Professor | Guangyu Yang | Asia Growth Partners

Name	Guangyu Yang
Contact Information	yanggy@sjtu.edu.cn
Language ability	Chinese, English
Province	Shanghai

Name

Guangyu Yang

Contact Information

yanggy@sjtu.edu.cn

Language ability

Chinese, English

Province

Shanghai

University/Lab Affiliation and Title	Shanghai Jiao Tong University
Faculty	Life Sciences
Academic Background & Achievements	2003.09-2009.07 PhD in Biochemistry and Molecular Biology, Jilin University, Supervisor: Professor Yan Feng 2007.11-2008.10 Joint PhD, University of British Columbia, Supervisor: Professor Stephen G. Withers 2012.03-2013.06 Postdoctoral Fellow, University of British Columbia, Supervisor: Professor Stephen G. Withers
Work Experience	2018.01 - Present, Shanghai Jiao Tong University, School of Life Sciences and Technology, Researcher, PhD Supervisor 2013.01-2017.12 Shanghai Jiao Tong University, School of Life Sciences and Technology, Associate Researcher 2009.07-2012.12 Shanghai Jiao Tong University, School of Life Sciences and Technology, Lecturer
Awards	2019 Shanghai Society of Biological Engineering 'Dongfulong' Outstanding Young Scientist Award 2017 Tang Lixin Outstanding Scholar Award 2017 Shanghai Jiao Tong University 'Morning Star' Outstanding Young Scholar 2016 Shanghai Jiao Tong University 'SMC Morning Star Scholar' Outstanding Young Teacher Award (A) 2015 Shanghai Jiao Tong University 'Young Post Talent' Title 2013 Shanghai Jiao Tong University 'SMC Morning Star Scholar' Outstanding Young Teacher Award (B) 2010 Shanghai Jiao Tong University 'SMC Morning Star Scholar' Outstanding Young Teacher Award (C)

University/Lab Affiliation and Title

Shanghai Jiao Tong University

Faculty

Life Sciences

Academic Background & Achievements

2003.09-2009.07 PhD in Biochemistry and Molecular Biology, Jilin University, Supervisor: Professor Yan Feng
2007.11-2008.10 Joint PhD, University of British Columbia, Supervisor: Professor Stephen G. Withers
2012.03-2013.06 Postdoctoral Fellow, University of British Columbia, Supervisor: Professor Stephen G. Withers

Work Experience

2018.01 - Present, Shanghai Jiao Tong University, School of Life Sciences and Technology, Researcher, PhD Supervisor
2013.01-2017.12 Shanghai Jiao Tong University, School of Life Sciences and Technology, Associate Researcher
2009.07-2012.12 Shanghai Jiao Tong University, School of Life Sciences and Technology, Lecturer

Awards

2019 Shanghai Society of Biological Engineering 'Dongfulong' Outstanding Young Scientist Award
2017 Tang Lixin Outstanding Scholar Award
2017 Shanghai Jiao Tong University 'Morning Star' Outstanding Young Scholar
2016 Shanghai Jiao Tong University 'SMC Morning Star Scholar' Outstanding Young Teacher Award (A)
2015 Shanghai Jiao Tong University 'Young Post Talent' Title
2013 Shanghai Jiao Tong University 'SMC Morning Star Scholar' Outstanding Young Teacher Award (B)
2010 Shanghai Jiao Tong University 'SMC Morning Star Scholar' Outstanding Young Teacher Award (C)

