Professor | Youhai Chen | Asia Growth Partners

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Name	Youhai Chen
Contact Information	yh.chen@siat.ac.cn
Language ability	English, Chinese
Province	Guangdong

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Name

Youhai Chen

Contact Information

yh.chen@siat.ac.cn

Language ability

English, Chinese

Province

Guangdong

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Academic Background & Achievements	1989-09--1993-05 PhD in Immunology: University of Manitoba 1983-09--1986-07 Master's in Immunology: Shandong University 1978-09--1983-07 Bachelor's in Medicine: Shandong University
Work Experience	2020-10~Present - Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences - Director of Cancer Immunology Research Center 2020-10~Present - Shenzhen Technology University - Dean of School of Pharmacy 2008-09~2020-10 - University of Pennsylvania, School of Medicine - Tenured Professor 2001-09~2008-09 - University of Pennsylvania, School of Medicine - Associate Professor (Tenured) 2001-01~2001-09 - University of Pennsylvania, School of Medicine - Associate Professor 1995-11~2000-12 - University of Pennsylvania, School of Medicine - Assistant Professor 1993-05~1995-05 - Harvard University - Postdoctoral Fellow in Immunology
Awards	1990-1993: Medical Research Council of Canada 'Outstanding Researcher Award' 1992: Canadian Immunology Society 'Travel Award' 1994-1995: Medical Research Council of Canada 'Scholar Award' 2002: Lady Barbara Colyton Prize 2008: Elected Fellow of the Henry Kunkel Society 2008: Changjiang Scholar Award by the Ministry of Education 2021: Listed in the Global Top 1% Scientists for Lifetime Impact 2022: Elected Fellow of the American Institute for Medical and Biological Engineering 2022: Elected Fellow of the Academia Europaea

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Academic Background & Achievements

1989-09--1993-05 PhD in Immunology: University of Manitoba
1983-09--1986-07 Master's in Immunology: Shandong University
1978-09--1983-07 Bachelor's in Medicine: Shandong University

Work Experience

2020-10~Present - Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences - Director of Cancer Immunology Research Center
2020-10~Present - Shenzhen Technology University - Dean of School of Pharmacy
2008-09~2020-10 - University of Pennsylvania, School of Medicine - Tenured Professor
2001-09~2008-09 - University of Pennsylvania, School of Medicine - Associate Professor (Tenured)
2001-01~2001-09 - University of Pennsylvania, School of Medicine - Associate Professor
1995-11~2000-12 - University of Pennsylvania, School of Medicine - Assistant Professor
1993-05~1995-05 - Harvard University - Postdoctoral Fellow in Immunology

Awards

1990-1993: Medical Research Council of Canada 'Outstanding Researcher Award'
1992: Canadian Immunology Society 'Travel Award'
1994-1995: Medical Research Council of Canada 'Scholar Award'
2002: Lady Barbara Colyton Prize
2008: Elected Fellow of the Henry Kunkel Society
2008: Changjiang Scholar Award by the Ministry of Education
2021: Listed in the Global Top 1% Scientists for Lifetime Impact
2022: Elected Fellow of the American Institute for Medical and Biological Engineering
2022: Elected Fellow of the Academia Europaea

