiang, Tingting Li, Caixia Guo, Tie-Shan Tang, Hongmei Liu, 2023
Ca2+ homeostasis maintained by TMCO1 underlies corpus callosum development via ERK signaling., Yang, KeYan, Zhao, Song, Feng, Haiping, Shen, Jiaqi, Chen, Yuwei, Wang, SiTong, Wang, SiJia, Zhang, YuXin, Wang, Yun, Guo, Caixia, Liu, Hongmei, Tang, TieShan, 2022
DNA polymerase η promotes nonhomologous end joining upon etoposide exposure dependent on the scaffolding protein Kap1., Xiaolu Ma, Chen Wang, Bo Zhou, Zina Cheng, Zhiyong Mao, TieShan Tang, Caixia Guo, 2022
Polymerases and DNA Repair in Neurons: Implications in Neuronal Survival and Neurodegenerative Diseases., Li, Xiaoling, Cao, Guanghui, Liu, Xiaokang, Tang, TieShan, Guo, Caixia, Liu, Hongmei, 2022
iASPP suppresses Gp78-mediated TMCO1 degradation to maintain Ca2+ homeostasis and control tumor growth and drug resistance., Zheng, Shanliang, Zhao, Dong, Hou, Guixue, Zhao, Song, Zhang, Wenxin, Wang, Xingwen, Li, Li, Lin, Liang, Tang, TieShan, Hu, Ying, 2022
Micropeptide PACMP inhibition elicits synthetic lethal effects by decreasing CtIP and poly(ADP-ribosyl)ation., Zhang, Chuanchao, Zhou, Bo, Gu, Feng, Liu, Hongmei, Wu, Honglin, Yao, Fuwen, Zheng, Hui, Fu, Hui, Chong, Wei, Cai, Shurui, Huang, Min, Ma, Xiaolu, Guo, Zhifang, Li, Tingting, Deng, Wenyuan, Zheng, Meiwen, Ji, Qiao, Zhao, Yongliang, Ma, Yongjie, Wang, QiEn, Tang, TieShan, Guo, Caixia, 2022
VDAC1 negatively regulates melanogenesis through the Ca2+-calcineurin-CRTC1-MITF pathway., Wang, Jianli, Gong, Juanjuan, Wang, Qiaochu, 唐铁山, Li, Wei, 2022
BMP4 Exerts Anti-Neurogenic Effect via Inducing Id3 during Aging., Tingting Li, Hongmei Liu, Dongfang Jiang, Keyan Yang, Jiaqi Shen, Haiping Feng, Sijia Wang, Yuxin Zhang, Yun Wang, TieShan Tang, 2022
Mitochondrial outer membrane protein FUNDC2 promotes ferroptosis and contributes to doxorubicin-induced cardiomyopathy., Ta, Na, Qu, Chuanren, Wu, Hao, Zhang, Di, Sun, Tiantian, Li, Yanjun, Wang, Jun, Wang, Xiaohui, Tang, TieShan, Chen, Quan, Liu, Lei, 2022
Mutations and clinical significance of calcium voltage-gated channel subunit alpha 1E (CACNA1E) in non-small cell lung cancer., Gao, SanHui, Wang, GuiZhen, Wang, LiPeng, Feng, Lin, Zhou, YongChun, Yu, XianJun, Liang, Fan, Yang, FuYing, Wang, Zheng, Sun, BeiBei, Wang, Di, Liang, LiJun, Xie, DaWei, Zhao, Song, Feng, HaiPing, Li, Xueqing, Li, Keqin Kathy, Tang, TieShan, Huang, YunChao, Wang, ShiQiang, Zhou, GuangBiao, 2022
Maternal EHMT2 is essential for homologous chromosome segregation by regulating Cyclin B3 transcription in oocyte meiosis., Meng, TieGang, Lei, WenLong, Lu, Xukun, Liu, XiaoYu, Ma, XueShan, Nie, XiaoQing, Zhao, ZhengHui, Li, QianNan, Huang, Lin, Hou, Yi, Ouyang, YingChun, Li, Lei, Tang, TieShan, Schatten, Heide, Xie, Wei, Gao, ShaoRong, Ou, XiangHong, Wang, ZhenBo, Sun, QingYuan, 2022
GUIDELINES FOR THE USE AND INTERPRETATION OF ASSAYS FOR MONITORING AUTOPHAGY (4TH EDITION)., Daniel J Klionsky, Amal Kamal AbdelAziz, TieShan Tang, 2021
Rescue of premature aging defects in Cockayne syndrome stem cells by CRISPR/Cas9-mediated gene correction., Si Wang, Zheying Min, Qianzhao Ji, Lingling Geng, Yao Su, Zunpeng Liu, Huifang Hu, Lixia Wang, Weiqi Zhang, Keiichiro Suzuiki, Yu Huang, Puyao Zhang, TieShan Tang, Jing Qu, Yang Yu, GuangHui Liu, Jie Qiao, 2020
Regulation of translesion DNA synthesis in mammalian cells., Ma, Xiaolu, Tang, TieShan, Guo, Caixia, 2020
Determining the Fate of Neurons in SCA3: ATX3, a Rising Decision Maker in Response to DNA Stresses and Beyond., Tu, Yingfeng, Li, Xiaoling, Zhu, Xuefei, Liu, Xiaokang, Guo, Caixia, Jia, Da, Tang, TieShan, 2020
Miro2 supplies a platform for Parkin translocation to damaged mitochondria., Wang, JiuQiang, Zhu, Shu, Wang, Yihan, Wang, Fengli, An, Chaoqiang, Jiang, Dongfang, Gao, Lijie, Tu, Yingfeng, Zhu, Xuefei, Wang, Yun, Liu, Hongmei, Gong, Juanjuan, Sun, Zhongshuai, Wang, Xi, Liu, Leimei, Yang, Keyan, Guo, Caixia, Tang, TieShan, 2019
ER stress mediated degradation of diacylglycerol acyltransferase impairs mitochondrial functions in TMCO1 deficient cells., Wang, Xi, Wang, QiaoChu, Sun, Zhongshuai, Li, Tingting, Yang, Keyan, An, Chaoqiang, Guo, Caixia, Tan, TieShan, 2019
多聚谷氨酰胺神经疾病的表观谱., 唐铁山, 2018
TMCO1 is essential for ovarian follicle development by regulating ER Ca2+ store of granulosa cells., Sun, Zhongshuai, Zhang, Hui, Wang, Xi, Wang, QiaoChu, Zhang, Chuanchao, Wang, JiuQiang, Wang, YiHan, An, ChaoQiang, Yang, KeYan, Wang, Yun, Gao, Fei, Guo, Caixia, Tang, TieShan, 2018
EB1 traps STIM1 and regulates local store-operated Ca2+ entry., Wang, QiaoChu, Wang, Xi, Tang, TieShan, 2018
RNA-splicing factor SART3 regulates translesion DNA synthesis., Huang, Min, Zhou, Bo, Gong, Juanjuan, Xing, Lingyu, Ma, Xiaolu, Wang, Fengli, Wu, Wei, Shen, Hongyan, Sun, Chenyi, Zhu, Xuefei, Yang, Yeran, Sun, Yazhou, Liu, Yang, Tang, TieShan, Guo, Caixia, 2018
DNA Damage Response and The Pathogenesis of

Neurodevelopmental Diseases Neurodegenerative Diseases Molecular Mechanisms Neurodevelopment Aging Neuroregeneration Cell Biology Neuroscience Disease Mechanisms Biological Research

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