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杨广宇
Life Science
上海交通大学
上海
Language: 英语, 汉语
酶
催化
机制
分子设计
进化
合成生物学
体外
系统构建
生物工程
生物催化
Areas of Focus
- 酶功能及催化机制解析
- 酶分子设计与定向进化
- 体外合成生物学催化体系的构建
Work Experience
- 2018.01 -迄今，上海交通大学生命科学技术学院，研究员，博士生导师
- 2013.01-2017.12上海交通大学生命科学技术学院，副研究员
- 2009.07-2012.12 上海交通大学生命科学技术学院，讲师
Academic Background & Achievements
- 2012.03-2013.06 不列颠哥伦比亚大学, 博士后, 导师：Stephen G.Withers教授
- 2007.11-2008.10 不列颠哥伦比亚大学，联合培养博士，导师：Stephen G. Withers教授
- 2007.03-2007.06 首尔国立大学, 访问学生，导师：Young Je Yoo教授
- 2003.09-2009.07 吉林大学，生物化学与分子生物学，博士，导师：冯雁教授
- 1999.09-2003.07 吉林大学，生物科学，学士
Publications
- Directed evolution of an α1,3-fucosyltransferase using a single-cell ultrahigh-throughput screening method, Yumeng Tan, Yong Zhang, Yunbin Han, Hao Liu, Haifeng Chen, Fuqiang Ma, Stephen G Withers, Yan Feng, Guangyu Yang, 2019
- Efficient molecular evolution to generate enantioselective enzymes using a dual-channel microfluidic droplet screening platform, Fuqiang Ma, Meng Ting Chung, Yuan Yao, Robert Nidet, Lap Man Lee, Allen P. Liu, Yan Feng, Katsuo Kurabayashi, Guang-Yu Yang, 2018
- Biosynthesis of plant-derived ginsenoside Rh2 in yeast via repurposing a key promiscuous microbial enzyme, Zhuang Y, Yang GY, Chen X, Liu Q, Zhang X, Deng Z, Feng Y, 2017
- Structural insights into the broad substrate specificity of a novel Endo-glycoceramidase I belonging to a new subfamily of GH5 glycosidase, Han YB, Chen LQ, Li Z, Tan YM, Feng Y, Yang GY, 2017
- Sequence Homolog-based Molecular Engineering for Shifting the Enzymatic pH Optimum, Fuqiang Ma, Yuan Xie, Manjie Luo, Shuhao Wang, You Hu, Yukun Liu, Yan Feng, Guang-Yu Yang, 2016
- Substrate engineering enabling fluorescence droplet entrapment for IVC-FACS-based ultrahigh-throughput screening, Fuqiang Ma, Michael Fischer, Yunbin Han, Stephen G. Withers, Yan Feng, Guang-Yu Yang, 2016
- A FRET Probe for Cell-Based Imaging of Ganglioside-Processing Enzyme Activity and High-Throughput Screening, Guang-Yu Yang, Caishun Li, Michael Fischer, Christopher W. Cairo, Yan Feng, Stephen G. Withers, 2015
- Comprehensive Characterization of Sphingolipid Ceramide N-deacylase for the Synthesis and Fatty Acid Remodeling of Glycosphingolipids, Yun-Bin Han, Lie Wu, Jamie R. Rich, Feng-Tao Huang, Stephen G. Withers, Yan Feng, Guang-Yu Yang, 2015
- A facile method for controlling the reaction equilibrium of sphingolipid ceramide N-deacylase for lyso-glycosphingolipid production, FT Huang, YB Han, Y Feng, GY Yang, 2015
- Fluorescence Activated Cell Sorting as a General Ultra High-throughput Screening Method for Directed Evolution of Glycosyltransferases, Guangyu Yang, Jamie R. Rich, Michel Gilbert, Warren W. Wakarchuk, Yan Feng, Stephen G. Withers, 2010
Awards
- 2019年获上海市生物工程学会“东富龙”优秀青年科学家奖
- 2017年获唐立新优秀学者奖
- 2017年获得上海交通大学“晨星优秀青年学者”称号
- 2016年获上海交通大学“SMC晨星学者优秀青年教师奖励计划”（A类）
- 2015年获上海交通大学“青年岗位能手”称号
- 2013获上海交通大学“SMC晨星学者优秀青年教师奖励计划”（B类）
- 2010获上海交通大学“SMC晨星学者优秀青年教师奖励计划”（C类）
