2001-09--2006-02 Ph.D.: University of Massachusetts Amherst
1998-09--2001-06 Master's: Tsinghua University
1993-09--1998-06 Bachelor's: Tsinghua University
2011-11~Present - Wuhan Institute of Virology, Chinese Academy of Sciences - Researcher
2011-03~2011-11 - Colorado State University - Research Scientist
2007-06~2011-02 - Colorado State University - Postdoctoral Researcher
2006-04~2007-06 - University of Massachusetts Amherst - Postdoctoral Researcher
Research
Mechanism of RNA virus genome replication
Crystal Structures of Flavivirus NS5 Guanylyltransferase Reveal a GMP-Arginine Adduct, Jia, Hengxia, Zhong, Yao, Peng, Chao, Gong, Peng, 2022
Insights into Two-Metal-Ion Catalytic Mechanism of Cap-Snatching Endonuclease of Ebinur Lake Virus in Bunyavirales, Kuang, Wenhua, Zhang, Huanyu, Cai, Yan, Zhang, Guilin, Deng, Fei, Li, Hailong, Hu, Zhihong, Guo, Yu, Wang, Manli, Zhou, Yiwu, Gong, Peng, 2022
Crystal structure of a pre-chemistry viral RNA-dependent RNA polymerase suggests participation of two basic residues in catalysis, Li, Rui, Wang, Meihua, Gong, Peng, 2022
Structural basis of transition from initiation to elongation in de novo viral RNA-dependent RNA polymerases, Jiqin Wu, Xinyu Wang, Qiaojie Liu, Guoliang Lu, Peng Gong, 2022
Crystal structure of a tick-borne flavivirus RNA-dependent RNA polymerase suggests a host adaptation hotspot in RNA viruses, Yang, Jieyu, Jing, Xuping, Yi, Wenfu, Li, XiaoDan, Yao, Chen, Zhang, Bo, Zheng, Zhenhua, Wang, Hanzhong, Gong, Peng, 2021
An induced-fit de novo initiation mechanism suggested by a pestivirus RNA-dependent RNA polymerase, Zhang, BuYu, Liu, Weichi, Jia, Hengxia, Lu, Guoliang, Gong, Peng, 2021
A nucleobase-binding pocket in a viral RNA-dependent RNA polymerase contributes to elongation complex stability, Shi, Wei, Ye, HanQing, Deng, ChengLin, Li, Rui, Zhang, Bo, Gong, Peng, 2020
Structural Basis for RNA Replication by the SARS-CoV-2 Polymerase, Wang, Quan, Wu, Jiqin, Wang, Haofeng, Gao, Yan, Liu, Qiaojie, Mu, An, Ji, Wenxin, Yan, Liming, Zhu, Yan, Zhu, Chen, Fang, Xiang, Yang, Xiaobao, Huang, Yucen, Gao, Hailong, Liu, Fengjiang, Ge, Ji, Sun, Qianqian, Yang, Xiuna, Xu, Wenqing, Liu, Zhijie, Yang, Haitao, Lou, Zhiyong, Jiang, Biao, Guddat, Luke W, Gong, Peng, Rao, Zihe, 2020
Stringent control of the RNA-dependent RNA polymerase translocation revealed by multiple intermediate structures, Meihua Wang, Rui Li, Bo Shu, Xuping Jing, HanQing Ye, Peng Gong, 2020
A conformation-based intra-molecular initiation factor identified in the flavivirus RNA-dependent RNA polymerase, Jiqin Wu, HanQing Ye, QiuYan Zhang, Guoliang Lu, Bo Zhang, Peng Gong, 2020
A unique intra-molecular fidelity-modulating mechanism identified in a viral RNA-dependent RNA polymerase, Liu, Weichi, Shi, Xiaoling, Gong, Peng, 2018
The uncoupling of catalysis and translocation in the viral RNA-dependent RNA polymerase, Shu, Bo, Gong, Peng, 2017
Uncoupling of Protease trans-Cleavage and Helicase Activities in Pestivirus NS3, Zheng, Fengwei, Lu, Guoliang, Li, Ling, Gong, Peng, Pan, Zishu, 2017
Three Conserved Regions in Baculovirus Sulfhydryl Oxidase P33 Are Critical for Enzymatic Activity and Function, Kuang, Wenhua, Zhang, Huanyu, Wang, Manli, Zhou, NingYi, Deng, Fei, Wang, Hualin, Gong, Peng, Hu, Zhihong, 2017
Structural basis of viral RNA-dependent RNA polymerase catalysis and translocation, Shu, Bo, Gong, Peng, 2016
A Structural Overview of RNA-Dependent RNA Polymerases from the Flaviviridae Family, Wu, Jiqin, Liu, Weichi, Gong, Peng, 2015
Perturbation in the Conserved Methyltransferase-Polymerase Interface of Flavivirus NS5 Differentially Affects Polymerase Initiation and Elongation, Wu, Jiqin, Lu, Guoliang, Zhang, Bo, Gong, Peng, 2015
The Interface between Methyltransferase and Polymerase of NS5 Is Essential for Flavivirus Replication, Li, XiaoDan, Shan, Chao, Deng, ChengLin, Ye, HanQing, Shi, PeiYong, Yuan, ZhiMing, Gong, Peng, Zhang, Bo, 2014
Crystal Structure of the Full-Length Japanese Encephalitis Virus NS5 Reveals a Conserved Methyltransferase-Polymerase Interface, Guoliang Lu, Peng Gong, 2013
Structures of Coxsackievirus, Rhinovirus, and Poliovirus Polymerase Elongation Complexes Solved by Engineering RNA Mediated Crystal Contacts, Gong, Peng, Kortus, Matthew G, Nix, Jay C, Davis, Ralph E, Peersen, Olve B, 2013
Structure basis for active site closure by the poliovirus RNA-dependent RNA polymerase, Gong Peng, 2010
A quantitative stopped-flow fluorescence assay for measuring polymerase elongation rates, Gong, Peng, Campagnola, Grace, Peersen, Olve B, 2009
An N-terminal clamp restrains the motor domains of the bacterial transcription-repair coupling factor Mfd, Murphy, Michael N, Gong, Peng, Ralto, Kenneth, Manelyte, Laura, Savery, Nigel J, Theis, Karsten, 2009
Mechanism of instability in abortive cycling by T7 RNA polymerase, Gong, Peng, Martin, Craig T, 2006
Structure and function in promoter escape by T7 RNA polymerase, Martin, CT, Esposito, EA, Theis, K, Gong, P, Moldave, K, 2005
Topological and conformational analysis of the initiation and elongation complex of T7 RNA polymerase suggests a new twist, Theis, K, Gong, P, Martin, CT, 2004
Initial bubble collapse plays a key role in the transition to elongation in T7 RNA polymerase, Gong, P, Esposito, EA, Martin, CT, 2004
Novel phosphoryl derivatization method for peptide sequencing by electrospray ionization mass spectrometry, Jing Chen, Yi Chen, Peng Gong, Yang Jiang, YanMei Li, YuFen Zhao, 2002