Areas of Focus	Cancer Inflammation Immunopharmacology
Publications	Tumor Necrosis Factor-a-Induced Protein 8-Like 2 Fosters Tumor-Associated Microbiota to Promote the Development of Colorectal Cancer, Lou, Yunwei, Song, Miaomiao, Han, Meijuan, Zhong, Jiateng, Tian, Xueqin, Ren, Yahan, Song, Yaru, Duan, Liangwei, Zhao, Peiqing, Song, Xiangfeng, Zhang, Wen, Chen, Youhai H, Wang, Hui, 2022 靶向NKG2D配体的嵌合抗原受体巨噬细胞具有肿瘤杀伤功能, 戴昆, 刘骏晨, 刘茂玄, 甘江彧, 王琪, 陈有海, 万晓春, 于广, 2022 TNFAIP8 protein functions as a tumor suppressor in inflammation-associated colorectal tumorigenesis, Lou, Yunwei, Tian, Xueqin, Sun, Chen, Song, Miaomiao, Han, Meijuan, Zhao, Yuxin, Song, Yaru, Song, Xiangfeng, Zhang, Wen, Chen, Youhai H, Wang, Hui, 2022 核酸药物的研发现状与应用前景展望, 陈有海, 杨海涛, 2022 TIPE2 Promotes Tumor Initiation But Inhibits Tumor Progression in Murine Colitis-Associated Colon Cancer, Youhai H Chen, 2021 Decoupling Tumor Cell Metastasis From Growth By Cellular Pilot Protein TNFAIP8, Mingyue Li, Xinyuan Li, Jason R Goldsmith, Songlin Shi, Li Zhang, Ali Zamani, Lin Wan, Honghong Sun, Ting Li, Jiyeon Yu, Zienab Etwebi, Mayassa J BouDargham, Youhai H Chen, 2021 c-Rel is a myeloid checkpoint for cancer immunotherapy, Li, Ting, Li, Xinyuan, Zamani, Ali, Wang, Wei, Lee, ChinNien, Li, Mingyue, Luo, George, Eiler, Emily, Sun, Honghong, Ghosh, Sankar, Jin, Jian, Murali, Ramachandran, Ruan, Qingguo, Shi, Weiyun, Chen, Youhai H, 2020 TIPE2 specifies the functional polarization of myeloid-derived suppressor cells during tumorigenesis, Dehong Yan, Jinghui Wang, Honghong Sun, Ali Zamani, Honglin Zhang, Weihong Chen, Aifa Tang, Qingguo Ruan, Xiaolu Yang, Youhai H Chen, Xiaochun Wan, 2020 Blocking the death checkpoint protein TRAIL improves cardiac function after myocardial infarction in monkeys, pigs, and rats, Wang, Yaohui, Zhang, Hailong, Wang, Zhizeng, Wei, Yinxiang, Wang, Mingli, Liu, Meichen, Wang, Xuance, Jiang, Yinan, Shi, Gongning, Zhao, Dongmei, Yang, Zhengyan, Ren, Zhiguang, Li, Jing, Zhang, Zhenkai, Wang, Zhenfeng, Zhang, Bei, Zong, Beibei, Lou, Xueke, Liu, Chengguo, Wang, Zihui, Zhang, Hao, Tao, Ningya, Li, Xuefang, Zhang, Xingkun, Guo, Yafei, Ye, Yang, Qi, Yu, Li, Hui, Wang, Man, Guo, Rongxin, Cheng, Guanchang, Li, Shulian, Zhang, Jun, Liu, Guangchao, Chai, Lihui, Lou, Qiang, Li, Xia, Cui, Xiukun, Gao, Erhe, Dong, Zheng, Hu, Yanzhong, Chen, Youhai H, Ma, Yuanfang, 2020 TIPE2 specifies the functional polarization of myeloid-derived suppressor cells during tumorigenesis, Dehong Yan, Jinghui Wang, Honghong Sun, Ali Zamani, Honglin Zhang, Weihong Chen, Aifa Tang, Qingguo Ruan, Xiaolu Yang, Youhai H. Chen, Xiaochun Wan, 2020 TNFAIP8 controls murine intestinal stem cell homeostasis and regeneration by regulating microbiome-induced Akt signaling, Jason R Goldsmith, Nina Spitofsky, Ali Zamani, Ryan Hood, Amanda Boggs, Xinyuan Li, Mingyue Li, Elizabeth Reiner, Arshad Ayyaz, Zienab Etwebi, Ling Lu, Javier Rivera Guzman, Mayassa J BouDargham, Terry Cathoupolis, Hakon Hakonarson, Honghong Sun, Jeffrey L Wrana, Michael V Gonzalez, Youhai H Chen, 2020 Treatment of acetaminophen-induced liver failure by blocking the death checkpoint protein TRAIL, Qian Chen, Dehong Yan, Qingmei Zhang, Guizhong Zhang, Meng Xia, Junxin Li, Wugen Zhan, Enyun Shen, Zhihuan Li, Lilong Lin, Youhai H Chen, Xiaochun Wan, 2020 Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response, Chen, Gang, Huang, Alexander C, Zhang, Wei, Zhang, Gao, Wu, Min, Xu, Wei, Yu, Zili, Yang, Jiegang, Wang, Beike, Sun, Honghong, Xia, Houfu, Man, Qiwen, Zhong, Wenqun, Antelo, Leonardo F, Wu, Bin, Xiong, Xuepeng, Liu, Xiaoming, Guan, Lei, Li, Ting, Liu, Shujing, Yang, Ruifeng, Lu, Youtao, Dong, Liyun, McGettigan, Suzanne, Somasundaram, Rajasekharan, Radhakrishnan, Ravi, Mills, Gordon, Lu, Yiling, Kim, Junhyong, Chen, Youhai H, Dong, Haidong, Zhao, Yifang, Karakousis, Giorgos C, Mitchell, Tara C, Schuchter, Lynn M, Herlyn, Meenhard, Wherry, E John, Xu, Xiaowei, Guo, Wei, 2018 Regulation of NF-κB by PML and PML-RARα, Abrar Ahmed, Xiaochun Wan, Izaskun Mitxitorena, Andrew J Lindsay, Pier Paolo Pandolfi, Mary W McCaffrey, Karen Keeshan, Youhai H Chen, Ruaidhr J Carmody, 2017 NK Cells Alleviate Lung Inflammation by Negatively Regulating Group 2 Innate Lymphoid Cells, Bi, Jiacheng, Cui, Lulu, Yu, Guang, Yang, Xiaolu, Chen, Youhai, Wan, Xiaochun, 2017 Direction of leukocyte polarization and migration by the phosphoinositide-transfer protein TIPE2, Fayngerts, Svetlana A, Wang, Zhaojun, Zamani, Ali, Sun, Honghong, Boggs, Amanda E, Porturas, Thomas P, Xie, Weidong, Lin, Mei, Cathopoulis, Terry, Goldsmith, Jason R, Vourekas, Anastassios, Chen, Youhai H, 2017

