Areas of Focus
- 生殖遗传过程中的RNA分子调控
- 生殖遗传过程中的染色质重塑调控
- RNA及功能基因组学方法与技术
Work Experience
- 2018-07~2020-09 - 美国加州大学圣地亚哥分校 - NIH K99 项目PI
- 2015-04~2020-09 - 美国加州大学圣地亚哥分校 - 博士后研究
- 2013-07~2015-03 - 中国科学院上海生命科学研究院生物化学与细胞生物学研究所 - 助理研究员
Academic Background & Achievements
- 2007-09--2013-07 生物化学与分子生物学博士: 中国科学院大学
Publications
- Loss-of-function variants in human C12orf40 cause male infertility by blocking meiotic progression, 第11作者, 2023
- Small RNAs: An expanding world with therapeutic promises, 第11作者, 2023
- The PIWI-specific insertion module helps load longer piRNAs for translational activation essential for male fertility, 第18作者, 2023
- piRNA 3′uridylation facilitates the assembly of MIWI/piRNA complex for efficient target regulation in mouse male germ cells, 第11作者, 2022
- LLPS of FXR1 drives spermiogenesis by activating translation of stored mRNAs, 第24作者, 2022
- Noncanonical functions of PIWIL1/piRNAs in animal male germ cells and human diseases, 第11作者, 2022
- Small Noncoding RNAs in Reproduction and Infertility, 第11作者, 2021
- Initiation of Parental Genome Reprogramming in Fertilized Oocyte by Splicing Kinase SRPK1-Catalyzed Protamine Phosphorylation, 第1作者, 2020
- A Translation-Activating Function of MIWI/piRNA during Mouse Spermiogenesis, 第3作者, 2019
- Ubiquitination-Deficient Mutations in Human Piwi Cause Male Infertility by Impairing Histone-to-Protamine Exchange during Spermiogenesis, 第1作者, 2017
- MIWI and piRNA-Mediated Cleavage of Messenger RNAs in Mouse Testes, 未提及, 2015
- Pachytene piRNAs instruct massive mRNA elimination during late spermiogenesis, 第1作者, 2014
- piRNA-Triggered MIWI Ubiquitination and Removal by APC/C in Late Spermatogenesis, 第2作者, 2013
Awards
- 上海市自然科学奖一等奖 (2022): 省级
- 全国妇幼健康科学技术奖:自然科学一等奖 (2019): 部委级
- NIH Pathway to Independence Award (K99/R00) (2018): 部委级
- 中国科学院优秀博士学位论文 (2014): 院级