Professor | Yanli Wang | Asia Growth Partners

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Name	Yanli Wang
Contact Information	ylwang@ibp.ac.cn
Language ability	English, Chinese
Province	Beijing

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Name

Yanli Wang

Contact Information

ylwang@ibp.ac.cn

Language ability

English, Chinese

Province

Beijing

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Academic Background & Achievements	2002-02--2005-01 PhD: University of Science and Technology of China 1996-09--1999-07 Master's Degree: Chinese Academy of Agricultural Sciences 1992-09--1996-07 Bachelor's Degree: Wuhan University
Work Experience	2011-04~Present - Institute of Biophysics, Chinese Academy of Sciences - Researcher 2006-09~2011-02 - Memorial Sloan-Kettering Cancer Center - Senior Research Scientist 2006-02~2006-08 - University of Georgia, USA - Visiting Scholar 2005-03~2006-02 - Institute of Biophysics, Chinese Academy of Sciences - Assistant Researcher 1999-08~2001-09 - Anhui Anke Biotechnology Company - Research Intern
Awards	CAS**** Final Excellence Award (2015): Institute Level CAS Excellent Mentor Award (2015): First Prize, Institute Level Cell Press China Annual Paper Award (2015): Other

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Academic Background & Achievements

2002-02--2005-01 PhD: University of Science and Technology of China
1996-09--1999-07 Master's Degree: Chinese Academy of Agricultural Sciences
1992-09--1996-07 Bachelor's Degree: Wuhan University

Work Experience

2011-04~Present - Institute of Biophysics, Chinese Academy of Sciences - Researcher
2006-09~2011-02 - Memorial Sloan-Kettering Cancer Center - Senior Research Scientist
2006-02~2006-08 - University of Georgia, USA - Visiting Scholar
2005-03~2006-02 - Institute of Biophysics, Chinese Academy of Sciences - Assistant Researcher
1999-08~2001-09 - Anhui Anke Biotechnology Company - Research Intern

Awards

CAS**** Final Excellence Award (2015): Institute Level
CAS Excellent Mentor Award (2015): First Prize, Institute Level
Cell Press China Annual Paper Award (2015): Other

