2005 - PhD in Biochemistry: University of Illinois at Urbana-Champaign
Published over 40 papers in international SCI journals
2005-2010 - Postdoctoral Research: Scripps Research Institute and Salk Institute
2010-Present - Professor: Sun Yat-sen University
Research
Protein structure and function relationship Molecular mechanisms of enzyme catalysis Structural basis of protein-protein and protein-nucleic acid interactions Inhibitor design based on the 3D structure of biomacromolecules
The C-terminal loop of Arabidopsis thaliana guanosine deaminase is essential to catalysis., Jia, Q., Zeng, H., Li H., Xiao, N., Tang, J., Gao, S., Zhang, J., Xie, W., 2021
The Crystal Structure of the Spodoptera litura Chemosensory Protein CSP8., Jia, Q., Zeng, H., Zhang, J., Gao, S., Xiao, N., Tang, J., Dong., X., Xie, W., 2021
ALKBH1 promotes lung cancer by regulating m6A RNA demethylation., Li, H., Zhang, Y., Guo, Y., Liu, R., Yu, Q., Gong, L., Liu, Z., Xie, W., Wang, C., 2021
Functional and structural investigation of N-terminal domain of the SpTad2/3 heterodimeric tRNA deaminase., Liu, X., Zhou, J., Ge, R., Xie, W., 2021
Mechanistic Insight into the Peptide Binding Modes to Two M. tb MazF Toxins., Chen, R., Zhou, J., Xie, W., 2021
A novel AKR1C3 specific prodrug th3424 with potent antitumor activity in liver Cancer., He, P., Wang, C., Wang, Y., Wang, C., Zhou, C., Cao, D., Li, J., Bushnell, D., Li, Q., Kornberg, R., Xie, W., Wang, Z., 2021
Structural insights into an MsmUdgX mutant capable of both crosslinking and uracil excision capability., Jia, Q., Zeng, H., Tu, J., Sun, L., Cao, W., Xie, W., 2021
Crystal structure of the yeast heterodimeric ADAT2/3 deaminase., Liu, X., Chen, R., Sun, Y., Chen, R., Zhou, J., Tian, Q., Tao, X., Zhang, Z., Luo, G., Xie, W., 2020
Conserved conformational changes in the regulation of Mycobacterium tuberculosis MazEF-mt1., Chen, R., Zhou, J., Sun, R., Du, C., Xie, W., 2020
Engineering of β-Glucosidase Bgl15 with simultaneously enhanced glucose tolerance and thermostability to improve its performance in high-solid cellulose hydrolysis., Cao, L., Chen, R., Huang, X., Li, S., Zhang, S., Yang, X., Qin, Z., Kong, W., Xie, W., Liu, Y., 2020
Structure of a tRNA-specific deaminase with compromised deamination activity., Liu, H., Wu, S., Ran, D., Xie W., 2020
Insight into tartrate inhibition patterns in vitro and in vivo based on cocrystal structure with UDP-glycosyltransferase 2B15., Zhang, L., Zhu, L., Qu, W., Wu, F., Hu, M., Xie, W., Liu, Z., Wang, C., 2020
Improving the cellobiose-hydrolysis activity and glucose-tolerance of a thermostable β-glucosidase through rational design., Liu, X., Cao, L., Zeng J., Liu, Y., Xie W., 2019
Suicide inactivation of the uracil DNA glycosylase UdgX by covalent complex formation., Tu, J., Chen, R., Yang, Y., Cao, W., Xie, W., 2019
Alternative conformation induced by substrate binding for Arabidopsis thaliana N6-methyl-AMP deaminase., Jia, Q., Xie, W., 2019
Structural and Biochemical Characterization of the Cognate and Heterologous Interactions of the MazEF-mt9 TA System., Chen, R., Tu, J., Tan, Y., Cai, X., Yang, C., Deng, X., Su, B., Ma, S., Liu, X., Ma, P., Du, C., Xie, W., 2019
Enhancing the Thermostability of Highly Active and Glucose-Tolerant β-Glucosidase Ks5A7 by Directed Evolution for Good Performance of Three Properties., Cao, L., Chen, R., Huang X., Qin Z., Kong W., Xie, W., and Liu, Y. H., 2018
Structure of Schlafen13 reveals a new class of tRNA/rRNA- targeting RNase engaged in translational control., Yang, J., Deng, X., Li, Y., Ma, X., Feng, J., Yu, B., Chen, Y., Luo, Y., Wang, X., Chen, M., Fang, Z., Zheng, F., Li, Y., Zhong, Q., Kang. T., Song, L., Xu, R., Zeng, M., Chen, W., Zhang, H., Xie, W., Gao, S., 2018