Areas of Focus

Cancer
Inflammation
Immunopharmacology

Publications

Tumor Necrosis Factor-a-Induced Protein 8-Like 2 Fosters Tumor-Associated Microbiota to Promote the Development of Colorectal Cancer, Lou, Yunwei, Song, Miaomiao, Han, Meijuan, Zhong, Jiateng, Tian, Xueqin, Ren, Yahan, Song, Yaru, Duan, Liangwei, Zhao, Peiqing, Song, Xiangfeng, Zhang, Wen, Chen, Youhai H, Wang, Hui, 2022
靶向NKG2D配体的嵌合抗原受体巨噬细胞具有肿瘤杀伤功能, 戴昆, 刘骏晨, 刘茂玄, 甘江彧, 王琪, 陈有海, 万晓春, 于广, 2022
TNFAIP8 protein functions as a tumor suppressor in inflammation-associated colorectal tumorigenesis, Lou, Yunwei, Tian, Xueqin, Sun, Chen, Song, Miaomiao, Han, Meijuan, Zhao, Yuxin, Song, Yaru, Song, Xiangfeng, Zhang, Wen, Chen, Youhai H, Wang, Hui, 2022
核酸药物的研发现状与应用前景展望, 陈有海, 杨海涛, 2022
TIPE2 Promotes Tumor Initiation But Inhibits Tumor Progression in Murine Colitis-Associated Colon Cancer, Youhai H Chen, 2021
Decoupling Tumor Cell Metastasis From Growth By Cellular Pilot Protein TNFAIP8, Mingyue Li, Xinyuan Li, Jason R Goldsmith, Songlin Shi, Li Zhang, Ali Zamani, Lin Wan, Honghong Sun, Ting Li, Jiyeon Yu, Zienab Etwebi, Mayassa J BouDargham, Youhai H Chen, 2021
c-Rel is a myeloid checkpoint for cancer immunotherapy, Li, Ting, Li, Xinyuan, Zamani, Ali, Wang, Wei, Lee, ChinNien, Li, Mingyue, Luo, George, Eiler, Emily, Sun, Honghong, Ghosh, Sankar, Jin, Jian, Murali, Ramachandran, Ruan, Qingguo, Shi, Weiyun, Chen, Youhai H, 2020
TIPE2 specifies the functional polarization of myeloid-derived suppressor cells during tumorigenesis, Dehong Yan, Jinghui Wang, Honghong Sun, Ali Zamani, Honglin Zhang, Weihong Chen, Aifa Tang, Qingguo Ruan, Xiaolu Yang, Youhai H Chen, Xiaochun Wan, 2020
Blocking the death checkpoint protein TRAIL improves cardiac function after myocardial infarction in monkeys, pigs, and rats, Wang, Yaohui, Zhang, Hailong, Wang, Zhizeng, Wei, Yinxiang, Wang, Mingli, Liu, Meichen, Wang, Xuance, Jiang, Yinan, Shi, Gongning, Zhao, Dongmei, Yang, Zhengyan, Ren, Zhiguang, Li, Jing, Zhang, Zhenkai, Wang, Zhenfeng, Zhang, Bei, Zong, Beibei, Lou, Xueke, Liu, Chengguo, Wang, Zihui, Zhang, Hao, Tao, Ningya, Li, Xuefang, Zhang, Xingkun, Guo, Yafei, Ye, Yang, Qi, Yu, Li, Hui, Wang, Man, Guo, Rongxin, Cheng, Guanchang, Li, Shulian, Zhang, Jun, Liu, Guangchao, Chai, Lihui, Lou, Qiang, Li, Xia, Cui, Xiukun, Gao, Erhe, Dong, Zheng, Hu, Yanzhong, Chen, Youhai H, Ma, Yuanfang, 2020
TIPE2 specifies the functional polarization of myeloid-derived suppressor cells during tumorigenesis, Dehong Yan, Jinghui Wang, Honghong Sun, Ali Zamani, Honglin Zhang, Weihong Chen, Aifa Tang, Qingguo Ruan, Xiaolu Yang, Youhai H. Chen, Xiaochun Wan, 2020
