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Shushan Gao
Life Science
University of Chinese Academy of Sciences
Tianjin
Language: Chinese, English
Microbial
Natural Product
Biosynthesis
Enzymatic Mechanisms
Protein Engineering
Catalytic Mechanisms
Drug Biosynthesis
Biocatalysis
Medicinal Intermediates
Synthesis
Areas of Focus
- Microbial Natural Product Biosynthesis and Enzymatic Mechanisms
- Protein Engineering and Catalytic Mechanisms in Drug Biosynthesis
- Biocatalysis and Synthesis of Medicinal Intermediates
Work Experience
- 2022-03~Present - Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences - Researcher
- 2018-02~2022-03 - Institute of Microbiology, Chinese Academy of Sciences - Researcher
- 2014-11~2017-06 - University of California, Los Angeles - Postdoctoral Researcher
- 2011-09~2014-09 - University of Bristol - Postdoctoral Researcher
Academic Background & Achievements
- 2006-09--2011-07 PhD: Institute of Oceanology, Chinese Academy of Sciences
- 2002-09--2006-07 Bachelor's: Soochow University
Publications
- Structure-guided semi-rational design of an imine reductase for enantio-complementary synthesis of pyrrolidinamine, Not mentioned, 2023
- Tuning an Imine Reductase for the Asymmetric Synthesis of Azacycloalkylamines by Concise Structure-Guided Engineering, Not mentioned, 2022
- Beyond the cyclopropyl ring formation: fungal Aj_EasH catalyzes asymmetric hydroxylation of ergot alkaloids, Not mentioned, 2022
- Overproduction of medicinal ergot alkaloids based on a fungal platform, Not mentioned, 2022
- CRISPR-Cas system and anti-CRISPR protein research progress in microorganisms, Not mentioned, 2021
- Heterologous Production of Unnatural Flavipucine Family Products Provides Insights into Flavipucines Biosynthesis, Not mentioned, 2021
- TerC Is a Multifunctional and Promiscuous Flavoprotein Monooxygenase That Catalyzes Bimodal Oxidative Transformations, Not mentioned, 2021
- De novo biosynthesis and gram-level production of m-cresol in Aspergillus nidulans, Not mentioned, 2021
- A Dual-Plasmid CRISPR/Cas System for Mycotoxin Elimination in Polykaryotic Industrial Fungi, Not mentioned, 2020
- An anaerobic bacterium host system for heterologous expression of natural product biosynthetic gene clusters, Not mentioned, 2019
- Catalase Involved in Oxidative Cyclization of the Tetracyclic Ergoline of Fungal Ergot Alkaloids, Not mentioned, 2019
- Natural medicinal products of fungal origin, Not mentioned, 2019
- Biosynthesis of Heptacyclic Duclauxins Requires Extensive Redox Modifications of the Phenalenone Aromatic Polyketide, Not mentioned, 2018
- Recent Examples of β-Ketoglutarate-Dependent Mononuclear Non-Haem Iron Enzymes in Natural Product Biosyntheses, Not mentioned, 2018
- Genome Mining and Assembly-Line Biosynthesis of the UCS1025A Pyrrolizidinone Family of Fungal Alkaloids, Not mentioned, 2018
- Selected Mutations Reveal New Intermediates in the Biosynthesis of the Thiomarinols and Mupirocin Antibiotics, Not mentioned, 2017
- Enzyme-Catalyzed Intramolecular Enantioselective Hydroalkoxylation, Not mentioned, 2017
- Collaborative Biosynthesis of Maleimide- and Succinimide-Containing Natural Products by Fungal Polyketide Megasynthases, Not mentioned, 2017
- Identification and Heterologous Production of a Benzoyl-Primed Tricarboxylic Acid Polyketide Intermediate from the Zaragozic Acid A Biosynthetic Pathway, Not mentioned, 2017
- Elucidation of the relative and absolute stereochemistry of the kalimantacin/batumin antibiotics, Not mentioned, 2017
- Biochemical Characterization of a Eukaryotic Decalin-Forming Diels-Alderase, Not mentioned, 2016
- Rhizovarins A-F, Indole-Diterpenes from the Mangrove-Derived Endophytic Fungus Mucor irregularis QEN-189, Not mentioned, 2016
- Phenalenone Polyketide Cyclization Catalyzed by Fungal Polyketide Synthase and Flavin-Dependent Monooxygenase, Not mentioned, 2016
- Biosynthesis of Thiomarinol A and Related Metabolites of Pseudoalteromonas SANK73390, Not mentioned, 2014
- Biosynthesis of Mupirocin by Pseudomonas fluorescens NCIMB 10586 Involves Parallel Pathways, Not mentioned, 2014
- Chemical constituents of marine mangrove-derived endophytic fungus Alternaria tenuissima EN-192, Not mentioned, 2013
- Triazoles and Other N-Containing Metabolites from the Marine-Derived Endophytic Fungus Penicillium chrysogenum EN-118, Not mentioned, 2013
- Two New Secoanthraquinone Derivatives from the Marine-Derived Endophytic Fungus Aspergillus wentii EN-48, Not mentioned, 2013
- Cytotoxic Anthranilic Acid Derivatives from Deep Sea Sediment-Derived Fungus Penicillium paneum SD-44, Not mentioned, 2013
- Asperolides A-C, Tetranorlabdane Diterpenoids from the Marine Alga-Derived Endophytic Fungus Aspergillus wentii EN-48, Not mentioned, 2012
- Secondary Metabolites Produced by Solid Fermentation of the Marine-Derived Fungus Penicillium commune QSD-17, Not mentioned, 2012
- Chemical profile of the secondary metabolites produced by a deep-sea sediment-derived fungus Penicillium commune SD-118, Not mentioned, 2012
- Comazaphilones a-f, azaphilone derivatives from the marine sediment-derived fungus penicillium commune qsd-17, Not mentioned, 2011
- Triazole and Dihydroimidazole Alkaloids from the Marine Sediment-Derived Fungus Penicillium paneum SD-44, Not mentioned, 2011
- Conidiogenones h and i, two new diterpenes of cyclopiane class from a marine-derived endophytic fungus penicillium chrysogenum qen-24s, Not mentioned, 2011
- Nigerapyrones a-h, alpha-pyrone derivatives from the marine mangrove-derived endophytic fungus aspergillus niger ma-132, Not mentioned, 2011
- Penicisteroids A and B, antifungal and cytotoxic polyoxygenated steroids from the marine alga-derived endophytic fungus Penicillium chrysogenum QEN-24S, Not mentioned, 2011
- Secondary Metabolites from a Marine-Derived Endophytic Fungus Penicillium chrysogenum QEN-24S, Not mentioned, 2010
- Chemical Constituents of a Marine-Derived Endophytic Fungus Penicillium commune G2M, Not mentioned, 2010
- Perylene derivatives produced by alternaria alternata, an endophytic fungus isolated from laurencia species, Not mentioned, 2009
Awards
- Chinese Academy of Sciences Youth Innovation Promotion Association Outstanding Member (2023): Institute Level
- Chinese Academy of Sciences Youth Promotion Association (2019): Institute Level
- Chinese Academy of Sciences Cross-Innovation Cooperation Platform (2019): Other
- Chinese Academy of Sciences President's Award for Excellence (2011): Institute Level
