1996-09--2000-07 PhD in Theoretical Physics: University of Cambridge
1995-09--1996-07 MSc in Applied Mathematics: University of Cambridge
1990-09--1995-07 BSc in Mathematical Physics: University of Edinburgh
2020-04~Present - Chinese Academy of Sciences, Shanghai Institute of Nutrition and Health - PI of Computational Systems Genomics Group
2013-09~2020-03 - CAS-MPG Partner Institute for Computational Biology - PI of Computational Systems Genomics Group
2008-09~2013-08 - University College London, UCL Cancer Institute - Principal Research Associate in Statistical Cancer Genomics
2003-09~2008-08 - University of Cambridge, Department of Oncology - Senior Postdoctoral Fellow in Computational Biology
2001-08~2003-08 - University of Warwick, Mathematics Institute - Research Assistant in Mathematical Ecology
2000-08~2001-07 - British Telecom Labs, Complexity Research - Member of the Complexity Research Group
Clarivate Highly Cited Researcher (2023): Other
CAS Excellent Teachers Award (2019): Institute
Research
Computational Biology Statistical Bioinformatics
Quantifying the stochastic component of epigenetic aging, Nature Aging, 2024
A meta-analysis of immune-cell fractions at high resolution reveals novel associations with common phenotypes and health outcomes, Genome Medicine, 2023
Insights into the role of long non-coding RNAs in DNA methylation mediated transcriptional regulation, FRONTIERS IN MOLECULAR BIOSCIENCES, 2022
Cell-type heterogeneity: Why we should adjust for it in epigenome and biomarker studies, CLINICAL EPIGENETICS, 2022
Novel epigenetic network biomarkers for early detection of esophageal cancer, CLINICAL EPIGENETICS, 2022
Distance covariance entropy reveals primed states and bifurcation dynamics in single-cell RNA-Seq data, ISCIENCE, 2022
Making sense of the ageing methylome, NATURE REVIEWS GENETICS, 2022
Database Resources of the National Genomics Data Center, China National Center for Bioinformation in 2022, Nucleic Acids Research, 2022
Clinical outcomes, Kadish-INSICA staging and therapeutic targeting of somatostatin receptor 2 in olfactory neuroblastoma, EUROPEAN JOURNAL OF CANCER, 2022
Computational Identification of Preneoplastic Cells Displaying High Stemness and Risk of Cancer Progression, CANCER RESEARCH, 2022
A comparison of epithelial cell content of oral samples estimated using cytology and DNA methylation, EPIGENETICS, 2022
Inference of age-associated transcription factor regulatory activity changes in single cells, Nature aging, 2022
dbDEMC 3.0:Functional Exploration of Differentially Expressed miRNAs in Cancers of Human and Model Organisms, GENOMICS PROTEOMICS & BIOINFORMATICS, 2022
A pan-tissue DNA methylation atlas enables in silico decomposition of human tissue methylomes at cell-type resolution, NATURE METHODS, 2022
Ultra-fast scalable estimation of single-cell differentiation potency from scRNA-Seq data, BIOINFORMATICS, 2021
Pan-cancer characterization of long non-coding RNA and DNA methylation mediated transcriptional dysregulation, EBIOMEDICINE, 2021
EPISCORE: cell type deconvolution of bulk tissue DNA methylomes from single-cell RNA-Seq data, GENOME BIOLOGY, 2020
A comparison of epigenetic mitotic-like clocks for cancer risk prediction, GENOME MEDICINE, 2020
EpiDISH web server: Epigenetic Dissection of Intra-Sample-Heterogeneity with online GUI, BIOINFORMATICS, 2020
Quantifying Waddington's epigenetic landscape: a comparison of single-cell potency measures, BRIEFINGS IN BIOINFORMATICS, 2020
A cell-type deconvolution meta-analysis of whole blood EWAS reveals lineage-specific smoking-associated DNA methylation changes, NATURE COMMUNICATIONS, 2020
Improved detection of tumor suppressor events in single-cell RNA-Seq data, NPJ GENOMIC MEDICINE, 2020
Detection of epigenetic field defects using a weighted epigenetic distance-based method, NUCLEIC ACIDS RESEARCH, 2019
eFORGE v2.0: updated analysis of cell type-specific signal in epigenomic data, BIOINFORMATICS, 2019
ebGSEA: an improved Gene Set Enrichment Analysis method for Epigenome-Wide-Association Studies, BIOINFORMATICS, 2019
Appraising the causal relevance of DNA methylation for risk of lung cancer, INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2019
Single-cell landscape in mammary epithelium reveals bipotent-like cells associated with breast cancer risk and outcome, COMMUNICATIONS BIOLOGY, 2019
Avoiding common pitfalls in machine learning omic data science, NATURE MATERIALS, 2019
Accounting for differential variability in detecting differentially methylated regions, BRIEFINGS IN BIOINFORMATICS, 2019
DNA methylation aging clocks: challenges and recommendations, GENOME BIOLOGY, 2019
Statistical and integrative system-level analysis of DNA methylation data, NATURE REVIEWS GENETICS, 2018
A novel cell-type deconvolution algorithm reveals substantial contamination by immune cells in saliva, buccal and cervix, EPIGENOMICS, 2018
Psychosocial adversity and socioeconomic position during childhood and epigenetic age: analysis of two prospective cohort studies, HUMAN MOLECULAR GENETICS, 2018
DNA Methylation Patterns in Normal Tissue Correlate more Strongly with Breast Cancer Status than Copy-Number Variants, EBIOMEDICINE, 2018
Tumor origin detection with tissue-specific miRNA and DNA methylation markers, BIOINFORMATICS, 2018
Roadmap for investigating epigenome deregulation and environmental origins of cancer, INTERNATIONAL JOURNAL OF CANCER, 2018
Epigenome-based cancer risk prediction: rationale, opportunities and challenges, NATURE REVIEWS CLINICAL ONCOLOGY, 2018
Identification of differentially methylated cell-types in Epigenome-Wide Association Studies, NATURE METHODS, 2018
Cell and tissue type independent age-associated DNA methylation changes are not rare but common, AGING (ALBANY NY), 2018
Epigenetic clocks galore: a new improved clock predicts age-acceleration in Hutchinson Gilford Progeria Syndrome patients, AGING (ALBANY NY), 2018
Tensorial blind source separation for improved analysis of multi-omic data, GENOME BIOLOGY, 2018
ChAMP: updated methylation analysis pipeline for Illumina BeadChips, BIOINFORMATICS, 2017
A comparison of reference-based algorithms for correcting cell-type heterogeneity in Epigenome-Wide Association Studies, BMC BIOINFORMATICS, 2017
Epigenetic and genetic deregulation in cancer target distinct signaling pathway domains, NUCLEIC ACIDS RESEARCH, 2017
Are objective measures of physical capability related to accelerated epigenetic age? Findings from a British birth cohort, BMJ OPEN, 2017
Cell-type deconvolution in epigenome-wide association studies: a review and recommendations, EPIGENOMICS, 2017
Single-cell entropy for accurate estimation of differentiation potency from a cell's transcriptome, NATURE COMMUNICATIONS, 2017
dbDEMC 2.0: updated database of differentially expressed miRNAs in human cancers, NUCLEIC ACIDS RESEARCH, 2017
Correcting for cell-type heterogeneity in epigenome-wide association studies: revisiting previous analyses
