Professor | Xinzheng Zhang | Asia Growth Partners

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Name	Xinzheng Zhang
Contact Information	xzzhang@ibp.ac.cn
Language ability	Chinese, English
Province	Beijing

Upload Avatar (500 x 500)

Name

Xinzheng Zhang

Contact Information

xzzhang@ibp.ac.cn

Language ability

Chinese, English

Province

Beijing

University/Lab Affiliation and Title	University of Chinese Academy of Sciences
Faculty	Life Sciences
Academic Background & Achievements	2003-09 to 2008-06 Ph.D. in Science: Peking University 1999-09 to 2003-06 Bachelor's in Science: Peking University
Work Experience	2014-10 to Present - Institute of Biophysics, Chinese Academy of Sciences - Researcher 2009-01 to 2014-09 - Purdue University, USA - Postdoctoral Researcher
Awards	Zhongyuan Concord Life Medicine Award, Innovation Breakthrough Award (2018)

University/Lab Affiliation and Title

University of Chinese Academy of Sciences

Faculty

Life Sciences

Academic Background & Achievements

2003-09 to 2008-06 Ph.D. in Science: Peking University
1999-09 to 2003-06 Bachelor's in Science: Peking University

Work Experience

2014-10 to Present - Institute of Biophysics, Chinese Academy of Sciences - Researcher
2009-01 to 2014-09 - Purdue University, USA - Postdoctoral Researcher

Awards

Zhongyuan Concord Life Medicine Award, Innovation Breakthrough Award (2018)