Areas of Focus	RNA interference-related protein and RNA complex structure and function research Structural biology, RNA RNA-mediated antiviral mechanism
Publications	Discovery of Acr Genes for Type II CRISPR-Cas Systems and Inhibition Mechanisms of Acr Protein Diversification, Yanli Wang, 2023 Pathogen protein modularity enables elaborate mimicry of a host phosphatase, Li, Hui, Wang, Jinlon, Kuan, Tung Ariel, Tang, Bozeng, Feng, Li, Wang, Jiuyu, Cheng, Zhi, Sklenar, Jan, Hulin, Michelle, Li, Yufei, Zhai, Yi, Hou, Yingnan, Menke, Frank L H, Wang, Yanli, Ma, Wenbo, 2023 Anti-CRISPR AcrIIC5 is a dsDNA mimic that inhibits type II-C Cas9 effectors by blocking PAM recognition, Wei Sun, Xiaolong Zhao, Jinlong Wang, Xiaoqi Yang, Zhi Cheng, Shuo Liu, Jiuyu Wang, Gang Sheng, Yanli Wang, 2023 AcrIIC4 inhibits type II-C Cas9 by preventing R-loop formation, Yanli Wang, 2023 Structural Study on Anti-CRISPR Protein AcrVA2, Chen Peng, Sun Wei, Cheng Zhi, Yang Jing, Wang Min, Wang JiuYu, Chen HuiQing, Liu Liang, Wang YanLi, 2021 Anti-CRISPR蛋白AcrVA2的结构生物学研究, 陈鹏, 孙伟, 程志, 杨晶, 王敏, 王久宇, 陈慧卿, 刘亮, 王艳丽, 2021 以Cas X为例简述新型CRISPR-Cas系统的基本属性和研究方法, 王康康, 王艳丽, 2021 诺贝尔化学奖授予CRISPR-Cas9基因编辑研究, 尤李兰, 孙伟, 杨晓琪, 王艳丽, 2020 Chemistry Nobel Honors CRISPR-Cas9, You LiLan, Sun Wei, Yang XiaoQi, Wang YanLi, 2020 Computational design of anti-CRISPR proteins with improved inhibition potency, Mathony, Jan, Harteveld, Zander, Schmelas, Carolin, zu Belzen, Julius Upmeier, Aschenbrenner, Sabine, Sun, Wei, Hoffmann, Mareike D, Stengl, Christina, Scheck, Andreas, Georgeon, Sandrine, Rosset, Stephane, Wang, Yanli, Grimm, Dirk, Eils, Roland, Correia, Bruno E, Niopek, Dominik, 2020 Structural basis for two metal-ion catalysis of DNA cleavage by Cas12i2, Xue Huang, Wei Sun, Zhi Cheng, Minxuan Chen, Xueyan Li, Jiuyu Wang, Gang Sheng, Weimin Gong, Yanli Wang, 2020 Crystal structure of Cas1 in complex with branched DNA, Yang, Jing, Li, Jiazhi, Wang, Jiuyu, Sheng, Gang, Wang, Min, Zhao, Hongtu, Yang, Yanhua, Wang, Yanli, 2020 Anti-CRISPR蛋白AcrVA2的结构生物学研究, 陈鹏, 孙伟, 程志, 杨晶, 王敏, 王久宇, 陈慧卿, 刘亮, 王艳丽, 2020 Structure Studies of the CRISPR-Csm Complex Reveal Mechanism of Co-transcriptional Interference, You, Lilan, Ma, Jun, Wang, Jiuyu, Artamonova, Daria, Wang, Min, Liu, Liang, Xiang, Hua, Severinov, Konstantin, Zhang, Xinzheng, Wang, Yanli, 2019 Structures of Neisseria meningitidis Cas9 Complexes in Catalytically Poised and Anti-CRISPR-Inhibited States, Sun, Wei, Yang, Jing, Cheng, Zhi, Amrani, Nadia, Liu, Chao, Wang, Kangkang, Ibraheim, Raed, Edraki, Alireza, Huang, Xue, Wang, Min, Wang, Jiuyu, Liu, Liang, Sheng, Gang, Yang, Yanhua, Lou, Jizhong, Sontheimer, Erik J, Wang, Yanli, 2019 AgoFISH: cost-effective in situ labelling of genomic loci based on DNA-guided dTtAgo protein, Chang, Lei, Sheng, Gang, Zhang, Yiwen, Shao, Shipeng, Wang, Yanli, Sun, Yujie, 2019 Inhibition of CRISPR-Cas9 