Professor | 杨广宇 | 数字化转型顾问

Name	杨广宇
Contact Information	yanggy@sjtu.edu.cn
Language ability	中文, 英语
Province	上海

Name

杨广宇

Contact Information

yanggy@sjtu.edu.cn

Language ability

中文, 英语

Province

上海

University/Lab Affiliation and Title	上海交通大学
Faculty	Life Sciences
Academic Background & Achievements	2003.09-2009.07 吉林大学，生物化学与分子生物学，博士，导师：冯雁教授 2007.11-2008.10 不列颠哥伦比亚大学，联合培养博士，导师：Stephen G. Withers教授 2012.03-2013.06 不列颠哥伦比亚大学, 博士后, 导师：Stephen G.Withers教授
Work Experience	2018.01 -迄今，上海交通大学生命科学技术学院，研究员，博士生导师 2013.01-2017.12上海交通大学生命科学技术学院，副研究员 2009.07-2012.12 上海交通大学生命科学技术学院，讲师
Awards	2019年获上海市生物工程学会“东富龙”优秀青年科学家奖 2017年获唐立新优秀学者奖 2017年获得上海交通大学“晨星优秀青年学者”称号 2016年获上海交通大学“SMC晨星学者优秀青年教师奖励计划”（A类） 2015年获上海交通大学“青年岗位能手”称号 2013获上海交通大学“SMC晨星学者优秀青年教师奖励计划”（B类） 2010获上海交通大学“SMC晨星学者优秀青年教师奖励计划”（C类）

University/Lab Affiliation and Title

上海交通大学

Faculty

Life Sciences

Academic Background & Achievements

2003.09-2009.07 吉林大学，生物化学与分子生物学，博士，导师：冯雁教授
2007.11-2008.10 不列颠哥伦比亚大学，联合培养博士，导师：Stephen G. Withers教授
2012.03-2013.06 不列颠哥伦比亚大学, 博士后, 导师：Stephen G.Withers教授

Work Experience

2018.01 -迄今，上海交通大学生命科学技术学院，研究员，博士生导师
2013.01-2017.12上海交通大学生命科学技术学院，副研究员
2009.07-2012.12 上海交通大学生命科学技术学院，讲师

Awards

2019年获上海市生物工程学会“东富龙”优秀青年科学家奖
2017年获唐立新优秀学者奖
2017年获得上海交通大学“晨星优秀青年学者”称号
2016年获上海交通大学“SMC晨星学者优秀青年教师奖励计划”（A类）
2015年获上海交通大学“青年岗位能手”称号
2013获上海交通大学“SMC晨星学者优秀青年教师奖励计划”（B类）
2010获上海交通大学“SMC晨星学者优秀青年教师奖励计划”（C类）

Areas of Focus	酶功能及催化机制解析酶分子设计与定向进化体外合成生物学催化体系的构建
Publications	Directed evolution of an α1,3-fucosyltransferase using a single-cell ultrahigh-throughput screening method, Yumeng Tan, Yong Zhang, Yunbin Han, Hao Liu, Haifeng Chen, Fuqiang Ma, Stephen G Withers, Yan Feng, Guangyu Yang, 2019 Efficient molecular evolution to generate enantioselective enzymes using a dual-channel microfluidic droplet screening platform, Fuqiang Ma, Meng Ting Chung, Yuan Yao, Robert Nidet, Lap Man Lee, Allen P. Liu, Yan Feng, Katsuo Kurabayashi, Guang-Yu Yang, 2018 Biosynthesis of plant-derived ginsenoside Rh2 in yeast via repurposing a key promiscuous microbial enzyme, Zhuang Y, Yang GY, Chen X, Liu Q, Zhang X, Deng Z, Feng Y, 2017 Structural insights into the broad substrate specificity of a novel Endo-glycoceramidase I belonging to a new subfamily of GH5 glycosidase, Han YB, Chen LQ, Li Z, Tan YM, Feng Y, Yang GY, 2017 Sequence Homolog-based Molecular Engineering for Shifting the Enzymatic pH Optimum, Fuqiang Ma, Yuan Xie, Manjie Luo, Shuhao Wang, You Hu, Yukun Liu, Yan Feng, Guang-Yu Yang, 2016 Substrate engineering enabling fluorescence droplet entrapment for IVC-FACS-based ultrahigh-throughput screening, Fuqiang Ma, Michael Fischer, Yunbin Han, Stephen G. Withers, Yan Feng, Guang-Yu Yang, 2016 A FRET Probe for Cell-Based Imaging of Ganglioside-Processing Enzyme Activity and High-Throughput Screening, Guang-Yu Yang, Caishun Li, Michael Fischer, Christopher W. Cairo, Yan Feng, Stephen G. Withers, 2015 Comprehensive Characterization of Sphingolipid Ceramide N-deacylase for the Synthesis and Fatty Acid Remodeling of Glycosphingolipids, Yun-Bin Han, Lie Wu, Jamie R. Rich, Feng-Tao Huang, Stephen G. Withers, Yan Feng, Guang-Yu Yang, 2015 A facile method for controlling the reaction equilibrium of sphingolipid ceramide N-deacylase for lyso-glycosphingolipid production, FT Huang, YB Han, Y Feng, GY Yang, 2015 Fluorescence Activated Cell Sorting as a General Ultra High-throughput Screening Method for Directed Evolution of Glycosyltransferases, Guangyu Yang, Jamie R. Rich, Michel Gilbert, Warren W. Wakarchuk, Yan Feng, Stephen G. Withers, 2010