Areas of Focus	Cryo-electron microscopy for studying the structure and function of important protein complexes Development of cryo-electron microscopy methods Cryo-electron microscopy for studying the 3D structure of viruses and mechanisms of virus invasion, infection, and antibody neutralization
Publications	In situ structure of the red algal phycobilisome–PSII–PSI–LHC megacomplex, Xin You, Xing Zhang, Jing Cheng, Yanan Xiao, ma jianfei, Shan Sun, Zhang, Xinzheng, Hong-Wei Wang, SenFang Sui, 2023 Determining protein structures in cellular lamella at pseudo-atomic resolution by GisSPA, Jing Cheng, Tong Liu, Xin You, Fa Zhang, Sen-Fang Sui, Xiaohua Wan, Xinzheng Zhang, 2023 Structure of Semliki Forest virus in complex with its receptor VLDLR, Duanfang Cao, Bingting Ma, Ziyi Cao, Xinzheng Zhang, Ye Xiang, 2023 The reduction of FIB damage on cryo-lamella by lowering energy of ion beam revealed by a quantitative analysis, Qi yang, chunling wu, dongjie zhu, Junxi Li, Jing Cheng, Xinzheng Zhang, 2023 An electron counting algorithm improves imaging of proteins with low-acceleration-voltage cryo-electron microscope, Zhu, Dongjie, Shi, Huigang, Wu, Chunling, Zhang, Xinzheng, 2022 Supramolecular assembly of chloroplast NADH dehydrogenase-like complex with photosystem I from Arabidopsis thaliana, su xiaodong, cao duanfang, pan xiaowei, Shi, Lifang, Liu, Zhenfeng, Dall’Osto Luca, bassi roberto, Zhang, Xinzheng, 李梅, 2022 Structure of Venezuelan equine encephalitis virus with its receptor LDLRAD3, Ma, Bingting, Huang, Cuiqing, Ma, Jun, Xiang, Ye, Zhang, Xinzheng, 2021 Structure of Machupo virus polymerase in complex with matrix protein Z, Ma, Jun, Zhang, Shuangyue, Zhang, Xinzheng, 2021 Structural Insight into Phospholipid Transport by the MlaFEBD Complex from P. aeruginosa, Zhou, Changping, Shi, Huigang, Zhang, Manfeng, Zhou, Lijun, Xiao, Le, Feng, Shasha, Im, Wonpil, Zhou, Min, Zhang, Xinzheng, Huang, Yihua, 2021 Low-cooling-rate freezing in biomolecular cryo-electron microscopy for recovery of initial frames, Wu, Chunling, Shi, Huigang, Zhu, Dongjie, Fan, Kelong, Zhang, Xinzheng, 2021 Effect of charge on protein preferred orientation at the air-water interface in cryo-electron microscopy, Li, Bufan, Zhu, Dongjie, Shi, Huigang, Zhang, Xinzheng, 2021 Determining structures in a native environment using single-particle cryoelectron microscopy images, Cheng, Jing, Li, Bufan, Si, Long, Zhang, Xinzheng, 2021 Structural insights into assembly, operation and inhibition of a type I restriction-modification system, Gao, Yina, Cao, Duanfang, Zhu, Jingpeng, Feng, Han, Luo, Xiu, Liu, Songqing, Yan, XiaoXue, Zhang, Xinzheng, Gao, Pu, 2020 Cryo-EM structure of the nonameric CsgG-CsgF complex and its implications for controlling curli biogenesis in Enterobacteriaceae, Zhang, Manfeng, Shi, Huigang, Zhang, Xuemei, Zhang, Xinzheng, Huang, Yihua, 2020 Structures of the portal vertex reveal essential protein-protein interactions for Herpesvirus assembly and maturation, Wang, Nan, Chen, Wenyuan, Zhu, Ling, Zhu, Dongjie, Feng, Rui, Wang, Jialing, Zhu, Bin, Zhang, Xinzheng, Chen, Xiaoqing, Liu, Xianjie, Yan, Runbin, Ni, Dongyao, Zhou, Grace Guoying, Liu, Hongrong, Rao, Zihe, Wang, Xiangxi, 2020 Structural basis for energy and electron transfer of the photosystem I-IsiA-flavodoxin supercomplex, Cao, Peng, Cao, Duanfang, Si, Long, Su, Xiaodong, Tian, Lijin, Chang, Wenrui, Liu, Zhenfeng, Zhang, Xinzheng, Li, Mei, 2020 Conformational activation of ribosome recycling by intra- and inter-molecular dynamics of