ribonucleoprotein complex assembly by anti-CRISPR AcrIIC2, Annoj Thavalingam, Zhi Cheng, Bianca Garcia, Xue Huang, Megha Shah, Wei Sun, Min Wang, Lucas Harrington, Sungwon Hwang, Yurima HidalgoReyes, Erik J. Sontheimer, Jennifer Doudna, Alan R. Davidson, Trevor F. Moraes, Yanli Wang, Karen L. Maxwell, 2019 Zoom in on DNA Cleavage by Cas9, WANG Yanli, 2019 Phage AcrIIA2 DNA Mimicry: Structural Basis of the CRISPR and Anti-CRISPR Arms Race, Liu, Liang, Yin, Maolu, Wang, Min, Wang, Yanli, 2019 Two symmetric arginine residues play distinct roles in Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage, Lei, Jinping, Sheng, Gang, Cheung, Peter PakHang, Wang, Shenglong, Li, Yu, Gao, Xin, Zhang, Yingkai, Wang, Yanli, Huang, Xuhui, 2019 Argonaute proteins from human gastrointestinal bacteria catalyze DNA-guided cleavage of single- and double-stranded DNA at 37 degrees C, Cao, Yuanwei, Sun, Wen, Wang, Jinfeng, Sheng, Gang, Xiang, Guanghai, Zhang, Tongtong, Shi, Wenyu, Li, Chun, Wang, Yanli, Zhao, Fangqing, Wang, Haoyi, 2019 A CRISPR-Cas13a system for efficient and specific therapeutic targeting of mutant KRAS for pancreatic cancer treatment, Zhao, Xiao, Liu, Liang, Liang, Jiayan, Cheng, Keman, Wang, Yongwei, Li, Xueyan, Shi, Jian, Wang, Yanli, Nie, Guangjun, 2018 RNA介导切割RNA的Cas13a复合物分子结构, Liang, Liu, Xueyan, Li, Jun, Ma, Zongqiang, Li, Lilan, You, Jiuyu, Wang, Min, Wang, 章新政, 王艳丽, 2018 C2c2依赖两个远离的活性中心发挥RNA酶活性, Liang, Liu, Xueyan, Li, Jiuyu, Wang, Min, Wang, Peng, Chen, Maolu, Yin, 王艳丽, 2018 C2c1-sgRNA复合物结构揭示RNA介导的C2c1切割DNA的机制, Liang, Liu, Peng, Chen, Min, Wang, Xueyan, Li, Jiuyu, Wang, Maolu, Yin, 王艳丽, 2018 Argonaute Facilitates the Lateral Diffusion of the Guide along Its Target and Prevents the Guide from Being Pushed Away by the Ribosome, Song, Guangtao, Chen, Hui, Sheng, Gang, Wang, Yanli, Lou, Jizhong, 2018 Two Distant Catalytic Sites Are Responsible for C2c2 RNase Activities, Liu, Liang, Li, Xueyan, Wang, Jiuyu, Wang, Min, Chen, Peng, Yin, Maolu, Wang, Yanli, 2017 Molecular mechanism of directional CTCF recognition of a diverse range of genomic sites, Maolu Yin, Jiuyu Wang, Min Wang, Xinmei Li, Mo Zhang, Qiang Wu, Yanli Wang, 2017 Structure/cleavage-based insights into helical perturbations at bulge sites within T. thermophilus Argonaute silencing complexes, Sheng, Gang, Gogakos, Tasos, Wang, Jiuyu, Zhao, Hongtu, Serganov, Artem, Juranek, Stefan, Tuschl, Thomas, Patel, Dinshaw J, Wang, Yanli, 2017 Understanding the core of RNA interference: The dynamic aspects of Argonaute-mediated processes, Zhu, Lizhe, Jiang, Hanlun, Sheong, Fu Kit, Cui, Xuefeng, Wang, Yanli, Gao, Xin, Huang, Xuhui, 2017 Molecular mechanism of directional CTCF recognition of a diverse range of genomic sites, Yin, Maolu, Wang, Jiuyu, Wang, Min, Li, Xinmei, Zhang, Mo, Wu, Qiang, Wang, Yanli, 2017 The Molecular Architecture for RNA-Guided RNA Cleavage by Cas13a, Liu,