Areas of Focus

酶功能及催化机制解析
酶分子设计与定向进化
体外合成生物学催化体系的构建

Publications

Directed evolution of an α1,3-fucosyltransferase using a single-cell ultrahigh-throughput screening method, Yumeng Tan, Yong Zhang, Yunbin Han, Hao Liu, Haifeng Chen, Fuqiang Ma, Stephen G Withers, Yan Feng, Guangyu Yang, 2019
Efficient molecular evolution to generate enantioselective enzymes using a dual-channel microfluidic droplet screening platform, Fuqiang Ma, Meng Ting Chung, Yuan Yao, Robert Nidet, Lap Man Lee, Allen P. Liu, Yan Feng, Katsuo Kurabayashi, Guang-Yu Yang, 2018
Biosynthesis of plant-derived ginsenoside Rh2 in yeast via repurposing a key promiscuous microbial enzyme, Zhuang Y, Yang GY, Chen X, Liu Q, Zhang X, Deng Z, Feng Y, 2017
Structural insights into the broad substrate specificity of a novel Endo-glycoceramidase I belonging to a new subfamily of GH5 glycosidase, Han YB, Chen LQ, Li Z, Tan YM, Feng Y, Yang GY, 2017
Sequence Homolog-based Molecular Engineering for Shifting the Enzymatic pH Optimum, Fuqiang Ma, Yuan Xie, Manjie Luo, Shuhao Wang, You Hu, Yukun Liu, Yan Feng, Guang-Yu Yang, 2016
Substrate engineering enabling fluorescence droplet entrapment for IVC-FACS-based ultrahigh-throughput screening, Fuqiang Ma, Michael Fischer, Yunbin Han, Stephen G. Withers, Yan Feng, Guang-Yu Yang, 2016
A FRET Probe for Cell-Based Imaging of Ganglioside-Processing Enzyme Activity and High-Throughput Screening, Guang-Yu Yang, Caishun Li, Michael Fischer, Christopher W. Cairo, Yan Feng, Stephen G. Withers, 2015
Comprehensive Characterization of Sphingolipid Ceramide N-deacylase for the Synthesis and Fatty Acid Remodeling of Glycosphingolipids, Yun-Bin Han, Lie Wu, Jamie R. Rich, Feng-Tao Huang, Stephen G. Withers, Yan Feng, Guang-Yu Yang, 2015
A facile method for controlling the reaction equilibrium of sphingolipid ceramide N-deacylase for lyso-glycosphingolipid production, FT Huang, YB Han, Y Feng, GY Yang, 2015
Fluorescence Activated Cell Sorting as a General Ultra High-throughput Screening Method for Directed Evolution of Glycosyltransferases, Guangyu Yang, Jamie R. Rich, Michel Gilbert, Warren W. Wakarchuk, Yan Feng, Stephen G. Withers, 2010

酶催化机制分子设计进化合成生物学体外生物催化蛋白质工程生物化学

毕焱 - 同济大学

Area of Focus
多能性 | 原态 | 人类 | 调控 | 机制 | 类胚胎 | 模型 | 体外 | 构建 | 应用

吴丽 - 同济大学

Area of Focus
重编程 | 体细胞 | 机制 | 多能干细胞 | 临床样本 | 体外 | 女性生殖系统 | 模拟 | 再生医学 | 研究

杨广宇 - 上海交通大学

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