Legionella pneumophila effector WipA, a bacterial PPP protein phosphatase with PTP activity., Jia Q., Lin Y., Gou X., He L., Shen D., Chen D., Xie W., Lu Y., 2018
Structural insight into the methyltransfer mechanism of the bifunctional Trm5., Wang, C., Jia, Q., Zeng, J., Chen, R., Xie, W., 2017
The crystal structure of the Pyrococcus abyssi mono-functional methyltransferase PaTrm5b., Wu, J., Jia, Q., Wu, S., Zeng, H., Sun, Y., Wang, C., Ge, R., Xie, W., 2017
A flexible cofactor-binding loop in the novel arginine methyltransferase Sfm1., Wang, C., Zeng, J., Xie, W., 2017
Crystal structure and thermostability characterization of EV-D68-3Dpol., Wang, C., Wang, C., Li, Q., Wang, Z., Xie, W., 2017
SMUG2 DNA glycosylase from Pedobacter heparinus as a new subfamily of the UDG superfamily., Pang, P., Yang, Y., Li, J., Wang, Z., Cao, W., Xie, W., 2017
Structural and biochemical insights into the 2'-O-methylation of pyrimidines 34 in tRNA., Pang, P., Deng, X., Wang, Z., Xie, W., 2017
Structures of a glucose-tolerant beta-glucosidase provide insights into its mechanism., Pang, P., Cao, L. C., Liu, Y. H., Xie, W., Wang, Z., 2017
Substrate Recognition Mechanism of the Putative Yeast Carnosine N-methyltransferase., Liu, X., Wu, J., Sun, Y., Xie, W., 2017
An unconventional family 1 uracil DNA glycosylase in Nitratifractor salsuginis., Li, J., Chen, R., Yang, Y., Zhang, Z., Fang, G. C., Xie, W., Cao, W., 2017
Structure of the MazF-mt9 toxin, a tRNA-specific endonuclease from Mycobacterium tuberculosis., Chen, R., Tu, J., Liu, Z., Meng, F., Ma, P., Ding, Z., Yang, C., Chen, L., Deng, X., Xie, W., 2017
Engineering of a thermostable esterase Est816 to improve its quorum-quenching activity and the underlying structural basis., Liu X, Cao L, Xin-jiong Fan, Liu Y, Xie, W., 2016
Crystal structures of the bifunctional tRNA methyltransferase Trm5a., Wang, C., Jia, Q., Chen, R., Wei, Y., Li, J., Ma, J., Xie, W., 2016
Crystal structures of RidA, an important enzyme for the prevention of toxic side products., Liu, X., Zeng J., Chen X., Xie, W., 2016
Crystal structure of the wild-type human GlyRS bound with tRNAGly in a productive conformation., Qin, X., Deng, X., Chen, L., Xie, W., 2016
Structural basis of substrate specificity in Geobacter metallireducens SMUG1., Zhang, Z., Shen, J., Yang, Y., Li, J., Cao, W., Xie, W., 2016
Large conformational changes of insertion 3 in human glycyl-tRNA synthetase (hGlyRS) during catalysis., Deng, X., Qin, X., Chen, L., Jia, Q., Zhang, Y., Zhang, Z., Lei, D., Ren, G., Zhou, Z., Wang, Z., Li, Q., Xie, W., 2016
Crystal structure of E. coli endonuclease V, an essential enzyme for deamination repair., Zhang, Z., Jia, Q., Zhou, C., Xie, W., 2015
SerRS-tRNASec complex structures reveal mechanism of the first step in selenocysteine biosynthesis., Wang, C., Guo, Y., Tian, Q., Jia, Q., Gao, Y., Zhang, Q., Zhou, C., Xie, W., 2015
Structural basis for recognition of G-1-containing tRNA by histidyl-tRNA synthetase., Tian, Q., Wang, C., Liu, Y., Xie, W., 2015
Enhancing the Thermostability of Feruloyl Esterase EstF27 by Directed Evolution and the Underlying Structural Basis., Cao, L. C., Chen, R., Xie, W., Liu, Y., 2015
Structure of human endonuclease V as an inosine-specific ribonuclease., Zhang, Z., Hao, Z., Wang, Z., Li, Q., Xie, W., 2014
Cocrystal structures of glycyl-tRNA synthetase in complex with tRNA suggest multiple conformational states in glycylation., Qin, X., Hao, Z., Tian, Q., Zhang, Z., Zhou, C., Xie, W., 2014
Area of Focus
Nmr | Biomolecules | 3D Structure | Molecular Biology | Cell Biology | Analytical Chemistry | Protein Structure | Dna | Molecular Mechanisms | Tumor Development