RRF, Song, Guangtao, Xu, Benjin, Shi, Huigang, Zhang, Yong, Zhang, Dejiu, Cao, Xintao, Liu, Zengrui, Guo, Ran, Guan, YanZhong, Chu, Yanhui, Zhang, Xinzheng, Lou, Jizhong, Qin, Yan, 2020 Structural basis for electron transport mechanism of complex I-like photosynthetic NAD(P)H dehydrogenase, Xiaowei Pan, Duanfang Cao, Fen Xie, Fang Xu, Xiaodong Su, Hualing Mi, Xinzheng Zhang, Mei Li, 2020 Cryo-EM analysis of the post-fusion structure of the SARS-CoV spike glycoprotein, Fan, Xiaoyi, Cao, Duanfang, Kong, Lingfei, Zhang, Xinzheng, 2020 Structural insights into sodium transport by the oxaloacetate decarboxylase sodium pump, Xu, Xin, Shi, Huigang, Gong, Xiaowen, Chen, Pu, Gao, Ying, Zhang, Xinzheng, Xiang, Song, 2020 Structural basis for nucleosome-mediated inhibition of cGAS activity, Cao, Duanfang, Han, Xiaonan, Fan, Xiaoyi, Xu, RuiMing, Zhang, Xinzheng, 2020 Structure Studies of the CRISPR-Csm Complex Reveal Mechanism of Co-transcriptional Interference, You, Lilan, Ma, Jun, Wang, Jiuyu, Artamonova, Daria, Wang, Min, Liu, Liang, Xiang, Hua, Severinov, Konstantin, Zhang, Xinzheng, Wang, Yanli, 2019 Structural insight into RNA synthesis by influenza D polymerase, Peng, Qi, Liu, Yuqian, Peng, Ruchao, Wang, Min, Yang, Wei, Song, Hao, Chen, Yuhai, Liu, Sheng, Han, Min, Zhang, Xinzheng, Wang, Peiyi, Yan, Jinghua, Zhang, Buchang, Qi, Jianxun, Deng, Tao, Gao, George F, Shi, Yi, 2019 Cryo-EM Structure of the African Swine Fever Virus, Liu, Sheng, Luo, Yuzi, Wang, Yajuan, Li, Shihua, Zhao, Zhennan, Bi, Yuhai, Sun, Junqing, Peng, Ruchao, Song, Hao, Zhu, Dongjie, Sun, Yuan, Li, Su, Zhang, Li, Wang, Wei, Sun, Yeping, Qi, Jianxun, Yan, Jinghua, Shi, Yi, Zhang, Xinzheng, Wang, Peiyi, Qiu, HuaJi, Gao, George F, 2019 High-quality, high-throughput cryo-electron microscopy data collection via beam tilt and astigmatism-free beam-image shift, Wu, Chunling, Huang, Xiaojun, Cheng, Jing, Zhu, Dongjie, Zhang, Xinzheng, 2019 Near-atomic structure of a giant virus, Qianglin Fang, Dongjie Zhu, Irina Agarkova, Jagat Adhikari, Thomas Klose, Yue Liu, Zhenguo Chen, Yingyuan Sun, Michael L Gross, James L Van Etten, Xinzheng Zhang, Michael G Rossmann, 2019 Antenna arrangement and energy transfer pathways of a green algal photosystem-I-LHCI supercomplex, Su, Xiaodong, Ma, Jun, Pan, Xiaowei, Zhao, Xuelin, Chang, Wenrui, Liu, Zhenfeng, Zhang, Xinzheng, Li, Mei, 2019 Structure of the maize photosystem I supercomplex with light-harvesting complexes I and II, Pan, Xiaowei, Ma, Jun, Su, Xiaodong, Cao, Peng, Chang, Wenrui, Liu, Zhenfeng, Zhang, Xinzheng, Li, Mei, 2018 Assembly mechanism of the CARMA1-BCL10-MALT1-TRAF6 signalosome, David, Liron, Li, Yang, Ma, Jun, Garner, Ethan, Zhang, Xinzheng, Wu, Hao, 2018 Structure of the herpes simplex virus type 2 C-capsid with capsid-vertex-specific component, Jialing Wang, Shuai Yuan, Dongjie Zhu, Hao Tang, Nan Wang, Wenyuan Chen, Qiang Gao, Yuhua Li, Junzhi Wang, Hongrong Liu, Xinzheng Zhang, Zihe Rao, Xiangxi Wang, 2018 RNA介导切割RNA的Cas13a复合物分子结构, Liang, Liu, Xueyan, Li, Jun, Ma, Zongqiang, Li, Lilan, You, Jiuyu, Wang, Min, Wang, 章新政, 王艳丽, 2018 Pushing the resolution limit by correcting the Ewald sphere effect in single-particle Cryo-EM reconstructions, Dongjie Zhu, Xiangxi Wang, Qianglin Fang, James L Van Etten, Michael G Rossmann, Zihe Rao, Xinzheng Zhang, 2018 Implication for alphavirus host-cell entry and assembly indicated by a 3.5 angstrom resolution cryo-EM structure, Chen, Lihong, Wang, Ming, Zhu, Dongjie, Sun, Zhenzhao, Ma, Jun, Wang, Jinglin, Kong, Lingfei, Wang, Shida, Liu, Zaisi, Wei, Lili, He, Yuwen, Wang, Jingfei, Zhang, Xinzheng, 2018

