2002-02--2005-01 PhD: University of Science and Technology of China
1996-09--1999-07 Master's Degree: Chinese Academy of Agricultural Sciences
1992-09--1996-07 Bachelor's Degree: Wuhan University
2011-04~Present - Institute of Biophysics, Chinese Academy of Sciences - Researcher
2006-09~2011-02 - Memorial Sloan-Kettering Cancer Center - Senior Research Scientist
2006-02~2006-08 - University of Georgia - Visiting Scholar
2005-03~2006-02 - Institute of Biophysics, Chinese Academy of Sciences - Assistant Researcher
1999-08~2001-09 - Anhui Anke Biotechnology Company - Research Intern
CAS Final Excellence Award (2015): Institute Level
CAS Excellent Mentor Award (2015): First Prize, Institute Level
Cell Press China Annual Paper Award (2015): Other
Research
RNA interference related protein and RNA complex structure and function research Structural biology, RNA RNA-mediated antiviral mechanism
Discovery of Acr genes targeting the type II CRISPR-Cas system and the diverse inhibition mechanisms of Acr proteins, Yanli Wang, 2023
Pathogen protein modularity enables elaborate mimicry of a host phosphatase, Li, Hui, Wang, Jinlon, Kuan, Tung Ariel, Tang, Bozeng, Feng, Li, Wang, Jiuyu, Cheng, Zhi, Sklenar, Jan, Hulin, Michelle, Li, Yufei, Zhai, Yi, Hou, Yingnan, Menke, Frank L H, Wang, Yanli, Ma, Wenbo, 2023
Anti-CRISPR AcrIIC5 is a dsDNA mimic that inhibits type II-C Cas9 effectors by blocking PAM recognition, Wei Sun, Xiaolong Zhao, Jinlong Wang, Xiaoqi Yang, Zhi Cheng, Shuo Liu, Jiuyu Wang, Gang Sheng, Yanli Wang, 2023
AcrIIC4 inhibits type II-C Cas9 by preventing R-loop formation, Yanli Wang, 2023
Structural Study on Anti-CRISPR Protein AcrVA2, Chen Peng, Sun Wei, Cheng Zhi, Yang Jing, Wang Min, Wang JiuYu, Chen HuiQing, Liu Liang, Wang YanLi, 2021
Chemistry Nobel Honors CRISPR-Cas9, You LiLan, Sun Wei, Yang XiaoQi, Wang YanLi, 2020
Computational design of anti-CRISPR proteins with improved inhibition potency, Mathony, Jan, Harteveld, Zander, Schmelas, Carolin, zu Belzen, Julius Upmeier, Aschenbrenner, Sabine, Sun, Wei, Hoffmann, Mareike D, Stengl, Christina, Scheck, Andreas, Georgeon, Sandrine, Rosset, Stephane, Wang, Yanli, Grimm, Dirk, Eils, Roland, Correia, Bruno E, Niopek, Dominik, 2020
Structural basis for two metal-ion catalysis of DNA cleavage by Cas12i2, Xue Huang, Wei Sun, Zhi Cheng, Minxuan Chen, Xueyan Li, Jiuyu Wang, Gang Sheng, Weimin Gong, Yanli Wang, 2020
Crystal structure of Cas1 in complex with branched DNA, Yang, Jing, Li, Jiazhi, Wang, Jiuyu, Sheng, Gang, Wang, Min, Zhao, Hongtu, Yang, Yanhua, Wang, Yanli, 2020
AgoFISH: cost-effective in situ labelling of genomic loci based on DNA-guided dTtAgo protein, Chang, Lei, Sheng, Gang, Zhang, Yiwen, Shao, Shipeng, Wang, Yanli, Sun, Yujie, 2019
Inhibition of CRISPR-Cas9 ribonucleoprotein complex assembly by anti-CRISPR AcrIIC2, Annoj Thavalingam, Zhi Cheng, Bianca Garcia, Xue Huang, Megha Shah, Wei Sun, Min Wang, Lucas Harrington, Sungwon Hwang, Yurima HidalgoReyes, Erik J. Sontheimer, Jennifer Doudna, Alan R. Davidson, Trevor F. Moraes, Yanli Wang, Karen L. Maxwell, 2019
Zoom in on DNA Cleavage by Cas9, WANG Yanli, 2019
Phage AcrIIA2 DNA Mimicry: Structural Basis of the CRISPR and Anti-CRISPR Arms Race, Liu, Liang, Yin, Maolu, Wang, Min, Wang, Yanli, 2019
Two symmetric arginine residues play distinct roles in Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage, Lei, Jinping, Sheng, Gang, Cheung, Peter PakHang, Wang, Shenglong, Li, Yu, Gao, Xin, Zhang, Yingkai, Wang, Yanli, Huang, Xuhui, 2019
Argonaute proteins from human gastrointestinal bacteria catalyze DNA-guided cleavage of single- and double-stranded DNA at 37 degrees C, Cao, Yuanwei, Sun, Wen, Wang, Jinfeng, Sheng, Gang, Xiang, Guanghai, Zhang, Tongtong, Shi, Wenyu, Li, Chun, Wang, Yanli, Zhao, Fangqing, Wang, Haoyi, 2019
A CRISPR-Cas13a system for efficient and specific therapeutic targeting of mutant KRAS for pancreatic cancer treatment, Zhao, Xiao, Liu, Liang, Liang, Jiayan, Cheng, Keman, Wang, Yongwei, Li, Xueyan, Shi, Jian, Wang, Yanli, Nie, Guangjun, 2018
Argonaute Facilitates the Lateral Diffusion of the Guide along Its Target and Prevents the Guide from Being Pushed Away by the Ribosome, Song, Guangtao, Chen, Hui, Sheng, Gang, Wang, Yanli, Lou, Jizhong, 2018
Two Distant Catalytic Sites Are Responsible for C2c2 RNase Activities, Liu, Liang, Li, Xueyan, Wang, Jiuyu, Wang, Min, Chen, Peng, Yin, Maolu, Li, Jiazhi, Sheng, Gang, Wang, Yanli, 2017
Molecular mechanism of directional CTCF recognition of a diverse range of genomic sites, Maolu Yin, Jiuyu Wang, Min Wang, Xinmei Li, Mo Zhang, Qiang Wu, Yanli Wang, 2017
Structure/cleavage-based insights into helical perturbations at bulge sites within T. thermophilus Argonaute silencing complexes, Sheng, Gang, Gogakos, Tasos, Wang, Jiuyu, Zhao, Hongtu, Serganov, Artem, Juranek, Stefan, Tuschl, Thomas, Patel, Dinshaw J, Wang, Yanli, 2017
Understanding the core of RNA interference: The dynamic aspects of Argonaute-mediated processes, Zhu, Lizhe, Jiang, Hanlun, Sheong, Fu Kit, Cui, Xuefeng, Wang, Yanli, Gao, Xin, Huang, Xuhui, 2017
Molecular mechanism of directional CTCF recognition of a diverse range of genomic sites, Yin, Maolu, Wang, Jiuyu, Wang, Min, Li, Xinmei, Zhang, Mo, Wu, Qiang, Wang, Yanli, 2017
The Molecular Architecture for RNA-Guided RNA Cleavage by Cas13a, Liu, Liang, Li,
