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Lantao Gou
Life Science
University of Chinese Academy of Sciences
Shanghai
Language: Chinese, English
Rna
Molecular Regulation
Reproductive Genetics
Chromatin
Remodeling
Functional Genomics
Techniques
Methods
Genetic Processes
Regulation
Areas of Focus
- RNA Molecular Regulation in Reproductive Genetic Processes
- Chromatin Remodeling Regulation in Reproductive Genetic Processes
- RNA and Functional Genomics Methods and Techniques
Work Experience
- 2018-07~2020-09 - University of California, San Diego - NIH K99 Project PI
- 2015-04~2020-09 - University of California, San Diego - Postdoctoral Researcher
- 2013-07~2015-03 - Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences - Assistant Researcher
Academic Background & Achievements
- 2007-09--2013-07 PhD in Biochemistry and Molecular Biology: University of Chinese Academy of Sciences
Publications
- Loss-of-function variants in human C12orf40 cause male infertility by blocking meiotic progression, 11th Author, 2023
- Small RNAs: An expanding world with therapeutic promises, 11th Author, 2023
- The PIWI-specific insertion module helps load longer piRNAs for translational activation essential for male fertility, 18th Author, 2023
- piRNA 3′uridylation facilitates the assembly of MIWI/piRNA complex for efficient target regulation in mouse male germ cells, 11th Author, 2022
- LLPS of FXR1 drives spermiogenesis by activating translation of stored mRNAs, 24th Author, 2022
- Noncanonical functions of PIWIL1/piRNAs in animal male germ cells and human diseases, 11th Author, 2022
- Small Noncoding RNAs in Reproduction and Infertility, 11th Author, 2021
- Initiation of Parental Genome Reprogramming in Fertilized Oocyte by Splicing Kinase SRPK1-Catalyzed Protamine Phosphorylation, 1st Author, 2020
- A Translation-Activating Function of MIWI/piRNA during Mouse Spermiogenesis, 3rd Author, 2019
- Ubiquitination-Deficient Mutations in Human Piwi Cause Male Infertility by Impairing Histone-to-Protamine Exchange during Spermiogenesis, 1st Author, 2017
- MIWI and piRNA-Mediated Cleavage of Messenger RNAs in Mouse Testes, Not mentioned, 2015
- Pachytene piRNAs instruct massive mRNA elimination during late spermiogenesis, 1st Author, 2014
- piRNA-Triggered MIWI Ubiquitination and Removal by APC/C in Late Spermatogenesis, 2nd Author, 2013
Awards
- Shanghai Natural Science Award First Prize (2022): Provincial Level
- National Maternal and Child Health Science and Technology Award: Natural Science First Prize (2019): Ministerial Level
- NIH Pathway to Independence Award (K99/R00) (2018): Ministerial Level
- Outstanding Doctoral Dissertation of the Chinese Academy of Sciences (2014): Institutional Level
