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Guangyu Yang
Life Science
Shanghai Jiao Tong University
Shanghai
Language: English, Chinese
Enzyme
Catalysis
Mechanism
Molecular Design
Evolution
Synthetic Biology
In Vitro
System Construction
Bioengineering
Biocatalysis
Areas of Focus
- Enzyme function and catalytic mechanism analysis
- Enzyme molecular design and directed evolution
- Construction of in vitro synthetic biology catalytic systems
Work Experience
- 2018.01 - Present, Shanghai Jiao Tong University, School of Life Sciences and Technology, Researcher, PhD Supervisor
- 2013.01-2017.12 Shanghai Jiao Tong University, School of Life Sciences and Technology, Associate Researcher
- 2009.07-2012.12 Shanghai Jiao Tong University, School of Life Sciences and Technology, Lecturer
Academic Background & Achievements
- 2012.03-2013.06 Postdoctoral Fellow, University of British Columbia, Supervisor: Prof. Stephen G. Withers
- 2007.11-2008.10 Joint PhD, University of British Columbia, Supervisor: Prof. Stephen G. Withers
- 2007.03-2007.06 Visiting Student, Seoul National University, Supervisor: Prof. Young Je Yoo
- 2003.09-2009.07 PhD in Biochemistry and Molecular Biology, Jilin University, Supervisor: Prof. Yan Feng
- 1999.09-2003.07 Bachelor of Biological Sciences, Jilin University
Publications
- Directed evolution of an α1,3-fucosyltransferase using a single-cell ultrahigh-throughput screening method, Yumeng Tan, Yong Zhang, Yunbin Han, Hao Liu, Haifeng Chen, Fuqiang Ma, Stephen G Withers, Yan Feng, Guangyu Yang, 2019
- Efficient molecular evolution to generate enantioselective enzymes using a dual-channel microfluidic droplet screening platform, Fuqiang Ma, Meng Ting Chung, Yuan Yao, Robert Nidet, Lap Man Lee, Allen P. Liu, Yan Feng, Katsuo Kurabayashi, Guang-Yu Yang, 2018
- Biosynthesis of plant-derived ginsenoside Rh2 in yeast via repurposing a key promiscuous microbial enzyme, Zhuang Y, Yang GY, Chen X, Liu Q, Zhang X, Deng Z, Feng Y, 2017
- Structural insights into the broad substrate specificity of a novel Endo-glycoceramidase I belonging to a new subfamily of GH5 glycosidase, Han YB, Chen LQ, Li Z, Tan YM, Feng Y, Yang GY, 2017
- Sequence Homolog-based Molecular Engineering for Shifting the Enzymatic pH Optimum, Fuqiang Ma, Yuan Xie, Manjie Luo, Shuhao Wang, You Hu, Yukun Liu, Yan Feng, Guang-Yu Yang, 2016
- Substrate engineering enabling fluorescence droplet entrapment for IVC-FACS-based ultrahigh-throughput screening, Fuqiang Ma, Michael Fischer, Yunbin Han, Stephen G. Withers, Yan Feng, Guang-Yu Yang, 2016
- A FRET Probe for Cell-Based Imaging of Ganglioside-Processing Enzyme Activity and High-Throughput Screening, Guang-Yu Yang, Caishun Li, Michael Fischer, Christopher W. Cairo, Yan Feng, Stephen G. Withers, 2015
- Comprehensive Characterization of Sphingolipid Ceramide N-deacylase for the Synthesis and Fatty Acid Remodeling of Glycosphingolipids, Yun-Bin Han, Lie Wu, Jamie R. Rich, Feng-Tao Huang, Stephen G. Withers, Yan Feng, Guang-Yu Yang, 2015
- A facile method for controlling the reaction equilibrium of sphingolipid ceramide N-deacylase for lyso-glycosphingolipid production, FT Huang, YB Han, Y Feng, GY Yang, 2015
- Fluorescence Activated Cell Sorting as a General Ultra High-throughput Screening Method for Directed Evolution of Glycosyltransferases, Guangyu Yang, Jamie R. Rich, Michel Gilbert, Warren W. Wakarchuk, Yan Feng, Stephen G. Withers, 2010
Awards
- 2019 Dongfulong Outstanding Young Scientist Award, Shanghai Society of Biological Engineering
- 2017 Tang Lixin Outstanding Scholar Award
- 2017 Morning Star Outstanding Young Scholar, Shanghai Jiao Tong University
- 2016 SMC Morning Star Scholar Outstanding Young Teacher Award (Type A), Shanghai Jiao Tong University
- 2015 Young Post Talent, Shanghai Jiao Tong University
- 2013 SMC Morning Star Scholar Outstanding Young Teacher Award (Type B), Shanghai Jiao Tong University
- 2010 SMC Morning Star Scholar Outstanding Young Teacher Award (Type C), Shanghai Jiao Tong University