Areas of Focus	Enzyme function and catalytic mechanism analysis Enzyme molecular design and directed evolution Construction of in vitro synthetic biology catalytic systems
Publications	Directed evolution of an α1,3-fucosyltransferase using a single-cell ultrahigh-throughput screening method, Yumeng Tan, Yong Zhang, Yunbin Han, Hao Liu, Haifeng Chen, Fuqiang Ma, Stephen G Withers, Yan Feng, Guangyu Yang, 2019 Efficient molecular evolution to generate enantioselective enzymes using a dual-channel microfluidic droplet screening platform, Fuqiang Ma, Meng Ting Chung, Yuan Yao, Robert Nidet, Lap Man Lee, Allen P. Liu, Yan Feng, Katsuo Kurabayashi, Guang-Yu Yang, 2018 Biosynthesis of plant-derived ginsenoside Rh2 in yeast via repurposing a key promiscuous microbial enzyme, Zhuang Y, Yang GY, Chen X, Liu Q, Zhang X, Deng Z, Feng Y, 2017 Structural insights into the broad substrate specificity of a novel Endo-glycoceramidase I belonging to a new subfamily of GH5 glycosidase, Han YB, Chen LQ, Li Z, Tan YM, Feng Y, Yang GY, 2017 Sequence Homolog-based Molecular Engineering for Shifting the Enzymatic pH Optimum, Fuqiang Ma, Yuan Xie, Manjie Luo, Shuhao Wang, You Hu, Yukun Liu, Yan Feng, Guang-Yu Yang, 2016 Substrate engineering enabling fluorescence droplet entrapment for IVC-FACS-based ultrahigh-throughput screening, Fuqiang Ma, Michael Fischer, Yunbin Han, Stephen G. Withers, Yan Feng, Guang-Yu Yang, 2016 A FRET Probe for Cell-Based Imaging of Ganglioside-Processing Enzyme Activity and High-Throughput Screening, Guang-Yu Yang, Caishun Li, Michael Fischer, Christopher W. Cairo, Yan Feng, Stephen G. Withers, 2015 Comprehensive Characterization of Sphingolipid Ceramide N-deacylase for the Synthesis and Fatty Acid Remodeling of Glycosphingolipids, Yun-Bin Han, Lie Wu, Jamie R. Rich, Feng-Tao Huang, Stephen G. Withers, Yan Feng, Guang-Yu Yang, 2015 A facile method for controlling the reaction equilibrium of sphingolipid ceramide N-deacylase for lyso-glycosphingolipid production, FT Huang, YB Han, Y Feng, GY Yang, 2015 Fluorescence Activated Cell Sorting as a General Ultra High-throughput Screening Method for Directed Evolution of Glycosyltransferases, Guangyu Yang, Jamie R. Rich, Michel Gilbert, Warren W. Wakarchuk, Yan Feng, Stephen G. Withers, 2010

Areas of Focus

Enzyme function and catalytic mechanism analysis
Enzyme molecular design and directed evolution
Construction of in vitro synthetic biology catalytic systems

Publications

Directed evolution of an α1,3-fucosyltransferase using a single-cell ultrahigh-throughput screening method, Yumeng Tan, Yong Zhang, Yunbin Han, Hao Liu, Haifeng Chen, Fuqiang Ma, Stephen G Withers, Yan Feng, Guangyu Yang, 2019
Efficient molecular evolution to generate enantioselective enzymes using a dual-channel microfluidic droplet screening platform, Fuqiang Ma, Meng Ting Chung, Yuan Yao, Robert Nidet, Lap Man Lee, Allen P. Liu, Yan Feng, Katsuo Kurabayashi, Guang-Yu Yang, 2018
Biosynthesis of plant-derived ginsenoside Rh2 in yeast via repurposing a key promiscuous microbial enzyme, Zhuang Y, Yang GY, Chen X, Liu Q, Zhang X, Deng Z, Feng Y, 2017
Structural insights into the broad substrate specificity of a novel Endo-glycoceramidase I belonging to a new subfamily of GH5 glycosidase, Han YB, Chen LQ, Li Z, Tan YM, Feng Y, Yang GY, 2017
Sequence Homolog-based Molecular Engineering for Shifting the Enzymatic pH Optimum, Fuqiang Ma, Yuan Xie, Manjie Luo, Shuhao Wang, You Hu, Yukun Liu, Yan Feng, Guang-Yu Yang, 2016
Substrate engineering enabling fluorescence droplet entrapment for IVC-FACS-based ultrahigh-throughput screening, Fuqiang Ma, Michael Fischer, Yunbin Han, Stephen G. Withers, Yan Feng, Guang-Yu Yang, 2016
A FRET Probe for Cell-Based Imaging of Ganglioside-Processing Enzyme Activity and High-Throughput Screening, Guang-Yu Yang, Caishun Li, Michael Fischer, Christopher W. Cairo, Yan Feng, Stephen G. Withers, 2015
Comprehensive Characterization of Sphingolipid Ceramide N-deacylase for the Synthesis and Fatty Acid Remodeling of Glycosphingolipids, Yun-Bin Han, Lie Wu, Jamie R. Rich, Feng-Tao Huang, Stephen G. Withers, Yan Feng, Guang-Yu Yang, 2015
A facile method for controlling the reaction equilibrium of sphingolipid ceramide N-deacylase for lyso-glycosphingolipid production, FT Huang, YB Han, Y Feng, GY Yang, 2015
Fluorescence Activated Cell Sorting as a General Ultra High-throughput Screening Method for Directed Evolution of Glycosyltransferases, Guangyu Yang, Jamie R. Rich, Michel Gilbert, Warren W. Wakarchuk, Yan Feng, Stephen G. Withers, 2010

Enzyme Catalysis Mechanism Molecular Design Evolution Synthetic Biology In Vitro Biocatalysis Protein Engineering Biochemistry

Jianbo Chen - Shanghai Normal University

Wei Ding - Shanghai Jiao Tong University

Jun Ni - Shanghai Jiao Tong University

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