Areas of Focus

RNA interference-related protein and RNA complex structure and function research
Structural biology, RNA
RNA-mediated antiviral mechanism

Publications

Discovery of Acr Genes for Type II CRISPR-Cas Systems and Inhibition Mechanisms of Acr Protein Diversification, Yanli Wang, 2023
Pathogen protein modularity enables elaborate mimicry of a host phosphatase, Li, Hui, Wang, Jinlon, Kuan, Tung Ariel, Tang, Bozeng, Feng, Li, Wang, Jiuyu, Cheng, Zhi, Sklenar, Jan, Hulin, Michelle, Li, Yufei, Zhai, Yi, Hou, Yingnan, Menke, Frank L H, Wang, Yanli, Ma, Wenbo, 2023
Anti-CRISPR AcrIIC5 is a dsDNA mimic that inhibits type II-C Cas9 effectors by blocking PAM recognition, Wei Sun, Xiaolong Zhao, Jinlong Wang, Xiaoqi Yang, Zhi Cheng, Shuo Liu, Jiuyu Wang, Gang Sheng, Yanli Wang, 2023
AcrIIC4 inhibits type II-C Cas9 by preventing R-loop formation, Yanli Wang, 2023
Structural Study on Anti-CRISPR Protein AcrVA2, Chen Peng, Sun Wei, Cheng Zhi, Yang Jing, Wang Min, Wang JiuYu, Chen HuiQing, Liu Liang, Wang YanLi, 2021
Anti-CRISPR蛋白AcrVA2的结构生物学研究, 陈鹏, 孙伟, 程志, 杨晶, 王敏, 王久宇, 陈慧卿, 刘亮, 王艳丽, 2021
以Cas X为例简述新型CRISPR-Cas系统的基本属性和研究方法, 王康康, 王艳丽, 2021
诺贝尔化学奖授予CRISPR-Cas9基因编辑研究, 尤李兰, 孙伟, 杨晓琪, 王艳丽, 2020
Chemistry Nobel Honors CRISPR-Cas9, You LiLan, Sun Wei, Yang XiaoQi, Wang YanLi, 2020
Computational design of anti-CRISPR proteins with improved inhibition potency, Mathony, Jan, Harteveld, Zander, Schmelas, Carolin, zu Belzen, Julius Upmeier, Aschenbrenner, Sabine, Sun, Wei, Hoffmann, Mareike D, Stengl, Christina, Scheck, Andreas, Georgeon, Sandrine, Rosset, Stephane, Wang, Yanli, Grimm, Dirk, Eils, Roland, Correia, Bruno E, Niopek, Dominik, 2020
Structural basis for two metal-ion catalysis of DNA cleavage by Cas12i2, Xue Huang, Wei Sun, Zhi Cheng, Minxuan Chen, Xueyan Li, Jiuyu Wang, Gang Sheng, Weimin Gong, Yanli Wang, 2020
Crystal structure of Cas1 in complex with branched DNA, Yang, Jing, Li, Jiazhi, Wang, Jiuyu, Sheng, Gang, Wang, Min, Zhao, Hongtu, Yang, Yanhua, Wang, Yanli, 2020
Anti-CRISPR蛋白AcrVA2的结构生物学研究, 陈鹏, 孙伟, 程志, 杨晶, 王敏, 王久宇, 陈慧卿, 刘亮, 王艳丽, 2020
Structure Studies of the CRISPR-Csm Complex Reveal Mechanism of Co-transcriptional Interference, You, Lilan, Ma, Jun, Wang, Jiuyu, Artamonova, Daria, Wang, Min, Liu, Liang, Xiang, Hua, Severinov, Konstantin, Zhang, Xinzheng, Wang, Yanli, 2019
Structures of Neisseria meningitidis Cas9 Complexes in Catalytically Poised and Anti-CRISPR-Inhibited States, Sun, Wei, Yang, Jing, Cheng, Zhi, Amrani, Nadia, Liu, Chao, Wang, Kangkang, Ibraheim, Raed, Edraki, Alireza, Huang, Xue, Wang, Min, Wang, Jiuyu, Liu, Liang, Sheng, Gang, Yang, Yanhua, Lou, Jizhong, Sontheimer, Erik J, Wang, Yanli, 2019
AgoFISH: cost-effective in situ labelling of genomic loci based on DNA-guided dTtAgo protein, Chang, Lei, Sheng, Gang, Zhang, Yiwen, Shao, Shipeng, Wang, Yanli, Sun, Yujie, 2019
Inhibition of CRISPR-Cas9 ribonucleoprotein complex assembly by anti-CRISPR AcrIIC2, Annoj Thavalingam, Zhi Cheng, Bianca Garcia, Xue Huang, Megha Shah, Wei Sun, Min Wang, Lucas Harrington, Sungwon Hwang, Yurima HidalgoReyes, Erik J. Sontheimer, Jennifer Doudna, Alan R. Davidson, Trevor F. Moraes, Yanli Wang, Karen L. Maxwell, 2019
