Deciphering Reaction Pathway of Mononuclear Iron Enzymes Catalyzed N-C Triple Bond Formation in Isocyanide Lipopeptides and Polyketides Biosynthesis., Jiahai Zhou, 2022
Dioxane Bridge Formation during the Biosynthesis of Spectinomycin Involves a Twitch Radical SAM Dehydrogenase that May Have Evolved from an Epimerase., Jiahai Zhou, 2022
Structural Insight into the Catalytic Mechanism of the Endoperoxide Synthase FtmOx1., Lian Wu, Zhanfeng Wang, Yixin Cen, Binju Wang, Jiahai Zhou, 2022
Harzianic Acid from Trichoderma afroharzianum Is a Natural Product Inhibitor of Acetohydroxyacid Synthase., Jiahai Zhou, 2021
Crystal Structures and Catalytic Mechanism of l-erythro-3,5-Diaminohexanoate Dehydrogenase and Rational Engineering for Asymmetric Synthesis of β-Amino Acids., Jiahai Zhou, 2021
A Polyketide Cyclase That Forms Medium-ring Lactones., DeWei Gao, Cooper S Jamieson, Gaoqian Wang, Yan Yan, Jiahai Zhou, K N Houk, Yi Tang, 2021
Harzianic Acid from Trichoderma afroharzianum Is a Natural Product Inhibitor of Acetohydroxyacid Synthase., Linan Xie, Xin Zang, Wei Cheng, Zhuan Zhang, Jiahai Zhou, Mengbin Chen, Yi Tang, 2021
Current Understanding toward Isonitrile Group Biosynthesis and Mechanism., TzuYu Chen, Jinfeng Chen, Yijie Tang, Jiahai Zhou, Yisong Guo, Weichen Chang, 2021
Crystal Structures and Catalytic Mechanism of l-erythro-3,5-Diaminohexanoate Dehydrogenase and Rational Engineering for Asymmetric Synthesis of beta-Amino Acids., Na Liu, Lian Wu, Jinhui Feng, Xiang Sheng, Jian Li, Xi Chen, Jianjiong Li, Weidong Liu, Jiahai Zhou, Qiaqing Wu, Dunming Zhu, 2021
Reductive inactivation of the hemiaminal pharmacophore for resistance against tetrahydroisoquinoline antibiotics., WanHong Wen, Yue Zhang, YingYing Zhang, Qian Yu, ChuChu Jiang, ManCheng Tang, JinYue Pu, Lian Wu, YiLei Zhao, Ting Shi, Jiahai Zhou, GongLi Tang, 2021
An enzymatic Alder-ene reaction., Masao Ohashi, Cooper S Jamieson, Yujuan Cai, Dan Tan, Daiki Kanayama, ManCheng Tang, Sarah M Anthony, Jason V Chari, Joyann S Barber, Elias Picazo, Thomas B Kakule, Shugeng Cao, Neil K Garg, Jiahai Zhou, K N Houk, Yi Tang, 2020
Biosynthesis of the fungal glyceraldehyde-3-phosphate dehydrogenase inhibitor heptelidic acid and mechanism of self-resistance., Yan Yan, Xin Zang, Cooper S Jamieson, HsiaoChing Lin, K N Houk, Jiahai Zhou, Yi Tang, 2020
Engineering of Decameric D-fructose-6-phosphate Aldolase A by Combinatorial Modulation of Inter- and Intra-subunit Interactions., Jiahai Zhou, 2020
Enhanced the catalytic efficiency and thermostability of maltooligosyltrehalose synthase from Arthrobacter ramosus by directed evolution., Chun Chen, Lingqia Su, Lian Wu, Jiahai Zhou, Jing Wu, 2020
Pathway from N-Alkylglycine to Alkylisonitrile Catalyzed by Iron(II) and 2-Oxoglutarate-Dependent Oxygenases., TzuYu Chen, Jinfeng Chen, Yijie Tang, Jiahai Zhou, Yisong Guo, Weichen Chang, 2020
Regio- and Stereoselective Steroid Hydroxylation at the C7-Position by Cytochrome P450 Monooxygenase Mutants., Jiahai Zhou, 2020
Structure-guided engineering of a Thermobifida fusca cutinase for enhanced hydrolysis on natural polyester substrate., Qilei Dong, Shuguang Yuan, Lian Wu, Lingqia Su, Qiaoling Zhao, Jing Wu, Weixue Huang, Jiahai Zhou, 2020
Discovery of enzymatic Alder-ene reaction and origins of catalytic selectivity., Jiahai Zhou, 2020
Single-Step Replacement of an Unreactive C-H Bond by a C-S Bond Using Polysulfide as the Direct Sulfur Source in the Anaerobic Ergothioneine Biosynthesis., Ronghai Cheng, Lian Wu, Rui Lai, Chao Peng, Nathchar Naowarojna, Weiyao Hu, Xinhao Li, Stephen A Whelan, Norman Lee, Juan Lopez, Changming Zhao, Youhua Yong, Jiahui Xue, Xuefeng Jiang, Mark W Grinstaff, Zixin Deng, Jiesheng Chen, Qiang Cui, Jiahai Zhou, Pinghua Liu, 2020
Structural Basis for Stereoselective Dehydration and Hydrogen-Bonding Catalysis by the SAM-Dependent Pericyclase LepI., Yujuan Cai, Yang Hai, Masao Ohashi, Cooper S Jamieson, Marc GarciaBorras, K N Houk, Jiahai Zhou, Yi Tang, 2019
Stereodivergent Protein Engineering of an Enzyme to Access All Possible Stereoisomers Bearing Multiple Stereocenters., Jiahai Zhou, 2019
Resistance-gene directed discovery of a natural product herbicide with a new mode of action., Yi Tang, Steve Jacobsen, 2019
Directed Evolution of a Highly Active \"Cysteine Lipase\" with a Cys-His-Asp Catalytic Triad., Jiahai Zhou, 2019
Structural Basis of a Broadly Selective Acyltransferase from the Polyketide Synthase of Splenocin., Yuan Li, Wan Zhang, Hui Zhang, Wenya Tian, Lian Wu, Shuwen Wang, Mengmeng Zheng, Jinru Zhang, Chenghai Sun, Zixin Deng, Yuhui Sun, Xudong Qu, Jiahai Zhou, 2018
Structural Insight into Enantioselective Inversion of an Alcohol Dehydrogenase Reveals a \"Polar Gate\" in Stereorecognition of Diaryl Ketones., Jieyu Zhou, Yue Wang, Guochao Xu, Lian Wu, Ruizhi Han, Ulrich Schwaneberg, Yijian Rao, YiLei Zhao, Jiahai Zhou, Ye Ni, 2018
Structural and Computational Insight into the Catalytic Mechanism of Limonene Epoxide Hydrolase Mutants in Stereoselective Transformations., Zhoutong Sun, Richard Lonsdale, Lian Wu, H C Stephen Chan, XuDong Kong, Shuguang Yuan, Jiahai Zhou, Manfred T Reetz, 2018