Areas of Focus

Cryo-electron microscopy for studying the structure and function of important protein complexes
Development of cryo-electron microscopy methods
Cryo-electron microscopy for studying the 3D structure of viruses and mechanisms of virus invasion, infection, and antibody neutralization

Publications

In situ structure of the red algal phycobilisome–PSII–PSI–LHC megacomplex, Xin You, Xing Zhang, Jing Cheng, Yanan Xiao, ma jianfei, Shan Sun, Zhang, Xinzheng, Hong-Wei Wang, SenFang Sui, 2023
Determining protein structures in cellular lamella at pseudo-atomic resolution by GisSPA, Jing Cheng, Tong Liu, Xin You, Fa Zhang, Sen-Fang Sui, Xiaohua Wan, Xinzheng Zhang, 2023
Structure of Semliki Forest virus in complex with its receptor VLDLR, Duanfang Cao, Bingting Ma, Ziyi Cao, Xinzheng Zhang, Ye Xiang, 2023
The reduction of FIB damage on cryo-lamella by lowering energy of ion beam revealed by a quantitative analysis, Qi yang, chunling wu, dongjie zhu, Junxi Li, Jing Cheng, Xinzheng Zhang, 2023
An electron counting algorithm improves imaging of proteins with low-acceleration-voltage cryo-electron microscope, Zhu, Dongjie, Shi, Huigang, Wu, Chunling, Zhang, Xinzheng, 2022
Supramolecular assembly of chloroplast NADH dehydrogenase-like complex with photosystem I from Arabidopsis thaliana, su xiaodong, cao duanfang, pan xiaowei, Shi, Lifang, Liu, Zhenfeng, Dall’Osto Luca, bassi roberto, Zhang, Xinzheng, 李梅, 2022
Structure of Venezuelan equine encephalitis virus with its receptor LDLRAD3, Ma, Bingting, Huang, Cuiqing, Ma, Jun, Xiang, Ye, Zhang, Xinzheng, 2021
Structure of Machupo virus polymerase in complex with matrix protein Z, Ma, Jun, Zhang, Shuangyue, Zhang, Xinzheng, 2021
Structural Insight into Phospholipid Transport by the MlaFEBD Complex from P. aeruginosa, Zhou, Changping, Shi, Huigang, Zhang, Manfeng, Zhou, Lijun, Xiao, Le, Feng, Shasha, Im, Wonpil, Zhou, Min, Zhang, Xinzheng, Huang, Yihua, 2021
Low-cooling-rate freezing in biomolecular cryo-electron microscopy for recovery of initial frames, Wu, Chunling, Shi, Huigang, Zhu, Dongjie, Fan, Kelong, Zhang, Xinzheng, 2021
Effect of charge on protein preferred orientation at the air-water interface in cryo-electron microscopy, Li, Bufan, Zhu, Dongjie, Shi, Huigang, Zhang, Xinzheng, 2021
Determining structures in a native environment using single-particle cryoelectron microscopy images, Cheng, Jing, Li, Bufan, Si, Long, Zhang, Xinzheng, 2021
Structural insights into assembly, operation and inhibition of a type I restriction-modification system, Gao, Yina, Cao, Duanfang, Zhu, Jingpeng, Feng, Han, Luo, Xiu, Liu, Songqing, Yan, XiaoXue, Zhang, Xinzheng, Gao, Pu, 2020
Cryo-EM structure of the nonameric CsgG-CsgF complex and its implications for controlling curli biogenesis in Enterobacteriaceae, Zhang, Manfeng, Shi, Huigang, Zhang, Xuemei, Zhang, Xinzheng, Huang, Yihua, 2020
Structures of the portal vertex reveal essential protein-protein interactions for Herpesvirus assembly and maturation, Wang, Nan, Chen, Wenyuan, Zhu, Ling, Zhu, Dongjie, Feng, Rui, Wang, Jialing, Zhu, Bin, Zhang, Xinzheng, Chen, Xiaoqing, Liu, Xianjie, Yan, Runbin, Ni, Dongyao, Zhou, Grace Guoying, Liu, Hongrong, Rao, Zihe, Wang, Xiangxi, 2020
Structural basis for energy and electron transfer of the photosystem I-IsiA-flavodoxin supercomplex, Cao, Peng, Cao, Duanfang, Si, Long, Su, Xiaodong, Tian, Lijin, Chang, Wenrui, Liu, Zhenfeng, Zhang, Xinzheng, Li, Mei, 2020
Conformational activation of ribosome recycling by intra- and inter-molecular dynamics of RRF, Song, Guangtao, Xu, Benjin, Shi, Huigang, Zhang, Yong, Zhang, Dejiu, Cao, Xintao, Liu, Zengrui, Guo, Ran, Guan, YanZhong, Chu, Yanhui, Zhang, Xinzheng, Lou, Jizhong, Qin, Yan, 2020