Zoom in on DNA Cleavage by Cas9, WANG Yanli, 2019
Phage AcrIIA2 DNA Mimicry: Structural Basis of the CRISPR and Anti-CRISPR Arms Race, Liu, Liang, Yin, Maolu, Wang, Min, Wang, Yanli, 2019
Two symmetric arginine residues play distinct roles in Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage, Lei, Jinping, Sheng, Gang, Cheung, Peter PakHang, Wang, Shenglong, Li, Yu, Gao, Xin, Zhang, Yingkai, Wang, Yanli, Huang, Xuhui, 2019
Argonaute proteins from human gastrointestinal bacteria catalyze DNA-guided cleavage of single- and double-stranded DNA at 37 degrees C, Cao, Yuanwei, Sun, Wen, Wang, Jinfeng, Sheng, Gang, Xiang, Guanghai, Zhang, Tongtong, Shi, Wenyu, Li, Chun, Wang, Yanli, Zhao, Fangqing, Wang, Haoyi, 2019
A CRISPR-Cas13a system for efficient and specific therapeutic targeting of mutant KRAS for pancreatic cancer treatment, Zhao, Xiao, Liu, Liang, Liang, Jiayan, Cheng, Keman, Wang, Yongwei, Li, Xueyan, Shi, Jian, Wang, Yanli, Nie, Guangjun, 2018
RNA介导切割RNA的Cas13a复合物分子结构, Liang, Liu, Xueyan, Li, Jun, Ma, Zongqiang, Li, Lilan, You, Jiuyu, Wang, Min, Wang, 章新政, 王艳丽, 2018
C2c2依赖两个远离的活性中心发挥RNA酶活性, Liang, Liu, Xueyan, Li, Jiuyu, Wang, Min, Wang, Peng, Chen, Maolu, Yin, 王艳丽, 2018
C2c1-sgRNA复合物结构揭示RNA介导的C2c1切割DNA的机制, Liang, Liu, Peng, Chen, Min, Wang, Xueyan, Li, Jiuyu, Wang, Maolu, Yin, 王艳丽, 2018
Argonaute Facilitates the Lateral Diffusion of the Guide along Its Target and Prevents the Guide from Being Pushed Away by the Ribosome, Song, Guangtao, Chen, Hui, Sheng, Gang, Wang, Yanli, Lou, Jizhong, 2018
Two Distant Catalytic Sites Are Responsible for C2c2 RNase Activities, Liu, Liang, Li, Xueyan, Wang, Jiuyu, Wang, Min, Chen, Peng, Yin, Maolu, Wang, Yanli, 2017
Molecular mechanism of directional CTCF recognition of a diverse range of genomic sites, Maolu Yin, Jiuyu Wang, Min Wang, Xinmei Li, Mo Zhang, Qiang Wu, Yanli Wang, 2017
Structure/cleavage-based insights into helical perturbations at bulge sites within T. thermophilus Argonaute silencing complexes, Sheng, Gang, Gogakos, Tasos, Wang, Jiuyu, Zhao, Hongtu, Serganov, Artem, Juranek, Stefan, Tuschl, Thomas, Patel, Dinshaw J, Wang, Yanli, 2017
Understanding the core of RNA interference: The dynamic aspects of Argonaute-mediated processes, Zhu, Lizhe, Jiang, Hanlun, Sheong, Fu Kit, Cui, Xuefeng, Wang, Yanli, Gao, Xin, Huang, Xuhui, 2017
Molecular mechanism of directional CTCF recognition of a diverse range of genomic sites, Yin, Maolu, Wang, Jiuyu, Wang, Min, Li, Xinmei, Zhang, Mo, Wu, Qiang, Wang, Yanli, 2017
The Molecular Architecture for RNA-Guided RNA Cleavage by Cas13a, Liu,

Rna Interference Protein Structure Rna Complex Structural Biology Rna Antiviral Mechanism Crispr Cas Proteins Gene Editing Molecular Biology

Yanli Wang - University of Chinese Academy of Sciences

Guohui Chuai - Tongji University

Zhang Hui - Shanghai Normal University

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