TNFAIP8 controls murine intestinal stem cell homeostasis and regeneration by regulating microbiome-induced Akt signaling, Jason R Goldsmith, Nina Spitofsky, Ali Zamani, Ryan Hood, Amanda Boggs, Xinyuan Li, Mingyue Li, Elizabeth Reiner, Arshad Ayyaz, Zienab Etwebi, Ling Lu, Javier Rivera Guzman, Mayassa J BouDargham, Terry Cathoupolis, Hakon Hakonarson, Honghong Sun, Jeffrey L Wrana, Michael V Gonzalez, Youhai H Chen, 2020
Treatment of acetaminophen-induced liver failure by blocking the death checkpoint protein TRAIL, Qian Chen, Dehong Yan, Qingmei Zhang, Guizhong Zhang, Meng Xia, Junxin Li, Wugen Zhan, Enyun Shen, Zhihuan Li, Lilong Lin, Youhai H Chen, Xiaochun Wan, 2020
Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response, Chen, Gang, Huang, Alexander C, Zhang, Wei, Zhang, Gao, Wu, Min, Xu, Wei, Yu, Zili, Yang, Jiegang, Wang, Beike, Sun, Honghong, Xia, Houfu, Man, Qiwen, Zhong, Wenqun, Antelo, Leonardo F, Wu, Bin, Xiong, Xuepeng, Liu, Xiaoming, Guan, Lei, Li, Ting, Liu, Shujing, Yang, Ruifeng, Lu, Youtao, Dong, Liyun, McGettigan, Suzanne, Somasundaram, Rajasekharan, Radhakrishnan, Ravi, Mills, Gordon, Lu, Yiling, Kim, Junhyong, Chen, Youhai H, Dong, Haidong, Zhao, Yifang, Karakousis, Giorgos C, Mitchell, Tara C, Schuchter, Lynn M, Herlyn, Meenhard, Wherry, E John, Xu, Xiaowei, Guo, Wei, 2018
Regulation of NF-κB by PML and PML-RARα, Abrar Ahmed, Xiaochun Wan, Izaskun Mitxitorena, Andrew J Lindsay, Pier Paolo Pandolfi, Mary W McCaffrey, Karen Keeshan, Youhai H Chen, Ruaidhr J Carmody, 2017
NK Cells Alleviate Lung Inflammation by Negatively Regulating Group 2 Innate Lymphoid Cells, Bi, Jiacheng, Cui, Lulu, Yu, Guang, Yang, Xiaolu, Chen, Youhai, Wan, Xiaochun, 2017
Direction of leukocyte polarization and migration by the phosphoinositide-transfer protein TIPE2, Fayngerts, Svetlana A, Wang, Zhaojun, Zamani, Ali, Sun, Honghong, Boggs, Amanda E, Porturas, Thomas P, Xie, Weidong, Lin, Mei, Cathopoulis, Terry, Goldsmith, Jason R, Vourekas, Anastassios, Chen, Youhai H, 2017

Cancer Tumor Oncology Carcinogenesis Neoplasm Malignancy Chemotherapy Radiotherapy Metastasis Tumorigenesis Inflammation Immune Response Cytokines Inflammatory Mediators Chronic Inflammation Acute Inflammation Inflammatory Diseases Autoimmunity Inflammatory Pathways Inflammatory Markers Immunopharmacology Immunotherapy Biologics Monoclonal Antibodies Vaccines Immune Modulation Drug Development Pharmacodynamics Pharmacokinetics Clinical Trials

Yuezhou Chen - Peking University

Yu Yong - Tongji University

Shun Li - University of Chinese Academy of Sciences

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