Structural basis for electron transport mechanism of complex I-like photosynthetic NAD(P)H dehydrogenase, Xiaowei Pan, Duanfang Cao, Fen Xie, Fang Xu, Xiaodong Su, Hualing Mi, Xinzheng Zhang, Mei Li, 2020
Cryo-EM analysis of the post-fusion structure of the SARS-CoV spike glycoprotein, Fan, Xiaoyi, Cao, Duanfang, Kong, Lingfei, Zhang, Xinzheng, 2020
Structural insights into sodium transport by the oxaloacetate decarboxylase sodium pump, Xu, Xin, Shi, Huigang, Gong, Xiaowen, Chen, Pu, Gao, Ying, Zhang, Xinzheng, Xiang, Song, 2020
Structural basis for nucleosome-mediated inhibition of cGAS activity, Cao, Duanfang, Han, Xiaonan, Fan, Xiaoyi, Xu, RuiMing, Zhang, Xinzheng, 2020
Structure Studies of the CRISPR-Csm Complex Reveal Mechanism of Co-transcriptional Interference, You, Lilan, Ma, Jun, Wang, Jiuyu, Artamonova, Daria, Wang, Min, Liu, Liang, Xiang, Hua, Severinov, Konstantin, Zhang, Xinzheng, Wang, Yanli, 2019
Structural insight into RNA synthesis by influenza D polymerase, Peng, Qi, Liu, Yuqian, Peng, Ruchao, Wang, Min, Yang, Wei, Song, Hao, Chen, Yuhai, Liu, Sheng, Han, Min, Zhang, Xinzheng, Wang, Peiyi, Yan, Jinghua, Zhang, Buchang, Qi, Jianxun, Deng, Tao, Gao, George F, Shi, Yi, 2019
Cryo-EM Structure of the African Swine Fever Virus, Liu, Sheng, Luo, Yuzi, Wang, Yajuan, Li, Shihua, Zhao, Zhennan, Bi, Yuhai, Sun, Junqing, Peng, Ruchao, Song, Hao, Zhu, Dongjie, Sun, Yuan, Li, Su, Zhang, Li, Wang, Wei, Sun, Yeping, Qi, Jianxun, Yan, Jinghua, Shi, Yi, Zhang, Xinzheng, Wang, Peiyi, Qiu, HuaJi, Gao, George F, 2019
High-quality, high-throughput cryo-electron microscopy data collection via beam tilt and astigmatism-free beam-image shift, Wu, Chunling, Huang, Xiaojun, Cheng, Jing, Zhu, Dongjie, Zhang, Xinzheng, 2019
Near-atomic structure of a giant virus, Qianglin Fang, Dongjie Zhu, Irina Agarkova, Jagat Adhikari, Thomas Klose, Yue Liu, Zhenguo Chen, Yingyuan Sun, Michael L Gross, James L Van Etten, Xinzheng Zhang, Michael G Rossmann, 2019
Antenna arrangement and energy transfer pathways of a green algal photosystem-I-LHCI supercomplex, Su, Xiaodong, Ma, Jun, Pan, Xiaowei, Zhao, Xuelin, Chang, Wenrui, Liu, Zhenfeng, Zhang, Xinzheng, Li, Mei, 2019
Structure of the maize photosystem I supercomplex with light-harvesting complexes I and II, Pan, Xiaowei, Ma, Jun, Su, Xiaodong, Cao, Peng, Chang, Wenrui, Liu, Zhenfeng, Zhang, Xinzheng, Li, Mei, 2018
Assembly mechanism of the CARMA1-BCL10-MALT1-TRAF6 signalosome, David, Liron, Li, Yang, Ma, Jun, Garner, Ethan, Zhang, Xinzheng, Wu, Hao, 2018
Structure of the herpes simplex virus type 2 C-capsid with capsid-vertex-specific component, Jialing Wang, Shuai Yuan, Dongjie Zhu, Hao Tang, Nan Wang, Wenyuan Chen, Qiang Gao, Yuhua Li, Junzhi Wang, Hongrong Liu, Xinzheng Zhang, Zihe Rao, Xiangxi Wang, 2018
RNA介导切割RNA的Cas13a复合物分子结构, Liang, Liu, Xueyan, Li, Jun, Ma, Zongqiang, Li, Lilan, You, Jiuyu, Wang, Min, Wang, 章新政, 王艳丽, 2018
Pushing the resolution limit by correcting the Ewald sphere effect in single-particle Cryo-EM reconstructions, Dongjie Zhu, Xiangxi Wang, Qianglin Fang, James L Van Etten, Michael G Rossmann, Zihe Rao, Xinzheng Zhang, 2018
Implication for alphavirus host-cell entry and assembly indicated by a 3.5 angstrom resolution cryo-EM structure, Chen, Lihong, Wang, Ming, Zhu, Dongjie, Sun, Zhenzhao, Ma, Jun, Wang, Jinglin, Kong, Lingfei, Wang, Shida, Liu, Zaisi, Wei, Lili, He, Yuwen, Wang, Jingfei, Zhang, Xinzheng, 2018

Cryo-Electron Microscopy Protein Complexes 3D Structure Virus Invasion Virus Infection Antibody Neutralization Structural Biology Microscopy Methods Biophysics Electron Microscopy

Peng Gong - University of Chinese Academy of Sciences

Jiahai Zhou - University of Chinese Academy of Sciences

Wei Xie - Sun Yat-Sen University

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